Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4799
Gene name	Nuclear transcription factor, X-box binding 1
Gene symbol	NFX1
Synonyms (NCBI Gene)	NFX2TEG-42Tex42
Chromosome	9
Chromosome location	9p13.3
Summary	MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a

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Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT647717	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT647716	hsa-miR-3135b	HITS-CLIP	23313552
MIRT647715	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT647714	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT647711	hsa-miR-3652	HITS-CLIP	23313552
MIRT647710	hsa-miR-4430	HITS-CLIP	23313552
MIRT647709	hsa-miR-4466	HITS-CLIP	23313552
MIRT647708	hsa-miR-675-5p	HITS-CLIP	23313552
MIRT647707	hsa-miR-143-5p	HITS-CLIP	23313552
MIRT647701	hsa-miR-5698	HITS-CLIP	23313552
MIRT647719	hsa-miR-1267	HITS-CLIP	23824327
MIRT647718	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT647717	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647716	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647715	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647714	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647712	hsa-miR-4284	HITS-CLIP	23824327
MIRT647713	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT647711	hsa-miR-3652	HITS-CLIP	23824327
MIRT647710	hsa-miR-4430	HITS-CLIP	23824327
MIRT647709	hsa-miR-4466	HITS-CLIP	23824327
MIRT647708	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT647707	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647706	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT647705	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT647704	hsa-miR-8057	HITS-CLIP	23824327
MIRT647703	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT647701	hsa-miR-5698	HITS-CLIP	23824327
MIRT440117	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT440117	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT647717	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT647716	hsa-miR-3135b	HITS-CLIP	23313552
MIRT647715	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT647714	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT647711	hsa-miR-3652	HITS-CLIP	23313552
MIRT647710	hsa-miR-4430	HITS-CLIP	23313552
MIRT647709	hsa-miR-4466	HITS-CLIP	23313552
MIRT647708	hsa-miR-675-5p	HITS-CLIP	23313552
MIRT647707	hsa-miR-143-5p	HITS-CLIP	23313552
MIRT647701	hsa-miR-5698	HITS-CLIP	23313552
MIRT647719	hsa-miR-1267	HITS-CLIP	23824327
MIRT647718	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT647717	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647716	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647715	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647714	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647712	hsa-miR-4284	HITS-CLIP	23824327
MIRT647713	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT647711	hsa-miR-3652	HITS-CLIP	23824327
MIRT647710	hsa-miR-4430	HITS-CLIP	23824327
MIRT647709	hsa-miR-4466	HITS-CLIP	23824327
MIRT647708	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT647707	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647706	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT647705	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT647704	hsa-miR-8057	HITS-CLIP	23824327
MIRT647703	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT647701	hsa-miR-5698	HITS-CLIP	23824327
MIRT1183604	hsa-miR-128	CLIP-seq
MIRT1183605	hsa-miR-2114	CLIP-seq
MIRT1183606	hsa-miR-2355-3p	CLIP-seq
MIRT1183607	hsa-miR-27a	CLIP-seq
MIRT1183608	hsa-miR-27b	CLIP-seq
MIRT1183609	hsa-miR-3672	CLIP-seq
MIRT1183610	hsa-miR-4330	CLIP-seq
MIRT1183611	hsa-miR-4646-3p	CLIP-seq
MIRT1183612	hsa-miR-4653-3p	CLIP-seq
MIRT1183613	hsa-miR-4684-5p	CLIP-seq
MIRT1183614	hsa-miR-4705	CLIP-seq
MIRT1183615	hsa-miR-4768-5p	CLIP-seq
MIRT1183616	hsa-miR-583	CLIP-seq
MIRT1183617	hsa-miR-1256	CLIP-seq
MIRT1183618	hsa-miR-4438	CLIP-seq
MIRT1183619	hsa-miR-5095	CLIP-seq
MIRT1183620	hsa-miR-122	CLIP-seq
MIRT1183621	hsa-miR-1269	CLIP-seq
MIRT1183622	hsa-miR-1269b	CLIP-seq
MIRT1183623	hsa-miR-1281	CLIP-seq
MIRT1183624	hsa-miR-137	CLIP-seq
MIRT1183625	hsa-miR-151-5p	CLIP-seq
MIRT1183626	hsa-miR-151b	CLIP-seq
MIRT1183627	hsa-miR-2110	CLIP-seq
MIRT1183628	hsa-miR-24	CLIP-seq
MIRT1183629	hsa-miR-25	CLIP-seq
MIRT1183630	hsa-miR-3150a-3p	CLIP-seq
MIRT1183631	hsa-miR-3168	CLIP-seq
MIRT1183632	hsa-miR-3177-5p	CLIP-seq
MIRT1183633	hsa-miR-3194-3p	CLIP-seq
MIRT1183634	hsa-miR-32	CLIP-seq
