OSBP (oxysterol binding protein)

Gene

• Entrez ID: 5007
• Gene name: Oxysterol binding protein
• Gene symbol: OSBP
• Synonyms (NCBI Gene): OSBP1
• Chromosome: 11
• Chromosome location: 11q12.1
• Summary: Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1565117343	G>A	Pathogenic	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019139	hsa-miR-335-5p	Microarray	18185580
MIRT023205	hsa-miR-124-3p	Microarray	18668037
MIRT044025	hsa-miR-365a-3p	CLASH	23622248
MIRT041032	hsa-miR-505-3p	CLASH	23622248
MIRT490895	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT490894	hsa-miR-4422	PAR-CLIP	23592263
MIRT490893	hsa-miR-5680	PAR-CLIP	23592263
MIRT490892	hsa-miR-3154	PAR-CLIP	23592263
MIRT490891	hsa-miR-130a-3p	PAR-CLIP	23592263
MIRT490890	hsa-miR-130b-3p	PAR-CLIP	23592263
MIRT490889	hsa-miR-301a-3p	PAR-CLIP	23592263
MIRT490888	hsa-miR-301b-3p	PAR-CLIP	23592263
MIRT490887	hsa-miR-3666	PAR-CLIP	23592263
MIRT490886	hsa-miR-4295	PAR-CLIP	23592263
MIRT490885	hsa-miR-454-3p	PAR-CLIP	23592263
MIRT490884	hsa-miR-7852-3p	PAR-CLIP	23592263
MIRT490882	hsa-miR-4691-3p	PAR-CLIP	23592263
MIRT490883	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT490881	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT490880	hsa-miR-3179	PAR-CLIP	23592263
MIRT490879	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT490878	hsa-miR-6077	PAR-CLIP	23592263
MIRT490877	hsa-miR-6073	PAR-CLIP	23592263
MIRT490876	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT490875	hsa-miR-4671-3p	PAR-CLIP	23592263
MIRT490874	hsa-miR-3157-5p	PAR-CLIP	23592263
MIRT442512	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT442511	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT442510	hsa-miR-6873-5p	PAR-CLIP	22100165
MIRT442509	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442507	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442508	hsa-miR-4510	PAR-CLIP	22100165
MIRT442506	hsa-miR-6127	PAR-CLIP	22100165
MIRT442505	hsa-miR-6129	PAR-CLIP	22100165
MIRT442504	hsa-miR-6130	PAR-CLIP	22100165
MIRT442503	hsa-miR-6133	PAR-CLIP	22100165
MIRT442502	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT442501	hsa-miR-6878-5p	PAR-CLIP	22100165
MIRT490895	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT490894	hsa-miR-4422	PAR-CLIP	23592263
MIRT490893	hsa-miR-5680	PAR-CLIP	23592263
MIRT490892	hsa-miR-3154	PAR-CLIP	23592263
MIRT490891	hsa-miR-130a-3p	PAR-CLIP	23592263
MIRT490890	hsa-miR-130b-3p	PAR-CLIP	23592263
MIRT490889	hsa-miR-301a-3p	PAR-CLIP	23592263
MIRT490888	hsa-miR-301b-3p	PAR-CLIP	23592263
MIRT490887	hsa-miR-3666	PAR-CLIP	23592263
MIRT490886	hsa-miR-4295	PAR-CLIP	23592263
MIRT490885	hsa-miR-454-3p	PAR-CLIP	23592263
MIRT490884	hsa-miR-7852-3p	PAR-CLIP	23592263
MIRT490882	hsa-miR-4691-3p	PAR-CLIP	23592263
MIRT490883	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT490881	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT490880	hsa-miR-3179	PAR-CLIP	23592263
MIRT490879	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT490878	hsa-miR-6077	PAR-CLIP	23592263
MIRT490877	hsa-miR-6073	PAR-CLIP	23592263
MIRT490876	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT490875	hsa-miR-4671-3p	PAR-CLIP	23592263
MIRT490874	hsa-miR-3157-5p	PAR-CLIP	23592263
MIRT442512	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT442511	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT442510	hsa-miR-6873-5p	PAR-CLIP	22100165
