Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5032
Gene name	Purinergic receptor P2Y11
Gene symbol	P2RY11
Synonyms (NCBI Gene)	P2Y11
Chromosome	19
Chromosome location	19p13.2
Summary	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048698	hsa-miR-99a-5p	CLASH	23622248
MIRT1208994	hsa-miR-1247	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT1208996	hsa-miR-1275	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1208999	hsa-miR-3140-3p	CLIP-seq
MIRT1209000	hsa-miR-3202	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT1209002	hsa-miR-4260	CLIP-seq
MIRT1209003	hsa-miR-4271	CLIP-seq
MIRT1209004	hsa-miR-4525	CLIP-seq
MIRT1209005	hsa-miR-4665-5p	CLIP-seq
MIRT1209006	hsa-miR-4723-5p	CLIP-seq
MIRT1209007	hsa-miR-4725-3p	CLIP-seq
MIRT1209008	hsa-miR-4747-5p	CLIP-seq
MIRT1209009	hsa-miR-4764-5p	CLIP-seq
MIRT1209010	hsa-miR-625	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT2060039	hsa-miR-1231	CLIP-seq
MIRT2060040	hsa-miR-193a-5p	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT2060041	hsa-miR-3170	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT2060042	hsa-miR-342-5p	CLIP-seq
MIRT2060043	hsa-miR-4313	CLIP-seq
MIRT2060044	hsa-miR-4651	CLIP-seq
MIRT2060045	hsa-miR-4664-5p	CLIP-seq
MIRT2060046	hsa-miR-4667-5p	CLIP-seq
MIRT2060047	hsa-miR-4700-5p	CLIP-seq
MIRT2060048	hsa-miR-608	CLIP-seq
MIRT2060049	hsa-miR-615-5p	CLIP-seq
MIRT2060050	hsa-miR-635	CLIP-seq
MIRT2060051	hsa-miR-637	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2455779	hsa-miR-2467-3p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2060044	hsa-miR-4651	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2060048	hsa-miR-608	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2455788	hsa-miR-885-3p	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2455779	hsa-miR-2467-3p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2060044	hsa-miR-4651	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2060048	hsa-miR-608	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2455788	hsa-miR-885-3p	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2586504	hsa-miR-4684-5p	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2686979	hsa-miR-2276	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2686980	hsa-miR-3064-5p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2686981	hsa-miR-3661	CLIP-seq
MIRT2686982	hsa-miR-3934	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2586504	hsa-miR-4684-5p	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2686983	hsa-miR-552	CLIP-seq
MIRT2686984	hsa-miR-604	CLIP-seq
MIRT2686985	hsa-miR-631	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2686986	hsa-miR-647	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IC	18048695
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9405388
GO:0006952	Process	Defense response	TAS	9405388
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	18048695
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	9405388
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	9405388
GO:0016020	Component	Membrane	IEA
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019722	Process	Calcium-mediated signaling	IDA	18048695
GO:0023041	Process	Neuronal signal transduction	IDA	18048695
GO:0023041	Process	Neuronal signal transduction	IEA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IDA	18048695
GO:0030594	Function	Neurotransmitter receptor activity	IEA
GO:0035589	Process	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA
GO:0038023	Function	Signaling receptor activity	TAS	9405388
GO:0045031	Function	G protein-coupled ATP receptor activity	IBA
GO:0045031	Function	G protein-coupled ATP receptor activity	IDA	18048695
GO:0045031	Function	G protein-coupled ATP receptor activity	IEA
GO:0071318	Process	Cellular response to ATP	IDA	18048695

MIM	HGNC	e!Ensembl
602697	8540	ENSG00000244165

Q96G91

Protein name

P2Y purinoceptor 11 (P2Y11)

Protein function

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	45 → 297	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highest expression in liver and spleen. {ECO:0000269|PubMed:11278528}.

Sequence

MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRP
WHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFI
TCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNC
SVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTV
AEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPY
VGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATA
APKPSEPQSRELSQ

Sequence length

374

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		G alpha (q) signalling events P2Y receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cataplexy and narcolepsy	association	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
NARCOLEPSY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NARCOLEPSY TYPE 1	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
P2RY11-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

P2RY11 (purinergic receptor P2Y11)