Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4978
Gene name	Opioid binding protein/cell adhesion molecule like
Gene symbol	OPCML
Synonyms (NCBI Gene)	IGLON1OBCAMOPCM
Chromosome	11
Chromosome location	11q25
Summary	This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an a

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SNP ID	Visualize variation	Clinical significance	Consequence
rs137852691	G>A,C	Pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant

196

Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT551259	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551258	hsa-miR-4307	PAR-CLIP	21572407
MIRT551257	hsa-miR-567	PAR-CLIP	21572407
MIRT551255	hsa-miR-8068	PAR-CLIP	21572407
MIRT551256	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551254	hsa-miR-3924	PAR-CLIP	21572407
MIRT551253	hsa-miR-675-3p	PAR-CLIP	21572407
MIRT551252	hsa-miR-297	PAR-CLIP	21572407
MIRT551251	hsa-miR-3149	PAR-CLIP	21572407
MIRT551253	hsa-miR-675-3p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	33400243
MIRT551259	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551258	hsa-miR-4307	PAR-CLIP	21572407
MIRT551257	hsa-miR-567	PAR-CLIP	21572407
MIRT551255	hsa-miR-8068	PAR-CLIP	21572407
MIRT551256	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551254	hsa-miR-3924	PAR-CLIP	21572407
MIRT551253	hsa-miR-675-3p	PAR-CLIP	21572407
MIRT551252	hsa-miR-297	PAR-CLIP	21572407
MIRT551251	hsa-miR-3149	PAR-CLIP	21572407
MIRT1204104	hsa-miR-1237	CLIP-seq
MIRT1204105	hsa-miR-1297	CLIP-seq
MIRT1204106	hsa-miR-130a	CLIP-seq
MIRT1204107	hsa-miR-130b	CLIP-seq
MIRT1204108	hsa-miR-138	CLIP-seq
MIRT1204109	hsa-miR-149	CLIP-seq
MIRT1204110	hsa-miR-185	CLIP-seq
MIRT1204111	hsa-miR-19a	CLIP-seq
MIRT1204112	hsa-miR-19b	CLIP-seq
MIRT1204113	hsa-miR-205	CLIP-seq
MIRT1204114	hsa-miR-2052	CLIP-seq
MIRT1204115	hsa-miR-224	CLIP-seq
MIRT1204116	hsa-miR-2355-3p	CLIP-seq
MIRT1204117	hsa-miR-2467-3p	CLIP-seq
MIRT1204118	hsa-miR-26a	CLIP-seq
MIRT1204119	hsa-miR-26b	CLIP-seq
MIRT1204120	hsa-miR-27a	CLIP-seq
MIRT1204121	hsa-miR-27b	CLIP-seq
MIRT1204122	hsa-miR-301a	CLIP-seq
MIRT1204123	hsa-miR-301b	CLIP-seq
MIRT1204124	hsa-miR-3064-5p	CLIP-seq
MIRT1204125	hsa-miR-3117-5p	CLIP-seq
MIRT1204126	hsa-miR-3121-5p	CLIP-seq
MIRT1204127	hsa-miR-3122	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT1204129	hsa-miR-3129-3p	CLIP-seq
MIRT1204130	hsa-miR-3155	CLIP-seq
MIRT1204131	hsa-miR-3155b	CLIP-seq
MIRT1204132	hsa-miR-3161	CLIP-seq
MIRT1204133	hsa-miR-3179	CLIP-seq
MIRT1204134	hsa-miR-3189-3p	CLIP-seq
MIRT1204135	hsa-miR-3202	CLIP-seq
MIRT1204136	hsa-miR-320e	CLIP-seq
MIRT1204137	hsa-miR-346	CLIP-seq
