NAP1L4 (nucleosome assembly protein 1 like 4)

Gene

• Entrez ID: 4676
• Gene name: Nucleosome assembly protein 1 like 4
• Gene symbol: NAP1L4
• Synonyms (NCBI Gene): NAP1L4b, NAP2, NAP2L, hNAP2
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several locat

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048253	hsa-miR-196a-5p	CLASH	23622248
MIRT692017	hsa-miR-3120-3p	HITS-CLIP	23313552
MIRT692016	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT692015	hsa-miR-10b-3p	HITS-CLIP	23313552
MIRT692014	hsa-miR-922	HITS-CLIP	23313552
MIRT692013	hsa-miR-214-3p	HITS-CLIP	23313552
MIRT692012	hsa-miR-3619-5p	HITS-CLIP	23313552
MIRT692011	hsa-miR-761	HITS-CLIP	23313552
MIRT692010	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT692009	hsa-miR-8064	HITS-CLIP	23313552
MIRT692008	hsa-miR-4261	HITS-CLIP	23313552
MIRT692007	hsa-miR-3652	HITS-CLIP	23313552
MIRT692006	hsa-miR-4430	HITS-CLIP	23313552
MIRT692005	hsa-miR-4291	HITS-CLIP	23313552
MIRT692004	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT692003	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT569140	hsa-miR-1228-3p	PAR-CLIP	20371350
MIRT569139	hsa-miR-1324	PAR-CLIP	20371350
MIRT569137	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT569138	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT569141	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT569140	hsa-miR-1228-3p	PAR-CLIP	20371350
MIRT569139	hsa-miR-1324	PAR-CLIP	20371350
MIRT569137	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT569138	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT733527	hsa-miR-362-5p	Western blotting, Microarray, RNA-seq	34120636
MIRT692017	hsa-miR-3120-3p	HITS-CLIP	23313552
MIRT692016	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT692015	hsa-miR-10b-3p	HITS-CLIP	23313552
MIRT692014	hsa-miR-922	HITS-CLIP	23313552
MIRT692013	hsa-miR-214-3p	HITS-CLIP	23313552
MIRT692012	hsa-miR-3619-5p	HITS-CLIP	23313552
MIRT692011	hsa-miR-761	HITS-CLIP	23313552
MIRT692010	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT692009	hsa-miR-8064	HITS-CLIP	23313552
MIRT692008	hsa-miR-4261	HITS-CLIP	23313552
MIRT692007	hsa-miR-3652	HITS-CLIP	23313552
MIRT692006	hsa-miR-4430	HITS-CLIP	23313552
MIRT692005	hsa-miR-4291	HITS-CLIP	23313552