MIRT442509	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442507	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442508	hsa-miR-4510	PAR-CLIP	22100165
MIRT442506	hsa-miR-6127	PAR-CLIP	22100165
MIRT442505	hsa-miR-6129	PAR-CLIP	22100165
MIRT442504	hsa-miR-6130	PAR-CLIP	22100165
MIRT442503	hsa-miR-6133	PAR-CLIP	22100165
MIRT442502	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT442501	hsa-miR-6878-5p	PAR-CLIP	22100165
MIRT1205886	hsa-miR-1200	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT1205888	hsa-miR-1236	CLIP-seq
MIRT1205889	hsa-miR-1244	CLIP-seq
MIRT1205890	hsa-miR-1252	CLIP-seq
MIRT1205891	hsa-miR-1256	CLIP-seq
MIRT1205892	hsa-miR-1266	CLIP-seq
MIRT1205893	hsa-miR-130a	CLIP-seq
MIRT1205894	hsa-miR-130b	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT1205896	hsa-miR-1537	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT1205899	hsa-miR-2392	CLIP-seq
MIRT1205900	hsa-miR-301a	CLIP-seq
MIRT1205901	hsa-miR-301b	CLIP-seq
MIRT1205902	hsa-miR-3065-5p	CLIP-seq
MIRT1205903	hsa-miR-3138	CLIP-seq
MIRT1205904	hsa-miR-3140-5p	CLIP-seq
MIRT1205905	hsa-miR-3145-3p	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT1205907	hsa-miR-3153	CLIP-seq
MIRT1205908	hsa-miR-3185	CLIP-seq
MIRT1205909	hsa-miR-3202	CLIP-seq
MIRT1205910	hsa-miR-325	CLIP-seq
MIRT1205911	hsa-miR-3614-5p	CLIP-seq
MIRT1205912	hsa-miR-3664-3p	CLIP-seq
MIRT1205913	hsa-miR-370	CLIP-seq
MIRT1205914	hsa-miR-3920	CLIP-seq
MIRT1205915	hsa-miR-3936	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT1205917	hsa-miR-4270	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT1205919	hsa-miR-4292	CLIP-seq
MIRT1205920	hsa-miR-4308	CLIP-seq
MIRT1205921	hsa-miR-4321	CLIP-seq
MIRT1205922	hsa-miR-4425	CLIP-seq
MIRT1205923	hsa-miR-4441	CLIP-seq
MIRT1205924	hsa-miR-4476	CLIP-seq
MIRT1205925	hsa-miR-450b-3p	CLIP-seq
MIRT1205926	hsa-miR-4518	CLIP-seq
MIRT1205927	hsa-miR-4533	CLIP-seq
MIRT1205928	hsa-miR-454	CLIP-seq
MIRT1205929	hsa-miR-4668-5p	CLIP-seq
MIRT1205930	hsa-miR-4713-3p	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT1205933	hsa-miR-4778-3p	CLIP-seq
MIRT1205934	hsa-miR-4781-5p	CLIP-seq
MIRT1205935	hsa-miR-4786-3p	CLIP-seq
MIRT1205936	hsa-miR-4796-3p	CLIP-seq
MIRT1205937	hsa-miR-489	CLIP-seq
MIRT1205938	hsa-miR-509-3p	CLIP-seq
MIRT1205939	hsa-miR-513c	CLIP-seq
MIRT1205940	hsa-miR-514b-5p	CLIP-seq
MIRT1205941	hsa-miR-548p	CLIP-seq
MIRT1205942	hsa-miR-548t	CLIP-seq
MIRT1205943	hsa-miR-609	CLIP-seq
MIRT1205944	hsa-miR-638	CLIP-seq
MIRT1205945	hsa-miR-767-3p	CLIP-seq
MIRT1205946	hsa-miR-769-3p	CLIP-seq
MIRT1205947	hsa-miR-802	CLIP-seq
MIRT1205948	hsa-miR-885-5p	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT2059328	hsa-miR-135a	CLIP-seq
MIRT2059329	hsa-miR-135b	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT2059330	hsa-miR-3121-5p	CLIP-seq
MIRT2059331	hsa-miR-3622a-3p	CLIP-seq
MIRT2059332	hsa-miR-3622b-3p	CLIP-seq
MIRT2059333	hsa-miR-3673	CLIP-seq
MIRT2059334	hsa-miR-4468	CLIP-seq
MIRT2059335	hsa-miR-4766-5p	CLIP-seq
MIRT2059336	hsa-miR-4787-3p	CLIP-seq
MIRT2059337	hsa-miR-516a-3p	CLIP-seq
MIRT1205948	hsa-miR-885-5p	CLIP-seq
MIRT2287624	hsa-miR-1	CLIP-seq
MIRT2287625	hsa-miR-1224-5p	CLIP-seq
MIRT2287626	hsa-miR-1227	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT2287627	hsa-miR-124	CLIP-seq
MIRT1205890	hsa-miR-1252	CLIP-seq
MIRT2287628	hsa-miR-1305	CLIP-seq