MIRT1183635	hsa-miR-33a	CLIP-seq
MIRT1183636	hsa-miR-33b	CLIP-seq
MIRT1183637	hsa-miR-363	CLIP-seq
MIRT1183638	hsa-miR-367	CLIP-seq
MIRT1183639	hsa-miR-376a	CLIP-seq
MIRT1183640	hsa-miR-376b	CLIP-seq
MIRT1183641	hsa-miR-4271	CLIP-seq
MIRT1183642	hsa-miR-4294	CLIP-seq
MIRT1183643	hsa-miR-431	CLIP-seq
MIRT1183644	hsa-miR-4529-3p	CLIP-seq
MIRT1183645	hsa-miR-4703-3p	CLIP-seq
MIRT1183646	hsa-miR-4725-3p	CLIP-seq
MIRT1183647	hsa-miR-4772-3p	CLIP-seq
MIRT1183648	hsa-miR-552	CLIP-seq
MIRT1183649	hsa-miR-635	CLIP-seq
MIRT1183650	hsa-miR-675	CLIP-seq
MIRT1183651	hsa-miR-924	CLIP-seq
MIRT1183652	hsa-miR-92a	CLIP-seq
MIRT1183653	hsa-miR-92b	CLIP-seq
MIRT1183604	hsa-miR-128	CLIP-seq
MIRT2053235	hsa-miR-1292	CLIP-seq
MIRT2053236	hsa-miR-2467-3p	CLIP-seq
MIRT1183607	hsa-miR-27a	CLIP-seq
MIRT1183608	hsa-miR-27b	CLIP-seq
MIRT2053237	hsa-miR-3144-3p	CLIP-seq
MIRT2053238	hsa-miR-342-5p	CLIP-seq
MIRT2053239	hsa-miR-4436a	CLIP-seq
MIRT2053240	hsa-miR-4470	CLIP-seq
MIRT2053241	hsa-miR-4514	CLIP-seq
MIRT2053242	hsa-miR-4639-3p	CLIP-seq
MIRT2053243	hsa-miR-4645-5p	CLIP-seq
MIRT2053244	hsa-miR-4664-5p	CLIP-seq
MIRT2053245	hsa-miR-4673	CLIP-seq
MIRT2053246	hsa-miR-4679	CLIP-seq
MIRT2053247	hsa-miR-4692	CLIP-seq
MIRT2053248	hsa-miR-4700-3p	CLIP-seq
MIRT1183614	hsa-miR-4705	CLIP-seq
MIRT2053249	hsa-miR-4708-3p	CLIP-seq
MIRT2053250	hsa-miR-4727-5p	CLIP-seq
MIRT2053251	hsa-miR-4755-3p	CLIP-seq
MIRT2053252	hsa-miR-4769-3p	CLIP-seq
MIRT2053253	hsa-miR-668	CLIP-seq
MIRT2053254	hsa-miR-875-5p	CLIP-seq
MIRT2053235	hsa-miR-1292	CLIP-seq
MIRT2282564	hsa-miR-4253	CLIP-seq
MIRT2282565	hsa-miR-4293	CLIP-seq
MIRT2282566	hsa-miR-4422	CLIP-seq
MIRT2053241	hsa-miR-4514	CLIP-seq
MIRT2053243	hsa-miR-4645-5p	CLIP-seq
MIRT2053245	hsa-miR-4673	CLIP-seq
MIRT2053247	hsa-miR-4692	CLIP-seq
MIRT2391532	hsa-miR-3121-5p	CLIP-seq
MIRT2442412	hsa-miR-1271	CLIP-seq
MIRT2442413	hsa-miR-182	CLIP-seq
MIRT2442414	hsa-miR-331-5p	CLIP-seq
MIRT2053240	hsa-miR-4470	CLIP-seq
MIRT2442415	hsa-miR-4678	CLIP-seq
MIRT2442416	hsa-miR-548u	CLIP-seq
MIRT2442417	hsa-miR-96	CLIP-seq
MIRT2465720	hsa-miR-411	CLIP-seq
MIRT2465721	hsa-miR-4735-5p	CLIP-seq
MIRT2465722	hsa-miR-4775	CLIP-seq
MIRT2465723	hsa-miR-590-3p	CLIP-seq
MIRT2580534	hsa-miR-144	CLIP-seq
MIRT2580535	hsa-miR-223	CLIP-seq
MIRT2580536	hsa-miR-23a	CLIP-seq
MIRT2580537	hsa-miR-23b	CLIP-seq
MIRT2580538	hsa-miR-23c	CLIP-seq
MIRT2053236	hsa-miR-2467-3p	CLIP-seq
MIRT2580539	hsa-miR-298	CLIP-seq
MIRT2580540	hsa-miR-3647-3p	CLIP-seq
MIRT1183609	hsa-miR-3672	CLIP-seq
MIRT2580541	hsa-miR-3685	CLIP-seq
MIRT2580542	hsa-miR-384	CLIP-seq
MIRT2580543	hsa-miR-4501	CLIP-seq
MIRT2580544	hsa-miR-4511	CLIP-seq
MIRT2053241	hsa-miR-4514	CLIP-seq
MIRT2580545	hsa-miR-4645-3p	CLIP-seq
MIRT2053243	hsa-miR-4645-5p	CLIP-seq
MIRT2053245	hsa-miR-4673	CLIP-seq
MIRT2053246	hsa-miR-4679	CLIP-seq
MIRT1183613	hsa-miR-4684-5p	CLIP-seq
MIRT2053247	hsa-miR-4692	CLIP-seq
MIRT2580546	hsa-miR-4697-3p	CLIP-seq
MIRT2580547	hsa-miR-4725-5p	CLIP-seq
MIRT2053250	hsa-miR-4727-5p	CLIP-seq
MIRT2053251	hsa-miR-4755-3p	CLIP-seq
MIRT2580548	hsa-miR-4764-5p	CLIP-seq
MIRT1183615	hsa-miR-4768-5p	CLIP-seq
MIRT2053252	hsa-miR-4769-3p	CLIP-seq
MIRT2580549	hsa-miR-504	CLIP-seq
MIRT1183616	hsa-miR-583	CLIP-seq
MIRT2580550	hsa-miR-592	CLIP-seq
MIRT2580551	hsa-miR-597	CLIP-seq
MIRT2580552	hsa-miR-603	CLIP-seq
MIRT2580553	hsa-miR-642b	CLIP-seq
MIRT2580535	hsa-miR-223	CLIP-seq
MIRT2580536	hsa-miR-23a	CLIP-seq
MIRT2580537	hsa-miR-23b	CLIP-seq
MIRT2580538	hsa-miR-23c	CLIP-seq
MIRT2580540	hsa-miR-3647-3p	CLIP-seq
MIRT2580546	hsa-miR-4697-3p	CLIP-seq
MIRT2580548	hsa-miR-4764-5p	CLIP-seq
MIRT2580550	hsa-miR-592	CLIP-seq
MIRT2580551	hsa-miR-597	CLIP-seq
MIRT2580552	hsa-miR-603	CLIP-seq
MIRT2580553	hsa-miR-642b	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7964459
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS	7964459
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	7964459
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	7964459
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006366	Process	Transcription by RNA polymerase II	TAS	7964459
GO:0006954	Process	Inflammatory response	TAS	7964459
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	TAS	15371341
GO:0016740	Function	Transferase activity	IEA
GO:0045347	Process	Negative regulation of MHC class II biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	10500182
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	10500182
GO:0061630	Function	Ubiquitin protein ligase activity	TAS	15371341