MIRT692004	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT692003	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT569140	hsa-miR-1228-3p	PAR-CLIP	20371350
MIRT569139	hsa-miR-1324	PAR-CLIP	20371350
MIRT569137	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT569138	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT569141	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT569140	hsa-miR-1228-3p	PAR-CLIP	20371350
MIRT569139	hsa-miR-1324	PAR-CLIP	20371350
MIRT569137	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT569138	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT1173691	hsa-miR-1228	CLIP-seq
MIRT1173692	hsa-miR-1254	CLIP-seq
MIRT1173693	hsa-miR-1281	CLIP-seq
MIRT1173694	hsa-miR-1289	CLIP-seq
MIRT1173695	hsa-miR-1295	CLIP-seq
MIRT1173696	hsa-miR-141	CLIP-seq
MIRT1173697	hsa-miR-200a	CLIP-seq
MIRT1173698	hsa-miR-203	CLIP-seq
MIRT1173699	hsa-miR-3064-3p	CLIP-seq
MIRT1173700	hsa-miR-3116	CLIP-seq
MIRT1173701	hsa-miR-3151	CLIP-seq
MIRT1173702	hsa-miR-3157-5p	CLIP-seq
MIRT1173703	hsa-miR-3198	CLIP-seq
MIRT1173704	hsa-miR-346	CLIP-seq
MIRT1173705	hsa-miR-4252	CLIP-seq
MIRT1173706	hsa-miR-4254	CLIP-seq
MIRT1173707	hsa-miR-4263	CLIP-seq
MIRT1173708	hsa-miR-4269	CLIP-seq
MIRT1173709	hsa-miR-4294	CLIP-seq
MIRT1173710	hsa-miR-4309	CLIP-seq
MIRT1173711	hsa-miR-4456	CLIP-seq
MIRT1173712	hsa-miR-4521	CLIP-seq
MIRT1173713	hsa-miR-4527	CLIP-seq
MIRT1173714	hsa-miR-4639-3p	CLIP-seq
MIRT1173715	hsa-miR-4645-5p	CLIP-seq
MIRT1173716	hsa-miR-4650-5p	CLIP-seq
MIRT1173717	hsa-miR-4673	CLIP-seq
MIRT1173718	hsa-miR-4690-3p	CLIP-seq
MIRT1173719	hsa-miR-4715-3p	CLIP-seq
MIRT1173720	hsa-miR-4727-5p	CLIP-seq
MIRT1173721	hsa-miR-4742-3p	CLIP-seq
MIRT1173722	hsa-miR-4755-3p	CLIP-seq
MIRT1173723	hsa-miR-4761-5p	CLIP-seq
MIRT1173724	hsa-miR-4762-3p	CLIP-seq
MIRT1173725	hsa-miR-4766-5p	CLIP-seq
MIRT1173726	hsa-miR-4769-3p	CLIP-seq
MIRT1173727	hsa-miR-4790-3p	CLIP-seq
MIRT1173728	hsa-miR-520d-5p	CLIP-seq
MIRT1173729	hsa-miR-524-5p	CLIP-seq
MIRT1173730	hsa-miR-541	CLIP-seq
MIRT1173731	hsa-miR-570	CLIP-seq
MIRT1173732	hsa-miR-586	CLIP-seq
MIRT1173733	hsa-miR-630	CLIP-seq
MIRT1173734	hsa-miR-654-5p	CLIP-seq
MIRT1173735	hsa-miR-876-3p	CLIP-seq
MIRT1173736	hsa-miR-935	CLIP-seq
MIRT2050304	hsa-miR-1286	CLIP-seq
MIRT2050305	hsa-miR-214	CLIP-seq
MIRT2050306	hsa-miR-3173-3p	CLIP-seq
MIRT2050307	hsa-miR-4251	CLIP-seq
MIRT1173708	hsa-miR-4269	CLIP-seq
