Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4756
Gene name	Neogenin 1
Gene symbol	NEO1
Synonyms (NCBI Gene)	IGDCC2NGNNTN1R2
Chromosome	15
Chromosome location	15q24.1
Summary	This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal do

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SNP ID	Visualize variation	Clinical significance	Consequence
rs483352721	C>G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant

297

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016178	hsa-miR-590-3p	Sequencing	20371350
MIRT028322	hsa-miR-32-5p	Sequencing	20371350
MIRT047083	hsa-miR-183-5p	CLASH	23622248
MIRT044583	hsa-miR-320a	CLASH	23622248
MIRT041971	hsa-miR-484	CLASH	23622248
MIRT041971	hsa-miR-484	CLASH	23622248
MIRT438693	hsa-miR-18a-5p	qRT-PCRWestern blot	24657544
MIRT438693	hsa-miR-18a-5p	qRT-PCRWestern blot	24657544
MIRT438693	hsa-miR-18a-5p	qRT-PCRWestern blot	24657544
MIRT438693	hsa-miR-18a-5p	qRT-PCRWestern blot	24657544
MIRT701463	hsa-miR-548ac	HITS-CLIP	23313552
MIRT701462	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT701461	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT701460	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT701459	hsa-miR-548z	HITS-CLIP	23313552
MIRT701458	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT701457	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT016178	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT701455	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT701456	hsa-miR-4775	HITS-CLIP	23313552
MIRT733903	hsa-miR-548ba	Luciferase reporter assayMicroarrayqRT-PCR	32042028
MIRT701463	hsa-miR-548ac	HITS-CLIP	23313552
MIRT701462	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT701461	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT701460	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT701459	hsa-miR-548z	HITS-CLIP	23313552
MIRT701458	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT701457	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT016178	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT701455	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT701456	hsa-miR-4775	HITS-CLIP	23313552
MIRT1180545	hsa-miR-1245b-5p	CLIP-seq
MIRT1180546	hsa-miR-1253	CLIP-seq
MIRT1180547	hsa-miR-128	CLIP-seq
MIRT1180548	hsa-miR-1305	CLIP-seq
MIRT1180549	hsa-miR-18a	CLIP-seq
MIRT1180550	hsa-miR-18b	CLIP-seq
MIRT1180551	hsa-miR-1972	CLIP-seq
MIRT1180552	hsa-miR-216a	CLIP-seq
MIRT1180553	hsa-miR-216b	CLIP-seq
MIRT1180554	hsa-miR-27a	CLIP-seq
MIRT1180555	hsa-miR-27b	CLIP-seq