MIRT1204138	hsa-miR-3591-5p	CLIP-seq
MIRT1204139	hsa-miR-362-5p	CLIP-seq
MIRT1204140	hsa-miR-3652	CLIP-seq
MIRT1204141	hsa-miR-3664-5p	CLIP-seq
MIRT1204142	hsa-miR-3666	CLIP-seq
MIRT1204143	hsa-miR-3913-5p	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1204145	hsa-miR-4287	CLIP-seq
MIRT1204146	hsa-miR-4288	CLIP-seq
MIRT1204147	hsa-miR-4295	CLIP-seq
MIRT1204148	hsa-miR-4299	CLIP-seq
MIRT1204149	hsa-miR-4306	CLIP-seq
MIRT1204150	hsa-miR-4420	CLIP-seq
MIRT1204151	hsa-miR-4430	CLIP-seq
MIRT1204152	hsa-miR-4436b-3p	CLIP-seq
MIRT1204153	hsa-miR-4438	CLIP-seq
MIRT1204154	hsa-miR-4457	CLIP-seq
MIRT1204155	hsa-miR-4465	CLIP-seq
MIRT1204156	hsa-miR-4469	CLIP-seq
MIRT1204157	hsa-miR-448	CLIP-seq
MIRT1204158	hsa-miR-4487	CLIP-seq
MIRT1204159	hsa-miR-4496	CLIP-seq
MIRT1204160	hsa-miR-4505	CLIP-seq
MIRT1204161	hsa-miR-4533	CLIP-seq
MIRT1204162	hsa-miR-454	CLIP-seq
MIRT1204163	hsa-miR-4644	CLIP-seq
MIRT1204164	hsa-miR-4646-3p	CLIP-seq
MIRT1204165	hsa-miR-4660	CLIP-seq
MIRT1204166	hsa-miR-4670-3p	CLIP-seq
MIRT1204167	hsa-miR-4680-5p	CLIP-seq
MIRT1204168	hsa-miR-4685-3p	CLIP-seq
MIRT1204169	hsa-miR-4699-5p	CLIP-seq
MIRT1204170	hsa-miR-4709-3p	CLIP-seq
MIRT1204171	hsa-miR-4713-5p	CLIP-seq
MIRT1204172	hsa-miR-4716-3p	CLIP-seq
MIRT1204173	hsa-miR-4731-3p	CLIP-seq
MIRT1204174	hsa-miR-4747-5p	CLIP-seq
MIRT1204175	hsa-miR-4766-5p	CLIP-seq
MIRT1204176	hsa-miR-4775	CLIP-seq
MIRT1204177	hsa-miR-4780	CLIP-seq
MIRT1204178	hsa-miR-4794	CLIP-seq
MIRT1204179	hsa-miR-4801	CLIP-seq
MIRT1204180	hsa-miR-484	CLIP-seq
MIRT1204181	hsa-miR-488	CLIP-seq
MIRT1204182	hsa-miR-498	CLIP-seq
MIRT1204183	hsa-miR-500b	CLIP-seq
MIRT1204184	hsa-miR-501-5p	CLIP-seq
MIRT1204185	hsa-miR-513a-5p	CLIP-seq
MIRT1204186	hsa-miR-519a	CLIP-seq
MIRT1204187	hsa-miR-519b-3p	CLIP-seq
MIRT1204188	hsa-miR-519c-3p	CLIP-seq
MIRT1204189	hsa-miR-570	CLIP-seq
MIRT1204190	hsa-miR-586	CLIP-seq
MIRT1204191	hsa-miR-590-3p	CLIP-seq
MIRT1204192	hsa-miR-592	CLIP-seq
MIRT1204193	hsa-miR-597	CLIP-seq
MIRT1204194	hsa-miR-623	CLIP-seq
MIRT1204195	hsa-miR-632	CLIP-seq
MIRT1204196	hsa-miR-654-3p	CLIP-seq
MIRT1204197	hsa-miR-668	CLIP-seq
MIRT1204198	hsa-miR-676	CLIP-seq
MIRT1204199	hsa-miR-875-3p	CLIP-seq
MIRT1204200	hsa-miR-885-3p	CLIP-seq
MIRT1551947	hsa-miR-193a-5p	CLIP-seq
MIRT1551948	hsa-miR-4527	CLIP-seq
MIRT1551949	hsa-miR-4728-3p	CLIP-seq
MIRT1551950	hsa-miR-4731-5p	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT1920718	hsa-miR-34b	CLIP-seq
MIRT1920719	hsa-miR-3653	CLIP-seq
MIRT1920720	hsa-miR-3658	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1920721	hsa-miR-4257	CLIP-seq
MIRT1204159	hsa-miR-4496	CLIP-seq
MIRT1920722	hsa-miR-4711-5p	CLIP-seq
