NCBP1 (nuclear cap binding protein subunit 1)

Gene

• Entrez ID: 4686
• Gene name: Nuclear cap binding protein subunit 1
• Gene symbol: NCBP1
• Synonyms (NCBI Gene): CBP80, NCBP, Sto1
• Chromosome: 9
• Chromosome location: 9q22.33
• Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5` cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024362	hsa-miR-215-5p	Microarray	19074876
MIRT026295	hsa-miR-192-5p	Microarray	19074876
MIRT028972	hsa-miR-26b-5p	Microarray	19088304
MIRT052408	hsa-let-7a-5p	CLASH	23622248
MIRT051610	hsa-let-7e-5p	CLASH	23622248
MIRT1175929	hsa-miR-1193	CLIP-seq
MIRT1175930	hsa-miR-1208	CLIP-seq
MIRT1175931	hsa-miR-122	CLIP-seq
MIRT1175932	hsa-miR-1231	CLIP-seq
MIRT1175933	hsa-miR-1258	CLIP-seq
MIRT1175934	hsa-miR-1267	CLIP-seq
MIRT1175935	hsa-miR-1284	CLIP-seq
MIRT1175936	hsa-miR-1286	CLIP-seq
MIRT1175937	hsa-miR-129-5p	CLIP-seq
MIRT1175938	hsa-miR-1302	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT1175940	hsa-miR-2052	CLIP-seq
MIRT1175941	hsa-miR-2110	CLIP-seq
MIRT1175942	hsa-miR-2113	CLIP-seq
MIRT1175943	hsa-miR-2278	CLIP-seq
MIRT1175944	hsa-miR-2392	CLIP-seq
MIRT1175945	hsa-miR-23a	CLIP-seq
MIRT1175946	hsa-miR-23b	CLIP-seq
MIRT1175947	hsa-miR-23c	CLIP-seq
MIRT1175948	hsa-miR-2681	CLIP-seq
MIRT1175949	hsa-miR-3074-3p	CLIP-seq
MIRT1175950	hsa-miR-3120-3p	CLIP-seq
MIRT1175951	hsa-miR-3127-5p	CLIP-seq
MIRT1175952	hsa-miR-3135b	CLIP-seq
MIRT1175953	hsa-miR-3144-5p	CLIP-seq
MIRT1175954	hsa-miR-3152-3p	CLIP-seq
MIRT1175955	hsa-miR-3162-5p	CLIP-seq
MIRT1175956	hsa-miR-3170	CLIP-seq
MIRT1175957	hsa-miR-3191	CLIP-seq
MIRT1175958	hsa-miR-323-3p	CLIP-seq
MIRT1175959	hsa-miR-330-3p	CLIP-seq
MIRT1175960	hsa-miR-3622a-3p	CLIP-seq
MIRT1175961	hsa-miR-3622b-3p	CLIP-seq
MIRT1175962	hsa-miR-3652	CLIP-seq
MIRT1175963	hsa-miR-369-3p	CLIP-seq
MIRT1175964	hsa-miR-374a	CLIP-seq
MIRT1175965	hsa-miR-374b	CLIP-seq
MIRT1175966	hsa-miR-410	CLIP-seq
MIRT1175967	hsa-miR-4256	CLIP-seq
MIRT1175968	hsa-miR-4261	CLIP-seq
MIRT1175969	hsa-miR-4271	CLIP-seq
MIRT1175970	hsa-miR-4288	CLIP-seq
MIRT1175971	hsa-miR-4298	CLIP-seq
MIRT1175972	hsa-miR-4328	CLIP-seq
MIRT1175973	hsa-miR-4420	CLIP-seq
MIRT1175974	hsa-miR-4430	CLIP-seq
MIRT1175975	hsa-miR-4454	CLIP-seq
MIRT1175976	hsa-miR-4476	CLIP-seq
MIRT1175977	hsa-miR-4496	CLIP-seq
MIRT1175978	hsa-miR-4528	CLIP-seq
MIRT1175979	hsa-miR-4540	CLIP-seq
MIRT1175980	hsa-miR-4637	CLIP-seq
MIRT1175981	hsa-miR-4652-5p	CLIP-seq
MIRT1175982	hsa-miR-4662a-5p	CLIP-seq
MIRT1175983	hsa-miR-4667-5p	CLIP-seq
MIRT1175984	hsa-miR-4676-5p	CLIP-seq
