Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4821
Gene name	NK2 homeobox 2
Gene symbol	NKX2-2
Synonyms (NCBI Gene)	NKX2.2NKX2B
Chromosome	20
Chromosome location	20p11.22
Summary	The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021435	hsa-miR-9-5p	Microarray	17612493
MIRT029734	hsa-miR-26b-5p	Microarray	19088304
MIRT455111	hsa-miR-5193	PAR-CLIP	20371350
MIRT455104	hsa-miR-4651	PAR-CLIP	20371350
MIRT455103	hsa-miR-608	PAR-CLIP	20371350
MIRT455097	hsa-miR-1181	PAR-CLIP	20371350
MIRT455096	hsa-miR-6089	PAR-CLIP	20371350
MIRT455111	hsa-miR-5193	PAR-CLIP	24398324
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	24398324
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	24398324
MIRT455104	hsa-miR-4651	PAR-CLIP	24398324
MIRT455103	hsa-miR-608	PAR-CLIP	24398324
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	24398324
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	24398324
MIRT455097	hsa-miR-1181	PAR-CLIP	24398324
MIRT455096	hsa-miR-6089	PAR-CLIP	24398324
MIRT455111	hsa-miR-5193	PAR-CLIP	23592263
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT487869	hsa-miR-661	PAR-CLIP	23592263
MIRT487868	hsa-miR-2861	PAR-CLIP	23592263
MIRT455109	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT455107	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT455106	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT455105	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT455104	hsa-miR-4651	PAR-CLIP	23592263
MIRT455103	hsa-miR-608	PAR-CLIP	23592263
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT455100	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT455099	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT455098	hsa-miR-1227-5p	PAR-CLIP	23592263
MIRT455097	hsa-miR-1181	PAR-CLIP	23592263
MIRT455096	hsa-miR-6089	PAR-CLIP	23592263
MIRT455111	hsa-miR-5193	PAR-CLIP	23592263
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT455109	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT455107	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT455106	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT455105	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT455104	hsa-miR-4651	PAR-CLIP	23592263
MIRT455103	hsa-miR-608	PAR-CLIP	23592263
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT455100	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT455099	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT455098	hsa-miR-1227-5p	PAR-CLIP	23592263
MIRT455097	hsa-miR-1181	PAR-CLIP	23592263
MIRT455096	hsa-miR-6089	PAR-CLIP	23592263
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455104	hsa-miR-4651	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455111	hsa-miR-5193	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455096	hsa-miR-6089	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455103	hsa-miR-608	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	26701625
MIRT455097	hsa-miR-1181	PAR-CLIP	27292025
MIRT455097	hsa-miR-1181	PAR-CLIP	27292025
MIRT455099	hsa-miR-3151-5p	PAR-CLIP	27292025
MIRT455104	hsa-miR-4651	PAR-CLIP	27292025
MIRT455104	hsa-miR-4651	PAR-CLIP	27292025
MIRT455111	hsa-miR-5193	PAR-CLIP	27292025
MIRT455111	hsa-miR-5193	PAR-CLIP	27292025
MIRT455096	hsa-miR-6089	PAR-CLIP	27292025
MIRT455096	hsa-miR-6089	PAR-CLIP	27292025
MIRT455103	hsa-miR-608	PAR-CLIP	27292025
MIRT455103	hsa-miR-608	PAR-CLIP	27292025
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	27292025
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	27292025
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	27292025
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	27292025
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	27292025
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	27292025
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	27292025
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	27292025
MIRT455100	hsa-miR-92a-2-5p	PAR-CLIP	27292025
MIRT455100	hsa-miR-92a-2-5p	PAR-CLIP	27292025
MIRT455111	hsa-miR-5193	PAR-CLIP	20371350
MIRT455104	hsa-miR-4651	PAR-CLIP	20371350
MIRT455103	hsa-miR-608	PAR-CLIP	20371350
MIRT455097	hsa-miR-1181	PAR-CLIP	20371350
MIRT455096	hsa-miR-6089	PAR-CLIP	20371350
MIRT455111	hsa-miR-5193	PAR-CLIP	24398324
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	24398324
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	24398324
MIRT455104	hsa-miR-4651	PAR-CLIP	24398324
MIRT455103	hsa-miR-608	PAR-CLIP	24398324
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	24398324
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	24398324
MIRT455097	hsa-miR-1181	PAR-CLIP	24398324
MIRT455096	hsa-miR-6089	PAR-CLIP	24398324
MIRT455111	hsa-miR-5193	PAR-CLIP	23592263
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT487869	hsa-miR-661	PAR-CLIP	23592263
MIRT487868	hsa-miR-2861	PAR-CLIP	23592263
MIRT455109	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT455107	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT455106	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT455105	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT455104	hsa-miR-4651	PAR-CLIP	23592263
MIRT455103	hsa-miR-608	PAR-CLIP	23592263
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT455100	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT455099	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT455098	hsa-miR-1227-5p	PAR-CLIP	23592263
MIRT455097	hsa-miR-1181	PAR-CLIP	23592263
MIRT455096	hsa-miR-6089	PAR-CLIP	23592263
MIRT455111	hsa-miR-5193	PAR-CLIP	23592263
MIRT455110	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT455108	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT455109	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT455107	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT455106	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT455105	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT455104	hsa-miR-4651	PAR-CLIP	23592263
MIRT455103	hsa-miR-608	PAR-CLIP	23592263
MIRT455102	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT455101	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT455100	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT455099	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT455098	hsa-miR-1227-5p	PAR-CLIP	23592263
MIRT455097	hsa-miR-1181	PAR-CLIP	23592263
MIRT455096	hsa-miR-6089	PAR-CLIP	23592263
MIRT1186530	hsa-miR-1538	CLIP-seq
MIRT1186531	hsa-miR-1909	CLIP-seq
MIRT1186532	hsa-miR-2467-3p	CLIP-seq
MIRT1186533	hsa-miR-3613-3p	CLIP-seq
MIRT1186534	hsa-miR-4436b-3p	CLIP-seq
MIRT1186535	hsa-miR-4493	CLIP-seq
MIRT1186536	hsa-miR-4666-5p	CLIP-seq
MIRT1186537	hsa-miR-4668-5p	CLIP-seq
MIRT1186538	hsa-miR-4745-3p	CLIP-seq
MIRT1186539	hsa-miR-4747-3p	CLIP-seq
MIRT1186540	hsa-miR-4802-3p	CLIP-seq
MIRT2581485	hsa-miR-571	CLIP-seq
MIRT2581485	hsa-miR-571	CLIP-seq

