Gene Gene information from NCBI Gene database.
Entrez ID 50848
Gene name F11 receptor
Gene symbol F11R
Synonyms (NCBI Gene)
CD321JAMJAM1JAMAJCAMKATPAM-1
Chromosome 1
Chromosome location 1q23.3
Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.
miRNA miRNA information provided by mirtarbase database.
929
miRTarBase ID miRNA Experiments Reference
MIRT002678 hsa-miR-124-3p Microarray 15685193
MIRT019092 hsa-miR-335-5p Microarray 18185580
MIRT021501 hsa-miR-145-5p Reporter assay 20818426
MIRT021501 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT002678 hsa-miR-124-3p Microarray 15685193
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
55
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IEA
GO:0001817 Process Regulation of cytokine production IEA
GO:0003008 Process System process IEA
GO:0005178 Function Integrin binding IPI 11812992, 15344881
GO:0005515 Function Protein binding IPI 15344881, 16189514, 17057644, 21516116, 23885123, 25416956, 32296183, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605721 14685 ENSG00000158769
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y624
Protein name Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)
Protein function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, the
PDB 1NBQ , 3EOY , 3TSZ , 4ODB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 33 129 Immunoglobulin V-set domain Domain
PF13927 Ig_3 134 216 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in endothelium, epithelium and leukocytes (at protein level). {ECO:0000269|PubMed:11812992}.
Sequence
Sequence length 299
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Epithelial cell signaling in Helicobacter pylori infection
  Cell surface interactions at the vascular wall
Integrin cell surface interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HYPERTENSIVE DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 28837251, 29946806
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 29946806
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 28231727, 28837251
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 28785100
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 29867568
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 19825993, 30834573, 9177396
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 31372852
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 17264957, 20627246, 24065611, 25472975, 28211187, 30877938
★☆☆☆☆
Found in Text Mining only
Asthenozoospermia Asthenozoospermia BEFREE 28062807
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 17264957, 20627246, 24065611, 25472975, 28211187, 30877938
★☆☆☆☆
Found in Text Mining only