Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51050
Gene name	Peptidase inhibitor 15
Gene symbol	PI15
Synonyms (NCBI Gene)	CRISP8P24TIP25TI
Chromosome	8
Chromosome location	8q21.13
Summary	This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and

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Show/Hide all (173)

miRTarBase ID	miRNA	Experiments
MIRT1232610	hsa-miR-105	CLIP-seq
MIRT1232611	hsa-miR-1256	CLIP-seq
MIRT1232612	hsa-miR-1261	CLIP-seq
MIRT1232613	hsa-miR-141	CLIP-seq
MIRT1232614	hsa-miR-146a	CLIP-seq
MIRT1232615	hsa-miR-146b-5p	CLIP-seq
MIRT1232616	hsa-miR-183	CLIP-seq
MIRT1232617	hsa-miR-190	CLIP-seq
MIRT1232618	hsa-miR-190b	CLIP-seq
MIRT1232619	hsa-miR-200a	CLIP-seq
MIRT1232620	hsa-miR-204	CLIP-seq
MIRT1232621	hsa-miR-2053	CLIP-seq
MIRT1232622	hsa-miR-211	CLIP-seq
MIRT1232623	hsa-miR-299-3p	CLIP-seq
MIRT1232624	hsa-miR-29a	CLIP-seq
MIRT1232625	hsa-miR-29b	CLIP-seq
MIRT1232626	hsa-miR-29c	CLIP-seq
MIRT1232627	hsa-miR-3065-3p	CLIP-seq
MIRT1232628	hsa-miR-3121-5p	CLIP-seq
MIRT1232629	hsa-miR-3124-3p	CLIP-seq
MIRT1232630	hsa-miR-3127-3p	CLIP-seq
MIRT1232631	hsa-miR-3159	CLIP-seq
MIRT1232632	hsa-miR-3165	CLIP-seq
MIRT1232633	hsa-miR-3201	CLIP-seq
MIRT739847	hsa-miR-323b-3p	CLIP-seq
MIRT1232634	hsa-miR-34b	CLIP-seq
MIRT1232635	hsa-miR-34c-3p	CLIP-seq
MIRT1232636	hsa-miR-3616-5p	CLIP-seq
MIRT1232637	hsa-miR-362-5p	CLIP-seq
MIRT1232638	hsa-miR-3647-5p	CLIP-seq
MIRT1232639	hsa-miR-3653	CLIP-seq
MIRT1232640	hsa-miR-3658	CLIP-seq
MIRT1232641	hsa-miR-3667-3p	CLIP-seq
MIRT1232642	hsa-miR-3671	CLIP-seq
MIRT1232643	hsa-miR-3676	CLIP-seq
MIRT1232644	hsa-miR-371-5p	CLIP-seq
MIRT1232645	hsa-miR-371b-5p	CLIP-seq
MIRT1232646	hsa-miR-382	CLIP-seq
MIRT1232647	hsa-miR-3910	CLIP-seq
MIRT1232648	hsa-miR-3973	CLIP-seq
MIRT1232649	hsa-miR-410	CLIP-seq
MIRT1232650	hsa-miR-4276	CLIP-seq
MIRT1232651	hsa-miR-4291	CLIP-seq
MIRT1232652	hsa-miR-4434	CLIP-seq
MIRT1232653	hsa-miR-4491	CLIP-seq
MIRT1232654	hsa-miR-4516	CLIP-seq
MIRT1232655	hsa-miR-451b	CLIP-seq
MIRT1232656	hsa-miR-4531	CLIP-seq
MIRT1232657	hsa-miR-4536	CLIP-seq
MIRT1232658	hsa-miR-4642	CLIP-seq
MIRT1232659	hsa-miR-4657	CLIP-seq
MIRT1232660	hsa-miR-4684-3p	CLIP-seq
MIRT1232661	hsa-miR-4694-3p	CLIP-seq
MIRT1232662	hsa-miR-4698	CLIP-seq
MIRT1232663	hsa-miR-4715-5p	CLIP-seq
MIRT1232664	hsa-miR-4755-5p	CLIP-seq
MIRT1232665	hsa-miR-4791	CLIP-seq
MIRT1232666	hsa-miR-4795-3p	CLIP-seq
MIRT1232667	hsa-miR-4795-5p	CLIP-seq
MIRT1232668	hsa-miR-500b	CLIP-seq
MIRT1232669	hsa-miR-501-5p	CLIP-seq
MIRT1232670	hsa-miR-511	CLIP-seq
MIRT1232671	hsa-miR-520g	CLIP-seq
MIRT1232672	hsa-miR-520h	CLIP-seq
MIRT1232673	hsa-miR-539	CLIP-seq
MIRT1232674	hsa-miR-548l	CLIP-seq
MIRT1232675	hsa-miR-548m	CLIP-seq
MIRT1232676	hsa-miR-548p	CLIP-seq