MIRT2050308	hsa-miR-4428	CLIP-seq
MIRT2050309	hsa-miR-4438	CLIP-seq
MIRT1173712	hsa-miR-4521	CLIP-seq
MIRT2050310	hsa-miR-5095	CLIP-seq
MIRT2050311	hsa-miR-539	CLIP-seq
MIRT2279275	hsa-miR-1226	CLIP-seq
MIRT2050304	hsa-miR-1286	CLIP-seq
MIRT2279276	hsa-miR-1287	CLIP-seq
MIRT1173695	hsa-miR-1295	CLIP-seq
MIRT2279277	hsa-miR-1910	CLIP-seq
MIRT2279278	hsa-miR-198	CLIP-seq
MIRT1173698	hsa-miR-203	CLIP-seq
MIRT2050305	hsa-miR-214	CLIP-seq
MIRT2279279	hsa-miR-2467-3p	CLIP-seq
MIRT2279280	hsa-miR-296-5p	CLIP-seq
MIRT1173699	hsa-miR-3064-3p	CLIP-seq
MIRT2279281	hsa-miR-31	CLIP-seq
MIRT2279282	hsa-miR-3135b	CLIP-seq
MIRT1173701	hsa-miR-3151	CLIP-seq
MIRT2279283	hsa-miR-3154	CLIP-seq
MIRT2279284	hsa-miR-3158-5p	CLIP-seq
MIRT2279285	hsa-miR-3678-3p	CLIP-seq
MIRT2279286	hsa-miR-3686	CLIP-seq
MIRT1173705	hsa-miR-4252	CLIP-seq
MIRT1173707	hsa-miR-4263	CLIP-seq
MIRT1173708	hsa-miR-4269	CLIP-seq
MIRT2050309	hsa-miR-4438	CLIP-seq
MIRT1173712	hsa-miR-4521	CLIP-seq
MIRT1173714	hsa-miR-4639-3p	CLIP-seq
MIRT1173716	hsa-miR-4650-5p	CLIP-seq
MIRT1173719	hsa-miR-4715-3p	CLIP-seq
MIRT2279287	hsa-miR-4742-5p	CLIP-seq
MIRT1173724	hsa-miR-4762-3p	CLIP-seq
MIRT1173725	hsa-miR-4766-5p	CLIP-seq
MIRT2279288	hsa-miR-4778-5p	CLIP-seq
MIRT1173727	hsa-miR-4790-3p	CLIP-seq
MIRT2050310	hsa-miR-5095	CLIP-seq
MIRT2279289	hsa-miR-513a-5p	CLIP-seq
MIRT2279290	hsa-miR-520a-5p	CLIP-seq
MIRT2279291	hsa-miR-525-5p	CLIP-seq
MIRT1173730	hsa-miR-541	CLIP-seq
MIRT2279292	hsa-miR-548v	CLIP-seq
MIRT1173731	hsa-miR-570	CLIP-seq
MIRT1173732	hsa-miR-586	CLIP-seq
MIRT1173734	hsa-miR-654-5p	CLIP-seq
MIRT1173699	hsa-miR-3064-3p	CLIP-seq
MIRT1173705	hsa-miR-4252	CLIP-seq
MIRT1173719	hsa-miR-4715-3p	CLIP-seq
MIRT2577385	hsa-miR-1207-5p	CLIP-seq
MIRT2577386	hsa-miR-1224-5p	CLIP-seq
MIRT2577387	hsa-miR-1245b-5p	CLIP-seq
MIRT2577388	hsa-miR-1253	CLIP-seq
MIRT2577389	hsa-miR-1266	CLIP-seq
MIRT2050304	hsa-miR-1286	CLIP-seq
MIRT2279276	hsa-miR-1287	CLIP-seq
MIRT2577390	hsa-miR-139-5p	CLIP-seq
MIRT2577391	hsa-miR-188-3p	CLIP-seq
MIRT2577392	hsa-miR-1915	CLIP-seq
MIRT2279278	hsa-miR-198	CLIP-seq
MIRT1173698	hsa-miR-203	CLIP-seq
MIRT2577393	hsa-miR-2114	CLIP-seq
MIRT2050305	hsa-miR-214	CLIP-seq
MIRT2279279	hsa-miR-2467-3p	CLIP-seq
MIRT1173699	hsa-miR-3064-3p	CLIP-seq
MIRT2577394	hsa-miR-3074-5p	CLIP-seq
MIRT2577395	hsa-miR-3127-5p	CLIP-seq
