ACO1 (aconitase 1)

Gene

• Entrez ID: 48
• Gene name: Aconitase 1
• Gene symbol: ACO1
• Synonyms (NCBI Gene): ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
• Chromosome: 9
• Chromosome location: 9p21.1
• Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4F

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT762807	hsa-miR-1207-3p	CLIP-seq
MIRT762808	hsa-miR-1252	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT762810	hsa-miR-1255a	CLIP-seq
MIRT762811	hsa-miR-1255b	CLIP-seq
MIRT762812	hsa-miR-1273e	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT762814	hsa-miR-141	CLIP-seq
MIRT762815	hsa-miR-185	CLIP-seq
MIRT762816	hsa-miR-19a	CLIP-seq
MIRT762817	hsa-miR-19b	CLIP-seq
MIRT762818	hsa-miR-200a	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT762820	hsa-miR-2116	CLIP-seq
MIRT762821	hsa-miR-3123	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT762823	hsa-miR-3150b-3p	CLIP-seq
MIRT762824	hsa-miR-3175	CLIP-seq
MIRT762825	hsa-miR-34b	CLIP-seq
MIRT762826	hsa-miR-3616-5p	CLIP-seq
MIRT762827	hsa-miR-3647-5p	CLIP-seq
MIRT762828	hsa-miR-4261	CLIP-seq
MIRT762829	hsa-miR-4294	CLIP-seq
MIRT762830	hsa-miR-4306	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT762832	hsa-miR-4496	CLIP-seq
MIRT762833	hsa-miR-4639-3p	CLIP-seq
MIRT762834	hsa-miR-4644	CLIP-seq
MIRT762835	hsa-miR-4689	CLIP-seq
MIRT762836	hsa-miR-4699-5p	CLIP-seq
MIRT762837	hsa-miR-4714-5p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762839	hsa-miR-4784	CLIP-seq
MIRT762840	hsa-miR-4795-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762842	hsa-miR-518a-5p	CLIP-seq
MIRT762843	hsa-miR-527	CLIP-seq
MIRT762844	hsa-miR-573	CLIP-seq
MIRT762845	hsa-miR-581	CLIP-seq
MIRT762846	hsa-miR-595	CLIP-seq
MIRT762847	hsa-miR-633	CLIP-seq
MIRT762848	hsa-miR-648	CLIP-seq
MIRT762849	hsa-miR-668	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924871	hsa-miR-1283	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT762814	hsa-miR-141	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762818	hsa-miR-200a	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762849	hsa-miR-668	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT762814	hsa-miR-141	CLIP-seq
MIRT762818	hsa-miR-200a	CLIP-seq
MIRT2166075	hsa-miR-374c	CLIP-seq
MIRT2166076	hsa-miR-4774-5p	CLIP-seq
MIRT2166077	hsa-miR-655	CLIP-seq
MIRT762849	hsa-miR-668	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT2464821	hsa-miR-3121-3p	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT2468613	hsa-miR-1271	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924871	hsa-miR-1283	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT2468614	hsa-miR-2113	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT2464821	hsa-miR-3121-3p	CLIP-seq
MIRT762821	hsa-miR-3123	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT2468615	hsa-miR-3668	CLIP-seq
MIRT2468616	hsa-miR-3714	CLIP-seq
MIRT2468617	hsa-miR-3925-5p	CLIP-seq
MIRT2468618	hsa-miR-3976	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT2468619	hsa-miR-4700-3p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT2468620	hsa-miR-495	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT2468621	hsa-miR-550a	CLIP-seq
MIRT2468622	hsa-miR-624	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT2468623	hsa-miR-96	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT2468613	hsa-miR-1271	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924871	hsa-miR-1283	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT2468614	hsa-miR-2113	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT2674260	hsa-miR-3065-3p	CLIP-seq
MIRT2464821	hsa-miR-3121-3p	CLIP-seq
MIRT762821	hsa-miR-3123	CLIP-seq
MIRT2674261	hsa-miR-3125	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT2674262	hsa-miR-335	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT2468615	hsa-miR-3668	CLIP-seq
MIRT2468616	hsa-miR-3714	CLIP-seq
MIRT2674263	hsa-miR-3916	CLIP-seq
MIRT2468617	hsa-miR-3925-5p	CLIP-seq
MIRT2468618	hsa-miR-3976	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT2674264	hsa-miR-4468	CLIP-seq
MIRT2674265	hsa-miR-4476	CLIP-seq
MIRT2468619	hsa-miR-4700-3p	CLIP-seq
MIRT2674266	hsa-miR-4725-5p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT2468620	hsa-miR-495	CLIP-seq
MIRT2674267	hsa-miR-504	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT2468621	hsa-miR-550a	CLIP-seq
MIRT2468622	hsa-miR-624	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT2468623	hsa-miR-96	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MTF1	Unknown	16886906
SP1	Unknown	16886906