MIRT1205893	hsa-miR-130a	CLIP-seq
MIRT1205894	hsa-miR-130b	CLIP-seq
MIRT2059328	hsa-miR-135a	CLIP-seq
MIRT2059329	hsa-miR-135b	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT2287629	hsa-miR-141	CLIP-seq
MIRT2287630	hsa-miR-150	CLIP-seq
MIRT1205896	hsa-miR-1537	CLIP-seq
MIRT2287631	hsa-miR-197	CLIP-seq
MIRT2287632	hsa-miR-200a	CLIP-seq
MIRT2287633	hsa-miR-206	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT2287634	hsa-miR-224	CLIP-seq
MIRT2287635	hsa-miR-2278	CLIP-seq
MIRT2287636	hsa-miR-2355-5p	CLIP-seq
MIRT2287637	hsa-miR-2467-5p	CLIP-seq
MIRT2287638	hsa-miR-29a	CLIP-seq
MIRT2287639	hsa-miR-29b	CLIP-seq
MIRT2287640	hsa-miR-29c	CLIP-seq
MIRT1205900	hsa-miR-301a	CLIP-seq
MIRT1205901	hsa-miR-301b	CLIP-seq
MIRT2287641	hsa-miR-3065-3p	CLIP-seq
MIRT2059330	hsa-miR-3121-5p	CLIP-seq
MIRT2287642	hsa-miR-3140-3p	CLIP-seq
MIRT1205905	hsa-miR-3145-3p	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT2287643	hsa-miR-3183	CLIP-seq
MIRT2287644	hsa-miR-3188	CLIP-seq
MIRT2287645	hsa-miR-3190	CLIP-seq
MIRT2287646	hsa-miR-335	CLIP-seq
MIRT1205911	hsa-miR-3614-5p	CLIP-seq
MIRT2287647	hsa-miR-3622a-5p	CLIP-seq
MIRT2287648	hsa-miR-365	CLIP-seq
MIRT2059333	hsa-miR-3673	CLIP-seq
MIRT2287649	hsa-miR-3677-3p	CLIP-seq
MIRT2287650	hsa-miR-3679-3p	CLIP-seq
MIRT2287651	hsa-miR-3687	CLIP-seq
MIRT2287652	hsa-miR-3691-5p	CLIP-seq
MIRT2287653	hsa-miR-3714	CLIP-seq
MIRT2287654	hsa-miR-3910	CLIP-seq
MIRT2287655	hsa-miR-3915	CLIP-seq
MIRT1205914	hsa-miR-3920	CLIP-seq
MIRT2287656	hsa-miR-3925-3p	CLIP-seq
MIRT2287657	hsa-miR-3928	CLIP-seq
MIRT2287658	hsa-miR-3973	CLIP-seq
MIRT2287659	hsa-miR-3975	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT2287660	hsa-miR-4266	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT2287661	hsa-miR-4287	CLIP-seq
MIRT2287662	hsa-miR-4318	CLIP-seq
MIRT1205921	hsa-miR-4321	CLIP-seq
MIRT2287663	hsa-miR-4328	CLIP-seq
MIRT2287664	hsa-miR-4423-3p	CLIP-seq
MIRT2287665	hsa-miR-4442	CLIP-seq
MIRT2059334	hsa-miR-4468	CLIP-seq
MIRT2287666	hsa-miR-4469	CLIP-seq
MIRT2287667	hsa-miR-4491	CLIP-seq
MIRT1205925	hsa-miR-450b-3p	CLIP-seq
MIRT1205928	hsa-miR-454	CLIP-seq
MIRT2287668	hsa-miR-4657	CLIP-seq
MIRT2287669	hsa-miR-4663	CLIP-seq
MIRT2287670	hsa-miR-4665-3p	CLIP-seq
MIRT2287671	hsa-miR-4685-3p	CLIP-seq
MIRT2287672	hsa-miR-4689	CLIP-seq
MIRT2287673	hsa-miR-4693-5p	CLIP-seq
MIRT2287674	hsa-miR-4698	CLIP-seq
MIRT2287675	hsa-miR-4705	CLIP-seq
MIRT1205930	hsa-miR-4713-3p	CLIP-seq
MIRT2287676	hsa-miR-4713-5p	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT2287677	hsa-miR-4716-5p	CLIP-seq
MIRT2287678	hsa-miR-4723-3p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT2287679	hsa-miR-4728-5p	CLIP-seq
MIRT2287680	hsa-miR-4764-5p	CLIP-seq
MIRT2287681	hsa-miR-4765	CLIP-seq
MIRT1205934	hsa-miR-4781-5p	CLIP-seq
MIRT1205935	hsa-miR-4786-3p	CLIP-seq
MIRT2287682	hsa-miR-4790-3p	CLIP-seq
MIRT2287683	hsa-miR-483-3p	CLIP-seq
MIRT2287684	hsa-miR-485-5p	CLIP-seq
MIRT2287685	hsa-miR-498	CLIP-seq
MIRT2287686	hsa-miR-506	CLIP-seq
MIRT1205938	hsa-miR-509-3p	CLIP-seq
MIRT2059337	hsa-miR-516a-3p	CLIP-seq
MIRT2287687	hsa-miR-520g	CLIP-seq
MIRT2287688	hsa-miR-520h	CLIP-seq
MIRT2287689	hsa-miR-522	CLIP-seq
MIRT2287690	hsa-miR-532-3p	CLIP-seq
MIRT2287691	hsa-miR-548ae	CLIP-seq
MIRT2287692	hsa-miR-548aj	CLIP-seq
MIRT2287693	hsa-miR-548am	CLIP-seq
MIRT2287694	hsa-miR-548x	CLIP-seq
MIRT2287695	hsa-miR-556-5p	CLIP-seq
