DCAF8 (DDB1 and CUL4 associated factor 8)

Gene

• Entrez ID: 50717
• Gene name: DDB1 and CUL4 associated factor 8
• Gene symbol: DCAF8
• Synonyms (NCBI Gene): GAN2, H326, WDR42A
• Chromosome: 1
• Chromosome location: 1q23.2
• Summary: This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs587777425	G>A,T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020276	hsa-miR-130b-3p	Sequencing	20371350
MIRT028104	hsa-miR-93-5p	Sequencing	20371350
MIRT030174	hsa-miR-26b-5p	Sequencing	20371350
MIRT031024	hsa-miR-21-5p	Microarray	20048743
MIRT031233	hsa-miR-19b-3p	Sequencing	20371350
MIRT051435	hsa-let-7e-5p	CLASH	23622248
MIRT051435	hsa-let-7e-5p	CLASH	23622248
MIRT046555	hsa-let-7g-5p	CLASH	23622248
MIRT038497	hsa-miR-296-3p	CLASH	23622248
MIRT037018	hsa-miR-877-3p	CLASH	23622248
MIRT036637	hsa-miR-937-3p	CLASH	23622248
MIRT036637	hsa-miR-937-3p	CLASH	23622248
MIRT567856	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT028104	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT567855	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT567854	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT567853	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT567852	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT567851	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT567850	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT567848	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT567849	hsa-miR-4422	PAR-CLIP	20371350
MIRT567847	hsa-miR-6507-3p	PAR-CLIP	20371350
MIRT567846	hsa-miR-548p	PAR-CLIP	20371350
MIRT567845	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT567844	hsa-miR-520h	PAR-CLIP	20371350
MIRT567843	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT567842	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT567840	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567841	hsa-miR-6828-3p	PAR-CLIP	20371350
MIRT567839	hsa-miR-6071	PAR-CLIP	20371350
MIRT567838	hsa-miR-544a	PAR-CLIP	20371350
MIRT567837	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT569427	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT569426	hsa-miR-3650	PAR-CLIP	20371350
MIRT569425	hsa-miR-567	PAR-CLIP	20371350
MIRT569424	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT569423	hsa-miR-3911	PAR-CLIP	20371350
MIRT569422	hsa-miR-644a	PAR-CLIP	20371350
MIRT569421	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569420	hsa-miR-3924	PAR-CLIP	20371350
MIRT569419	hsa-miR-297	PAR-CLIP	20371350
MIRT569418	hsa-miR-147a	PAR-CLIP	20371350
MIRT567856	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT028104	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT567855	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT567854	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT567853	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT567852	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT567851	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT567850	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT567848	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT567849	hsa-miR-4422	PAR-CLIP	20371350
MIRT567847	hsa-miR-6507-3p	PAR-CLIP	20371350
MIRT567846	hsa-miR-548p	PAR-CLIP	20371350
MIRT567845	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT567844	hsa-miR-520h	PAR-CLIP	20371350