MIRT1175985	hsa-miR-4691-3p	CLIP-seq
MIRT1175986	hsa-miR-4700-3p	CLIP-seq
MIRT1175987	hsa-miR-4700-5p	CLIP-seq
MIRT1175988	hsa-miR-4704-3p	CLIP-seq
MIRT1175989	hsa-miR-4707-3p	CLIP-seq
MIRT1175990	hsa-miR-4711-5p	CLIP-seq
MIRT1175991	hsa-miR-4725-3p	CLIP-seq
MIRT1175992	hsa-miR-4725-5p	CLIP-seq
MIRT1175993	hsa-miR-4735-5p	CLIP-seq
MIRT1175994	hsa-miR-4742-3p	CLIP-seq
MIRT1175995	hsa-miR-4760-3p	CLIP-seq
MIRT1175996	hsa-miR-4772-5p	CLIP-seq
MIRT1175997	hsa-miR-4780	CLIP-seq
MIRT1175998	hsa-miR-4789-5p	CLIP-seq
MIRT1175999	hsa-miR-4794	CLIP-seq
MIRT1176000	hsa-miR-504	CLIP-seq
MIRT1176001	hsa-miR-520d-5p	CLIP-seq
MIRT1176002	hsa-miR-524-5p	CLIP-seq
MIRT1176003	hsa-miR-575	CLIP-seq
MIRT1176004	hsa-miR-587	CLIP-seq
MIRT1176005	hsa-miR-599	CLIP-seq
MIRT1176006	hsa-miR-619	CLIP-seq
MIRT1176007	hsa-miR-627	CLIP-seq
MIRT1176008	hsa-miR-632	CLIP-seq
MIRT1176009	hsa-miR-653	CLIP-seq
MIRT1176010	hsa-miR-892a	CLIP-seq
MIRT1175929	hsa-miR-1193	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT1175944	hsa-miR-2392	CLIP-seq
MIRT1175954	hsa-miR-3152-3p	CLIP-seq
MIRT1175975	hsa-miR-4454	CLIP-seq
MIRT1175982	hsa-miR-4662a-5p	CLIP-seq
MIRT1175984	hsa-miR-4676-5p	CLIP-seq
MIRT1175989	hsa-miR-4707-3p	CLIP-seq
MIRT1176003	hsa-miR-575	CLIP-seq
MIRT1175929	hsa-miR-1193	CLIP-seq
MIRT2050978	hsa-miR-1206	CLIP-seq
MIRT1175930	hsa-miR-1208	CLIP-seq
MIRT1175931	hsa-miR-122	CLIP-seq
MIRT2050979	hsa-miR-1236	CLIP-seq
MIRT1175933	hsa-miR-1258	CLIP-seq
MIRT2050980	hsa-miR-1273d	CLIP-seq
MIRT1175936	hsa-miR-1286	CLIP-seq
MIRT2050981	hsa-miR-1298	CLIP-seq
MIRT1175938	hsa-miR-1302	CLIP-seq
MIRT2050982	hsa-miR-139-5p	CLIP-seq
MIRT2050983	hsa-miR-1915	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT1175942	hsa-miR-2113	CLIP-seq
MIRT1175943	hsa-miR-2278	CLIP-seq
MIRT1175944	hsa-miR-2392	CLIP-seq
MIRT1175945	hsa-miR-23a	CLIP-seq
MIRT1175946	hsa-miR-23b	CLIP-seq
MIRT1175947	hsa-miR-23c	CLIP-seq
MIRT2050984	hsa-miR-24	CLIP-seq
MIRT2050985	hsa-miR-3123	CLIP-seq
MIRT1175951	hsa-miR-3127-5p	CLIP-seq
MIRT1175952	hsa-miR-3135b	CLIP-seq
MIRT2050986	hsa-miR-3140-3p	CLIP-seq
MIRT2050987	hsa-miR-3146	CLIP-seq
MIRT2050988	hsa-miR-3149	CLIP-seq
MIRT1175954	hsa-miR-3152-3p	CLIP-seq
MIRT2050989	hsa-miR-3168	CLIP-seq
MIRT1175958	hsa-miR-323-3p	CLIP-seq
MIRT1175962	hsa-miR-3652	CLIP-seq
MIRT2050990	hsa-miR-3681	CLIP-seq
MIRT2050991	hsa-miR-3918	CLIP-seq
MIRT2050992	hsa-miR-411	CLIP-seq
MIRT2050993	hsa-miR-412	CLIP-seq
MIRT2050994	hsa-miR-4277	CLIP-seq
MIRT2050995	hsa-miR-4284	CLIP-seq
MIRT1175971	hsa-miR-4298	CLIP-seq