MIRT1920723	hsa-miR-4738-3p	CLIP-seq
MIRT1920724	hsa-miR-548g	CLIP-seq
MIRT1920725	hsa-miR-646	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1920721	hsa-miR-4257	CLIP-seq
MIRT1204159	hsa-miR-4496	CLIP-seq
MIRT1920722	hsa-miR-4711-5p	CLIP-seq
MIRT1920723	hsa-miR-4738-3p	CLIP-seq
MIRT1920724	hsa-miR-548g	CLIP-seq
MIRT1920725	hsa-miR-646	CLIP-seq
MIRT2058953	hsa-miR-642b	CLIP-seq
MIRT2058954	hsa-miR-1272	CLIP-seq
MIRT1204110	hsa-miR-185	CLIP-seq
MIRT1204117	hsa-miR-2467-3p	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT2058955	hsa-miR-3150b-3p	CLIP-seq
MIRT2058956	hsa-miR-3682-3p	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1204149	hsa-miR-4306	CLIP-seq
MIRT1204163	hsa-miR-4644	CLIP-seq
MIRT2058957	hsa-miR-4689	CLIP-seq
MIRT1551950	hsa-miR-4731-5p	CLIP-seq
MIRT2058958	hsa-miR-4784	CLIP-seq
MIRT1204145	hsa-miR-4287	CLIP-seq
MIRT1204156	hsa-miR-4469	CLIP-seq
MIRT2287045	hsa-miR-4659a-3p	CLIP-seq
MIRT2287046	hsa-miR-4659b-3p	CLIP-seq
MIRT1204168	hsa-miR-4685-3p	CLIP-seq
MIRT2287047	hsa-miR-4762-5p	CLIP-seq
MIRT2287048	hsa-miR-4778-3p	CLIP-seq
MIRT2439144	hsa-miR-219-1-3p	CLIP-seq
MIRT2439145	hsa-miR-3545-3p	CLIP-seq
MIRT2439146	hsa-miR-4753-3p	CLIP-seq
MIRT2439147	hsa-miR-571	CLIP-seq
MIRT2439148	hsa-miR-942	CLIP-seq
MIRT2585271	hsa-miR-1178	CLIP-seq
MIRT1204104	hsa-miR-1237	CLIP-seq
MIRT2585272	hsa-miR-1273e	CLIP-seq
MIRT2585273	hsa-miR-2053	CLIP-seq
MIRT2585274	hsa-miR-223	CLIP-seq
MIRT1204115	hsa-miR-224	CLIP-seq
MIRT2585275	hsa-miR-302a	CLIP-seq
MIRT2585276	hsa-miR-302b	CLIP-seq
MIRT2585277	hsa-miR-302c	CLIP-seq
MIRT2585278	hsa-miR-302d	CLIP-seq
MIRT2585279	hsa-miR-302e	CLIP-seq
MIRT1204125	hsa-miR-3117-5p	CLIP-seq
MIRT2585280	hsa-miR-3152-3p	CLIP-seq
MIRT2585281	hsa-miR-3182	CLIP-seq
MIRT2585282	hsa-miR-3647-3p	CLIP-seq
MIRT2585283	hsa-miR-371b-3p	CLIP-seq
MIRT2585284	hsa-miR-372	CLIP-seq
MIRT2585285	hsa-miR-373	CLIP-seq
MIRT1204145	hsa-miR-4287	CLIP-seq
MIRT2585286	hsa-miR-4290	CLIP-seq
MIRT1204156	hsa-miR-4469	CLIP-seq
MIRT2585287	hsa-miR-4652-3p	CLIP-seq
MIRT1204168	hsa-miR-4685-3p	CLIP-seq
MIRT1204171	hsa-miR-4713-5p	CLIP-seq
MIRT2585288	hsa-miR-520a-3p	CLIP-seq
MIRT2585289	hsa-miR-520b	CLIP-seq
MIRT2585290	hsa-miR-520c-3p	CLIP-seq
MIRT2585291	hsa-miR-520d-3p	CLIP-seq
MIRT2585292	hsa-miR-520e	CLIP-seq
MIRT2585293	hsa-miR-520f	CLIP-seq
MIRT2585294	hsa-miR-569	CLIP-seq
MIRT2585295	hsa-miR-636	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1333602
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	7721093
GO:0008038	Process	Neuron recognition	IEA
GO:0008038	Process	Neuron recognition	TAS	7891157
GO:0016020	Component	Membrane	IEA
GO:0098552	Component	Side of membrane	IEA