MIRT567843	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT567842	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT567840	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567841	hsa-miR-6828-3p	PAR-CLIP	20371350
MIRT567839	hsa-miR-6071	PAR-CLIP	20371350
MIRT567838	hsa-miR-544a	PAR-CLIP	20371350
MIRT567837	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT498302	hsa-miR-3200-3p	PAR-CLIP	22291592
MIRT498301	hsa-miR-6813-3p	PAR-CLIP	22291592
MIRT498300	hsa-miR-3691-3p	PAR-CLIP	22291592
MIRT267229	hsa-miR-4724-3p	PAR-CLIP	22291592
MIRT498299	hsa-miR-2681-5p	PAR-CLIP	22291592
MIRT478411	hsa-miR-3609	PAR-CLIP	23592263
MIRT478410	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT478409	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT478408	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT478407	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT478406	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT478405	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT478403	hsa-miR-4648	PAR-CLIP	23592263
MIRT478404	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT478402	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT478401	hsa-miR-4654	PAR-CLIP	23592263
MIRT478400	hsa-miR-4769-5p	PAR-CLIP	23592263
MIRT478399	hsa-miR-4709-3p	PAR-CLIP	23592263
MIRT478398	hsa-miR-3978	PAR-CLIP	23592263
MIRT478396	hsa-miR-6728-5p	PAR-CLIP	23592263
MIRT440846	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440846	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT567856	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT028104	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT567855	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT567854	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT567853	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT567852	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT567851	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT567850	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT567848	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT567849	hsa-miR-4422	PAR-CLIP	20371350
MIRT567847	hsa-miR-6507-3p	PAR-CLIP	20371350
MIRT567846	hsa-miR-548p	PAR-CLIP	20371350
MIRT567845	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT567844	hsa-miR-520h	PAR-CLIP	20371350
MIRT567843	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT567842	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT567840	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567841	hsa-miR-6828-3p	PAR-CLIP	20371350
MIRT567839	hsa-miR-6071	PAR-CLIP	20371350
MIRT567838	hsa-miR-544a	PAR-CLIP	20371350
MIRT567837	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT569427	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT569426	hsa-miR-3650	PAR-CLIP	20371350
MIRT569425	hsa-miR-567	PAR-CLIP	20371350
MIRT569424	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT569423	hsa-miR-3911	PAR-CLIP	20371350
MIRT569422	hsa-miR-644a	PAR-CLIP	20371350
MIRT569421	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569420	hsa-miR-3924	PAR-CLIP	20371350
MIRT569419	hsa-miR-297	PAR-CLIP	20371350
MIRT569418	hsa-miR-147a	PAR-CLIP	20371350