MIRT1175973	hsa-miR-4420	CLIP-seq
MIRT1175974	hsa-miR-4430	CLIP-seq
MIRT1175975	hsa-miR-4454	CLIP-seq
MIRT1175976	hsa-miR-4476	CLIP-seq
MIRT2050996	hsa-miR-4495	CLIP-seq
MIRT1175982	hsa-miR-4662a-5p	CLIP-seq
MIRT1175984	hsa-miR-4676-5p	CLIP-seq
MIRT2050997	hsa-miR-4699-3p	CLIP-seq
MIRT1175989	hsa-miR-4707-3p	CLIP-seq
MIRT2050998	hsa-miR-4716-5p	CLIP-seq
MIRT1175992	hsa-miR-4725-5p	CLIP-seq
MIRT2050999	hsa-miR-4726-3p	CLIP-seq
MIRT1175997	hsa-miR-4780	CLIP-seq
MIRT2051000	hsa-miR-4793-5p	CLIP-seq
MIRT2051001	hsa-miR-4795-5p	CLIP-seq
MIRT1176000	hsa-miR-504	CLIP-seq
MIRT2051002	hsa-miR-548n	CLIP-seq
MIRT2051003	hsa-miR-548t	CLIP-seq
MIRT2051004	hsa-miR-562	CLIP-seq
MIRT1176003	hsa-miR-575	CLIP-seq
MIRT2051005	hsa-miR-582-5p	CLIP-seq
MIRT1176005	hsa-miR-599	CLIP-seq
MIRT2051006	hsa-miR-875-5p	CLIP-seq
MIRT1176010	hsa-miR-892a	CLIP-seq
MIRT2051007	hsa-miR-944	CLIP-seq
MIRT1175929	hsa-miR-1193	CLIP-seq
MIRT1175930	hsa-miR-1208	CLIP-seq
MIRT1175933	hsa-miR-1258	CLIP-seq
MIRT2050980	hsa-miR-1273d	CLIP-seq
MIRT1175935	hsa-miR-1284	CLIP-seq
MIRT2280048	hsa-miR-150	CLIP-seq
MIRT2280049	hsa-miR-192	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT2280050	hsa-miR-215	CLIP-seq
MIRT1175944	hsa-miR-2392	CLIP-seq
MIRT1175945	hsa-miR-23a	CLIP-seq
MIRT1175946	hsa-miR-23b	CLIP-seq
MIRT1175947	hsa-miR-23c	CLIP-seq
MIRT1175948	hsa-miR-2681	CLIP-seq
MIRT1175949	hsa-miR-3074-3p	CLIP-seq
MIRT1175951	hsa-miR-3127-5p	CLIP-seq
MIRT2050988	hsa-miR-3149	CLIP-seq
MIRT1175954	hsa-miR-3152-3p	CLIP-seq
MIRT1175958	hsa-miR-323-3p	CLIP-seq
MIRT2050990	hsa-miR-3681	CLIP-seq
MIRT1175963	hsa-miR-369-3p	CLIP-seq
MIRT1175964	hsa-miR-374a	CLIP-seq
MIRT1175965	hsa-miR-374b	CLIP-seq
MIRT2280051	hsa-miR-380	CLIP-seq
MIRT1175966	hsa-miR-410	CLIP-seq
MIRT2280052	hsa-miR-4255	CLIP-seq
MIRT1175968	hsa-miR-4261	CLIP-seq
MIRT2280053	hsa-miR-4291	CLIP-seq
MIRT2280054	hsa-miR-4310	CLIP-seq
MIRT1175973	hsa-miR-4420	CLIP-seq
MIRT1175975	hsa-miR-4454	CLIP-seq
MIRT1175976	hsa-miR-4476	CLIP-seq
MIRT2050996	hsa-miR-4495	CLIP-seq
MIRT1175977	hsa-miR-4496	CLIP-seq
MIRT1175982	hsa-miR-4662a-5p	CLIP-seq
MIRT1175984	hsa-miR-4676-5p	CLIP-seq
MIRT2050997	hsa-miR-4699-3p	CLIP-seq
MIRT1175986	hsa-miR-4700-3p	CLIP-seq
MIRT1175989	hsa-miR-4707-3p	CLIP-seq
MIRT1175990	hsa-miR-4711-5p	CLIP-seq
MIRT2050998	hsa-miR-4716-5p	CLIP-seq
MIRT1175993	hsa-miR-4735-5p	CLIP-seq
MIRT1175995	hsa-miR-4760-3p	CLIP-seq
MIRT2051000	hsa-miR-4793-5p	CLIP-seq
MIRT2051001	hsa-miR-4795-5p	CLIP-seq
MIRT2280055	hsa-miR-548m	CLIP-seq
