PABPC3 (poly(A) binding protein cytoplasmic 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 5042 |
| Gene name | Poly(A) binding protein cytoplasmic 3 |
| Gene symbol | PABPC3 |
| Synonyms (NCBI Gene) |
PABP3PABPL3tPABP
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| Chromosome | 13 |
| Chromosome location | 13q12.13 |
| Summary | Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002] |
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miRNA
miRNA information provided by mirtarbase database.
273
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9H361 | ||||||||||||||||||||||||||||||
| Protein name | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | ||||||||||||||||||||||||||||||
| Protein function | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. | ||||||||||||||||||||||||||||||
| PDB | 2D9P , 4IVE | ||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:11328870}. | ||||||||||||||||||||||||||||||
| Sequence |
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| Sequence length | 631 | ||||||||||||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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