MIRT2287696	hsa-miR-579	CLIP-seq
MIRT2287697	hsa-miR-600	CLIP-seq
MIRT2287698	hsa-miR-613	CLIP-seq
MIRT2287699	hsa-miR-624	CLIP-seq
MIRT1205944	hsa-miR-638	CLIP-seq
MIRT2287700	hsa-miR-647	CLIP-seq
MIRT2287701	hsa-miR-668	CLIP-seq
MIRT1205946	hsa-miR-769-3p	CLIP-seq
MIRT1205948	hsa-miR-885-5p	CLIP-seq
MIRT2287702	hsa-miR-892a	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT2391938	hsa-miR-134	CLIP-seq
MIRT2287631	hsa-miR-197	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT2391939	hsa-miR-3118	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT2391940	hsa-miR-3164	CLIP-seq
MIRT2391941	hsa-miR-3607-5p	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT1205919	hsa-miR-4292	CLIP-seq
MIRT1205920	hsa-miR-4308	CLIP-seq
MIRT2391942	hsa-miR-4501	CLIP-seq
MIRT2287675	hsa-miR-4705	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT1205937	hsa-miR-489	CLIP-seq
MIRT2287627	hsa-miR-124	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT2287629	hsa-miR-141	CLIP-seq
MIRT2585641	hsa-miR-185	CLIP-seq
MIRT2585642	hsa-miR-1913	CLIP-seq
MIRT2287632	hsa-miR-200a	CLIP-seq
MIRT2585643	hsa-miR-200b	CLIP-seq
MIRT2585644	hsa-miR-200c	CLIP-seq
MIRT2585645	hsa-miR-203	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT2585646	hsa-miR-216b	CLIP-seq
MIRT2585647	hsa-miR-217	CLIP-seq
MIRT2287635	hsa-miR-2278	CLIP-seq
MIRT2585648	hsa-miR-300	CLIP-seq
MIRT1205902	hsa-miR-3065-5p	CLIP-seq
MIRT1205905	hsa-miR-3145-3p	CLIP-seq
MIRT2287645	hsa-miR-3190	CLIP-seq
MIRT2585649	hsa-miR-324-3p	CLIP-seq
MIRT2287649	hsa-miR-3677-3p	CLIP-seq
MIRT2287652	hsa-miR-3691-5p	CLIP-seq
MIRT1205913	hsa-miR-370	CLIP-seq
MIRT2585650	hsa-miR-381	CLIP-seq
MIRT2585651	hsa-miR-3940-5p	CLIP-seq
MIRT2287661	hsa-miR-4287	CLIP-seq
MIRT2585652	hsa-miR-429	CLIP-seq
MIRT2585653	hsa-miR-4306	CLIP-seq
MIRT2585654	hsa-miR-4418	CLIP-seq
MIRT2585655	hsa-miR-4426	CLIP-seq
MIRT2585656	hsa-miR-4427	CLIP-seq
MIRT2585657	hsa-miR-4433	CLIP-seq
MIRT2287666	hsa-miR-4469	CLIP-seq
MIRT2585658	hsa-miR-4471	CLIP-seq
MIRT2585659	hsa-miR-4475	CLIP-seq
MIRT1205924	hsa-miR-4476	CLIP-seq
MIRT2585660	hsa-miR-4477b	CLIP-seq
MIRT2585661	hsa-miR-4488	CLIP-seq
MIRT2287667	hsa-miR-4491	CLIP-seq
MIRT2585662	hsa-miR-4507	CLIP-seq
MIRT2585663	hsa-miR-4534	CLIP-seq
MIRT2585664	hsa-miR-4641	CLIP-seq
MIRT2585665	hsa-miR-4644	CLIP-seq
MIRT2585666	hsa-miR-4647	CLIP-seq
MIRT2287668	hsa-miR-4657	CLIP-seq
MIRT2585667	hsa-miR-4662b	CLIP-seq
MIRT2287670	hsa-miR-4665-3p	CLIP-seq
MIRT2585668	hsa-miR-4680-3p	CLIP-seq
MIRT2287671	hsa-miR-4685-3p	CLIP-seq
MIRT2585669	hsa-miR-4694-3p	CLIP-seq
MIRT2585670	hsa-miR-4697-5p	CLIP-seq
MIRT2585671	hsa-miR-4714-5p	CLIP-seq
MIRT2585672	hsa-miR-4722-5p	CLIP-seq
MIRT2287680	hsa-miR-4764-5p	CLIP-seq
MIRT2585673	hsa-miR-486-3p	CLIP-seq
MIRT2585674	hsa-miR-495	CLIP-seq
MIRT2287686	hsa-miR-506	CLIP-seq
MIRT2585675	hsa-miR-509-3-5p	CLIP-seq
MIRT2585676	hsa-miR-509-5p	CLIP-seq
MIRT2585677	hsa-miR-511	CLIP-seq
MIRT2585678	hsa-miR-513b	CLIP-seq
MIRT1205939	hsa-miR-513c	CLIP-seq
MIRT1205940	hsa-miR-514b-5p	CLIP-seq
MIRT2287689	hsa-miR-522	CLIP-seq
MIRT2287697	hsa-miR-600	CLIP-seq
MIRT2585679	hsa-miR-617	CLIP-seq
MIRT2585680	hsa-miR-618	CLIP-seq
MIRT2287699	hsa-miR-624	CLIP-seq
MIRT2585681	hsa-miR-758	CLIP-seq
MIRT1205945	hsa-miR-767-3p	CLIP-seq
MIRT2287627	hsa-miR-124	CLIP-seq
MIRT2287629	hsa-miR-141	CLIP-seq
