Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4738
Gene name	NEDD8 ubiquitin like modifier
Gene symbol	NEDD8
Synonyms (NCBI Gene)	NEDD-8
Chromosome	14
Chromosome location	14q12

225

Show/Hide all (225)

miRTarBase ID	miRNA	Experiments
MIRT1179899	hsa-miR-1185	CLIP-seq
MIRT1179900	hsa-miR-1272	CLIP-seq
MIRT1179901	hsa-miR-1288	CLIP-seq
MIRT1179902	hsa-miR-1322	CLIP-seq
MIRT1179903	hsa-miR-3130-5p	CLIP-seq
MIRT1179904	hsa-miR-3169	CLIP-seq
MIRT1179905	hsa-miR-34a	CLIP-seq
MIRT1179906	hsa-miR-34c-5p	CLIP-seq
MIRT1179907	hsa-miR-3591-3p	CLIP-seq
MIRT1179908	hsa-miR-3657	CLIP-seq
MIRT1179909	hsa-miR-3679-5p	CLIP-seq
MIRT1179910	hsa-miR-4459	CLIP-seq
MIRT1179911	hsa-miR-4482	CLIP-seq
MIRT1179912	hsa-miR-449a	CLIP-seq
MIRT1179913	hsa-miR-449b	CLIP-seq
MIRT1179914	hsa-miR-4528	CLIP-seq
MIRT1179915	hsa-miR-4676-5p	CLIP-seq
MIRT1179916	hsa-miR-4693-3p	CLIP-seq
MIRT1179917	hsa-miR-4695-5p	CLIP-seq
MIRT1179918	hsa-miR-4700-3p	CLIP-seq
MIRT1179919	hsa-miR-486-3p	CLIP-seq
MIRT1179920	hsa-miR-549	CLIP-seq
MIRT1179921	hsa-miR-556-5p	CLIP-seq
MIRT1179922	hsa-miR-575	CLIP-seq
MIRT1179923	hsa-miR-665	CLIP-seq
MIRT1179899	hsa-miR-1185	CLIP-seq
MIRT2052014	hsa-miR-128	CLIP-seq
MIRT2052015	hsa-miR-1285	CLIP-seq
MIRT1179901	hsa-miR-1288	CLIP-seq
MIRT2052016	hsa-miR-1343	CLIP-seq
MIRT2052017	hsa-miR-200b	CLIP-seq
MIRT2052018	hsa-miR-200c	CLIP-seq
MIRT2052019	hsa-miR-27a	CLIP-seq
MIRT2052020	hsa-miR-27b	CLIP-seq
MIRT1179903	hsa-miR-3130-5p	CLIP-seq
MIRT1179904	hsa-miR-3169	CLIP-seq
MIRT2052021	hsa-miR-3187-5p	CLIP-seq
MIRT1179905	hsa-miR-34a	CLIP-seq
MIRT1179906	hsa-miR-34c-5p	CLIP-seq
MIRT1179907	hsa-miR-3591-3p	CLIP-seq
MIRT1179908	hsa-miR-3657	CLIP-seq
MIRT1179909	hsa-miR-3679-5p	CLIP-seq
MIRT2052022	hsa-miR-3945	CLIP-seq
MIRT2052023	hsa-miR-4253	CLIP-seq
MIRT2052024	hsa-miR-429	CLIP-seq
MIRT1179910	hsa-miR-4459	CLIP-seq
MIRT1179911	hsa-miR-4482	CLIP-seq
MIRT1179912	hsa-miR-449a	CLIP-seq
MIRT1179913	hsa-miR-449b	CLIP-seq
MIRT2052025	hsa-miR-450b-3p	CLIP-seq
MIRT2052026	hsa-miR-4685-5p	CLIP-seq
MIRT1179916	hsa-miR-4693-3p	CLIP-seq
MIRT1179917	hsa-miR-4695-5p	CLIP-seq
MIRT1179918	hsa-miR-4700-3p	CLIP-seq
MIRT2052027	hsa-miR-4713-3p	CLIP-seq
MIRT2052028	hsa-miR-4724-5p	CLIP-seq
MIRT2052029	hsa-miR-4728-5p	CLIP-seq
MIRT1179919	hsa-miR-486-3p	CLIP-seq
MIRT1179920	hsa-miR-549	CLIP-seq