MIRT1180556	hsa-miR-302a	CLIP-seq
MIRT1180557	hsa-miR-302b	CLIP-seq
MIRT1180558	hsa-miR-302c	CLIP-seq
MIRT1180559	hsa-miR-302d	CLIP-seq
MIRT1180560	hsa-miR-302e	CLIP-seq
MIRT1180561	hsa-miR-3121-3p	CLIP-seq
MIRT1180562	hsa-miR-3124-3p	CLIP-seq
MIRT1180563	hsa-miR-3125	CLIP-seq
MIRT1180564	hsa-miR-3142	CLIP-seq
MIRT1180565	hsa-miR-3183	CLIP-seq
MIRT1180566	hsa-miR-3185	CLIP-seq
MIRT1180567	hsa-miR-342-3p	CLIP-seq
MIRT1180568	hsa-miR-3607-3p	CLIP-seq
MIRT1180569	hsa-miR-3611	CLIP-seq
MIRT1180570	hsa-miR-361-3p	CLIP-seq
MIRT1180571	hsa-miR-3664-5p	CLIP-seq
MIRT1180572	hsa-miR-3671	CLIP-seq
MIRT1180573	hsa-miR-3686	CLIP-seq
MIRT1180574	hsa-miR-372	CLIP-seq
MIRT1180575	hsa-miR-373	CLIP-seq
MIRT1180576	hsa-miR-3909	CLIP-seq
MIRT1180577	hsa-miR-3916	CLIP-seq
MIRT1180578	hsa-miR-4499	CLIP-seq
MIRT1180579	hsa-miR-4539	CLIP-seq
MIRT1180580	hsa-miR-4650-5p	CLIP-seq
MIRT1180581	hsa-miR-4651	CLIP-seq
MIRT1180582	hsa-miR-4712-3p	CLIP-seq
MIRT1180583	hsa-miR-4714-5p	CLIP-seq
MIRT1180584	hsa-miR-4723-3p	CLIP-seq
MIRT1180585	hsa-miR-4724-5p	CLIP-seq
MIRT1180586	hsa-miR-4731-5p	CLIP-seq
MIRT1180587	hsa-miR-4735-3p	CLIP-seq
MIRT1180588	hsa-miR-4747-3p	CLIP-seq
MIRT1180589	hsa-miR-4749-3p	CLIP-seq
MIRT1180590	hsa-miR-498	CLIP-seq
MIRT1180591	hsa-miR-502-5p	CLIP-seq
MIRT1180592	hsa-miR-512-3p	CLIP-seq
MIRT1180593	hsa-miR-520a-3p	CLIP-seq
MIRT1180594	hsa-miR-520b	CLIP-seq
MIRT1180595	hsa-miR-520c-3p	CLIP-seq
MIRT1180596	hsa-miR-520d-3p	CLIP-seq
MIRT1180597	hsa-miR-520e	CLIP-seq
MIRT1180598	hsa-miR-541	CLIP-seq
MIRT1180599	hsa-miR-555	CLIP-seq
MIRT1180600	hsa-miR-572	CLIP-seq
MIRT1180601	hsa-miR-607	CLIP-seq
MIRT1180602	hsa-miR-608	CLIP-seq
MIRT1180603	hsa-miR-626	CLIP-seq
MIRT1180604	hsa-miR-654-5p	CLIP-seq
MIRT1180605	hsa-miR-718	CLIP-seq
MIRT1180606	hsa-miR-938	CLIP-seq
MIRT1180607	hsa-miR-944	CLIP-seq
MIRT1180608	hsa-miR-155	CLIP-seq
MIRT1180609	hsa-miR-3074-5p	CLIP-seq
MIRT1180610	hsa-miR-3160-5p	CLIP-seq
MIRT1180611	hsa-miR-370	CLIP-seq
MIRT1180612	hsa-miR-3921	CLIP-seq
MIRT1180613	hsa-miR-4312	CLIP-seq
MIRT1180614	hsa-miR-4653-5p	CLIP-seq
MIRT1180615	hsa-miR-4768-5p	CLIP-seq
MIRT1180616	hsa-let-7a	CLIP-seq
MIRT1180617	hsa-let-7b	CLIP-seq
MIRT1180618	hsa-let-7c	CLIP-seq
MIRT1180619	hsa-let-7d	CLIP-seq
MIRT1180620	hsa-let-7e	CLIP-seq
MIRT1180621	hsa-let-7f	CLIP-seq
MIRT1180622	hsa-let-7g	CLIP-seq
MIRT1180623	hsa-let-7i	CLIP-seq
MIRT1180624	hsa-miR-1182	CLIP-seq
MIRT1180625	hsa-miR-1193	CLIP-seq
MIRT1180626	hsa-miR-1197	CLIP-seq
MIRT1180546	hsa-miR-1253	CLIP-seq
MIRT1180627	hsa-miR-125a-5p	CLIP-seq
