NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2)

Gene

• Entrez ID: 4835
• Gene name: N-ribosyldihydronicotinamide:quinone dehydrogenase 2
• Gene symbol: NQO2
• Synonyms (NCBI Gene): DHQV, DIA6, NMOR2, QR2
• Chromosome: 6
• Chromosome location: 6p25.2
• Summary: This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutati

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044829	hsa-miR-320a	CLASH	23622248
MIRT044829	hsa-miR-320a	HITS-CLIP	19536157
MIRT723160	hsa-miR-320b	HITS-CLIP	19536157
MIRT723159	hsa-miR-320c	HITS-CLIP	19536157
MIRT723158	hsa-miR-320d	HITS-CLIP	19536157
MIRT723157	hsa-miR-4429	HITS-CLIP	19536157
MIRT723156	hsa-miR-193a-3p	HITS-CLIP	19536157
MIRT723155	hsa-miR-193b-3p	HITS-CLIP	19536157
MIRT723154	hsa-miR-892b	HITS-CLIP	19536157
MIRT723153	hsa-miR-1278	HITS-CLIP	19536157
MIRT723152	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT723151	hsa-miR-4268	HITS-CLIP	19536157
MIRT723150	hsa-miR-4448	HITS-CLIP	19536157
MIRT723149	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT723148	hsa-miR-9-3p	HITS-CLIP	19536157
MIRT723147	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT723146	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT694062	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT694061	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT694060	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT694059	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT694058	hsa-miR-4794	HITS-CLIP	23313552
MIRT694057	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694056	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT694055	hsa-miR-4775	HITS-CLIP	23313552
MIRT694054	hsa-miR-4715-3p	HITS-CLIP	23313552
MIRT694053	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT647028	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT647027	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT647026	hsa-miR-4532	HITS-CLIP	23824327
MIRT647025	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647024	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647023	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647022	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT647021	hsa-miR-1976	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647020	hsa-miR-4279	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT457801	hsa-miR-941	PAR-CLIP	23592263
MIRT457800	hsa-miR-4258	PAR-CLIP	23592263
MIRT457799	hsa-miR-4707-3p	PAR-CLIP	23592263
MIRT457798	hsa-miR-6789-3p	PAR-CLIP	23592263
MIRT457800	hsa-miR-4258	PAR-CLIP	27292025
MIRT457799	hsa-miR-4707-3p	PAR-CLIP	27292025
MIRT457798	hsa-miR-6789-3p	PAR-CLIP	27292025
MIRT457801	hsa-miR-941	PAR-CLIP	27292025
MIRT044829	hsa-miR-320a	HITS-CLIP	19536157
MIRT723160	hsa-miR-320b	HITS-CLIP	19536157
MIRT723159	hsa-miR-320c	HITS-CLIP	19536157
MIRT723158	hsa-miR-320d	HITS-CLIP	19536157
MIRT723157	hsa-miR-4429	HITS-CLIP	19536157
MIRT723156	hsa-miR-193a-3p	HITS-CLIP	19536157
MIRT723155	hsa-miR-193b-3p	HITS-CLIP	19536157
MIRT723154	hsa-miR-892b	HITS-CLIP	19536157
MIRT723153	hsa-miR-1278	HITS-CLIP	19536157
MIRT723152	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT723151	hsa-miR-4268	HITS-CLIP	19536157
MIRT723150	hsa-miR-4448	HITS-CLIP	19536157
MIRT723149	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT723148	hsa-miR-9-3p	HITS-CLIP	19536157
MIRT723147	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT723146	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT694062	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT694061	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT694060	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT694059	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT694058	hsa-miR-4794	HITS-CLIP	23313552
MIRT694057	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694056	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT694055	hsa-miR-4775	HITS-CLIP	23313552
MIRT694054	hsa-miR-4715-3p	HITS-CLIP	23313552
MIRT694053	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT647028	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT647027	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT647026	hsa-miR-4532	HITS-CLIP	23824327
MIRT647025	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647024	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647023	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647022	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT647021	hsa-miR-1976	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647020	hsa-miR-4279	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT457801	hsa-miR-941	PAR-CLIP	23592263
MIRT457800	hsa-miR-4258	PAR-CLIP	23592263
MIRT457799	hsa-miR-4707-3p	PAR-CLIP	23592263
MIRT457798	hsa-miR-6789-3p	PAR-CLIP	23592263
MIRT2582381	hsa-miR-1539	CLIP-seq
MIRT2582382	hsa-miR-2277-3p	CLIP-seq
MIRT2582383	hsa-miR-2861	CLIP-seq
MIRT2582384	hsa-miR-29a	CLIP-seq
MIRT2582385	hsa-miR-29b	CLIP-seq
MIRT2582386	hsa-miR-29c	CLIP-seq
MIRT2582387	hsa-miR-3065-3p	CLIP-seq
MIRT2582388	hsa-miR-3152-5p	CLIP-seq
MIRT2582389	hsa-miR-4753-3p	CLIP-seq
MIRT2582390	hsa-miR-4763-5p	CLIP-seq
MIRT2582391	hsa-miR-4774-3p	CLIP-seq
MIRT2582392	hsa-miR-648	CLIP-seq
MIRT2582393	hsa-miR-661	CLIP-seq
MIRT2582394	hsa-miR-767-5p	CLIP-seq
MIRT2582395	hsa-miR-942	CLIP-seq
MIRT2582381	hsa-miR-1539	CLIP-seq
MIRT2582382	hsa-miR-2277-3p	CLIP-seq
MIRT2582383	hsa-miR-2861	CLIP-seq
MIRT2582384	hsa-miR-29a	CLIP-seq
MIRT2582385	hsa-miR-29b	CLIP-seq
MIRT2582386	hsa-miR-29c	CLIP-seq
MIRT2582387	hsa-miR-3065-3p	CLIP-seq
MIRT2582388	hsa-miR-3152-5p	CLIP-seq
MIRT2582389	hsa-miR-4753-3p	CLIP-seq
MIRT2582390	hsa-miR-4763-5p	CLIP-seq
MIRT2582391	hsa-miR-4774-3p	CLIP-seq
MIRT2582392	hsa-miR-648	CLIP-seq
MIRT2582393	hsa-miR-661	CLIP-seq
MIRT2582394	hsa-miR-767-5p	CLIP-seq
MIRT2582395	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
JUND	Unknown	16545679
SP1	Unknown	11154737;15451063