MIRT567856	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT028104	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT567855	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT567854	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT567853	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT567852	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT567851	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT567850	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT567848	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT567849	hsa-miR-4422	PAR-CLIP	20371350
MIRT567847	hsa-miR-6507-3p	PAR-CLIP	20371350
MIRT567846	hsa-miR-548p	PAR-CLIP	20371350
MIRT567845	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT567844	hsa-miR-520h	PAR-CLIP	20371350
MIRT567843	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT567842	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT567840	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567841	hsa-miR-6828-3p	PAR-CLIP	20371350
MIRT567839	hsa-miR-6071	PAR-CLIP	20371350
MIRT567838	hsa-miR-544a	PAR-CLIP	20371350
MIRT567837	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT498302	hsa-miR-3200-3p	PAR-CLIP	22291592
MIRT498301	hsa-miR-6813-3p	PAR-CLIP	22291592
MIRT498300	hsa-miR-3691-3p	PAR-CLIP	22291592
MIRT267229	hsa-miR-4724-3p	PAR-CLIP	22291592
MIRT498299	hsa-miR-2681-5p	PAR-CLIP	22291592
MIRT478411	hsa-miR-3609	PAR-CLIP	23592263
MIRT478410	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT478409	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT478408	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT478407	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT478406	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT478405	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT478403	hsa-miR-4648	PAR-CLIP	23592263
MIRT478404	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT478402	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT478401	hsa-miR-4654	PAR-CLIP	23592263
MIRT478400	hsa-miR-4769-5p	PAR-CLIP	23592263
MIRT478399	hsa-miR-4709-3p	PAR-CLIP	23592263
MIRT478398	hsa-miR-3978	PAR-CLIP	23592263
MIRT478396	hsa-miR-6728-5p	PAR-CLIP	23592263
MIRT925544	hsa-miR-106a	CLIP-seq
MIRT925545	hsa-miR-106b	CLIP-seq
MIRT925546	hsa-miR-1184	CLIP-seq
MIRT925547	hsa-miR-1205	CLIP-seq
MIRT925548	hsa-miR-1237	CLIP-seq
MIRT925549	hsa-miR-1248	CLIP-seq
MIRT925550	hsa-miR-1253	CLIP-seq
MIRT925551	hsa-miR-1343	CLIP-seq
MIRT925552	hsa-miR-147	CLIP-seq
MIRT925553	hsa-miR-15a	CLIP-seq
MIRT925554	hsa-miR-15b	CLIP-seq
MIRT925555	hsa-miR-16	CLIP-seq
MIRT925556	hsa-miR-17	CLIP-seq
MIRT925557	hsa-miR-195	CLIP-seq
MIRT925558	hsa-miR-1976	CLIP-seq
MIRT925559	hsa-miR-20a	CLIP-seq
MIRT925560	hsa-miR-20b	CLIP-seq
MIRT925561	hsa-miR-2355-3p	CLIP-seq
MIRT925562	hsa-miR-2909	CLIP-seq
MIRT925563	hsa-miR-3065-5p	CLIP-seq
MIRT925564	hsa-miR-3154	CLIP-seq
MIRT925565	hsa-miR-3158-5p	CLIP-seq
MIRT925566	hsa-miR-3161	CLIP-seq
MIRT925567	hsa-miR-3192	CLIP-seq
MIRT925568	hsa-miR-3613-3p	CLIP-seq
MIRT925569	hsa-miR-3617	CLIP-seq
MIRT925570	hsa-miR-3622b-5p	CLIP-seq
MIRT925571	hsa-miR-371b-3p	CLIP-seq
MIRT925572	hsa-miR-3974	CLIP-seq
MIRT925573	hsa-miR-424	CLIP-seq
MIRT925574	hsa-miR-4278	CLIP-seq
MIRT925575	hsa-miR-4279	CLIP-seq
MIRT925576	hsa-miR-4434	CLIP-seq
MIRT925577	hsa-miR-4471	CLIP-seq
MIRT925578	hsa-miR-4509	CLIP-seq
MIRT925579	hsa-miR-4514	CLIP-seq
MIRT925580	hsa-miR-4516	CLIP-seq
MIRT925581	hsa-miR-4524	CLIP-seq