MIRT1180628	hsa-miR-125b	CLIP-seq
MIRT1180629	hsa-miR-1291	CLIP-seq
MIRT1180630	hsa-miR-1298	CLIP-seq
MIRT1180631	hsa-miR-136	CLIP-seq
MIRT1180632	hsa-miR-15a	CLIP-seq
MIRT1180633	hsa-miR-15b	CLIP-seq
MIRT1180634	hsa-miR-16	CLIP-seq
MIRT1180549	hsa-miR-18a	CLIP-seq
MIRT1180550	hsa-miR-18b	CLIP-seq
MIRT1180635	hsa-miR-194	CLIP-seq
MIRT1180636	hsa-miR-195	CLIP-seq
MIRT1180637	hsa-miR-202	CLIP-seq
MIRT1180638	hsa-miR-214	CLIP-seq
MIRT1180639	hsa-miR-299-5p	CLIP-seq
MIRT1180640	hsa-miR-3117-5p	CLIP-seq
MIRT1180641	hsa-miR-3180-5p	CLIP-seq
MIRT1180566	hsa-miR-3185	CLIP-seq
MIRT1180642	hsa-miR-3189-3p	CLIP-seq
MIRT1180643	hsa-miR-3591-3p	CLIP-seq
MIRT1180569	hsa-miR-3611	CLIP-seq
MIRT1180644	hsa-miR-3619-5p	CLIP-seq
MIRT1180572	hsa-miR-3671	CLIP-seq
MIRT1180645	hsa-miR-3922-5p	CLIP-seq
MIRT1180646	hsa-miR-424	CLIP-seq
MIRT1180647	hsa-miR-4258	CLIP-seq
MIRT1180648	hsa-miR-4261	CLIP-seq
MIRT1180649	hsa-miR-4274	CLIP-seq
MIRT1180650	hsa-miR-4311	CLIP-seq
MIRT1180651	hsa-miR-4319	CLIP-seq
MIRT1180652	hsa-miR-4434	CLIP-seq
MIRT1180653	hsa-miR-4436a	CLIP-seq
MIRT1180654	hsa-miR-4458	CLIP-seq
MIRT1180578	hsa-miR-4499	CLIP-seq
MIRT1180655	hsa-miR-4500	CLIP-seq
MIRT1180656	hsa-miR-4516	CLIP-seq
MIRT1180657	hsa-miR-4524	CLIP-seq
MIRT1180658	hsa-miR-4531	CLIP-seq
MIRT1180579	hsa-miR-4539	CLIP-seq
MIRT1180659	hsa-miR-4700-3p	CLIP-seq
MIRT1180585	hsa-miR-4724-5p	CLIP-seq
MIRT1180587	hsa-miR-4735-3p	CLIP-seq
MIRT1180660	hsa-miR-4752	CLIP-seq
MIRT1180661	hsa-miR-493	CLIP-seq
MIRT1180662	hsa-miR-495	CLIP-seq
MIRT1180663	hsa-miR-497	CLIP-seq
MIRT1180591	hsa-miR-502-5p	CLIP-seq
MIRT1180664	hsa-miR-503	CLIP-seq
MIRT1180665	hsa-miR-520a-5p	CLIP-seq
MIRT1180666	hsa-miR-525-5p	CLIP-seq
MIRT1180667	hsa-miR-544b	CLIP-seq
MIRT1180668	hsa-miR-548ag	CLIP-seq
MIRT1180669	hsa-miR-548ai	CLIP-seq
MIRT1180601	hsa-miR-607	CLIP-seq
MIRT1180670	hsa-miR-617	CLIP-seq
MIRT1180671	hsa-miR-646	CLIP-seq
MIRT1180672	hsa-miR-761	CLIP-seq
MIRT1180673	hsa-miR-98	CLIP-seq
MIRT2052260	hsa-miR-1184	CLIP-seq
MIRT2052261	hsa-miR-1910	CLIP-seq
MIRT2052262	hsa-miR-2682	CLIP-seq
MIRT1180554	hsa-miR-27a	CLIP-seq
MIRT1180555	hsa-miR-27b	CLIP-seq
MIRT1180609	hsa-miR-3074-5p	CLIP-seq
MIRT2052263	hsa-miR-3136-3p	CLIP-seq
MIRT1180610	hsa-miR-3160-5p	CLIP-seq
MIRT2052264	hsa-miR-328	CLIP-seq
MIRT2052265	hsa-miR-34a	CLIP-seq
MIRT2052266	hsa-miR-34c-5p	CLIP-seq
MIRT2052267	hsa-miR-3616-5p	CLIP-seq
MIRT2052268	hsa-miR-3647-5p	CLIP-seq
MIRT2052269	hsa-miR-3665	CLIP-seq
MIRT2052270	hsa-miR-3714	CLIP-seq
MIRT2052271	hsa-miR-4271	CLIP-seq
