Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51020
Gene name	HD domain containing 2
Gene symbol	HDDC2
Synonyms (NCBI Gene)	C6orf74CGI-130NS5ATP2dJ167O5.2
Chromosome	6
Chromosome location	6q22.31

206

Show/Hide all (206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048783	hsa-miR-93-5p	CLASH	23622248
MIRT036945	hsa-miR-877-3p	CLASH	23622248
MIRT549530	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT549528	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT549527	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT549522	hsa-miR-3664-3p	PAR-CLIP	20371350
MIRT549521	hsa-miR-1266-5p	PAR-CLIP	20371350
MIRT549519	hsa-miR-4518	PAR-CLIP	20371350
MIRT549520	hsa-miR-4693-3p	PAR-CLIP	20371350
MIRT549517	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT549516	hsa-miR-107	PAR-CLIP	20371350
MIRT549510	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT549506	hsa-miR-1303	PAR-CLIP	20371350
MIRT549530	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT549529	hsa-miR-4700-3p	PAR-CLIP	21572407
MIRT549528	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT549527	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT549526	hsa-miR-4433b-3p	PAR-CLIP	21572407
MIRT549524	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT549525	hsa-miR-4459	PAR-CLIP	21572407
MIRT549523	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT549522	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT549521	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT549519	hsa-miR-4518	PAR-CLIP	21572407
MIRT549520	hsa-miR-4693-3p	PAR-CLIP	21572407
MIRT549518	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT549517	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT549516	hsa-miR-107	PAR-CLIP	21572407
MIRT549515	hsa-miR-504-3p	PAR-CLIP	21572407
MIRT549514	hsa-miR-122-5p	PAR-CLIP	21572407
MIRT549512	hsa-miR-4284	PAR-CLIP	21572407
MIRT549513	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT549510	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549511	hsa-miR-644a	PAR-CLIP	21572407
MIRT549508	hsa-miR-5095	PAR-CLIP	21572407
MIRT549509	hsa-miR-7151-3p	PAR-CLIP	21572407
MIRT549507	hsa-miR-4474-3p	PAR-CLIP	21572407
MIRT549506	hsa-miR-1303	PAR-CLIP	21572407
MIRT549530	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT549528	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT549527	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT549522	hsa-miR-3664-3p	PAR-CLIP	20371350
MIRT549521	hsa-miR-1266-5p	PAR-CLIP	20371350
MIRT549519	hsa-miR-4518	PAR-CLIP	20371350
MIRT549520	hsa-miR-4693-3p	PAR-CLIP	20371350
MIRT549517	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT549516	hsa-miR-107	PAR-CLIP	20371350
MIRT549510	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT549506	hsa-miR-1303	PAR-CLIP	20371350
MIRT549530	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT549529	hsa-miR-4700-3p	PAR-CLIP	21572407
MIRT549528	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT549527	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT549526	hsa-miR-4433b-3p	PAR-CLIP	21572407
MIRT549524	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT549525	hsa-miR-4459	PAR-CLIP	21572407