MIRT925582	hsa-miR-4645-5p	CLIP-seq
MIRT925583	hsa-miR-4646-3p	CLIP-seq
MIRT925584	hsa-miR-4670-3p	CLIP-seq
MIRT925585	hsa-miR-4673	CLIP-seq
MIRT925586	hsa-miR-4692	CLIP-seq
MIRT925587	hsa-miR-4716-3p	CLIP-seq
MIRT925588	hsa-miR-4720-5p	CLIP-seq
MIRT925589	hsa-miR-4744	CLIP-seq
MIRT925590	hsa-miR-4772-5p	CLIP-seq
MIRT925591	hsa-miR-4799-3p	CLIP-seq
MIRT925592	hsa-miR-483-3p	CLIP-seq
MIRT925593	hsa-miR-495	CLIP-seq
MIRT925594	hsa-miR-497	CLIP-seq
MIRT925595	hsa-miR-503	CLIP-seq
MIRT925596	hsa-miR-511	CLIP-seq
MIRT925597	hsa-miR-519d	CLIP-seq
MIRT925598	hsa-miR-520g	CLIP-seq
MIRT925599	hsa-miR-544	CLIP-seq
MIRT925600	hsa-miR-545	CLIP-seq
MIRT925601	hsa-miR-548ac	CLIP-seq
MIRT925602	hsa-miR-548d-3p	CLIP-seq
MIRT925603	hsa-miR-548z	CLIP-seq
MIRT925604	hsa-miR-641	CLIP-seq
MIRT925605	hsa-miR-642a	CLIP-seq
MIRT925606	hsa-miR-644	CLIP-seq
MIRT925607	hsa-miR-646	CLIP-seq
MIRT925608	hsa-miR-676	CLIP-seq
MIRT925609	hsa-miR-885-3p	CLIP-seq
MIRT925610	hsa-miR-93	CLIP-seq
MIRT925611	hsa-miR-940	CLIP-seq
MIRT1974249	hsa-miR-135a	CLIP-seq
MIRT1974250	hsa-miR-135b	CLIP-seq
MIRT925552	hsa-miR-147	CLIP-seq
MIRT1974251	hsa-miR-18a	CLIP-seq
MIRT1974252	hsa-miR-18b	CLIP-seq
MIRT1974253	hsa-miR-190	CLIP-seq
MIRT1974254	hsa-miR-190b	CLIP-seq
MIRT1974255	hsa-miR-200b	CLIP-seq
MIRT1974256	hsa-miR-200c	CLIP-seq
MIRT1974257	hsa-miR-3123	CLIP-seq
MIRT925566	hsa-miR-3161	CLIP-seq
MIRT1974258	hsa-miR-3201	CLIP-seq
MIRT1974259	hsa-miR-3667-3p	CLIP-seq
MIRT1974260	hsa-miR-380	CLIP-seq
MIRT1974261	hsa-miR-3919	CLIP-seq
MIRT1974262	hsa-miR-3942-3p	CLIP-seq
MIRT1974263	hsa-miR-4276	CLIP-seq
MIRT1974264	hsa-miR-429	CLIP-seq
MIRT1974265	hsa-miR-4318	CLIP-seq
MIRT1974266	hsa-miR-4323	CLIP-seq
MIRT1974267	hsa-miR-4494	CLIP-seq
MIRT1974268	hsa-miR-4495	CLIP-seq
MIRT1974269	hsa-miR-4536	CLIP-seq
MIRT1974270	hsa-miR-4639-3p	CLIP-seq
MIRT1974271	hsa-miR-4666-5p	CLIP-seq
MIRT1974272	hsa-miR-4693-5p	CLIP-seq
MIRT1974273	hsa-miR-4791	CLIP-seq
MIRT1974274	hsa-miR-4797-5p	CLIP-seq
MIRT925592	hsa-miR-483-3p	CLIP-seq
MIRT1974275	hsa-miR-499a-5p	CLIP-seq
MIRT1974276	hsa-miR-548ah	CLIP-seq
MIRT925606	hsa-miR-644	CLIP-seq
MIRT925607	hsa-miR-646	CLIP-seq
MIRT1974277	hsa-miR-892a	CLIP-seq
MIRT2209672	hsa-miR-1193	CLIP-seq
MIRT2209673	hsa-miR-1266	CLIP-seq
MIRT925551	hsa-miR-1343	CLIP-seq
MIRT1974249	hsa-miR-135a	CLIP-seq
MIRT1974250	hsa-miR-135b	CLIP-seq
MIRT925553	hsa-miR-15a	CLIP-seq
MIRT925554	hsa-miR-15b	CLIP-seq
MIRT925555	hsa-miR-16	CLIP-seq
MIRT2209674	hsa-miR-1910	CLIP-seq
MIRT925557	hsa-miR-195	CLIP-seq
MIRT2209675	hsa-miR-204	CLIP-seq
MIRT2209676	hsa-miR-211	CLIP-seq
MIRT2209677	hsa-miR-3120-3p	CLIP-seq
MIRT1974259	hsa-miR-3667-3p	CLIP-seq
MIRT925573	hsa-miR-424	CLIP-seq
MIRT2209678	hsa-miR-4270	CLIP-seq
MIRT1974266	hsa-miR-4323	CLIP-seq
MIRT2209679	hsa-miR-4441	CLIP-seq
MIRT2209680	hsa-miR-4446-5p	CLIP-seq
MIRT925578	hsa-miR-4509	CLIP-seq
MIRT925579	hsa-miR-4514	CLIP-seq
MIRT2209681	hsa-miR-4518	CLIP-seq
MIRT925581	hsa-miR-4524	CLIP-seq
MIRT2209682	hsa-miR-455-3p	CLIP-seq
MIRT1974270	hsa-miR-4639-3p	CLIP-seq
MIRT925582	hsa-miR-4645-5p	CLIP-seq
MIRT1974271	hsa-miR-4666-5p	CLIP-seq
MIRT2209683	hsa-miR-4667-3p	CLIP-seq
MIRT925585	hsa-miR-4673	CLIP-seq
MIRT925586	hsa-miR-4692	CLIP-seq
MIRT2209684	hsa-miR-4693-3p	CLIP-seq
MIRT2209685	hsa-miR-4755-5p	CLIP-seq
MIRT2209686	hsa-miR-4760-5p	CLIP-seq