MIRT1232677	hsa-miR-569	CLIP-seq
MIRT1232678	hsa-miR-573	CLIP-seq
MIRT1232679	hsa-miR-580	CLIP-seq
MIRT1232680	hsa-miR-589	CLIP-seq
MIRT1232681	hsa-miR-607	CLIP-seq
MIRT1232682	hsa-miR-623	CLIP-seq
MIRT1232683	hsa-miR-651	CLIP-seq
MIRT1232684	hsa-miR-656	CLIP-seq
MIRT1232685	hsa-miR-767-5p	CLIP-seq
MIRT1232686	hsa-miR-888	CLIP-seq
MIRT1232687	hsa-miR-9	CLIP-seq
MIRT1232621	hsa-miR-2053	CLIP-seq
MIRT1232629	hsa-miR-3124-3p	CLIP-seq
MIRT1232630	hsa-miR-3127-3p	CLIP-seq
MIRT2068344	hsa-miR-3198	CLIP-seq
MIRT1232634	hsa-miR-34b	CLIP-seq
MIRT1232635	hsa-miR-34c-3p	CLIP-seq
MIRT1232641	hsa-miR-3667-3p	CLIP-seq
MIRT1232642	hsa-miR-3671	CLIP-seq
MIRT2068345	hsa-miR-4309	CLIP-seq
MIRT2068346	hsa-miR-4652-3p	CLIP-seq
MIRT2068347	hsa-miR-4653-3p	CLIP-seq
MIRT2068348	hsa-miR-4778-5p	CLIP-seq
MIRT1232676	hsa-miR-548p	CLIP-seq
MIRT1232677	hsa-miR-569	CLIP-seq
MIRT1232681	hsa-miR-607	CLIP-seq
MIRT1232629	hsa-miR-3124-3p	CLIP-seq
MIRT1232630	hsa-miR-3127-3p	CLIP-seq
MIRT2295622	hsa-miR-3661	CLIP-seq
MIRT1232641	hsa-miR-3667-3p	CLIP-seq
MIRT1232648	hsa-miR-3973	CLIP-seq
MIRT1232671	hsa-miR-520g	CLIP-seq
MIRT1232672	hsa-miR-520h	CLIP-seq
MIRT1232674	hsa-miR-548l	CLIP-seq
MIRT2295623	hsa-miR-552	CLIP-seq
MIRT2295624	hsa-miR-579	CLIP-seq
MIRT2295625	hsa-miR-590-3p	CLIP-seq
MIRT1232681	hsa-miR-607	CLIP-seq
MIRT2295626	hsa-miR-631	CLIP-seq
MIRT2295627	hsa-miR-634	CLIP-seq
MIRT2295628	hsa-miR-664	CLIP-seq
MIRT2392501	hsa-miR-3664-5p	CLIP-seq
MIRT1232685	hsa-miR-767-5p	CLIP-seq
MIRT2456441	hsa-miR-1244	CLIP-seq
MIRT2456442	hsa-miR-135a	CLIP-seq
MIRT2456443	hsa-miR-135b	CLIP-seq
MIRT2456444	hsa-miR-142-3p	CLIP-seq
MIRT2456445	hsa-miR-3618	CLIP-seq
MIRT2456446	hsa-miR-455-5p	CLIP-seq
MIRT2456447	hsa-miR-934	CLIP-seq
MIRT1232642	hsa-miR-3671	CLIP-seq
MIRT1232681	hsa-miR-607	CLIP-seq
MIRT2593300	hsa-miR-1295	CLIP-seq
MIRT2593301	hsa-miR-129-5p	CLIP-seq
MIRT2593302	hsa-miR-203	CLIP-seq
MIRT2593303	hsa-miR-3064-3p	CLIP-seq
MIRT2593304	hsa-miR-3074-3p	CLIP-seq
MIRT2593305	hsa-miR-331-5p	CLIP-seq
MIRT2593306	hsa-miR-3545-3p	CLIP-seq
MIRT2593307	hsa-miR-3925-3p	CLIP-seq
MIRT2593308	hsa-miR-411	CLIP-seq
MIRT2593309	hsa-miR-4257	CLIP-seq
MIRT2593310	hsa-miR-4427	CLIP-seq
MIRT2593311	hsa-miR-4539	CLIP-seq
MIRT2593312	hsa-miR-4710	CLIP-seq
MIRT2593313	hsa-miR-4715-3p	CLIP-seq
MIRT2593314	hsa-miR-4717-5p	CLIP-seq
MIRT2593315	hsa-miR-4724-5p	CLIP-seq
MIRT2593316	hsa-miR-4747-3p	CLIP-seq
MIRT2593317	hsa-miR-4776-3p	CLIP-seq
MIRT2593318	hsa-miR-4792	CLIP-seq
MIRT2593319	hsa-miR-495	CLIP-seq
MIRT2593320	hsa-miR-515-5p	CLIP-seq
MIRT2593321	hsa-miR-548a-3p	CLIP-seq
MIRT2593322	hsa-miR-548e	CLIP-seq
MIRT2593323	hsa-miR-548f	CLIP-seq
MIRT2593324	hsa-miR-548u	CLIP-seq
MIRT1232681	hsa-miR-607	CLIP-seq
MIRT2593325	hsa-miR-766	CLIP-seq
