P2RX5 (purinergic receptor P2X 5)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5026
Gene name Purinergic receptor P2X 5
Gene symbol P2RX5
Synonyms (NCBI Gene)
LRH-1P2X5P2X5R
Chromosome 17
Chromosome location 17p13.2
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the
miRNA miRNA information provided by mirtarbase database.
7
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (7)
miRTarBase ID miRNA Experiments Reference
MIRT027737 hsa-miR-98-5p Microarray 19088304
MIRT732003 hsa-miR-381-3p Luciferase reporter assayqRT-PCRWestern blot 26677080
MIRT732003 hsa-miR-381-3p Luciferase reporter assayqRT-PCRWestern blot 26677080
MIRT2455774 hsa-miR-3177-5p CLIP-seq
MIRT2455775 hsa-miR-361-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (45)
GO ID Ontology Definition Evidence Reference
GO:0001614 Function Purinergic nucleotide receptor activity IEA
GO:0001614 Function Purinergic nucleotide receptor activity NAS 17895406
GO:0004888 Function Transmembrane signaling receptor activity TAS 9414125
GO:0004931 Function Extracellularly ATP-gated monoatomic cation channel activity IBA
GO:0004931 Function Extracellularly ATP-gated monoatomic cation channel activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602836 8536 ENSG00000083454
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q93086
Protein name P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor)
Protein function [Isoform 6]: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:12761352). Unlike other P2RX receptors, the P2X5 receptor is also permeable to chloride (PubMed:12761352). May play a supporting
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00864 P2X_receptor 14 → 331 Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high levels in brain and immune system.
Sequence
Sequence length 422
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Calcium signaling pathway
Neuroactive ligand-receptor interaction 		  Elevation of cytosolic Ca2+ levels
Platelet homeostasis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
P2RX5-related disorder Benign; Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (96)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 21949357
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 17990272
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 27355755
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis, Gouty Gouty arthritis BEFREE 28797095
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 27355755
★★★★★
★☆☆☆☆
Found in Text Mining only
Autosomal Recessive Polycystic Kidney Disease Polycystic kidney disease BEFREE 15325248, 30417216
★★★★★
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder BEFREE 18543274, 18614336
★★★★★
★☆☆☆☆
Found in Text Mining only
Borderline Personality Disorder Borderline personality disorder BEFREE 18543274, 23602648
★★★★★
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 21157381, 28536012
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 15695411, 16427184, 20817789, 21392518, 22359603, 24520076, 25435372, 29137369, 30122988
★★★★★
★☆☆☆☆
Found in Text Mining only