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001512	Function	Dihydronicotinamide riboside quinone reductase activity	IDA	18254726
GO:0001512	Function	Dihydronicotinamide riboside quinone reductase activity	IEA
GO:0003955	Function	NAD(P)H dehydrogenase (quinone) activity	IBA
GO:0005515	Function	Protein binding	IPI	16189514, 24606901, 25416956, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	10945627
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IDA	18254726
GO:0009055	Function	Electron transfer activity	IDA	10945627, 18254726
GO:0016491	Function	Oxidoreductase activity	IDA	10945627
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016661	Function	Oxidoreductase activity, acting on other nitrogenous compounds as donors	IDA	10945627
GO:0031404	Function	Chloride ion binding	IDA	18254726
GO:0042803	Function	Protein homodimerization activity	IPI	18254726
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071949	Function	FAD binding	IDA	18254726
GO:1901662	Process	Quinone catabolic process	IDA	18254726
GO:1904408	Function	Melatonin binding	IDA	18254726
GO:1905594	Function	Resveratrol binding	IDA	18254726

Other IDs

• MIM: 160998
• HGNC: 7856
• e!Ensembl: ENSG00000124588

Protein

• UniProt ID: P16083
• Protein name: Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)
• Protein function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutama
• PDB: 1QR2, 1SG0, 1XI2, 1ZX1, 2BZS, 2QMY, 2QMZ, 2QR2, 2QWX, 2QX4, 2QX6, 2QX8, 2QX9, 3FW1, 3G5M, 3GAM, 3NFR, 3NHF, 3NHJ, 3NHK, 3NHL, 3NHP, 3NHR, 3NHS, 3NHU, 3NHW, 3NHY, 3O2N, 3O73, 3OVM, 3OWH, 3OWX, 3OX1, 3OX2, 3OX3, 3TE7, 3TEM, 3TZB, 3UXE, 3UXH, 4FGJ, 4FGK, 4FGL, 4GQI, 4GR9, 4QOD, 4QOE, 4QOF, 4QOG, 4QOH, 4QOI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02525	Flavodoxin_2	4 → 212	Flavodoxin-like fold	Domain

• Sequence:

  MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
  SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
  LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
  GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ

• Sequence length: 231

Pathways

Reactome:

Phase I - Functionalization of compounds

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE MARROW DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONTACT DERMATITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, CONTACT	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EARLY-ONSET ALZHEIMERS DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEREDITARY BREAST CANCER	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEMORY DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONORGANIC PSYCHOSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOTIC DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma Of Esophagus	Esophageal Cancer	BEFREE	22736108		★☆☆☆☆ Found in Text Mining only
Age-Related Memory Disorders	Age-Related Memory Disorders	CTD_human_DG	20861374		★☆☆☆☆ Found in Text Mining only
Agranulocytosis	Agranulocytosis	BEFREE	14617031, 27168101, 29281794		★☆☆☆☆ Found in Text Mining only
Agranulocytosis	Agranulocytosis	CTD_human_DG	14617031		★☆☆☆☆ Found in Text Mining only
Amnesia	Amnesia	BEFREE	20861374		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	20861374		★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	20861374		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	17332305		★☆☆☆☆ Found in Text Mining only
Bone Marrow Diseases	Bone Marrow Diseases	CTD_human_DG	12351651		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain Ischemia	Brain ischemia	Pubtator	31564827	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19351655, 20683025, 21946896		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	HPO_DG			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	17332305, 21480392, 27586145		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27165481	Associate	★☆☆☆☆ Found in Text Mining only
Contact Dermatitis	Dermatitis	CTD_human_DG	25724174		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epithelial ovarian cancer	Ovarian cancer	BEFREE	21480392, 27586145		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	22736108, 22770696		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	22736108, 22770696		★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	36770840	Associate	★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Hepatoblastoma	BEFREE	8182056		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	18538895		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37891619	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	23918565	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19351655, 20683025, 21946896		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	22736108, 22770696		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	17332305		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	20966810		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23054000, 24682418		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21294640		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19661309, 29567345, 31514018		★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	15993843		★☆☆☆☆ Found in Text Mining only
Memory Disorders	Memory Disorders	CTD_human_DG	20861374		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	24142791		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22770696		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	18579530		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	18314446		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	32295184	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	36770840	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	26609153		★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	16191666		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonorganic psychosis	Nonorganic Psychosis	PSYGENET_DG	16191666		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ovarian neoplasm	Ovarian neoplasm	BEFREE	17332305		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	20966810		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	LHGDN	11688992, 15451063, 18314446, 18579530		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	BEFREE	15451063, 15694256, 18314446, 18579530		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	23054000, 24682418		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	15381063, 22266466	Associate	★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	16191666		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psychotic Disorders	Psychosis	PSYGENET_DG	16191666		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	14639047, 20861374		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	LHGDN	14639047		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	14639047, 20861374		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24354914		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21294640		★☆☆☆☆ Found in Text Mining only