MIRT925590	hsa-miR-4772-5p	CLIP-seq
MIRT1974274	hsa-miR-4797-5p	CLIP-seq
MIRT925594	hsa-miR-497	CLIP-seq
MIRT925595	hsa-miR-503	CLIP-seq
MIRT925600	hsa-miR-545	CLIP-seq
MIRT2209687	hsa-miR-548ag	CLIP-seq
MIRT2209688	hsa-miR-548ai	CLIP-seq
MIRT2209689	hsa-miR-574-5p	CLIP-seq
MIRT2209690	hsa-miR-623	CLIP-seq
MIRT925607	hsa-miR-646	CLIP-seq
MIRT2209691	hsa-miR-759	CLIP-seq
MIRT925609	hsa-miR-885-3p	CLIP-seq
MIRT2209692	hsa-miR-889	CLIP-seq
MIRT925611	hsa-miR-940	CLIP-seq
MIRT2209672	hsa-miR-1193	CLIP-seq
MIRT1974259	hsa-miR-3667-3p	CLIP-seq
MIRT2209683	hsa-miR-4667-3p	CLIP-seq
MIRT2448062	hsa-miR-1915	CLIP-seq
MIRT2448063	hsa-miR-335	CLIP-seq
MIRT2448064	hsa-miR-4477b	CLIP-seq
MIRT2448065	hsa-miR-4688	CLIP-seq
MIRT2448066	hsa-miR-4726-3p	CLIP-seq
MIRT2448067	hsa-miR-617	CLIP-seq
MIRT2513355	hsa-let-7a	CLIP-seq
MIRT2513356	hsa-let-7b	CLIP-seq
MIRT2513357	hsa-let-7c	CLIP-seq
MIRT2513358	hsa-let-7d	CLIP-seq
MIRT2513359	hsa-let-7e	CLIP-seq
MIRT2513360	hsa-let-7f	CLIP-seq
MIRT2513361	hsa-let-7g	CLIP-seq
MIRT2513362	hsa-let-7i	CLIP-seq
MIRT925546	hsa-miR-1184	CLIP-seq
MIRT925547	hsa-miR-1205	CLIP-seq
MIRT2513363	hsa-miR-1224-3p	CLIP-seq
MIRT2513364	hsa-miR-1236	CLIP-seq
MIRT2513365	hsa-miR-1244	CLIP-seq
MIRT925550	hsa-miR-1253	CLIP-seq
MIRT2513366	hsa-miR-1260	CLIP-seq
MIRT2513367	hsa-miR-1260b	CLIP-seq
MIRT2513368	hsa-miR-1263	CLIP-seq
MIRT2513369	hsa-miR-1280	CLIP-seq
MIRT2513370	hsa-miR-137	CLIP-seq
MIRT2513371	hsa-miR-140-3p	CLIP-seq
MIRT925553	hsa-miR-15a	CLIP-seq
MIRT925554	hsa-miR-15b	CLIP-seq
MIRT925555	hsa-miR-16	CLIP-seq
MIRT2513372	hsa-miR-1827	CLIP-seq
MIRT2513373	hsa-miR-186	CLIP-seq
MIRT2513374	hsa-miR-1913	CLIP-seq
MIRT2448062	hsa-miR-1915	CLIP-seq
MIRT2513375	hsa-miR-192	CLIP-seq
MIRT925557	hsa-miR-195	CLIP-seq
MIRT2513376	hsa-miR-1972	CLIP-seq
MIRT2209675	hsa-miR-204	CLIP-seq
MIRT2513377	hsa-miR-205	CLIP-seq
MIRT2209676	hsa-miR-211	CLIP-seq
MIRT2513378	hsa-miR-2114	CLIP-seq
MIRT2513379	hsa-miR-215	CLIP-seq
MIRT2513380	hsa-miR-25	CLIP-seq
MIRT925562	hsa-miR-2909	CLIP-seq
MIRT1974257	hsa-miR-3123	CLIP-seq
MIRT2513381	hsa-miR-3133	CLIP-seq
MIRT925565	hsa-miR-3158-5p	CLIP-seq
MIRT2513382	hsa-miR-3160-3p	CLIP-seq
MIRT2513383	hsa-miR-3173-3p	CLIP-seq
MIRT2513384	hsa-miR-3176	CLIP-seq
MIRT2513385	hsa-miR-3189-3p	CLIP-seq
MIRT2513386	hsa-miR-3190	CLIP-seq
MIRT2513387	hsa-miR-3194-5p	CLIP-seq
MIRT2513388	hsa-miR-32	CLIP-seq
MIRT2513389	hsa-miR-3200-5p	CLIP-seq
MIRT2513390	hsa-miR-324-3p	CLIP-seq
MIRT2513391	hsa-miR-331-5p	CLIP-seq
MIRT2513392	hsa-miR-337-3p	CLIP-seq
MIRT2513393	hsa-miR-33a	CLIP-seq
MIRT2513394	hsa-miR-33b	CLIP-seq
MIRT925568	hsa-miR-3613-3p	CLIP-seq
MIRT2513395	hsa-miR-361-3p	CLIP-seq
MIRT2513396	hsa-miR-3622a-3p	CLIP-seq
MIRT2513397	hsa-miR-3622b-3p	CLIP-seq
MIRT2513398	hsa-miR-362-5p	CLIP-seq
MIRT2513399	hsa-miR-363	CLIP-seq
MIRT1974259	hsa-miR-3667-3p	CLIP-seq
MIRT2513400	hsa-miR-367	CLIP-seq
MIRT2513401	hsa-miR-3679-3p	CLIP-seq
MIRT2513402	hsa-miR-3692	CLIP-seq
MIRT1974261	hsa-miR-3919	CLIP-seq
MIRT2513403	hsa-miR-3922-3p	CLIP-seq
MIRT2513404	hsa-miR-3934	CLIP-seq
MIRT2513405	hsa-miR-3938	CLIP-seq
MIRT2513406	hsa-miR-3973	CLIP-seq
MIRT925573	hsa-miR-424	CLIP-seq
MIRT925574	hsa-miR-4278	CLIP-seq
MIRT2513407	hsa-miR-4427	CLIP-seq
MIRT2513408	hsa-miR-4428	CLIP-seq
MIRT2513409	hsa-miR-4458	CLIP-seq