MIRT1180649	hsa-miR-4274	CLIP-seq
MIRT2052272	hsa-miR-4464	CLIP-seq
MIRT2052273	hsa-miR-449a	CLIP-seq
MIRT2052274	hsa-miR-449b	CLIP-seq
MIRT2052275	hsa-miR-449c	CLIP-seq
MIRT2052276	hsa-miR-4514	CLIP-seq
MIRT2052277	hsa-miR-4641	CLIP-seq
MIRT2052278	hsa-miR-4663	CLIP-seq
MIRT2052279	hsa-miR-4692	CLIP-seq
MIRT2052280	hsa-miR-4725-3p	CLIP-seq
MIRT1180586	hsa-miR-4731-5p	CLIP-seq
MIRT2052281	hsa-miR-4736	CLIP-seq
MIRT2052282	hsa-miR-4747-5p	CLIP-seq
MIRT2052283	hsa-miR-4748	CLIP-seq
MIRT1180589	hsa-miR-4749-3p	CLIP-seq
MIRT2052284	hsa-miR-510	CLIP-seq
MIRT2052285	hsa-miR-548u	CLIP-seq
MIRT2052286	hsa-miR-573	CLIP-seq
MIRT2052287	hsa-miR-587	CLIP-seq
MIRT2052288	hsa-miR-940	CLIP-seq
MIRT2052287	hsa-miR-587	CLIP-seq
MIRT1180624	hsa-miR-1182	CLIP-seq
MIRT2281673	hsa-miR-1236	CLIP-seq
MIRT1180631	hsa-miR-136	CLIP-seq
MIRT1180632	hsa-miR-15a	CLIP-seq
MIRT1180633	hsa-miR-15b	CLIP-seq
MIRT1180634	hsa-miR-16	CLIP-seq
MIRT2281674	hsa-miR-181a	CLIP-seq
MIRT2281675	hsa-miR-181b	CLIP-seq
MIRT2281676	hsa-miR-181c	CLIP-seq
MIRT2281677	hsa-miR-181d	CLIP-seq
MIRT2052261	hsa-miR-1910	CLIP-seq
MIRT1180636	hsa-miR-195	CLIP-seq
MIRT1180638	hsa-miR-214	CLIP-seq
MIRT1180554	hsa-miR-27a	CLIP-seq
MIRT1180555	hsa-miR-27b	CLIP-seq
MIRT2281678	hsa-miR-3074-3p	CLIP-seq
MIRT2052263	hsa-miR-3136-3p	CLIP-seq
MIRT2281679	hsa-miR-3150a-5p	CLIP-seq
MIRT2281680	hsa-miR-3150b-5p	CLIP-seq
MIRT2052264	hsa-miR-328	CLIP-seq
MIRT2281681	hsa-miR-3618	CLIP-seq
MIRT1180644	hsa-miR-3619-5p	CLIP-seq
MIRT2281682	hsa-miR-362-5p	CLIP-seq
MIRT1180646	hsa-miR-424	CLIP-seq
MIRT2281683	hsa-miR-4262	CLIP-seq
MIRT1180649	hsa-miR-4274	CLIP-seq
MIRT2281684	hsa-miR-4282	CLIP-seq
MIRT2281685	hsa-miR-4291	CLIP-seq
MIRT2281686	hsa-miR-4328	CLIP-seq
MIRT2052277	hsa-miR-4641	CLIP-seq
MIRT1180659	hsa-miR-4700-3p	CLIP-seq
MIRT1180589	hsa-miR-4749-3p	CLIP-seq
MIRT1180663	hsa-miR-497	CLIP-seq
MIRT2281687	hsa-miR-500b	CLIP-seq
MIRT2281688	hsa-miR-513a-5p	CLIP-seq
MIRT1180672	hsa-miR-761	CLIP-seq
MIRT2281689	hsa-miR-922	CLIP-seq
MIRT2391495	hsa-miR-1254	CLIP-seq
MIRT2391496	hsa-miR-3116	CLIP-seq
MIRT2391497	hsa-miR-3194-5p	CLIP-seq
MIRT2391498	hsa-miR-4254	CLIP-seq
MIRT2391499	hsa-miR-4672	CLIP-seq
MIRT2391500	hsa-miR-661	CLIP-seq
MIRT2455061	hsa-miR-1238	CLIP-seq
MIRT1180547	hsa-miR-128	CLIP-seq
MIRT1180552	hsa-miR-216a	CLIP-seq
MIRT1180553	hsa-miR-216b	CLIP-seq
MIRT1180554	hsa-miR-27a	CLIP-seq
MIRT1180555	hsa-miR-27b	CLIP-seq
MIRT1180567	hsa-miR-342-3p	CLIP-seq
MIRT1180568	hsa-miR-3607-3p	CLIP-seq
MIRT1180570	hsa-miR-361-3p	CLIP-seq