MIRT2052030	hsa-miR-612	CLIP-seq
MIRT2052031	hsa-miR-638	CLIP-seq
MIRT1179923	hsa-miR-665	CLIP-seq
MIRT2052032	hsa-miR-769-3p	CLIP-seq
MIRT1179899	hsa-miR-1185	CLIP-seq
MIRT2281384	hsa-miR-1224-3p	CLIP-seq
MIRT2281385	hsa-miR-1260	CLIP-seq
MIRT2281386	hsa-miR-1260b	CLIP-seq
MIRT1179900	hsa-miR-1272	CLIP-seq
MIRT2052014	hsa-miR-128	CLIP-seq
MIRT2281387	hsa-miR-1280	CLIP-seq
MIRT2052015	hsa-miR-1285	CLIP-seq
MIRT1179901	hsa-miR-1288	CLIP-seq
MIRT1179902	hsa-miR-1322	CLIP-seq
MIRT2052016	hsa-miR-1343	CLIP-seq
MIRT2281388	hsa-miR-150	CLIP-seq
MIRT2052017	hsa-miR-200b	CLIP-seq
MIRT2052018	hsa-miR-200c	CLIP-seq
MIRT2052019	hsa-miR-27a	CLIP-seq
MIRT2052020	hsa-miR-27b	CLIP-seq
MIRT1179904	hsa-miR-3169	CLIP-seq
MIRT2052021	hsa-miR-3187-5p	CLIP-seq
MIRT2281389	hsa-miR-323-3p	CLIP-seq
MIRT1179905	hsa-miR-34a	CLIP-seq
MIRT1179906	hsa-miR-34c-5p	CLIP-seq
MIRT1179907	hsa-miR-3591-3p	CLIP-seq
MIRT1179908	hsa-miR-3657	CLIP-seq
MIRT2281390	hsa-miR-3662	CLIP-seq
MIRT1179909	hsa-miR-3679-5p	CLIP-seq
MIRT2052022	hsa-miR-3945	CLIP-seq
MIRT2281391	hsa-miR-411	CLIP-seq
MIRT2052023	hsa-miR-4253	CLIP-seq
MIRT2052024	hsa-miR-429	CLIP-seq
MIRT1179912	hsa-miR-449a	CLIP-seq
MIRT1179913	hsa-miR-449b	CLIP-seq
MIRT2052025	hsa-miR-450b-3p	CLIP-seq
MIRT1179914	hsa-miR-4528	CLIP-seq
MIRT2052026	hsa-miR-4685-5p	CLIP-seq
MIRT1179916	hsa-miR-4693-3p	CLIP-seq
MIRT2281392	hsa-miR-4694-3p	CLIP-seq
MIRT1179918	hsa-miR-4700-3p	CLIP-seq
MIRT2052027	hsa-miR-4713-3p	CLIP-seq
MIRT2281393	hsa-miR-4713-5p	CLIP-seq
MIRT2052028	hsa-miR-4724-5p	CLIP-seq
MIRT2052029	hsa-miR-4728-5p	CLIP-seq
MIRT1179919	hsa-miR-486-3p	CLIP-seq
MIRT2281394	hsa-miR-532-3p	CLIP-seq
MIRT1179920	hsa-miR-549	CLIP-seq
MIRT1179921	hsa-miR-556-5p	CLIP-seq
MIRT2052030	hsa-miR-612	CLIP-seq
MIRT2052031	hsa-miR-638	CLIP-seq
MIRT2052032	hsa-miR-769-3p	CLIP-seq
MIRT2281395	hsa-miR-936	CLIP-seq
MIRT1179901	hsa-miR-1288	CLIP-seq
MIRT1179903	hsa-miR-3130-5p	CLIP-seq
MIRT1179904	hsa-miR-3169	CLIP-seq
MIRT1179907	hsa-miR-3591-3p	CLIP-seq
MIRT1179911	hsa-miR-4482	CLIP-seq
MIRT1179915	hsa-miR-4676-5p	CLIP-seq
MIRT1179918	hsa-miR-4700-3p	CLIP-seq
MIRT1179922	hsa-miR-575	CLIP-seq
MIRT1179899	hsa-miR-1185	CLIP-seq
MIRT2281384	hsa-miR-1224-3p	CLIP-seq
MIRT2281385	hsa-miR-1260	CLIP-seq
MIRT2281386	hsa-miR-1260b	CLIP-seq
MIRT1179900	hsa-miR-1272	CLIP-seq
MIRT2052014	hsa-miR-128	CLIP-seq
