Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4886
Gene name	Neuropeptide Y receptor Y1
Gene symbol	NPY1R
Synonyms (NCBI Gene)	NPY1-RNPYR
Chromosome	4
Chromosome location	4q32.2
Summary	This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast ago

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Show/Hide all (248)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018353	hsa-miR-335-5p	Microarray	18185580
MIRT1191684	hsa-miR-101	CLIP-seq
MIRT1191685	hsa-miR-106a	CLIP-seq
MIRT1191686	hsa-miR-106b	CLIP-seq
MIRT1191687	hsa-miR-1184	CLIP-seq
MIRT1191688	hsa-miR-1193	CLIP-seq
MIRT1191689	hsa-miR-1205	CLIP-seq
MIRT1191690	hsa-miR-1249	CLIP-seq
MIRT1191691	hsa-miR-1264	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT1191693	hsa-miR-1323	CLIP-seq
MIRT1191694	hsa-miR-144	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191698	hsa-miR-153	CLIP-seq
MIRT1191699	hsa-miR-17	CLIP-seq
MIRT1191700	hsa-miR-1911	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191703	hsa-miR-20a	CLIP-seq
MIRT1191704	hsa-miR-20b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191706	hsa-miR-2116	CLIP-seq
MIRT1191707	hsa-miR-218	CLIP-seq
MIRT1191708	hsa-miR-223	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT1191710	hsa-miR-2467-5p	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT1191712	hsa-miR-3065-5p	CLIP-seq
MIRT1191713	hsa-miR-3140-3p	CLIP-seq
MIRT1191714	hsa-miR-3143	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191716	hsa-miR-3158-5p	CLIP-seq
MIRT1191717	hsa-miR-3163	CLIP-seq
MIRT1191718	hsa-miR-3180-5p	CLIP-seq
MIRT1191719	hsa-miR-3188	CLIP-seq
MIRT1191720	hsa-miR-323b-3p	CLIP-seq
MIRT1191721	hsa-miR-3609	CLIP-seq
MIRT1191722	hsa-miR-3619-3p	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191725	hsa-miR-3665	CLIP-seq
MIRT1191726	hsa-miR-3667-5p	CLIP-seq
MIRT1191727	hsa-miR-3682-5p	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT1191729	hsa-miR-375	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191731	hsa-miR-380	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191734	hsa-miR-3975	CLIP-seq
MIRT1191735	hsa-miR-425	CLIP-seq
MIRT1191736	hsa-miR-4273	CLIP-seq
MIRT1191737	hsa-miR-4303	CLIP-seq
MIRT1191738	hsa-miR-431	CLIP-seq
MIRT1191739	hsa-miR-4328	CLIP-seq
MIRT1191740	hsa-miR-433	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT1191742	hsa-miR-4446-5p	CLIP-seq
MIRT1191743	hsa-miR-448	CLIP-seq
MIRT1191744	hsa-miR-4497	CLIP-seq
MIRT1191745	hsa-miR-450b-5p	CLIP-seq
MIRT1191746	hsa-miR-452	CLIP-seq
MIRT1191747	hsa-miR-4633-5p	CLIP-seq
MIRT1191748	hsa-miR-4649-3p	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191750	hsa-miR-4668-3p	CLIP-seq
MIRT1191751	hsa-miR-4676-3p	CLIP-seq
MIRT1191752	hsa-miR-4677-5p	CLIP-seq
MIRT1191753	hsa-miR-4686	CLIP-seq
MIRT1191754	hsa-miR-4704-3p	CLIP-seq
MIRT1191755	hsa-miR-4705	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT1191757	hsa-miR-4719	CLIP-seq
MIRT1191758	hsa-miR-4755-5p	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191760	hsa-miR-4796-3p	CLIP-seq
MIRT1191761	hsa-miR-485-5p	CLIP-seq
MIRT1191762	hsa-miR-488	CLIP-seq
MIRT1191763	hsa-miR-491-3p	CLIP-seq
MIRT1191764	hsa-miR-507	CLIP-seq
MIRT1191765	hsa-miR-513a-3p	CLIP-seq
MIRT1191766	hsa-miR-513b	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191768	hsa-miR-519d	CLIP-seq
MIRT1191769	hsa-miR-520a-5p	CLIP-seq
MIRT1191770	hsa-miR-525-5p	CLIP-seq
MIRT1191771	hsa-miR-532-5p	CLIP-seq
MIRT1191772	hsa-miR-548ah	CLIP-seq
MIRT1191773	hsa-miR-548c-3p	CLIP-seq
MIRT1191774	hsa-miR-548n	CLIP-seq
MIRT1191775	hsa-miR-548o	CLIP-seq
MIRT1191776	hsa-miR-548t	CLIP-seq
MIRT1191777	hsa-miR-549	CLIP-seq
MIRT1191778	hsa-miR-557	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT1191780	hsa-miR-586	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT1191782	hsa-miR-633	CLIP-seq
MIRT1191783	hsa-miR-636	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT1191785	hsa-miR-656	CLIP-seq
MIRT1191786	hsa-miR-657	CLIP-seq
MIRT1191787	hsa-miR-670	CLIP-seq
MIRT1191788	hsa-miR-93	CLIP-seq
MIRT1191789	hsa-miR-935	CLIP-seq
MIRT1191790	hsa-miR-944	CLIP-seq
MIRT1191687	hsa-miR-1184	CLIP-seq
MIRT1191688	hsa-miR-1193	CLIP-seq
MIRT1191689	hsa-miR-1205	CLIP-seq
MIRT2055569	hsa-miR-1207-5p	CLIP-seq
MIRT2055570	hsa-miR-1236	CLIP-seq
MIRT2055571	hsa-miR-1283	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT2055572	hsa-miR-132	CLIP-seq
MIRT2055573	hsa-miR-136	CLIP-seq
MIRT2055574	hsa-miR-141	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191700	hsa-miR-1911	CLIP-seq
MIRT2055575	hsa-miR-1914	CLIP-seq
MIRT2055576	hsa-miR-200a	CLIP-seq
MIRT2055577	hsa-miR-200b	CLIP-seq
MIRT2055578	hsa-miR-200c	CLIP-seq
MIRT2055579	hsa-miR-2054	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191706	hsa-miR-2116	CLIP-seq