MIRT549523	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT549522	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT549521	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT549519	hsa-miR-4518	PAR-CLIP	21572407
MIRT549520	hsa-miR-4693-3p	PAR-CLIP	21572407
MIRT549518	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT549517	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT549516	hsa-miR-107	PAR-CLIP	21572407
MIRT549515	hsa-miR-504-3p	PAR-CLIP	21572407
MIRT549514	hsa-miR-122-5p	PAR-CLIP	21572407
MIRT549512	hsa-miR-4284	PAR-CLIP	21572407
MIRT549513	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT549510	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549511	hsa-miR-644a	PAR-CLIP	21572407
MIRT549508	hsa-miR-5095	PAR-CLIP	21572407
MIRT549509	hsa-miR-7151-3p	PAR-CLIP	21572407
MIRT549507	hsa-miR-4474-3p	PAR-CLIP	21572407
MIRT549506	hsa-miR-1303	PAR-CLIP	21572407
MIRT1042579	hsa-miR-103a	CLIP-seq
MIRT1042580	hsa-miR-1206	CLIP-seq
MIRT1042581	hsa-miR-1324	CLIP-seq
MIRT1042582	hsa-miR-1825	CLIP-seq
MIRT1042583	hsa-miR-199a-5p	CLIP-seq
MIRT1042584	hsa-miR-199b-5p	CLIP-seq
MIRT1042585	hsa-miR-203	CLIP-seq
MIRT1042586	hsa-miR-23a	CLIP-seq
MIRT1042587	hsa-miR-23b	CLIP-seq
MIRT1042588	hsa-miR-23c	CLIP-seq
MIRT1042589	hsa-miR-3148	CLIP-seq
MIRT1042590	hsa-miR-3591-5p	CLIP-seq
MIRT1042591	hsa-miR-3688-3p	CLIP-seq
MIRT1042592	hsa-miR-371-3p	CLIP-seq
MIRT1042593	hsa-miR-371b-3p	CLIP-seq
MIRT1042594	hsa-miR-382	CLIP-seq
MIRT1042595	hsa-miR-3925-3p	CLIP-seq
MIRT1042596	hsa-miR-409-3p	CLIP-seq
MIRT1042597	hsa-miR-421	CLIP-seq
MIRT1042598	hsa-miR-4255	CLIP-seq
MIRT1042599	hsa-miR-4433	CLIP-seq
MIRT1042600	hsa-miR-4470	CLIP-seq
MIRT1042601	hsa-miR-4473	CLIP-seq
MIRT1042602	hsa-miR-4666-3p	CLIP-seq
MIRT1042603	hsa-miR-4670-3p	CLIP-seq
MIRT1042604	hsa-miR-4671-3p	CLIP-seq
MIRT1042605	hsa-miR-4694-3p	CLIP-seq
MIRT1042606	hsa-miR-4709-5p	CLIP-seq
MIRT1042607	hsa-miR-4715-3p	CLIP-seq
MIRT1042608	hsa-miR-495	CLIP-seq
MIRT1042609	hsa-miR-515-3p	CLIP-seq
MIRT1042610	hsa-miR-516a-3p	CLIP-seq
MIRT1042611	hsa-miR-519e	CLIP-seq
MIRT1042612	hsa-miR-570	CLIP-seq
MIRT1042613	hsa-miR-578	CLIP-seq
MIRT1042614	hsa-miR-628-5p	CLIP-seq
MIRT1042580	hsa-miR-1206	CLIP-seq
MIRT2009039	hsa-miR-183	CLIP-seq
MIRT2009040	hsa-miR-433	CLIP-seq
MIRT1042610	hsa-miR-516a-3p	CLIP-seq
MIRT1042586	hsa-miR-23a	CLIP-seq
MIRT1042587	hsa-miR-23b	CLIP-seq
MIRT1042588	hsa-miR-23c	CLIP-seq
MIRT1042594	hsa-miR-382	CLIP-seq
MIRT2241376	hsa-miR-4269	CLIP-seq
MIRT1042603	hsa-miR-4670-3p	CLIP-seq
MIRT1042607	hsa-miR-4715-3p	CLIP-seq
MIRT1042613	hsa-miR-578	CLIP-seq
MIRT1042614	hsa-miR-628-5p	CLIP-seq
MIRT1042580	hsa-miR-1206	CLIP-seq
MIRT1042582	hsa-miR-1825	CLIP-seq
MIRT1042583	hsa-miR-199a-5p	CLIP-seq
MIRT1042584	hsa-miR-199b-5p	CLIP-seq
MIRT1042595	hsa-miR-3925-3p	CLIP-seq
MIRT1042598	hsa-miR-4255	CLIP-seq
MIRT1042607	hsa-miR-4715-3p	CLIP-seq
MIRT1042579	hsa-miR-103a	CLIP-seq
MIRT1042580	hsa-miR-1206	CLIP-seq
MIRT1042581	hsa-miR-1324	CLIP-seq
MIRT1042582	hsa-miR-1825	CLIP-seq
MIRT2009039	hsa-miR-183	CLIP-seq
MIRT1042583	hsa-miR-199a-5p	CLIP-seq
MIRT1042584	hsa-miR-199b-5p	CLIP-seq
MIRT1042585	hsa-miR-203	CLIP-seq
MIRT1042586	hsa-miR-23a	CLIP-seq
MIRT1042587	hsa-miR-23b	CLIP-seq
MIRT1042588	hsa-miR-23c	CLIP-seq
MIRT1042589	hsa-miR-3148	CLIP-seq
MIRT1042590	hsa-miR-3591-5p	CLIP-seq
MIRT1042591	hsa-miR-3688-3p	CLIP-seq
