Gene Gene information from NCBI Gene database.
Entrez ID 4836
Gene name N-myristoyltransferase 1
Gene symbol NMT1
Synonyms (NCBI Gene)
HsNMT1NMT
Chromosome 17
Chromosome location 17q21.31
Summary Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer o
miRNA miRNA information provided by mirtarbase database.
406
miRTarBase ID miRNA Experiments Reference
MIRT047822 hsa-miR-30d-5p CLASH 23622248
MIRT046372 hsa-miR-23b-3p CLASH 23622248
MIRT045083 hsa-miR-186-5p CLASH 23622248
MIRT041243 hsa-miR-193b-3p CLASH 23622248
MIRT039990 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IBA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IDA 25255805, 32103017, 32111831, 32686708, 34999170
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IEA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
160993 7857 ENSG00000136448
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30419
Protein name Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-)
Protein function Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoy
PDB 1RXT , 3IU1 , 3IU2 , 3IWE , 3JTK , 4C2Y , 4C2Z , 5MU6 , 5NPQ , 5O6H , 5O6J , 5O9S , 5O9T , 5O9U , 5O9V , 5UUT , 6EHJ , 6F56 , 6FZ2 , 6FZ3 , 6FZ5 , 6PAV , 6QRM , 6SJZ , 6SK2 , 6SK3 , 6SK8 , 6SKJ , 7OWM , 7OWN , 7OWO , 7OWP , 7OWQ , 7OWR , 7OWU , 7RK3 , 8Q23 , 8Q24 , 8Q26 , 8Q2Z , 8Q3D , 8Q3S , 8Q3T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01233 NMT 137 294 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Domain
PF02799 NMT_C 308 494 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Heart, gut, kidney, liver and placenta. {ECO:0000269|PubMed:1570339}.
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Late Phase of HIV Life Cycle
Inactivation, recovery and regulation of the phototransduction cascade
Activation, myristolyation of BID and translocation to mitochondria
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CRANIOFACIAL MICROSOMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amelogenesis imperfecta nephrocalcinosis Amelogenesis Imperfecta BEFREE 31295750
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 15756927
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30154572, 30446635
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30154572 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 36617552 Associate
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases GWASCAT_DG 30595370
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic Neoplasms LHGDN 18021392
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 16600465 Associate
★☆☆☆☆
Found in Text Mining only
Dementia Dementia Pubtator 31784277 Associate
★☆☆☆☆
Found in Text Mining only
Immune System Diseases Immune system disease Pubtator 29579063 Associate
★☆☆☆☆
Found in Text Mining only