OAZ2 (ornithine decarboxylase antizyme 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 4947 |
| Gene name | Ornithine decarboxylase antizyme 2 |
| Gene symbol | OAZ2 |
| Synonyms (NCBI Gene) |
AZ2
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| Chromosome | 15 |
| Chromosome location | 15q22.31 |
| Summary | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enha |
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miRNA
miRNA information provided by mirtarbase database.
379
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O95190 | ||||||||||
| Protein name | Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2) | ||||||||||
| Protein function | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 189 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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