MIRT2051004	hsa-miR-562	CLIP-seq
MIRT2280056	hsa-miR-563	CLIP-seq
MIRT1176003	hsa-miR-575	CLIP-seq
MIRT1176006	hsa-miR-619	CLIP-seq
MIRT2051006	hsa-miR-875-5p	CLIP-seq
MIRT1176010	hsa-miR-892a	CLIP-seq
MIRT2051007	hsa-miR-944	CLIP-seq
MIRT2280048	hsa-miR-150	CLIP-seq
MIRT2050983	hsa-miR-1915	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT2391419	hsa-miR-4279	CLIP-seq
MIRT2391420	hsa-miR-4421	CLIP-seq
MIRT2050999	hsa-miR-4726-3p	CLIP-seq
MIRT2391421	hsa-miR-498	CLIP-seq
MIRT2051004	hsa-miR-562	CLIP-seq
MIRT2050980	hsa-miR-1273d	CLIP-seq
MIRT1175936	hsa-miR-1286	CLIP-seq
MIRT1175938	hsa-miR-1302	CLIP-seq
MIRT2280048	hsa-miR-150	CLIP-seq
MIRT2050983	hsa-miR-1915	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT1175943	hsa-miR-2278	CLIP-seq
MIRT2454957	hsa-miR-3199	CLIP-seq
MIRT2454958	hsa-miR-377	CLIP-seq
MIRT2391419	hsa-miR-4279	CLIP-seq
MIRT2454959	hsa-miR-4282	CLIP-seq
MIRT1175971	hsa-miR-4298	CLIP-seq
MIRT2391420	hsa-miR-4421	CLIP-seq
MIRT2050998	hsa-miR-4716-5p	CLIP-seq
MIRT2050999	hsa-miR-4726-3p	CLIP-seq
MIRT1175999	hsa-miR-4794	CLIP-seq
MIRT2391421	hsa-miR-498	CLIP-seq
MIRT2051004	hsa-miR-562	CLIP-seq
MIRT1175931	hsa-miR-122	CLIP-seq
MIRT2050980	hsa-miR-1273d	CLIP-seq
MIRT2578550	hsa-miR-1283	CLIP-seq
MIRT1175936	hsa-miR-1286	CLIP-seq
MIRT1175938	hsa-miR-1302	CLIP-seq
MIRT2578551	hsa-miR-1323	CLIP-seq
MIRT2280048	hsa-miR-150	CLIP-seq
MIRT2050983	hsa-miR-1915	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT1175942	hsa-miR-2113	CLIP-seq
MIRT2578552	hsa-miR-218	CLIP-seq
MIRT1175943	hsa-miR-2278	CLIP-seq
MIRT2050984	hsa-miR-24	CLIP-seq
MIRT2578553	hsa-miR-297	CLIP-seq
MIRT1175952	hsa-miR-3135b	CLIP-seq
MIRT2050988	hsa-miR-3149	CLIP-seq
MIRT2578554	hsa-miR-3153	CLIP-seq
MIRT2578555	hsa-miR-3161	CLIP-seq
MIRT2454957	hsa-miR-3199	CLIP-seq
MIRT2578556	hsa-miR-361-3p	CLIP-seq
MIRT2578557	hsa-miR-3651	CLIP-seq
MIRT1175962	hsa-miR-3652	CLIP-seq
MIRT2578558	hsa-miR-376c	CLIP-seq
MIRT2454958	hsa-miR-377	CLIP-seq
MIRT2578559	hsa-miR-3908	CLIP-seq
MIRT1175966	hsa-miR-410	CLIP-seq
MIRT2391419	hsa-miR-4279	CLIP-seq
MIRT2454959	hsa-miR-4282	CLIP-seq
MIRT2050995	hsa-miR-4284	CLIP-seq
MIRT1175971	hsa-miR-4298	CLIP-seq
MIRT2391420	hsa-miR-4421	CLIP-seq
MIRT1175974	hsa-miR-4430	CLIP-seq
MIRT2578560	hsa-miR-4503	CLIP-seq
MIRT1175978	hsa-miR-4528	CLIP-seq
MIRT2578561	hsa-miR-4668-5p	CLIP-seq
MIRT2578562	hsa-miR-4709-3p	CLIP-seq
MIRT2050998	hsa-miR-4716-5p	CLIP-seq
MIRT2578563	hsa-miR-4720-3p	CLIP-seq
MIRT2050999	hsa-miR-4726-3p	CLIP-seq
MIRT2578564	hsa-miR-4751	CLIP-seq