MIRT1232685	hsa-miR-767-5p	CLIP-seq
MIRT2593300	hsa-miR-1295	CLIP-seq
MIRT2593301	hsa-miR-129-5p	CLIP-seq
MIRT2593302	hsa-miR-203	CLIP-seq
MIRT2593303	hsa-miR-3064-3p	CLIP-seq
MIRT2593304	hsa-miR-3074-3p	CLIP-seq
MIRT2593305	hsa-miR-331-5p	CLIP-seq
MIRT2593306	hsa-miR-3545-3p	CLIP-seq
MIRT2593307	hsa-miR-3925-3p	CLIP-seq
MIRT2593308	hsa-miR-411	CLIP-seq
MIRT2593309	hsa-miR-4257	CLIP-seq
MIRT2593310	hsa-miR-4427	CLIP-seq
MIRT2593311	hsa-miR-4539	CLIP-seq
MIRT2593312	hsa-miR-4710	CLIP-seq
MIRT2593313	hsa-miR-4715-3p	CLIP-seq
MIRT2593315	hsa-miR-4724-5p	CLIP-seq
MIRT2593316	hsa-miR-4747-3p	CLIP-seq
MIRT2593317	hsa-miR-4776-3p	CLIP-seq
MIRT2593318	hsa-miR-4792	CLIP-seq
MIRT2593321	hsa-miR-548a-3p	CLIP-seq
MIRT2593322	hsa-miR-548e	CLIP-seq
MIRT2593323	hsa-miR-548f	CLIP-seq
MIRT2593324	hsa-miR-548u	CLIP-seq
MIRT1232681	hsa-miR-607	CLIP-seq
MIRT2593325	hsa-miR-766	CLIP-seq
MIRT1232685	hsa-miR-767-5p	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
607076	8946	ENSG00000137558

O43692

Protein name

Peptidase inhibitor 15 (PI-15) (25 kDa trypsin inhibitor) (p25TI) (Cysteine-rich secretory protein 8) (CRISP-8) (SugarCrisp)

Protein function

Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00188	CAP	71 → 211	Cysteine-rich secretory protein family	Domain

Tissue specificity

TISSUE SPECIFICITY: Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland. {ECO:0000269|PubMed:11287197, ECO:0000269|PubMed:9473672}.

Sequence

MIAISAVSSALLFSLLCEASTVVLLNSTDSSPPTNNFTDIEAALKAQLDSADIPKARRKR
YISQNDMIAILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHGPSYLLRF
LGQNLSVRTGRYRSILQLVKPWYDEVKDYAFPYPQDCNPRCPMRCFGPMCTHYTQMVWAT
SNRIGCAIHTCQNMNVWGSVWRRAVYLVCNYAPKGNWIGEAPYKVGVPCSSCPPSYGGSC
TDNLCFPGVTSNYLYWFK

Sequence length

258

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLON CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29928337		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29928337		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	30638862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	30638862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25117815	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	30638862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	9473672		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	9473672		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30638862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29928337		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	9473672		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	24831101, 26261572	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27358489	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PI15 (peptidase inhibitor 15)