Show/Hide all (52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IEA
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	ISS
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS
GO:0003309	Process	Type B pancreatic cell differentiation	IEA
GO:0003323	Process	Type B pancreatic cell development	IEA
GO:0003326	Process	Pancreatic A cell fate commitment	IEA
GO:0003327	Process	Type B pancreatic cell fate commitment	IEA
GO:0003329	Process	Pancreatic PP cell fate commitment	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	30177510
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007224	Process	Smoothened signaling pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007420	Process	Brain development	TAS	1346742
GO:0009749	Process	Response to glucose	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0014003	Process	Oligodendrocyte development	IEA
GO:0021522	Process	Spinal cord motor neuron differentiation	IEA
GO:0021529	Process	Spinal cord oligodendrocyte cell differentiation	IEA
GO:0021530	Process	Spinal cord oligodendrocyte cell fate specification	IEA
GO:0021554	Process	Optic nerve development	IEA
GO:0021953	Process	Central nervous system neuron differentiation	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0030858	Process	Positive regulation of epithelial cell differentiation	IEA
GO:0031018	Process	Endocrine pancreas development	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048468	Process	Cell development	IEA
GO:0048565	Process	Digestive tract development	IEA
GO:0048665	Process	Neuron fate specification	IEA
GO:0048708	Process	Astrocyte differentiation	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA
GO:0060580	Process	Ventral spinal cord interneuron fate determination	IEA
GO:0061101	Process	Neuroendocrine cell differentiation	IEA

MIM	HGNC	e!Ensembl
604612	7835	ENSG00000125820

O95096

Protein name

Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B)

Protein function

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	129 → 185	Homeodomain	Domain

Sequence

MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLP
LKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPG
GGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHR
YKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQ
SLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW

Sequence length

273

Interactions

View interactions

	KEGG		Reactome
	Maturity onset diabetes of the young		Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEONATAL DIABETES MELLITUS	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NKX2-2-related disorder	Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	30680064	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	17146289	★★★★★ ★☆☆☆☆ Found in Text Mining only
Desmoplastic Small Round Cell Tumor	Desmoplastic Tumor	BEFREE	26847175	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	26847175, 30093639	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	30680064	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesenchymal Chondrosarcoma	Mesenchymal Chondrosarcoma	BEFREE	26847175	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neonatal diabetes mellitus	Diabetes Mellitus	BEFREE	24411943	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neonatal diabetes mellitus	Diabetes Mellitus	GENOMICS_ENGLAND_DG	24411943	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	17146289, 18056173, 26847175, 30210629	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	20830616	★★★★★ ★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	17146289	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30210629	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	LHGDN	16697960, 18414662	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	26847175, 29920735	★★★★★ ★☆☆☆☆ Found in Text Mining only
Soft Tissue Neoplasms	Soft Tissue Neoplasms	BEFREE	26847175	★★★★★ ★☆☆☆☆ Found in Text Mining only
synovial sarcoma	Synovial sarcoma	BEFREE	26847175	★★★★★ ★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	17146289	★★★★★ ★☆☆☆☆ Found in Text Mining only

NKX2-2 (NK2 homeobox 2)