MIRT1175998	hsa-miR-4789-5p	CLIP-seq
MIRT1175999	hsa-miR-4794	CLIP-seq
MIRT2578565	hsa-miR-4804-3p	CLIP-seq
MIRT2578566	hsa-miR-495	CLIP-seq
MIRT2391421	hsa-miR-498	CLIP-seq
MIRT2578567	hsa-miR-513a-3p	CLIP-seq
MIRT2578568	hsa-miR-548aa	CLIP-seq
MIRT2578569	hsa-miR-548o	CLIP-seq
MIRT2051004	hsa-miR-562	CLIP-seq
MIRT2578570	hsa-miR-567	CLIP-seq
MIRT2578571	hsa-miR-577	CLIP-seq
MIRT1176005	hsa-miR-599	CLIP-seq
MIRT2578572	hsa-miR-628-5p	CLIP-seq
MIRT2578573	hsa-miR-636	CLIP-seq
MIRT2051007	hsa-miR-944	CLIP-seq
MIRT2685894	hsa-miR-106a	CLIP-seq
MIRT2685895	hsa-miR-106b	CLIP-seq
MIRT2050980	hsa-miR-1273d	CLIP-seq
MIRT1175936	hsa-miR-1286	CLIP-seq
MIRT1175938	hsa-miR-1302	CLIP-seq
MIRT2578551	hsa-miR-1323	CLIP-seq
MIRT2280048	hsa-miR-150	CLIP-seq
MIRT2685896	hsa-miR-17	CLIP-seq
MIRT2050983	hsa-miR-1915	CLIP-seq
MIRT1175939	hsa-miR-1976	CLIP-seq
MIRT2685897	hsa-miR-20a	CLIP-seq
MIRT2685898	hsa-miR-20b	CLIP-seq
MIRT1175942	hsa-miR-2113	CLIP-seq
MIRT1175943	hsa-miR-2278	CLIP-seq
MIRT2685899	hsa-miR-302a	CLIP-seq
MIRT2685900	hsa-miR-302b	CLIP-seq
MIRT2685901	hsa-miR-302c	CLIP-seq
MIRT2685902	hsa-miR-302d	CLIP-seq
MIRT2685903	hsa-miR-302e	CLIP-seq
MIRT2578555	hsa-miR-3161	CLIP-seq
MIRT2454957	hsa-miR-3199	CLIP-seq
MIRT2578556	hsa-miR-361-3p	CLIP-seq
MIRT2578557	hsa-miR-3651	CLIP-seq
MIRT2685904	hsa-miR-372	CLIP-seq
MIRT2685905	hsa-miR-373	CLIP-seq
MIRT2454958	hsa-miR-377	CLIP-seq
MIRT2391419	hsa-miR-4279	CLIP-seq
MIRT2454959	hsa-miR-4282	CLIP-seq
MIRT1175971	hsa-miR-4298	CLIP-seq
MIRT2391420	hsa-miR-4421	CLIP-seq
MIRT1175978	hsa-miR-4528	CLIP-seq
MIRT2685906	hsa-miR-4659a-3p	CLIP-seq
MIRT2685907	hsa-miR-4659b-3p	CLIP-seq
MIRT2578562	hsa-miR-4709-3p	CLIP-seq
MIRT2050998	hsa-miR-4716-5p	CLIP-seq
MIRT2050999	hsa-miR-4726-3p	CLIP-seq
MIRT2685908	hsa-miR-4731-5p	CLIP-seq
MIRT2578564	hsa-miR-4751	CLIP-seq
MIRT1175998	hsa-miR-4789-5p	CLIP-seq
MIRT1175999	hsa-miR-4794	CLIP-seq
MIRT2578566	hsa-miR-495	CLIP-seq
MIRT2391421	hsa-miR-498	CLIP-seq
MIRT2685909	hsa-miR-512-3p	CLIP-seq
MIRT2685910	hsa-miR-519d	CLIP-seq
MIRT2685911	hsa-miR-520a-3p	CLIP-seq
MIRT2685912	hsa-miR-520b	CLIP-seq
MIRT2685913	hsa-miR-520c-3p	CLIP-seq
MIRT2685914	hsa-miR-520d-3p	CLIP-seq
MIRT2685915	hsa-miR-520e	CLIP-seq
MIRT2685916	hsa-miR-520g	CLIP-seq
MIRT2685917	hsa-miR-520h	CLIP-seq
MIRT2578569	hsa-miR-548o	CLIP-seq
MIRT2051004	hsa-miR-562	CLIP-seq
MIRT1176005	hsa-miR-599	CLIP-seq
MIRT2578572	hsa-miR-628-5p	CLIP-seq
MIRT2685918	hsa-miR-93	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
UPF1	Unknown	20691628

