Gene Gene information from NCBI Gene database.
Entrez ID 5028
Gene name Purinergic receptor P2Y1
Gene symbol P2RY1
Synonyms (NCBI Gene)
P2Y1SARCC
Chromosome 3
Chromosome location 3q25.2
Summary The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor
miRNA miRNA information provided by mirtarbase database.
592
miRTarBase ID miRNA Experiments Reference
MIRT695108 hsa-miR-3617-5p HITS-CLIP 22927820
MIRT695107 hsa-miR-641 HITS-CLIP 22927820
MIRT611478 hsa-miR-624-3p HITS-CLIP 22927820
MIRT611477 hsa-miR-4731-3p HITS-CLIP 22927820
MIRT611476 hsa-miR-4801 HITS-CLIP 22927820
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
87
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001621 Function G protein-coupled ADP receptor activity IBA
GO:0001621 Function G protein-coupled ADP receptor activity IEA
GO:0001621 Function G protein-coupled ADP receptor activity IMP 9442040
GO:0001973 Process G protein-coupled adenosine receptor signaling pathway IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601167 8539 ENSG00000169860
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P47900
Protein name P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor)
Protein function Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platele
PDB 4XNV , 4XNW , 7XXH , 8WJX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 68 324 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 373
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Taste transduction
  G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
THROMBOSIS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 22724420, 29308737, 30734681
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 25379720
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 17990272
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 27355755
★☆☆☆☆
Found in Text Mining only
Arthritis, Gouty Gouty arthritis BEFREE 28797095
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 8733591, 8913364
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 27355755
★☆☆☆☆
Found in Text Mining only
Autosomal Recessive Polycystic Kidney Disease Polycystic kidney disease BEFREE 15325248, 30417216
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder BEFREE 18543274, 18614336
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 30778022
★☆☆☆☆
Found in Text Mining only