MIRT2585641	hsa-miR-185	CLIP-seq
MIRT2585642	hsa-miR-1913	CLIP-seq
MIRT2287632	hsa-miR-200a	CLIP-seq
MIRT2585645	hsa-miR-203	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT2585646	hsa-miR-216b	CLIP-seq
MIRT2287635	hsa-miR-2278	CLIP-seq
MIRT2585648	hsa-miR-300	CLIP-seq
MIRT2287645	hsa-miR-3190	CLIP-seq
MIRT2585649	hsa-miR-324-3p	CLIP-seq
MIRT2287649	hsa-miR-3677-3p	CLIP-seq
MIRT2287652	hsa-miR-3691-5p	CLIP-seq
MIRT1205913	hsa-miR-370	CLIP-seq
MIRT2585650	hsa-miR-381	CLIP-seq
MIRT2287661	hsa-miR-4287	CLIP-seq
MIRT2585653	hsa-miR-4306	CLIP-seq
MIRT2287663	hsa-miR-4328	CLIP-seq
MIRT2585655	hsa-miR-4426	CLIP-seq
MIRT2585657	hsa-miR-4433	CLIP-seq
MIRT2287666	hsa-miR-4469	CLIP-seq
MIRT1205924	hsa-miR-4476	CLIP-seq
MIRT2585661	hsa-miR-4488	CLIP-seq
MIRT2287667	hsa-miR-4491	CLIP-seq
MIRT2585663	hsa-miR-4534	CLIP-seq
MIRT2585664	hsa-miR-4641	CLIP-seq
MIRT2585665	hsa-miR-4644	CLIP-seq
MIRT2585666	hsa-miR-4647	CLIP-seq
MIRT2287668	hsa-miR-4657	CLIP-seq
MIRT2585667	hsa-miR-4662b	CLIP-seq
MIRT2287670	hsa-miR-4665-3p	CLIP-seq
MIRT2287671	hsa-miR-4685-3p	CLIP-seq
MIRT2585669	hsa-miR-4694-3p	CLIP-seq
MIRT2585670	hsa-miR-4697-5p	CLIP-seq
MIRT2287674	hsa-miR-4698	CLIP-seq
MIRT2585672	hsa-miR-4722-5p	CLIP-seq
MIRT2287680	hsa-miR-4764-5p	CLIP-seq
MIRT2585673	hsa-miR-486-3p	CLIP-seq
MIRT2585674	hsa-miR-495	CLIP-seq
MIRT2287686	hsa-miR-506	CLIP-seq
MIRT2585677	hsa-miR-511	CLIP-seq
MIRT2287689	hsa-miR-522	CLIP-seq
MIRT2287697	hsa-miR-600	CLIP-seq
MIRT2585679	hsa-miR-617	CLIP-seq
MIRT2287699	hsa-miR-624	CLIP-seq
MIRT1205945	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	24209621
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	21566117, 21988961, 24209621, 25036637, 25681634, 26496610, 28514442, 29547901, 29997244, 32814053, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	21988961
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	12023275
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IDA	29514919
GO:0005829	Component	Cytosol	EXP	24209621
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	24209621, 29514919
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006686	Process	Sphingomyelin biosynthetic process	IMP	12023275
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0006869	Process	Lipid transport	EXP	24209621
GO:0006869	Process	Lipid transport	IEA
GO:0008142	Function	Oxysterol binding	TAS	1970801
GO:0008289	Function	Lipid binding	IEA
GO:0015914	Process	Phospholipid transport	IDA	24209621
GO:0015918	Process	Sterol transport	IDA	24209621
GO:0016020	Component	Membrane	IDA	21988961
GO:0016020	Component	Membrane	IEA
GO:0019904	Function	Protein domain specific binding	IPI	20178991
GO:0030054	Component	Cell junction	IDA
GO:0032367	Process	Intracellular cholesterol transport	IMP	29514919
GO:0032934	Function	Sterol binding	IBA
GO:0032934	Function	Sterol binding	IEA
GO:0035627	Process	Ceramide transport	IMP	12023275
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	24209621
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IDA	24209621
GO:0097038	Component	Perinuclear endoplasmic reticulum	IBA
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0120013	Function	Lipid transfer activity	EXP	24209621
GO:0120015	Function	Sterol transfer activity	IDA	24209621
GO:0120015	Function	Sterol transfer activity	TAS
GO:1904411	Process	Positive regulation of secretory granule organization	IEA