MIRT2513410	hsa-miR-4469	CLIP-seq
MIRT2448064	hsa-miR-4477b	CLIP-seq
MIRT2513411	hsa-miR-4488	CLIP-seq
MIRT2513412	hsa-miR-4500	CLIP-seq
MIRT925581	hsa-miR-4524	CLIP-seq
MIRT1974270	hsa-miR-4639-3p	CLIP-seq
MIRT2513413	hsa-miR-4640-3p	CLIP-seq
MIRT2513414	hsa-miR-4649-3p	CLIP-seq
MIRT2209683	hsa-miR-4667-3p	CLIP-seq
MIRT2513415	hsa-miR-4676-5p	CLIP-seq
MIRT2513416	hsa-miR-4678	CLIP-seq
MIRT2513417	hsa-miR-4683	CLIP-seq
MIRT2513418	hsa-miR-4690-3p	CLIP-seq
MIRT2513419	hsa-miR-4697-5p	CLIP-seq
MIRT2513420	hsa-miR-4715-3p	CLIP-seq
MIRT925587	hsa-miR-4716-3p	CLIP-seq
MIRT2513421	hsa-miR-4719	CLIP-seq
MIRT2513422	hsa-miR-4724-5p	CLIP-seq
MIRT2448066	hsa-miR-4726-3p	CLIP-seq
MIRT2513423	hsa-miR-4727-5p	CLIP-seq
MIRT2513424	hsa-miR-4733-5p	CLIP-seq
MIRT2513425	hsa-miR-4749-3p	CLIP-seq
MIRT2513426	hsa-miR-4752	CLIP-seq
MIRT2513427	hsa-miR-4756-3p	CLIP-seq
MIRT2513428	hsa-miR-4775	CLIP-seq
MIRT925592	hsa-miR-483-3p	CLIP-seq
MIRT925594	hsa-miR-497	CLIP-seq
MIRT2513429	hsa-miR-500b	CLIP-seq
MIRT2513430	hsa-miR-501-5p	CLIP-seq
MIRT925595	hsa-miR-503	CLIP-seq
MIRT2513431	hsa-miR-514	CLIP-seq
MIRT2513432	hsa-miR-514b-3p	CLIP-seq
MIRT2513433	hsa-miR-532-3p	CLIP-seq
MIRT925600	hsa-miR-545	CLIP-seq
MIRT2513434	hsa-miR-548a-5p	CLIP-seq
MIRT2513435	hsa-miR-548ab	CLIP-seq
MIRT2513436	hsa-miR-548ak	CLIP-seq
MIRT2513437	hsa-miR-548b-5p	CLIP-seq
MIRT2513438	hsa-miR-548c-5p	CLIP-seq
MIRT2513439	hsa-miR-548d-5p	CLIP-seq
MIRT2513440	hsa-miR-548h	CLIP-seq
MIRT2513441	hsa-miR-548i	CLIP-seq
MIRT2513442	hsa-miR-548j	CLIP-seq
MIRT2513443	hsa-miR-548k	CLIP-seq
MIRT2513444	hsa-miR-548l	CLIP-seq
MIRT2513445	hsa-miR-548u	CLIP-seq
MIRT2513446	hsa-miR-548w	CLIP-seq
MIRT2513447	hsa-miR-548y	CLIP-seq
MIRT2513448	hsa-miR-559	CLIP-seq
MIRT2513449	hsa-miR-575	CLIP-seq
MIRT2513450	hsa-miR-581	CLIP-seq
MIRT2513451	hsa-miR-590-3p	CLIP-seq
MIRT2513452	hsa-miR-597	CLIP-seq
MIRT2513453	hsa-miR-637	CLIP-seq
MIRT925607	hsa-miR-646	CLIP-seq
MIRT2513454	hsa-miR-668	CLIP-seq
MIRT2513455	hsa-miR-885-5p	CLIP-seq
MIRT2209692	hsa-miR-889	CLIP-seq
MIRT2513456	hsa-miR-92a	CLIP-seq
MIRT2513457	hsa-miR-92b	CLIP-seq
MIRT2513458	hsa-miR-98	CLIP-seq
MIRT2513355	hsa-let-7a	CLIP-seq
MIRT2513356	hsa-let-7b	CLIP-seq
MIRT2513357	hsa-let-7c	CLIP-seq
MIRT2513358	hsa-let-7d	CLIP-seq
MIRT2513359	hsa-let-7e	CLIP-seq
MIRT2513360	hsa-let-7f	CLIP-seq
MIRT2513361	hsa-let-7g	CLIP-seq
MIRT2513362	hsa-let-7i	CLIP-seq
MIRT925546	hsa-miR-1184	CLIP-seq
MIRT925547	hsa-miR-1205	CLIP-seq
MIRT2513363	hsa-miR-1224-3p	CLIP-seq
MIRT2513364	hsa-miR-1236	CLIP-seq
MIRT2513365	hsa-miR-1244	CLIP-seq
MIRT2513366	hsa-miR-1260	CLIP-seq
MIRT2513367	hsa-miR-1260b	CLIP-seq
MIRT2513368	hsa-miR-1263	CLIP-seq
MIRT2513369	hsa-miR-1280	CLIP-seq
MIRT2513370	hsa-miR-137	CLIP-seq
MIRT2513371	hsa-miR-140-3p	CLIP-seq
MIRT925553	hsa-miR-15a	CLIP-seq
MIRT925554	hsa-miR-15b	CLIP-seq
MIRT925555	hsa-miR-16	CLIP-seq
MIRT2513372	hsa-miR-1827	CLIP-seq
MIRT2513373	hsa-miR-186	CLIP-seq
MIRT2513374	hsa-miR-1913	CLIP-seq
MIRT2448062	hsa-miR-1915	CLIP-seq
MIRT2513375	hsa-miR-192	CLIP-seq
MIRT925557	hsa-miR-195	CLIP-seq
MIRT2513376	hsa-miR-1972	CLIP-seq
MIRT2209675	hsa-miR-204	CLIP-seq
MIRT2513377	hsa-miR-205	CLIP-seq
MIRT2209676	hsa-miR-211	CLIP-seq
MIRT2513378	hsa-miR-2114	CLIP-seq
MIRT2513379	hsa-miR-215	CLIP-seq
MIRT2513380	hsa-miR-25	CLIP-seq