MIRT2281681	hsa-miR-3618	CLIP-seq
MIRT1180573	hsa-miR-3686	CLIP-seq
MIRT2455062	hsa-miR-4297	CLIP-seq
MIRT2455063	hsa-miR-4691-5p	CLIP-seq
MIRT2455064	hsa-miR-4693-5p	CLIP-seq
MIRT2455065	hsa-miR-4699-3p	CLIP-seq
MIRT1180582	hsa-miR-4712-3p	CLIP-seq
MIRT1180588	hsa-miR-4747-3p	CLIP-seq
MIRT1180589	hsa-miR-4749-3p	CLIP-seq
MIRT2455066	hsa-miR-4765	CLIP-seq
MIRT2455067	hsa-miR-759	CLIP-seq
MIRT2455068	hsa-miR-934	CLIP-seq
MIRT2455061	hsa-miR-1238	CLIP-seq
MIRT1180609	hsa-miR-3074-5p	CLIP-seq
MIRT2579887	hsa-miR-33a	CLIP-seq
MIRT2579888	hsa-miR-33b	CLIP-seq
MIRT1180643	hsa-miR-3591-3p	CLIP-seq
MIRT2281684	hsa-miR-4282	CLIP-seq
MIRT1180652	hsa-miR-4434	CLIP-seq
MIRT1180656	hsa-miR-4516	CLIP-seq
MIRT1180658	hsa-miR-4531	CLIP-seq
MIRT2455063	hsa-miR-4691-5p	CLIP-seq
MIRT1180660	hsa-miR-4752	CLIP-seq
MIRT2455066	hsa-miR-4765	CLIP-seq
MIRT2455067	hsa-miR-759	CLIP-seq
MIRT2455061	hsa-miR-1238	CLIP-seq
MIRT1180643	hsa-miR-3591-3p	CLIP-seq
MIRT2281684	hsa-miR-4282	CLIP-seq
MIRT1180652	hsa-miR-4434	CLIP-seq
MIRT1180656	hsa-miR-4516	CLIP-seq
MIRT1180658	hsa-miR-4531	CLIP-seq
MIRT2455063	hsa-miR-4691-5p	CLIP-seq
MIRT1180660	hsa-miR-4752	CLIP-seq
MIRT2455066	hsa-miR-4765	CLIP-seq
MIRT2686210	hsa-miR-643	CLIP-seq
MIRT2455067	hsa-miR-759	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IBA
GO:0005515	Function	Protein binding	IPI	18335997, 22084112
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	9169140
GO:0005886	Component	Plasma membrane	TAS	9169140
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	NAS	9169140
GO:0007411	Process	Axon guidance	IBA
GO:0007520	Process	Myoblast fusion	IEA
GO:0009306	Process	Protein secretion	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030513	Process	Positive regulation of BMP signaling pathway	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0039706	Function	Co-receptor binding	IPI	18335997
GO:0045296	Function	Cadherin binding	IEA
GO:0048679	Process	Regulation of axon regeneration	IEA
GO:0048681	Process	Negative regulation of axon regeneration	IEA
GO:0050709	Process	Negative regulation of protein secretion	IEA
GO:0060586	Process	Multicellular organismal-level iron ion homeostasis	IGI	16075058
GO:0070700	Function	BMP receptor binding	IEA
GO:0097708	Component	Intracellular vesicle	IEA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098797	Component	Plasma membrane protein complex	IDA	18335997
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099550	Process	Trans-synaptic signaling, modulating synaptic transmission	IEA