MIM	HGNC	e!Ensembl
600632	8143	ENSG00000183715

Q14982

Protein name

Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)

Protein function

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

PDB

5UV6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	36 → 132	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	135 → 206		Domain
PF07679	I-set	223 → 312	Immunoglobulin I-set domain	Domain

Sequence

MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
DRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTD
NHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGF
VSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKG
ILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATN
KLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF

Sequence length

345

Interactions

View interactions

	Reactome
			Post-translational modification: synthesis of GPI-anchored proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Ovarian neoplasm	Pathogenic	rs137852691	RCV000009546	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (29)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL DYSPLASIA OF THE HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EATING DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPCML-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	ClinVar, HPO ClinVar, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Uncertain significance	ClinVar Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMOOTH SURFACE DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VESICOURETERAL REFLUX	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (80)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	LHGDN	17967182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	17967182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	18714356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	39755674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 1	Lateral Sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE	Amyotrophic lateral sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)	Amyotrophic lateral sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis, Sporadic	Lateral Sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	21273058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	17239010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28775148		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28775148	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	23495067	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	18714356, 21273058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	21273058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	16115914, 25966226	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	12819783, 16384911, 22585860, 24327526, 28693156		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	18584347		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	30832707		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	30832707	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	34697068, 35478117	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	25625843	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	21448164, 30832707		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	BEFREE	24616287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	23233742	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Degenerative polyarthritis	Arthritis	GWASDB_DG	22763110		★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	23495067	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diverticular Diseases	Diverticular Diseases	GWASCAT_DG	30177863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysgerminoma	Dysgerminoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	12819783, 16384911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	30880778	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	26442469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	17239010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	17239010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	17239010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	23495067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	28775148	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	18714356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	20112070, 27835605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	17967182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	18714356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	18714356	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	30571770		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	28775148		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	17967182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	UNIPROT_DG	12819783		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	24327526		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26890304		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	17109515, 27358143, 28407749		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	21273058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18714356, 23495067, 28407749, 28775148, 29805691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	18714356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	18714356	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12819783, 16384911, 17109515, 18584347, 18714356, 21273058, 22585860, 24327526, 27358143, 28407749, 28775148, 29805691, 29907679, 30880778, 31316070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	21255913		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	LHGDN	12819783, 17159813		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
ovarian neoplasm	Ovarian neoplasm	BEFREE	24327526		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
ovarian neoplasm	Ovarian neoplasm	CTD_human_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
ovarian neoplasm	Ovarian neoplasm	CGI_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
ovarian neoplasm	Ovarian neoplasm	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	16115914, 25625843, 27384440	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	28775148, 31316070	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian papillary adenocarcinoma	Ovarian papillary adenocarcinoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	34101221	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	26890304		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26890304	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	21833655, 29434535, 31577955		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Schizophrenia	Schizophrenia	PSYGENET_DG	21833655		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Schizophrenia	Schizophrenia	GWASCAT_DG	26198764		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	30880778		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	26442469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	17109515, 27358143, 28407749		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	17109515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	17109515	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	21273058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	GWASCAT_DG	30571770		★★★★★ ★☆☆☆☆ Found in Text Mining only

OPCML (opioid binding protein/cell adhesion molecule like)