MIRT2281387	hsa-miR-1280	CLIP-seq
MIRT2052015	hsa-miR-1285	CLIP-seq
MIRT1179902	hsa-miR-1322	CLIP-seq
MIRT2052016	hsa-miR-1343	CLIP-seq
MIRT2281388	hsa-miR-150	CLIP-seq
MIRT2052017	hsa-miR-200b	CLIP-seq
MIRT2052018	hsa-miR-200c	CLIP-seq
MIRT2052019	hsa-miR-27a	CLIP-seq
MIRT2052020	hsa-miR-27b	CLIP-seq
MIRT1179903	hsa-miR-3130-5p	CLIP-seq
MIRT2052021	hsa-miR-3187-5p	CLIP-seq
MIRT2281389	hsa-miR-323-3p	CLIP-seq
MIRT2579575	hsa-miR-326	CLIP-seq
MIRT2579576	hsa-miR-330-5p	CLIP-seq
MIRT1179905	hsa-miR-34a	CLIP-seq
MIRT1179906	hsa-miR-34c-5p	CLIP-seq
MIRT1179907	hsa-miR-3591-3p	CLIP-seq
MIRT1179908	hsa-miR-3657	CLIP-seq
MIRT1179909	hsa-miR-3679-5p	CLIP-seq
MIRT2579577	hsa-miR-378g	CLIP-seq
MIRT2052022	hsa-miR-3945	CLIP-seq
MIRT2281391	hsa-miR-411	CLIP-seq
MIRT2052023	hsa-miR-4253	CLIP-seq
MIRT2052024	hsa-miR-429	CLIP-seq
MIRT1179911	hsa-miR-4482	CLIP-seq
MIRT2579578	hsa-miR-4486	CLIP-seq
MIRT1179912	hsa-miR-449a	CLIP-seq
MIRT1179913	hsa-miR-449b	CLIP-seq
MIRT2052025	hsa-miR-450b-3p	CLIP-seq
MIRT1179914	hsa-miR-4528	CLIP-seq
MIRT2579579	hsa-miR-4640-5p	CLIP-seq
MIRT1179915	hsa-miR-4676-5p	CLIP-seq
MIRT2052026	hsa-miR-4685-5p	CLIP-seq
MIRT1179916	hsa-miR-4693-3p	CLIP-seq
MIRT2052027	hsa-miR-4713-3p	CLIP-seq
MIRT2281393	hsa-miR-4713-5p	CLIP-seq
MIRT2052028	hsa-miR-4724-5p	CLIP-seq
MIRT2579580	hsa-miR-4726-5p	CLIP-seq
MIRT2052029	hsa-miR-4728-5p	CLIP-seq
MIRT1179919	hsa-miR-486-3p	CLIP-seq
MIRT2281394	hsa-miR-532-3p	CLIP-seq
MIRT1179922	hsa-miR-575	CLIP-seq
MIRT2052030	hsa-miR-612	CLIP-seq
MIRT2052031	hsa-miR-638	CLIP-seq
MIRT2052032	hsa-miR-769-3p	CLIP-seq
MIRT2281395	hsa-miR-936	CLIP-seq
MIRT1179899	hsa-miR-1185	CLIP-seq
MIRT2281384	hsa-miR-1224-3p	CLIP-seq
MIRT2281385	hsa-miR-1260	CLIP-seq
MIRT2281386	hsa-miR-1260b	CLIP-seq
MIRT1179900	hsa-miR-1272	CLIP-seq
MIRT2052014	hsa-miR-128	CLIP-seq
MIRT2281387	hsa-miR-1280	CLIP-seq
MIRT2052015	hsa-miR-1285	CLIP-seq
MIRT1179902	hsa-miR-1322	CLIP-seq
MIRT2052016	hsa-miR-1343	CLIP-seq
MIRT2281388	hsa-miR-150	CLIP-seq
MIRT2052017	hsa-miR-200b	CLIP-seq
MIRT2052018	hsa-miR-200c	CLIP-seq
MIRT2052019	hsa-miR-27a	CLIP-seq
MIRT2052020	hsa-miR-27b	CLIP-seq
MIRT1179903	hsa-miR-3130-5p	CLIP-seq
MIRT2052021	hsa-miR-3187-5p	CLIP-seq
MIRT2281389	hsa-miR-323-3p	CLIP-seq
MIRT2579575	hsa-miR-326	CLIP-seq
MIRT2579576	hsa-miR-330-5p	CLIP-seq
MIRT1179905	hsa-miR-34a	CLIP-seq
