NCAM2 (neural cell adhesion molecule 2)

Gene

• Entrez ID: 4685
• Gene name: Neural cell adhesion molecule 2
• Gene symbol: NCAM2
• Synonyms (NCBI Gene): NCAM21
• Chromosome: 21
• Chromosome location: 21q21.1
• Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018062	hsa-miR-335-5p	Microarray	18185580
MIRT029650	hsa-miR-26b-5p	Microarray	19088304
MIRT503840	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503839	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT503838	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503836	hsa-miR-3924	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT563183	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT563182	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT563181	hsa-miR-3653-3p	PAR-CLIP	20371350
MIRT563180	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT563179	hsa-miR-3658	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT527323	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527322	hsa-miR-5688	PAR-CLIP	22012620
MIRT527321	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT527320	hsa-miR-3065-5p	PAR-CLIP	22012620
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT444930	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT444929	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT444928	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444927	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT503840	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503839	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT503838	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503836	hsa-miR-3924	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT563183	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT563182	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT563181	hsa-miR-3653-3p	PAR-CLIP	20371350
MIRT563180	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT563179	hsa-miR-3658	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT527323	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527322	hsa-miR-5688	PAR-CLIP	22012620
MIRT527321	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT527320	hsa-miR-3065-5p	PAR-CLIP	22012620
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT444930	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT444929	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT444928	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444927	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT1175679	hsa-miR-1182	CLIP-seq
MIRT1175680	hsa-miR-1324	CLIP-seq
MIRT1175681	hsa-miR-133a	CLIP-seq
MIRT1175682	hsa-miR-133b	CLIP-seq
MIRT1175683	hsa-miR-203	CLIP-seq
MIRT1175684	hsa-miR-2278	CLIP-seq
MIRT1175685	hsa-miR-3120-3p	CLIP-seq
MIRT1175686	hsa-miR-3121-3p	CLIP-seq
MIRT1175687	hsa-miR-3130-3p	CLIP-seq
MIRT1175688	hsa-miR-340	CLIP-seq
MIRT1175689	hsa-miR-34b	CLIP-seq
MIRT1175690	hsa-miR-3616-5p	CLIP-seq
MIRT1175691	hsa-miR-3646	CLIP-seq
MIRT1175692	hsa-miR-3647-5p	CLIP-seq
MIRT1175693	hsa-miR-369-3p	CLIP-seq
MIRT1175694	hsa-miR-374a	CLIP-seq
MIRT1175695	hsa-miR-374b	CLIP-seq
MIRT1175696	hsa-miR-3974	CLIP-seq
MIRT1175697	hsa-miR-4264	CLIP-seq
MIRT1175698	hsa-miR-4421	CLIP-seq
MIRT1175699	hsa-miR-4422	CLIP-seq
MIRT1175700	hsa-miR-4517	CLIP-seq
MIRT1175701	hsa-miR-4635	CLIP-seq
MIRT1175702	hsa-miR-4662a-5p	CLIP-seq
MIRT1175703	hsa-miR-4704-3p	CLIP-seq
MIRT1175704	hsa-miR-4793-3p	CLIP-seq
MIRT1175705	hsa-miR-4797-3p	CLIP-seq
MIRT1175706	hsa-miR-4803	CLIP-seq
MIRT1175707	hsa-miR-515-5p	CLIP-seq
MIRT1175708	hsa-miR-545	CLIP-seq
MIRT1175709	hsa-miR-548p	CLIP-seq
MIRT1175710	hsa-miR-561	CLIP-seq
MIRT1175711	hsa-miR-573	CLIP-seq
MIRT1175712	hsa-miR-610	CLIP-seq
MIRT1175713	hsa-miR-668	CLIP-seq
MIRT2050850	hsa-miR-2116	CLIP-seq
MIRT2050851	hsa-miR-3613-3p	CLIP-seq
MIRT1175690	hsa-miR-3616-5p	CLIP-seq
MIRT1175692	hsa-miR-3647-5p	CLIP-seq
MIRT2050852	hsa-miR-3662	CLIP-seq
MIRT1175701	hsa-miR-4635	CLIP-seq
MIRT2050853	hsa-miR-4659a-3p	CLIP-seq
MIRT2050854	hsa-miR-4659b-3p	CLIP-seq
MIRT2050855	hsa-miR-548c-3p	CLIP-seq
MIRT1175710	hsa-miR-561	CLIP-seq
MIRT1175711	hsa-miR-573	CLIP-seq
MIRT2050856	hsa-miR-622	CLIP-seq
MIRT2279957	hsa-miR-1243	CLIP-seq
MIRT2279958	hsa-miR-1255a	CLIP-seq
MIRT2279959	hsa-miR-1255b	CLIP-seq
MIRT2279960	hsa-miR-127-5p	CLIP-seq
MIRT2279961	hsa-miR-197	CLIP-seq
MIRT1175685	hsa-miR-3120-3p	CLIP-seq
MIRT1175693	hsa-miR-369-3p	CLIP-seq
MIRT1175694	hsa-miR-374a	CLIP-seq
MIRT1175695	hsa-miR-374b	CLIP-seq
MIRT2279962	hsa-miR-383	CLIP-seq
MIRT1175698	hsa-miR-4421	CLIP-seq
MIRT1175699	hsa-miR-4422	CLIP-seq
MIRT2279963	hsa-miR-4699-3p	CLIP-seq
MIRT2279964	hsa-miR-4772-5p	CLIP-seq
MIRT2279965	hsa-miR-495	CLIP-seq
MIRT2279966	hsa-miR-5096	CLIP-seq
MIRT2279967	hsa-miR-520g	CLIP-seq
MIRT2279968	hsa-miR-520h	CLIP-seq
MIRT1175712	hsa-miR-610	CLIP-seq
MIRT1175713	hsa-miR-668	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9226371
GO:0007155	Process	Cell adhesion	IEA
GO:0007158	Process	Neuron cell-cell adhesion	TAS	9226371
GO:0007413	Process	Axonal fasciculation	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9226371
GO:0016604	Component	Nuclear body	IDA
GO:0030424	Component	Axon	IEA
GO:0042802	Function	Identical protein binding	IPI	21300289
GO:0043005	Component	Neuron projection	IBA
GO:0097060	Component	Synaptic membrane	IEA

