Gene Gene information from NCBI Gene database.
Entrez ID 5042
Gene name Poly(A) binding protein cytoplasmic 3
Gene symbol PABPC3
Synonyms (NCBI Gene)
PABP3PABPL3tPABP
Chromosome 13
Chromosome location 13q12.13
Summary Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]
miRNA miRNA information provided by mirtarbase database.
273
miRTarBase ID miRNA Experiments Reference
MIRT047748 hsa-miR-10a-5p CLASH 23622248
MIRT045517 hsa-miR-149-5p CLASH 23622248
MIRT249020 hsa-miR-561-3p HITS-CLIP 21572407
MIRT500041 hsa-miR-3200-3p HITS-CLIP 21572407
MIRT249021 hsa-miR-3973 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding IEA
GO:0003730 Function MRNA 3'-UTR binding IBA
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604680 8556 ENSG00000151846
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H361
Protein name Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein)
Protein function Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.
PDB 2D9P , 4IVE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 13 83 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 101 168 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 193 262 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 296 364 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00658 PABP 542 609 Poly-adenylate binding protein, unique domain Family
Tissue specificity TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:11328870}.
Sequence
MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ
HTKDAEHALDTMNFDVIKGKPVR
IMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS
AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKV
FVGQFKSRKERE
AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER
HEDAQKAVDEMNGKELNGKQIY
VGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN
LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT
KPLY
VALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPS
QIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQRVANTS
TQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETL
TASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRS
KVDEAVAVL
QAHQAKEATQKAVNSATGVPTV
Sequence length 631
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  mRNA surveillance pathway
RNA degradation
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BRAIN ANEURYSM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Azoospermia Azoospermia Pubtator 26843391 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Ovarian Epithelial Epithelial ovarian carcinoma Pubtator 36229065 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 34311674 Associate
★☆☆☆☆
Found in Text Mining only
Headache Headache Pubtator 32461543 Associate
★☆☆☆☆
Found in Text Mining only
Meningioma Meningioma Pubtator 32461543 Associate
★☆☆☆☆
Found in Text Mining only
Non-obstructive azoospermia Non-obstructive azoospermia BEFREE 26843391
★☆☆☆☆
Found in Text Mining only
Oligospermia Oligospermia BEFREE 26843391
★☆☆☆☆
Found in Text Mining only
Testicular Germ Cell Tumor Testicular germ cell tumor Pubtator 26843391 Inhibit
★☆☆☆☆
Found in Text Mining only