MIRT2679060	hsa-miR-31	CLIP-seq
MIRT1974257	hsa-miR-3123	CLIP-seq
MIRT2513381	hsa-miR-3133	CLIP-seq
MIRT925565	hsa-miR-3158-5p	CLIP-seq
MIRT2513383	hsa-miR-3173-3p	CLIP-seq
MIRT2513384	hsa-miR-3176	CLIP-seq
MIRT2513385	hsa-miR-3189-3p	CLIP-seq
MIRT2513386	hsa-miR-3190	CLIP-seq
MIRT2513387	hsa-miR-3194-5p	CLIP-seq
MIRT2513388	hsa-miR-32	CLIP-seq
MIRT2513389	hsa-miR-3200-5p	CLIP-seq
MIRT2513390	hsa-miR-324-3p	CLIP-seq
MIRT2513392	hsa-miR-337-3p	CLIP-seq
MIRT2513393	hsa-miR-33a	CLIP-seq
MIRT2513394	hsa-miR-33b	CLIP-seq
MIRT925568	hsa-miR-3613-3p	CLIP-seq
MIRT2513395	hsa-miR-361-3p	CLIP-seq
MIRT2513396	hsa-miR-3622a-3p	CLIP-seq
MIRT2513397	hsa-miR-3622b-3p	CLIP-seq
MIRT2513398	hsa-miR-362-5p	CLIP-seq
MIRT2513399	hsa-miR-363	CLIP-seq
MIRT1974259	hsa-miR-3667-3p	CLIP-seq
MIRT2513400	hsa-miR-367	CLIP-seq
MIRT2513401	hsa-miR-3679-3p	CLIP-seq
MIRT2513402	hsa-miR-3692	CLIP-seq
MIRT1974261	hsa-miR-3919	CLIP-seq
MIRT2513403	hsa-miR-3922-3p	CLIP-seq
MIRT2513404	hsa-miR-3934	CLIP-seq
MIRT2513405	hsa-miR-3938	CLIP-seq
MIRT2513406	hsa-miR-3973	CLIP-seq
MIRT925573	hsa-miR-424	CLIP-seq
MIRT2513407	hsa-miR-4427	CLIP-seq
MIRT2513408	hsa-miR-4428	CLIP-seq
MIRT2513409	hsa-miR-4458	CLIP-seq
MIRT2513410	hsa-miR-4469	CLIP-seq
MIRT2448064	hsa-miR-4477b	CLIP-seq
MIRT2513411	hsa-miR-4488	CLIP-seq
MIRT2513412	hsa-miR-4500	CLIP-seq
MIRT925581	hsa-miR-4524	CLIP-seq
MIRT1974270	hsa-miR-4639-3p	CLIP-seq
MIRT2513413	hsa-miR-4640-3p	CLIP-seq
MIRT2513414	hsa-miR-4649-3p	CLIP-seq
MIRT2209683	hsa-miR-4667-3p	CLIP-seq
MIRT2513415	hsa-miR-4676-5p	CLIP-seq
MIRT2513417	hsa-miR-4683	CLIP-seq
MIRT2513418	hsa-miR-4690-3p	CLIP-seq
MIRT2513419	hsa-miR-4697-5p	CLIP-seq
MIRT2513420	hsa-miR-4715-3p	CLIP-seq
MIRT2513421	hsa-miR-4719	CLIP-seq
MIRT2513422	hsa-miR-4724-5p	CLIP-seq
MIRT2448066	hsa-miR-4726-3p	CLIP-seq
MIRT2513423	hsa-miR-4727-5p	CLIP-seq
MIRT2513424	hsa-miR-4733-5p	CLIP-seq
MIRT2513425	hsa-miR-4749-3p	CLIP-seq
MIRT2513426	hsa-miR-4752	CLIP-seq
MIRT2513427	hsa-miR-4756-3p	CLIP-seq
MIRT925592	hsa-miR-483-3p	CLIP-seq
MIRT925593	hsa-miR-495	CLIP-seq
MIRT925594	hsa-miR-497	CLIP-seq
MIRT2513429	hsa-miR-500b	CLIP-seq
MIRT2513430	hsa-miR-501-5p	CLIP-seq
MIRT925595	hsa-miR-503	CLIP-seq
MIRT2513433	hsa-miR-532-3p	CLIP-seq
MIRT925600	hsa-miR-545	CLIP-seq
MIRT2513434	hsa-miR-548a-5p	CLIP-seq
MIRT2513435	hsa-miR-548ab	CLIP-seq
MIRT2513436	hsa-miR-548ak	CLIP-seq
MIRT2513437	hsa-miR-548b-5p	CLIP-seq
MIRT2513438	hsa-miR-548c-5p	CLIP-seq
MIRT2513439	hsa-miR-548d-5p	CLIP-seq
MIRT2513440	hsa-miR-548h	CLIP-seq
MIRT2513441	hsa-miR-548i	CLIP-seq
MIRT2513442	hsa-miR-548j	CLIP-seq
MIRT2513443	hsa-miR-548k	CLIP-seq
MIRT2513444	hsa-miR-548l	CLIP-seq
MIRT2513445	hsa-miR-548u	CLIP-seq
MIRT2513446	hsa-miR-548w	CLIP-seq
MIRT2513447	hsa-miR-548y	CLIP-seq
MIRT2513448	hsa-miR-559	CLIP-seq
MIRT2513449	hsa-miR-575	CLIP-seq
MIRT2513450	hsa-miR-581	CLIP-seq
MIRT2513452	hsa-miR-597	CLIP-seq
MIRT2513453	hsa-miR-637	CLIP-seq
MIRT925607	hsa-miR-646	CLIP-seq
MIRT2513454	hsa-miR-668	CLIP-seq
MIRT2513455	hsa-miR-885-5p	CLIP-seq
MIRT2209692	hsa-miR-889	CLIP-seq
MIRT2513456	hsa-miR-92a	CLIP-seq
MIRT2513457	hsa-miR-92b	CLIP-seq
MIRT2513458	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 16949367, 19060904, 19966799, 22190034, 22500989, 23455924, 24500646, 25416956, 28514442, 31391242, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	22500989