Other IDs

• MIM: 602040
• HGNC: 7657
• e!Ensembl: ENSG00000154654

Protein

• UniProt ID: O15394
• Protein name: Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2)
• Protein function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
• PDB: 2DOC, 2JLL, 2KBG, 2V5T, 2VAJ, 2WIM, 2XY1, 2XY2, 2XYC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	21 → 111	Immunoglobulin I-set domain	Domain
  PF07679	I-set	115 → 198	Immunoglobulin I-set domain	Domain
  PF07679	I-set	211 → 298	Immunoglobulin I-set domain	Domain
  PF07679	I-set	302 → 397	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	401 → 479		Domain
  PF00041	fn3	497 → 581	Fibronectin type III domain	Domain
  PF00041	fn3	593 → 678	Fibronectin type III domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed most strongly in adult and fetal brain.
• Sequence:

  MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK
  IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV
  VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD
  EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP
  AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
  QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH
  GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI
  SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH
  IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE
  IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
  GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM
  GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD
  VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT
  NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA

• Sequence length: 837

Pathways

KEGG:

Virion - Ebolavirus, Lyssavirus and Morbillivirus
Cell adhesion molecules
Prion disease

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NCAM2-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	20932310	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	25335167	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	27596683		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	20034085, 27596683		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	20034085	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21214674		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	38238328	Associate	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	29522129, 9226371		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	GWASCAT_DG	30093612		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual Disability	Mental retardation	BEFREE	27375131		★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	BEFREE	27596683		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21214674		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	19893039		★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	25464110		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	GWASDB_DG	21552555		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	GWASCAT_DG	21552555		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ovarian neoplasm	Ovarian neoplasm	GWASCAT_DG	30898391		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	19893039		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	15583692	Associate	★☆☆☆☆ Found in Text Mining only