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA	11551508, 17873884
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP	18369367
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	NAS	16186820
GO:0000245	Process	Spliceosomal complex assembly	IMP	23793891
GO:0000339	Function	RNA cap binding	IBA
GO:0000339	Function	RNA cap binding	IEA
GO:0000339	Function	RNA cap binding	TAS	8069914
GO:0000340	Function	RNA 7-methylguanosine cap binding	IMP	23793891
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	NAS	21536667
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	23793891
GO:0002191	Process	Cap-dependent translational initiation	NAS	19648179
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	8069914
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	7478990, 9111328, 11545740, 12374755, 12434151, 16189514, 17190602, 17289661, 17332742, 17468741, 18423201, 19262567, 19648179, 19668212, 20379136, 22365833, 23665581, 23788676, 23793891, 24981860, 25220460, 26382858, 26496610, 27871484, 29101316, 29997244, 31467278, 32296183, 32814
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	8069914, 9342333, 19648179, 26382858
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS	7937105
GO:0005737	Component	Cytoplasm	IDA	26382858
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	19648179
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005846	Component	Nuclear cap binding complex	IBA
GO:0005846	Component	Nuclear cap binding complex	IDA	7651522, 9342333, 12434151
GO:0005846	Component	Nuclear cap binding complex	IEA
GO:0005846	Component	Nuclear cap binding complex	IPI	8069914, 26382858
GO:0006370	Process	7-methylguanosine mRNA capping	IDA	12434151
GO:0006370	Process	7-methylguanosine mRNA capping	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006401	Process	RNA catabolic process	IMP	25578728
GO:0006406	Process	MRNA export from nucleus	IBA
GO:0006406	Process	MRNA export from nucleus	IEA
GO:0006406	Process	MRNA export from nucleus	IMP	17190602, 26382858
GO:0006406	Process	MRNA export from nucleus	IPI	21326824
GO:0006408	Process	SnRNA export from nucleus	IMP	26382858
GO:0006408	Process	SnRNA export from nucleus	NAS	10786834
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IDA	11551508
GO:0008334	Process	Histone mRNA metabolic process	IEA
GO:0008334	Process	Histone mRNA metabolic process	IMP	17499042
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	8069914
GO:0016070	Process	RNA metabolic process	IEA
GO:0016071	Process	MRNA metabolic process	IMP	9342333
GO:0030307	Process	Positive regulation of cell growth	IMP	26382858
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031053	Process	Primary miRNA processing	NAS	19632182
GO:0031124	Process	MRNA 3'-end processing	NAS	9342333
GO:0031442	Process	Positive regulation of mRNA 3'-end processing	IMP	9342333
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	NAS	21536667
GO:0034518	Component	RNA cap binding complex	IMP	23793891
GO:0034518	Component	RNA cap binding complex	TAS	26382858
GO:0035194	Process	Regulatory ncRNA-mediated post-transcriptional gene silencing	NAS	19632182, 26382858
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	NAS	19632182
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	21326824
GO:0042789	Process	MRNA transcription by RNA polymerase II	NAS	26382858
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IMP	23793891
GO:0050684	Process	Regulation of mRNA processing	IBA
GO:0051028	Process	MRNA transport	IEA
GO:0051607	Process	Defense response to virus	IMP	26382858
GO:0060090	Function	Molecular adaptor activity	EXP	11545740
GO:1905216	Process	Positive regulation of RNA binding	IMP	23793891
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