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22500989
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0014904	Process	Myotube cell development	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IDA	16949367
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IEA

Other IDs

• MIM: 615820
• HGNC: 24891
• e!Ensembl: ENSG00000132716

Protein

• UniProt ID: Q5TAQ9
• Protein name: DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)
• Protein function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
• PDB: 3I8E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	183 → 221	WD domain, G-beta repeat	Repeat
  PF00400	WD40	422 → 463	WD domain, G-beta repeat	Repeat
  PF00400	WD40	467 → 505	WD domain, G-beta repeat	Repeat

• Sequence:

  MSSKGSSTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRT
  STESRGTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQR
  KRANRDQDSSDDERALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFV
  QRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVF
  QAKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFL
  SAGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYD
  QRKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSD
  GAQYVKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGV
  VNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLKDVIKKNKRERDEDSLHQTDLF
  DSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSDEEEGPDRVQCMPS

• Sequence length: 597

Pathways

Reactome:

Neddylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Giant axonal neuropathy 2	Likely pathogenic	rs587777425	RCV000119848	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL DOMINANT CHARCOT-MARIE-TOOTH DISEASE TYPE 2 WITH GIANT AXONS	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DCAF8-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT	—	HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GIANT AXONAL NEUROPATHY, AUTOSOMAL DOMINANT	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurofibromatosis, type 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autosomal dominant Charcot-Marie-Tooth disease type 2 with giant axons	Charcot-Marie-Tooth Disease With Giant Axons	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	39380996	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	24500646		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	24500646	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Distal amyotrophy	Distal amyotrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT	Giant Axonal Neuropathy	UNIPROT_DG	24500646		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT	Giant Axonal Neuropathy	GENOMICS_ENGLAND_DG	24500646		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT	Giant Axonal Neuropathy	ORPHANET_DG	24500646		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT	Giant Axonal Neuropathy	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Giant Axonal Neuropathy, Autosomal Dominant	Giant Axonal Neuropathy	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary Motor and Sensory Neuropathies	Hereditary motor and sensory neuropathy	BEFREE	24500646		★☆☆☆☆ Found in Text Mining only
Peripheral axonal neuropathy	Peripheral axonal neuropathy	HPO_DG			★☆☆☆☆ Found in Text Mining only