MIM	HGNC	e!Ensembl
601907	7754	ENSG00000067141

Q92859

Protein name

Neogenin (Immunoglobulin superfamily DCC subclass member 2)

Protein function

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guida

PDB

1X5F , 1X5G , 1X5H , 1X5I , 1X5J , 1X5K , 3P4L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13895	Ig_2	55 → 148	Immunoglobulin domain	Domain
PF13927	Ig_3	152 → 225		Domain
PF07679	I-set	249 → 337	Immunoglobulin I-set domain	Domain
PF07679	I-set	341 → 427	Immunoglobulin I-set domain	Domain
PF00041	fn3	440 → 525	Fibronectin type III domain	Domain
PF00041	fn3	540 → 621	Fibronectin type III domain	Domain
PF00041	fn3	635 → 721	Fibronectin type III domain	Domain
PF00041	fn3	740 → 820	Fibronectin type III domain	Domain
PF00041	fn3	855 → 942	Fibronectin type III domain	Domain
PF00041	fn3	956 → 1044	Fibronectin type III domain	Domain
PF06583	Neogenin_C	1158 → 1461	Neogenin C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed and also in cancer cell lines.

Sequence

MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKE
GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPG
PAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLK
KYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPA
TQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPA
TDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSP
HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFV
INAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP
ANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKD
VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ
ELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGS
DYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRA
ACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPV
DNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDN
PHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTC
CTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALP
STPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDE
LTKEMAHLEGLMKDLNAITTA

Sequence length

1461

Interactions

View interactions

	KEGG
	TGF-beta signaling pathway Axon guidance Cell adhesion molecules

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANTI-GAD65 AUTOIMMUNE NEUROLOGICAL SYNDROMES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEO1-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (48)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	15952876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Myeloblastic Leukemia	Myeloblastic Leukemia	BEFREE	19665076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	28730177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arrhythmogenic Right Ventricular Dysplasia	Arrhythmogenic right ventricular cardiomyopathy	Pubtator	31843279	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	26518331		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	25416629, 25998984		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	16324219, 25416629	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	16324219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ductal	Ductal carcinoma	Pubtator	16324219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	29137400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Myeloid Leukemia	Acute Myeloid Leukemia	BEFREE	19665076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	28253401		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	10708514, 19303019, 28730177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25416629	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30858446	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	21980448	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	24657544, 9121761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	24657544, 9121761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	22666451		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	22666451	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis	Glomerulonephritis	BEFREE	30623619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary hemochromatosis	Hereditary Hemochromatosis	BEFREE	16103117		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	BEFREE	28700939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron Overload	BEFREE	20065295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	19665076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25416629, 25998984		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	9121761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30064133, 31289590		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22666451, 25998984, 28238104, 9121761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	28253401		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	24812271	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	27288875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	27288875, 36361539	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Microphthalmos	Microphthalmos	BEFREE	31336386		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22666451, 25416629, 25998984, 28038459, 28238104, 29526577, 30403907, 30532711, 30858446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28038459, 30160193		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	BEFREE	31392393		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	36297056	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	30569177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis, Postmenopausal	Osteoporosis	BEFREE	30569177		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	LHGDN	12833147		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	9121761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyneuropathy	Polyneuropathy	BEFREE	31392393		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	31819067	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	11489794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30064133, 31289590		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	25909166, 30064133	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular germ cell tumor	Pubtator	17711579	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

NEO1 (neogenin 1)