MIRT1179906	hsa-miR-34c-5p	CLIP-seq
MIRT1179907	hsa-miR-3591-3p	CLIP-seq
MIRT1179908	hsa-miR-3657	CLIP-seq
MIRT1179909	hsa-miR-3679-5p	CLIP-seq
MIRT2579577	hsa-miR-378g	CLIP-seq
MIRT2052022	hsa-miR-3945	CLIP-seq
MIRT2281391	hsa-miR-411	CLIP-seq
MIRT2052023	hsa-miR-4253	CLIP-seq
MIRT2052024	hsa-miR-429	CLIP-seq
MIRT1179911	hsa-miR-4482	CLIP-seq
MIRT2579578	hsa-miR-4486	CLIP-seq
MIRT1179912	hsa-miR-449a	CLIP-seq
MIRT1179913	hsa-miR-449b	CLIP-seq
MIRT2052025	hsa-miR-450b-3p	CLIP-seq
MIRT1179914	hsa-miR-4528	CLIP-seq
MIRT2579579	hsa-miR-4640-5p	CLIP-seq
MIRT1179915	hsa-miR-4676-5p	CLIP-seq
MIRT2052026	hsa-miR-4685-5p	CLIP-seq
MIRT1179916	hsa-miR-4693-3p	CLIP-seq
MIRT2052027	hsa-miR-4713-3p	CLIP-seq
MIRT2281393	hsa-miR-4713-5p	CLIP-seq
MIRT2052028	hsa-miR-4724-5p	CLIP-seq
MIRT2579580	hsa-miR-4726-5p	CLIP-seq
MIRT2052029	hsa-miR-4728-5p	CLIP-seq
MIRT1179919	hsa-miR-486-3p	CLIP-seq
MIRT2281394	hsa-miR-532-3p	CLIP-seq
MIRT1179921	hsa-miR-556-5p	CLIP-seq
MIRT1179922	hsa-miR-575	CLIP-seq
MIRT2052030	hsa-miR-612	CLIP-seq
MIRT2052031	hsa-miR-638	CLIP-seq
MIRT2052032	hsa-miR-769-3p	CLIP-seq
MIRT2281395	hsa-miR-936	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15988528, 16169070, 17318178, 18264111, 18274552, 18723677, 18805092, 19713960, 21102408, 21145461, 21474709, 21765416, 22466964, 24192928, 24949976, 25416956, 28514442, 30659753, 32726803, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9353319
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006508	Process	Proteolysis	TAS	9694792
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	9353319
GO:0008104	Process	Intracellular protein localization	IEA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	9694792
GO:0016567	Process	Protein ubiquitination	IBA
GO:0019941	Process	Modification-dependent protein catabolic process	IBA
GO:0030162	Process	Regulation of proteolysis	IBA
GO:0031386	Function	Protein tag activity	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15694336
GO:0036211	Process	Protein modification process	TAS	9694792
GO:0045116	Process	Protein neddylation	IBA
GO:0045116	Process	Protein neddylation	IDA	10500095
GO:0045116	Process	Protein neddylation	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0072757	Process	Cellular response to camptothecin	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA

