Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	5064
Gene name	Paralemmin
Gene symbol	PALM
Synonyms (NCBI Gene)	PALM1
Chromosome	19
Chromosome location	19p13.3
Summary	This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons a

Show/Hide all (94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043056	hsa-miR-324-5p	CLASH	23622248
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT1211847	hsa-miR-1207-5p	CLIP-seq
MIRT1211848	hsa-miR-1915	CLIP-seq
MIRT1211849	hsa-miR-3135b	CLIP-seq
MIRT1211850	hsa-miR-3652	CLIP-seq
MIRT1211851	hsa-miR-3689d	CLIP-seq
MIRT1211852	hsa-miR-4279	CLIP-seq
MIRT1211853	hsa-miR-4430	CLIP-seq
MIRT1211854	hsa-miR-4436b-3p	CLIP-seq
MIRT1211855	hsa-miR-4512	CLIP-seq
MIRT1211856	hsa-miR-4688	CLIP-seq
MIRT1211857	hsa-miR-4691-3p	CLIP-seq
MIRT1211858	hsa-miR-4726-3p	CLIP-seq
MIRT1211859	hsa-miR-4740-3p	CLIP-seq
MIRT1211860	hsa-miR-4757-5p	CLIP-seq
MIRT1211861	hsa-miR-4761-3p	CLIP-seq
MIRT1211862	hsa-miR-4763-3p	CLIP-seq
MIRT1211863	hsa-miR-4300	CLIP-seq
MIRT1211864	hsa-miR-920	CLIP-seq
MIRT2060789	hsa-miR-122	CLIP-seq
MIRT2060790	hsa-miR-1268	CLIP-seq
MIRT2060791	hsa-miR-1268b	CLIP-seq
MIRT2060792	hsa-miR-2467-3p	CLIP-seq
MIRT2060793	hsa-miR-2861	CLIP-seq
MIRT2060794	hsa-miR-3147	CLIP-seq
MIRT2060795	hsa-miR-3177-3p	CLIP-seq
MIRT2060796	hsa-miR-3180	CLIP-seq
MIRT2060797	hsa-miR-3180-3p	CLIP-seq
MIRT2060798	hsa-miR-3196	CLIP-seq
MIRT2060799	hsa-miR-3659	CLIP-seq
MIRT2060800	hsa-miR-4260	CLIP-seq
MIRT2060801	hsa-miR-4425	CLIP-seq
MIRT2060802	hsa-miR-4459	CLIP-seq
MIRT2060803	hsa-miR-4723-5p	CLIP-seq
MIRT2060804	hsa-miR-4787-5p	CLIP-seq
MIRT2060805	hsa-miR-665	CLIP-seq
MIRT2060806	hsa-miR-760	CLIP-seq
MIRT2289505	hsa-miR-3665	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16386234, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA	16386234
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	9615234
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0008104	Process	Intracellular protein localization	IEA
GO:0008360	Process	Regulation of cell shape	IEA
GO:0008360	Process	Regulation of cell shape	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	TAS	9813098
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0030175	Component	Filopodium	IBA
GO:0030175	Component	Filopodium	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031410	Component	Cytoplasmic vesicle	TAS	9813098
GO:0031527	Component	Filopodium membrane	IDA	14978216
GO:0031527	Component	Filopodium membrane	IEA
GO:0031750	Function	D3 dopamine receptor binding	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0044309	Component	Neuron spine	IBA
GO:0044309	Component	Neuron spine	IEA
GO:0045202	Component	Synapse	IEA
GO:0051491	Process	Positive regulation of filopodium assembly	IBA
GO:0051491	Process	Positive regulation of filopodium assembly	IDA	14978216
GO:0060074	Process	Synapse maturation	IBA
GO:0060074	Process	Synapse maturation	IEA
GO:0060160	Process	Negative regulation of dopamine receptor signaling pathway	IDA	16386234
GO:0071257	Process	Cellular response to electrical stimulus	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0097060	Component	Synaptic membrane	IBA
GO:0098794	Component	Postsynapse	IBA

MIM	HGNC	e!Ensembl
608134	8594	ENSG00000099864

O75781

Protein name

Paralemmin-1 (Paralemmin)

Protein function

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03285	Paralemmin	71 → 387	Paralemmin	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.

Sequence

MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTP
SSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRA
PAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDK
VTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKAD
EVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTM
IFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREEN
QAGPEATTSDPQDLDMKKHRCKCCSIM

Sequence length

387

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
atypical cerebral palsy	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liposarcoma, well differentiated	liposarcoma	BEFREE	12210086	★★★★★ ★☆☆☆☆ Found in Text Mining only

PALM (paralemmin)