Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	4678
Gene name	Nuclear autoantigenic sperm protein
Gene symbol	NASP
Synonyms (NCBI Gene)	FLB7527HMDRA1PRO1999
Chromosome	1
Chromosome location	1p34.1
Summary	This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localize

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006250	hsa-miR-29a-3p	Luciferase reporter assayWestern blot	22080513
MIRT006251	hsa-miR-29b-3p	Luciferase reporter assayWestern blot	22080513
MIRT006250	hsa-miR-29a-3p	Luciferase reporter assay	22194605
MIRT006250	hsa-miR-29a-3p	Luciferase reporter assay	22194605
MIRT006250	hsa-miR-29a-3p	Luciferase reporter assay	22194605
MIRT020617	hsa-miR-155-5p	Proteomics	18668040
MIRT022289	hsa-miR-124-3p	Microarray	18668037
MIRT025284	hsa-miR-34a-5p	Proteomics	21566225
MIRT030415	hsa-miR-24-3p	Microarray	19748357
MIRT045140	hsa-miR-186-5p	CLASH	23622248
MIRT041894	hsa-miR-484	CLASH	23622248
MIRT041894	hsa-miR-484	CLASH	23622248
MIRT038742	hsa-miR-93-3p	CLASH	23622248
MIRT687532	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT687531	hsa-miR-1910-5p	HITS-CLIP	23313552
MIRT687530	hsa-miR-3127-3p	HITS-CLIP	23313552
MIRT687529	hsa-miR-6756-3p	HITS-CLIP	23313552
MIRT687528	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT687527	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT687526	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT687525	hsa-miR-516b-5p	HITS-CLIP	23313552
MIRT687524	hsa-miR-607	HITS-CLIP	23313552
MIRT472460	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT472459	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT279387	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT472458	hsa-miR-3148	PAR-CLIP	23592263
MIRT472457	hsa-miR-6124	PAR-CLIP	23592263
MIRT279388	hsa-miR-5682	PAR-CLIP	23592263
MIRT472456	hsa-miR-3978	PAR-CLIP	23592263
MIRT006250	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT006251	hsa-miR-29b-3p	PAR-CLIP	26701625
MIRT472458	hsa-miR-3148	PAR-CLIP	26701625
MIRT472456	hsa-miR-3978	PAR-CLIP	26701625
MIRT279388	hsa-miR-5682	PAR-CLIP	26701625
MIRT472459	hsa-miR-570-3p	PAR-CLIP	26701625
MIRT472457	hsa-miR-6124	PAR-CLIP	26701625
MIRT472460	hsa-miR-6871-3p	PAR-CLIP	26701625
MIRT279387	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT687532	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT687531	hsa-miR-1910-5p	HITS-CLIP	23313552
MIRT687530	hsa-miR-3127-3p	HITS-CLIP	23313552
MIRT687529	hsa-miR-6756-3p	HITS-CLIP	23313552
MIRT687528	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT687527	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT687526	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT687525	hsa-miR-516b-5p	HITS-CLIP	23313552
MIRT687524	hsa-miR-607	HITS-CLIP	23313552
MIRT472460	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT472459	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT279387	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT472458	hsa-miR-3148	PAR-CLIP	23592263
MIRT472457	hsa-miR-6124	PAR-CLIP	23592263
MIRT279388	hsa-miR-5682	PAR-CLIP	23592263
MIRT472456	hsa-miR-3978	PAR-CLIP	23592263
MIRT1174281	hsa-miR-4493	CLIP-seq
MIRT1174282	hsa-miR-4661-3p	CLIP-seq
MIRT1174283	hsa-miR-4753-5p	CLIP-seq
MIRT1174284	hsa-miR-4772-5p	CLIP-seq
MIRT1174285	hsa-miR-651	CLIP-seq
MIRT1174286	hsa-miR-873	CLIP-seq
MIRT2279501	hsa-miR-1184	CLIP-seq
MIRT2279502	hsa-miR-1205	CLIP-seq
MIRT2279503	hsa-miR-1253	CLIP-seq
MIRT2279504	hsa-miR-29a	CLIP-seq
MIRT2279505	hsa-miR-29b	CLIP-seq
MIRT2279506	hsa-miR-29c	CLIP-seq
MIRT2279507	hsa-miR-3065-3p	CLIP-seq
MIRT2279508	hsa-miR-3156-5p	CLIP-seq
MIRT2279509	hsa-miR-3158-5p	CLIP-seq
MIRT2279510	hsa-miR-3180-5p	CLIP-seq
MIRT2279511	hsa-miR-3691-3p	CLIP-seq
MIRT2279512	hsa-miR-4291	CLIP-seq
MIRT2279513	hsa-miR-4436a	CLIP-seq
MIRT2279514	hsa-miR-451b	CLIP-seq
MIRT2279515	hsa-miR-4691-3p	CLIP-seq
MIRT2279516	hsa-miR-4709-3p	CLIP-seq
MIRT2279517	hsa-miR-544	CLIP-seq
MIRT2279518	hsa-miR-555	CLIP-seq
MIRT2279519	hsa-miR-580	CLIP-seq
MIRT2279520	hsa-miR-665	CLIP-seq
MIRT2391355	hsa-miR-561	CLIP-seq
MIRT2279504	hsa-miR-29a	CLIP-seq
MIRT2279505	hsa-miR-29b	CLIP-seq
MIRT2279506	hsa-miR-29c	CLIP-seq
MIRT2454863	hsa-miR-570	CLIP-seq
MIRT2279510	hsa-miR-3180-5p	CLIP-seq
MIRT2577724	hsa-miR-3942-3p	CLIP-seq
MIRT2577725	hsa-miR-4726-3p	CLIP-seq
MIRT2279520	hsa-miR-665	CLIP-seq
MIRT2577726	hsa-miR-759	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	14718166
GO:0001824	Process	Blastocyst development	ISS
GO:0005515	Function	Protein binding	IPI	16189514, 19410544, 19498464, 20080577, 21044950, 24981860, 25281560, 25416956, 29568061, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006334	Process	Nucleosome assembly	IDA	14718166, 25615412
GO:0006335	Process	DNA replication-dependent chromatin assembly	IBA
GO:0006335	Process	DNA replication-dependent chromatin assembly	ISS
GO:0006335	Process	DNA replication-dependent chromatin assembly	ISS
GO:0008584	Process	Male gonad development	IEA
GO:0015031	Process	Protein transport	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0033574	Process	Response to testosterone	IEA
GO:0034080	Process	CENP-A containing chromatin assembly	IBA
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IDA	27618665
GO:0044877	Function	Protein-containing complex binding	IDA	25615412

MIM	HGNC	e!Ensembl
603185	7644	ENSG00000132780

P49321

Protein name

Nuclear autoantigenic sperm protein (NASP)

Protein function

Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA

PDB

7V1K , 7V1L , 7V1M , 7V6P , 7V6Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10516	SHNi-TPR	542 → 579	SHNi-TPR	Repeat

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is testis- and sperm-specific.

Sequence

MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP
AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG
EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK
GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE
EEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESL
DPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAG
SEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVP
SQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGS
EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY
AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY
DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ
RSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKR
KPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAG
ATVESTAC

Sequence length

788

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34633056	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30076957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	30076957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	30076957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28173777		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30076957, 31797734		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30076957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	20164540	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28173777		★★★★★ ★☆☆☆☆ Found in Text Mining only

NASP (nuclear autoantigenic sperm protein)