MIM	HGNC	e!Ensembl
603171	7732	ENSG00000129559

Q15843

Protein name

Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)

Protein function

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:146

PDB

1NDD , 1R4M , 1R4N , 1XT9 , 2BKR , 2KO3 , 2N7K , 2NVU , 3DBH , 3DBL , 3DBR , 3DQV , 3GZN , 4F8C , 4FBJ , 4HCP , 4P5O , 6R7F , 6R7I , 6TTU , 7B5L , 7B5N , 7ONI , 8B3G , 8B3I , 8CAF , 8H38 , 8Q7H , 8RX0 , 8WQC , 8WQG , 8WZN , 8WZO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	3 → 74	Ubiquitin family	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:9353319}.

Sequence

MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYK
ILGGSVLHLVLALRGGGGLRQ

Sequence length

Interactions

View interactions

	Reactome
			TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (77)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	29464016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	29348128		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	29910671		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31243299		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	29464016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	20525923		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	28178525		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	28535453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Antiphospholipid Syndrome	Antiphospholipid syndrome	Pubtator	18759277	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	30407690		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	12554766, 16998474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36632463	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	30407690		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31208947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	28535453	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	27814385	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	23633453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	29464016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30402022		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27771609		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37353483, 37381158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28717191		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	20525923		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	22219386	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31044422, 31771104		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31044422, 31771104		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	22895816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	26752167	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	27976900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron overload	Pubtator	35644542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kaposi Sarcoma	Kaposi Sarcoma	BEFREE	28701396		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	31349760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	34857808	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	34857808, 35880551	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	40103351	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	20203261, 25971362, 26045051, 26851293, 28297583, 28892104, 29348128, 30018073, 30699367		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lipodystrophy	Lipodystrophy	BEFREE	19281774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29846044, 31002342, 31577950, 31817100		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	23290524, 30018073		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	22895816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	26675347		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	12554766, 16998474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31208947		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	23633453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29157102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30885218, 31782573		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	30407690		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11757036, 21159650, 21193393, 23633453, 25615422, 26156395, 27333051, 28447739, 28569775, 29301501, 30586948, 30892082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	30402022		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	12554766		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	26675347		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	22502714, 27783255		★★★★★ ★☆☆☆☆ Found in Text Mining only
Monoclonal Gammopathy of Undetermined Significance	Monoclonal Gammapathies	BEFREE	26156395		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	22246439, 23527154, 24713927, 26156395, 31583781		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	26156395	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	26851293, 28297583		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	28569775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15060148, 25615422, 26592553, 28177892, 30020196, 30407690		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 2	Neurofibromatosis	BEFREE	28468780		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	23633453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29157102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	22388932		★★★★★ ★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	Parkinson Disease	BEFREE	22271254		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	29464016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30885218, 31782573		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	BEFREE	19399181		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	28469786		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28717191		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spinal Muscular Atrophy	Spinal Muscular Atrophy	BEFREE	28178525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	17660949		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	17660949		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	29434977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	31705877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	28838998, 30341788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	26679092	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	18759277	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	26592553		★★★★★ ★☆☆☆☆ Found in Text Mining only

NEDD8 (NEDD8 ubiquitin like modifier)