Other IDs

• MIM: 600469
• HGNC: 7658
• e!Ensembl: ENSG00000136937

Protein

• UniProt ID: Q09161
• Protein name: Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)
• Protein function: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silenc
• PDB: 1H2T, 1H2U, 1H2V, 1H6K, 1N52, 1N54, 3FEX, 3FEY, 5OO6, 5OOB, 6D0Y, 7ABG, 8BY6, 8PMP, 8PNT, 8SRR, 8SUY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02854	MIF4G	28 → 240	MIF4G domain	Family
  PF09088	MIF4G_like	308 → 471	MIF4G like	Family
  PF09090	MIF4G_like_2	485 → 760	MIF4G like	Family

• Sequence:

  MSRRRHSDENDGGQPHKRRKTSDANETEDHLESLICKVGEKSACSLESNLEGLAGVLEAD
  LPNYKSKILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANN
  YNEAVYLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEEDVPQVRRDWYVYAFLSSLPWV
  GKELYEKKDAEMDRIFANTESYLKRRQKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLK
  KDRWQERHILRPYLAFDSILCEALQHNLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEG
  PVMPGSHSVERFVIEENLHCIIKSHWKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELF
  QLPAPPHIDVMYTTLLIELCKLQPGSLPQVLAQATEMLYMRLDTMNTTCVDRFINWFSHH
  LSNFQFRWSWEDWSDCLSQDPESPKPKFVREVLEKCMRLSYHQRILDIVPPTFSALCPAN
  PTCIYKYGDESSNSLPGHSVALCLAVAFKSKATNDEIFSILKDVPNPNQDDDDDEGFSFN
  PLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFKTLAESDEGKLHVLRVMFEVWRNHPQM
  IAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLFVWEILHSTIRKMNKHVLKIQKELE
  EAKEKLARQHKRRSDDDDRSSDRKDGVLEEQIERLQEKVESAQSEQKNLFLVIFQRFIMI
  LTEHLVRCETDGTSVLTPWYKNCIERLQQIFLQHHQIIQQYMVTLENLLFTAELDPHILA
  VFQQFCALQA

• Sequence length: 790

Pathways

KEGG:

Nucleocytoplasmic transport
mRNA surveillance pathway
Spliceosome
Amyotrophic lateral sclerosis

Reactome:

SLBP independent Processing of Histone Pre-mRNAs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
snRNP Assembly
RNA Polymerase II Pre-transcription Events
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3'-end processing
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription Termination
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Processing of Intronless Pre-mRNAs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mycotic Aneurysm, Intracranial	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31448526		★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	34344401	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	38071502	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31448526		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	37185598	Associate	★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial aneurysm	Pubtator	35228681	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31448526		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	2820743		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31448526		★☆☆☆☆ Found in Text Mining only