MIM	HGNC	e!Ensembl
603255	7803	ENSG00000086102

Q12986

Protein name

Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1)

Protein function

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gam

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01422	zf-NF-X1	453 → 470	NF-X1 type zinc finger	Family
PF01422	zf-NF-X1	506 → 524	NF-X1 type zinc finger	Family
PF01422	zf-NF-X1	567 → 585	NF-X1 type zinc finger	Family
PF01422	zf-NF-X1	622 → 654	NF-X1 type zinc finger	Family
PF01422	zf-NF-X1	694 → 706	NF-X1 type zinc finger	Family
PF01422	zf-NF-X1	721 → 739	NF-X1 type zinc finger	Family
PF01422	zf-NF-X1	832 → 857	NF-X1 type zinc finger	Family
PF01424	R3H	995 → 1060	R3H domain	Domain

Sequence

MAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQV
PYDEISAVHQHSYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKK
AQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVYSYGR
GPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRR
YPQKRPPWEVEGARPRPGRNPPKQEGHRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENL
AVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKYECMV
CCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYT
CFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECG
RTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDV
LCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTP
LSQLLELGSSSRKTCMDPVPSCGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVIS
CRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLR
CGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDH
PVYHSCHSEEKCPPCTFLTQKWCMGKHEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRL
CHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCECGRRKEMVI
CSEASSTYQRIAAISMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERKKRL
AEAFHISEDSDPFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKS
HSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREM
QARPPPPIPHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD

Sequence length

1120

Interactions

View interactions

	KEGG
	Human papillomavirus infection

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ERECTILE DYSFUNCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autoimmune Diseases	Autoimmune disease	Pubtator	7964459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	30776478		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	31517622	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial aneurysm	Pubtator	31401562	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	31517622	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency	Pubtator	7964459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NFX1 (nuclear transcription factor, X-box binding 1)