MIRT2055580	hsa-miR-212	CLIP-seq
MIRT2055581	hsa-miR-216b	CLIP-seq
MIRT1191708	hsa-miR-223	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT2055582	hsa-miR-3121-5p	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191716	hsa-miR-3158-5p	CLIP-seq
MIRT2055583	hsa-miR-3160-5p	CLIP-seq
MIRT2055584	hsa-miR-3189-3p	CLIP-seq
MIRT2055585	hsa-miR-3189-5p	CLIP-seq
MIRT2055586	hsa-miR-3200-3p	CLIP-seq
MIRT2055587	hsa-miR-3607-3p	CLIP-seq
MIRT2055588	hsa-miR-3616-5p	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT2055589	hsa-miR-3647-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191727	hsa-miR-3682-5p	CLIP-seq
MIRT2055590	hsa-miR-3686	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT2055591	hsa-miR-3689a-3p	CLIP-seq
MIRT2055592	hsa-miR-3689c	CLIP-seq
MIRT2055593	hsa-miR-369-3p	CLIP-seq
MIRT2055594	hsa-miR-374a	CLIP-seq
MIRT2055595	hsa-miR-374b	CLIP-seq
MIRT2055596	hsa-miR-374c	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191731	hsa-miR-380	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191736	hsa-miR-4273	CLIP-seq
MIRT2055597	hsa-miR-429	CLIP-seq
MIRT2055598	hsa-miR-4300	CLIP-seq
MIRT1191738	hsa-miR-431	CLIP-seq
MIRT1191739	hsa-miR-4328	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT2055599	hsa-miR-4426	CLIP-seq
MIRT2055600	hsa-miR-4647	CLIP-seq
MIRT2055601	hsa-miR-4662b	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191752	hsa-miR-4677-5p	CLIP-seq
MIRT1191753	hsa-miR-4686	CLIP-seq
MIRT2055602	hsa-miR-4694-3p	CLIP-seq
MIRT2055603	hsa-miR-4694-5p	CLIP-seq
MIRT1191754	hsa-miR-4704-3p	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT2055604	hsa-miR-4724-5p	CLIP-seq
MIRT2055605	hsa-miR-4729	CLIP-seq
MIRT2055606	hsa-miR-4736	CLIP-seq
MIRT2055607	hsa-miR-4742-3p	CLIP-seq
MIRT2055608	hsa-miR-4758-3p	CLIP-seq
MIRT2055609	hsa-miR-4763-3p	CLIP-seq
MIRT2055610	hsa-miR-4768-5p	CLIP-seq
MIRT2055611	hsa-miR-4773	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191762	hsa-miR-488	CLIP-seq
MIRT2055612	hsa-miR-502-5p	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191771	hsa-miR-532-5p	CLIP-seq
MIRT1191773	hsa-miR-548c-3p	CLIP-seq
MIRT2055613	hsa-miR-558	CLIP-seq
MIRT2055614	hsa-miR-568	CLIP-seq
MIRT2055615	hsa-miR-573	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT2055616	hsa-miR-591	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT2055617	hsa-miR-605	CLIP-seq
MIRT2055618	hsa-miR-622	CLIP-seq
MIRT1191782	hsa-miR-633	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT2055619	hsa-miR-654-3p	CLIP-seq
MIRT2055620	hsa-miR-655	CLIP-seq
MIRT2055621	hsa-miR-920	CLIP-seq
MIRT1191789	hsa-miR-935	CLIP-seq
MIRT2284504	hsa-miR-1231	CLIP-seq
MIRT2055571	hsa-miR-1283	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT2284505	hsa-miR-2392	CLIP-seq
MIRT1191710	hsa-miR-2467-5p	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT1191712	hsa-miR-3065-5p	CLIP-seq
MIRT2284506	hsa-miR-3136-3p	CLIP-seq
MIRT1191714	hsa-miR-3143	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191719	hsa-miR-3188	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191734	hsa-miR-3975	CLIP-seq
MIRT1191735	hsa-miR-425	CLIP-seq
MIRT1191737	hsa-miR-4303	CLIP-seq
MIRT1191740	hsa-miR-433	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT1191747	hsa-miR-4633-5p	CLIP-seq
MIRT1191748	hsa-miR-4649-3p	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191755	hsa-miR-4705	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191761	hsa-miR-485-5p	CLIP-seq
MIRT1191763	hsa-miR-491-3p	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191777	hsa-miR-549	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT2055619	hsa-miR-654-3p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001601	Function	Peptide YY receptor activity	IEA
GO:0001602	Function	Pancreatic polypeptide receptor activity	IEA
GO:0003151	Process	Outflow tract morphogenesis	IMP	19593212
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004983	Function	Neuropeptide Y receptor activity	IEA
GO:0004983	Function	Neuropeptide Y receptor activity	TAS	1317848
GO:0005515	Function	Protein binding	IPI	23597562
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1317848
GO:0006006	Process	Glucose metabolic process	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1317848
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	1321422
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0007631	Process	Feeding behavior	IEA
GO:0008188	Function	Neuropeptide receptor activity	IBA
GO:0008217	Process	Regulation of blood pressure	IEA
GO:0016020	Component	Membrane	IEA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0023052	Process	Signaling	IEA
GO:0040014	Process	Regulation of multicellular organism growth	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA

MIM	HGNC	e!Ensembl
162641	7956	ENSG00000164128

P25929

Protein name

Neuropeptide Y receptor type 1 (NPY1-R)

Protein function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

PDB

5ZBQ , 7VGX , 7X9A , 8K6M , 8K6O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	57 → 320	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI

Sequence length

384

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes		Peptide ligand-binding receptors G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURAL TUBE DEFECT, FOLATE-SENSITIVE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURAL TUBE DEFECTS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURAL TUBE DEFECTS X-LINKED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONORGANIC PSYCHOSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSES, SUBSTANCE-INDUCED	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOTIC DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (58)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acrania	Acrania	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	24841617		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	CTD_human_DG	11440811		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anxiety Disorders	Anxiety Disorder	BEFREE	24841617		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anxiety States, Neurotic	Anxiety Disorder	CTD_human_DG	11440811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	15090072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	15090072	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	33878734	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35093384, 35741056	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39966932	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33878734	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	19712806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	19712806	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic myeloproliferative disorder	Myeloproliferative disorder	BEFREE	24681953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32058945, 34419055, 35545337	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Craniorachischisis	Craniorachischisis	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depression, Neurotic	Mental Depression	CTD_human_DG	9729278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	CTD_human_DG	9729278		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive Syndrome	Mental Depression	CTD_human_DG	9729278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	22029806	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diastematomyelia	Diastematomyelia	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endogenous depression	Mental Depression	CTD_human_DG	9729278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	16399808		★★★★★ ★☆☆☆☆ Found in Text Mining only
Exencephaly	Anencephaly	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	19593212, 19712806	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	19712806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	Pubtator	34104248	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	35093384	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Iniencephaly	Anencephaly	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial aneurysm	Pubtator	36451838	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melancholia	Melancholia	CTD_human_DG	9729278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	28894112		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	20975297	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	20975297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	27405725	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neural Tube Defects	Neural Tube Defect	CTD_human_DG	17400914		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurenteric Cyst	Neurenteric Cyst	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	24488767		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	19566775		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonorganic psychosis	Nonorganic Psychosis	PSYGENET_DG	19566775		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	CTD_human_DG	20975297		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	Pubtator	20975297, 35401881	Stimulate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	Pubtator	23900445	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	16339211		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	19566775		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psychotic Disorders	Psychosis	PSYGENET_DG	19566775		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinal Detachment	Retinal Detachment	LHGDN	12203398		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	LHGDN	18698022		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	14741323, 21512575		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	14741323, 21512575		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Spinal Cord Myelodysplasia	Spinal Cord Myelodysplasia	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30510283	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Substance Withdrawal Syndrome	Substance abuse	Pubtator	18828811	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tethered Cord Syndrome	Primary Tethered cord syndrome	CTD_human_DG	17400914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	33878734	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroiditis Autoimmune	Thyroiditis	Pubtator	34104248	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	CTD_human_DG	9729278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Wallerian Degeneration	Wallerian degeneration	Pubtator	23354834	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NPY1R (neuropeptide Y receptor Y1)