MIRT1042592	hsa-miR-371-3p	CLIP-seq
MIRT1042593	hsa-miR-371b-3p	CLIP-seq
MIRT1042594	hsa-miR-382	CLIP-seq
MIRT1042595	hsa-miR-3925-3p	CLIP-seq
MIRT1042596	hsa-miR-409-3p	CLIP-seq
MIRT1042597	hsa-miR-421	CLIP-seq
MIRT1042598	hsa-miR-4255	CLIP-seq
MIRT2009040	hsa-miR-433	CLIP-seq
MIRT1042599	hsa-miR-4433	CLIP-seq
MIRT1042600	hsa-miR-4470	CLIP-seq
MIRT1042601	hsa-miR-4473	CLIP-seq
MIRT1042602	hsa-miR-4666-3p	CLIP-seq
MIRT1042603	hsa-miR-4670-3p	CLIP-seq
MIRT1042604	hsa-miR-4671-3p	CLIP-seq
MIRT1042605	hsa-miR-4694-3p	CLIP-seq
MIRT1042606	hsa-miR-4709-5p	CLIP-seq
MIRT1042607	hsa-miR-4715-3p	CLIP-seq
MIRT1042608	hsa-miR-495	CLIP-seq
MIRT1042609	hsa-miR-515-3p	CLIP-seq
MIRT1042610	hsa-miR-516a-3p	CLIP-seq
MIRT1042611	hsa-miR-519e	CLIP-seq
MIRT1042612	hsa-miR-570	CLIP-seq
MIRT1042613	hsa-miR-578	CLIP-seq
MIRT1042614	hsa-miR-628-5p	CLIP-seq
MIRT1042579	hsa-miR-103a	CLIP-seq
MIRT1042580	hsa-miR-1206	CLIP-seq
MIRT1042581	hsa-miR-1324	CLIP-seq
MIRT1042582	hsa-miR-1825	CLIP-seq
MIRT2009039	hsa-miR-183	CLIP-seq
MIRT1042583	hsa-miR-199a-5p	CLIP-seq
MIRT1042584	hsa-miR-199b-5p	CLIP-seq
MIRT1042585	hsa-miR-203	CLIP-seq
MIRT1042586	hsa-miR-23a	CLIP-seq
MIRT1042587	hsa-miR-23b	CLIP-seq
MIRT1042588	hsa-miR-23c	CLIP-seq
MIRT1042589	hsa-miR-3148	CLIP-seq
MIRT1042590	hsa-miR-3591-5p	CLIP-seq
MIRT1042591	hsa-miR-3688-3p	CLIP-seq
MIRT1042592	hsa-miR-371-3p	CLIP-seq
MIRT1042593	hsa-miR-371b-3p	CLIP-seq
MIRT1042594	hsa-miR-382	CLIP-seq
MIRT1042595	hsa-miR-3925-3p	CLIP-seq
MIRT1042596	hsa-miR-409-3p	CLIP-seq
MIRT1042597	hsa-miR-421	CLIP-seq
MIRT1042598	hsa-miR-4255	CLIP-seq
MIRT2009040	hsa-miR-433	CLIP-seq
MIRT1042599	hsa-miR-4433	CLIP-seq
MIRT1042600	hsa-miR-4470	CLIP-seq
MIRT1042601	hsa-miR-4473	CLIP-seq
MIRT1042602	hsa-miR-4666-3p	CLIP-seq
MIRT1042603	hsa-miR-4670-3p	CLIP-seq
MIRT1042604	hsa-miR-4671-3p	CLIP-seq
MIRT1042605	hsa-miR-4694-3p	CLIP-seq
MIRT1042606	hsa-miR-4709-5p	CLIP-seq
MIRT1042607	hsa-miR-4715-3p	CLIP-seq
MIRT1042608	hsa-miR-495	CLIP-seq
MIRT1042609	hsa-miR-515-3p	CLIP-seq
MIRT1042610	hsa-miR-516a-3p	CLIP-seq
MIRT1042611	hsa-miR-519e	CLIP-seq
MIRT1042612	hsa-miR-570	CLIP-seq
MIRT1042613	hsa-miR-578	CLIP-seq
MIRT1042614	hsa-miR-628-5p	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002953	Function	5'-deoxynucleotidase activity	IBA
GO:0002953	Function	5'-deoxynucleotidase activity	IEA
GO:0005515	Function	Protein binding	IPI	22190034, 32296183
GO:0009159	Process	Deoxyribonucleoside monophosphate catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q7Z4H3

Protein name

5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2)

Protein function

Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P531

PDB

4DMB , 4L1J , 4L7E , 4L7W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13023	HD_3	24 → 183	HD domain	Domain

Sequence

MASVSSATFSGHGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVI
KDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKE
LYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLEHKPGRLQDFYDSTAGKFNHPEI
VQLVSELEAERSTNIAAAASEPHS

Sequence length

204

Interactions

View interactions

	KEGG
	Purine metabolism Pyrimidine metabolism Metabolic pathways Nucleotide metabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

HDDC2 (HD domain containing 2)