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	EXP	1946430, 7983023, 8041788
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IEA
GO:0003723	Function	RNA binding	IDA	1946430
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	1903202
GO:0003994	Function	Aconitate hydratase activity	IBA
GO:0003994	Function	Aconitate hydratase activity	IDA	1946430, 8041788
GO:0003994	Function	Aconitate hydratase activity	IEA
GO:0003994	Function	Aconitate hydratase activity	IMP	1281544
GO:0005515	Function	Protein binding	IPI	19762596, 19762597, 35512704
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	1281544
GO:0005737	Component	Cytoplasm	NAS	1738601
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA	16144863
GO:0005794	Component	Golgi apparatus	IDA	16144863
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	1281544, 16527810
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006101	Process	Citrate metabolic process	IBA
GO:0006101	Process	Citrate metabolic process	IDA	8041788, 16527810
GO:0006101	Process	Citrate metabolic process	IMP	1281544
GO:0006417	Process	Regulation of translation	IEA
GO:0006740	Process	NADPH regeneration	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IBA
GO:0006879	Process	Intracellular iron ion homeostasis	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	TAS
GO:0009791	Process	Post-embryonic development	IEA
GO:0010040	Process	Response to iron(II) ion	IDA	8041788
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030350	Function	Iron-responsive element binding	IBA
GO:0030350	Function	Iron-responsive element binding	IDA	8041788
GO:0030350	Function	Iron-responsive element binding	IEA
GO:0030350	Function	Iron-responsive element binding	IMP	1281544, 23891004
GO:0046872	Function	Metal ion binding	IEA
GO:0050892	Process	Intestinal absorption	IEA
GO:0051536	Function	Iron-sulfur cluster binding	EXP	16407072
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051538	Function	3 iron, 4 sulfur cluster binding	IBA
GO:0051538	Function	3 iron, 4 sulfur cluster binding	IMP	1281544
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IBA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IDA	16407072
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IMP	1281544
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 100880
• HGNC: 117
• e!Ensembl: ENSG00000122729

Protein

• UniProt ID: P21399
• Protein name: Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)
• Protein function: Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes
• PDB: 2B3X, 2B3Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00330	Aconitase	59 → 564	Aconitase family (aconitate hydratase)	Family
  PF00694	Aconitase_C	692 → 821	Aconitase C-terminal domain	Domain

• Sequence:

  MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
  ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA
  DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV
  NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP
  QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC
  PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE
  LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT
  EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY
  YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG
  RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE
  RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK
  SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA
  RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR
  DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP
  ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK

• Sequence length: 889

Pathways

KEGG:

Citrate cycle (TCA cycle)
Glyoxylate and dicarboxylate metabolism
Metabolic pathways
Carbon metabolism
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids

Reactome:

Iron uptake and transport

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY SKIN DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	29534684		★☆☆☆☆ Found in Text Mining only
Age related macular degeneration	Age-related macular degeneration	BEFREE	22331484		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	27206843	Associate	★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	27545647		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	26782057		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	19307463	Associate	★☆☆☆☆ Found in Text Mining only
Chuvash erythrocytosis	Chuvash Erythrocytosis	BEFREE	29480820		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24536049	Associate	★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	BEFREE	20574843		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	CTD_human_DG	18784066		★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	23935819		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	34170849	Associate	★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	25753988		★☆☆☆☆ Found in Text Mining only
Glycogen Storage Disease Type II	Glycogen storage disease	Pubtator	22331484	Associate	★☆☆☆☆ Found in Text Mining only
Graves Ophthalmopathy	Graves ophthalmopathy	Pubtator	39735537	Associate	★☆☆☆☆ Found in Text Mining only
Hemochromatosis	Hemochromatosis	LHGDN	11783942, 12196178		★☆☆☆☆ Found in Text Mining only
Hemochromatosis	Hemochromatosis	BEFREE	12196178		★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	12052872	Associate	★☆☆☆☆ Found in Text Mining only
Hereditary hemochromatosis	Hereditary Hemochromatosis	BEFREE	12196178, 16503547		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	30002810		★☆☆☆☆ Found in Text Mining only
Hyperferritinemia hereditary with congenital cataracts	Hyperferritinemia	Pubtator	7492760	Associate	★☆☆☆☆ Found in Text Mining only
Hyperferritinemia, hereditary, with congenital cataracts	Hereditary hyperferritinemia with congenital cataracts	BEFREE	19800271		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	25771171		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	29534684	Associate	★☆☆☆☆ Found in Text Mining only
Iron deficiency anemia	Iron deficiency anemia	BEFREE	16503547		★☆☆☆☆ Found in Text Mining only
Iron deficiency anemia	Iron deficiency anemia	LHGDN	16503547		★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron Overload	BEFREE	18304497		★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron overload	Pubtator	35644542	Associate	★☆☆☆☆ Found in Text Mining only
Iron-Refractory Iron Deficiency Anemia	Anemia	BEFREE	29746238		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	23155415	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	23155415	Inhibit	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17200797		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	17200797		★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	12052872	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	16386771	Associate	★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	22331484	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	26755275		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	20957285		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12052872, 17127713, 31734690		★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	20574843	Associate	★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	31442913	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17127713, 20405006, 24909164, 29534684		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	26506412, 28502703		★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	25753988		★☆☆☆☆ Found in Text Mining only
Osteoarthrosis Deformans	Osteoarthrosis Deformans	CTD_human_DG	18784066		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	26755275		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	26755275	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	12423242		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	12423242	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	23303856	Inhibit	★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	BEFREE	29534684		★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	Pubtator	29534684	Associate	★☆☆☆☆ Found in Text Mining only
Polycythemia	Polycythemia	BEFREE	25771171, 29480820		★☆☆☆☆ Found in Text Mining only
Polycythemia	Polycythemia	Pubtator	29534684	Associate	★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia Vera	BEFREE	29534684		★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia vera	Pubtator	29534684	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	25574825		★★☆☆☆ Found in Text Mining + Unknown/Other Associations