Other IDs

• MIM: 167040
• HGNC: 8503
• e!Ensembl: ENSG00000110048

Protein

• UniProt ID: P22059
• Protein name: Oxysterol-binding protein 1
• Protein function: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for
• PDB: 2RR3, 7V62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	90 → 181	PH domain	Domain
  PF01237	Oxysterol_BP	418 → 793	Oxysterol-binding protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11278871}.
• Sequence:

  MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGP
  GAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYY
  RSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAK
  AKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS
  ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQ
  RIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFF
  DAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLW
  SIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT
  VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLR
  QEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI
  VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIG
  ENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD
  QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVT
  KELTHIYRGEYWECKEKQDWSSCPDIF

• Sequence length: 807

Pathways

Reactome:

Sphingolipid de novo biosynthesis
Synthesis of bile acids and bile salts

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Short stature	Pathogenic	rs1565117343	RCV000736214	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSBP-related disorder	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	26812496		★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 8 (disorder)	Amyotrophic lateral sclerosis	BEFREE	24271015		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	17478758		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	17478758		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	27588468		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	21763455		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Common Cold	Common cold	Pubtator	30209171	Associate	★☆☆☆☆ Found in Text Mining only
Hyperlipidemia, Familial Combined	Hyperlipidemia	BEFREE	19554302		★☆☆☆☆ Found in Text Mining only
Hypocholesterolemia	Hypocholesterolemia	BEFREE	28471037		★☆☆☆☆ Found in Text Mining only
liposarcoma	Liposarcoma	BEFREE	30415825		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	20128820		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28733164, 29596003		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	19325544	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	19325544		★☆☆☆☆ Found in Text Mining only
Motor Neuron Disease	Motor neuron disease	Pubtator	20178991	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26495757		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	20128820		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	30209171	Associate	★☆☆☆☆ Found in Text Mining only