Gene Gene information from NCBI Gene database.
Entrez ID 5029
Gene name Purinergic receptor P2Y2
Gene symbol P2RY2
Synonyms (NCBI Gene)
HP2UP2RU1P2UP2U1P2URP2Y2P2Y2R
Chromosome 11
Chromosome location 11q13.4
Summary The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different
miRNA miRNA information provided by mirtarbase database.
76
miRTarBase ID miRNA Experiments Reference
MIRT018463 hsa-miR-335-5p Microarray 18185580
MIRT535549 hsa-miR-6793-3p PAR-CLIP 22012620
MIRT535548 hsa-miR-6511a-3p PAR-CLIP 22012620
MIRT535547 hsa-miR-6511b-3p PAR-CLIP 22012620
MIRT535545 hsa-miR-6784-3p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 8159738
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600041 8541 ENSG00000175591
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41231
Protein name P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor)
Protein function Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 50 306 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Spleen, testis, kidney, liver, lung, heart and brain.
Sequence
Sequence length 377
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Efferocytosis
Inflammatory mediator regulation of TRP channels
  G alpha (q) signalling events
P2Y receptors
Surfactant metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DENTAL CARIES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 15778502 Associate
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 24193664
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 17990272
★☆☆☆☆
Found in Text Mining only
Aortic valve disorder Aortic Valve Disease BEFREE 24631773
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 19763137, 19797825, 27355755, 27856454, 30539820
★☆☆☆☆
Found in Text Mining only
Arthritis, Gouty Gouty arthritis BEFREE 28797095
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 27129210
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis LHGDN 12714597
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 15841322 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 19763137, 19797825, 27355755, 27856454, 30539820
★☆☆☆☆
Found in Text Mining only