MIRT2279282	hsa-miR-3135b	CLIP-seq
MIRT2577396	hsa-miR-3142	CLIP-seq
MIRT2577397	hsa-miR-3148	CLIP-seq
MIRT2577398	hsa-miR-3153	CLIP-seq
MIRT1173702	hsa-miR-3157-5p	CLIP-seq
MIRT2279284	hsa-miR-3158-5p	CLIP-seq
MIRT2577399	hsa-miR-3193	CLIP-seq
MIRT2577400	hsa-miR-3609	CLIP-seq
MIRT2577401	hsa-miR-3618	CLIP-seq
MIRT2577402	hsa-miR-3620	CLIP-seq
MIRT2279285	hsa-miR-3678-3p	CLIP-seq
MIRT2577403	hsa-miR-370	CLIP-seq
MIRT2577404	hsa-miR-3918	CLIP-seq
MIRT2577405	hsa-miR-3940-3p	CLIP-seq
MIRT1173705	hsa-miR-4252	CLIP-seq
MIRT1173708	hsa-miR-4269	CLIP-seq
MIRT2577406	hsa-miR-4270	CLIP-seq
MIRT2577407	hsa-miR-4290	CLIP-seq
MIRT2577408	hsa-miR-4434	CLIP-seq
MIRT2050309	hsa-miR-4438	CLIP-seq
MIRT2577409	hsa-miR-4441	CLIP-seq
MIRT1173711	hsa-miR-4456	CLIP-seq
MIRT2577410	hsa-miR-4503	CLIP-seq
MIRT2577411	hsa-miR-4516	CLIP-seq
MIRT2577412	hsa-miR-4518	CLIP-seq
MIRT2577413	hsa-miR-4531	CLIP-seq
MIRT1173716	hsa-miR-4650-5p	CLIP-seq
MIRT2577414	hsa-miR-4659a-3p	CLIP-seq
MIRT2577415	hsa-miR-4659b-3p	CLIP-seq
MIRT1173718	hsa-miR-4690-3p	CLIP-seq
MIRT1173719	hsa-miR-4715-3p	CLIP-seq
MIRT2577416	hsa-miR-4736	CLIP-seq
MIRT2577417	hsa-miR-4751	CLIP-seq
MIRT1173723	hsa-miR-4761-5p	CLIP-seq
MIRT1173724	hsa-miR-4762-3p	CLIP-seq
MIRT2577418	hsa-miR-4763-3p	CLIP-seq
MIRT1173725	hsa-miR-4766-5p	CLIP-seq
MIRT2050310	hsa-miR-5095	CLIP-seq
MIRT2279290	hsa-miR-520a-5p	CLIP-seq
MIRT2279291	hsa-miR-525-5p	CLIP-seq
MIRT2577419	hsa-miR-532-3p	CLIP-seq
MIRT2577420	hsa-miR-548ah	CLIP-seq
MIRT2577421	hsa-miR-548p	CLIP-seq
MIRT2577422	hsa-miR-548t	CLIP-seq
MIRT2279292	hsa-miR-548v	CLIP-seq
MIRT2577423	hsa-miR-566	CLIP-seq
MIRT1173732	hsa-miR-586	CLIP-seq
MIRT2577424	hsa-miR-601	CLIP-seq
MIRT2577425	hsa-miR-617	CLIP-seq
MIRT2577426	hsa-miR-767-3p	CLIP-seq
MIRT2577385	hsa-miR-1207-5p	CLIP-seq
MIRT2577386	hsa-miR-1224-5p	CLIP-seq
MIRT2577387	hsa-miR-1245b-5p	CLIP-seq
MIRT2577388	hsa-miR-1253	CLIP-seq
MIRT2577389	hsa-miR-1266	CLIP-seq
MIRT2050304	hsa-miR-1286	CLIP-seq
MIRT2279276	hsa-miR-1287	CLIP-seq
MIRT2577390	hsa-miR-139-5p	CLIP-seq
MIRT2577391	hsa-miR-188-3p	CLIP-seq
MIRT2577392	hsa-miR-1915	CLIP-seq
MIRT2279278	hsa-miR-198	CLIP-seq
MIRT1173698	hsa-miR-203	CLIP-seq
MIRT2577393	hsa-miR-2114	CLIP-seq
MIRT2050305	hsa-miR-214	CLIP-seq
MIRT2279279	hsa-miR-2467-3p	CLIP-seq
MIRT1173699	hsa-miR-3064-3p	CLIP-seq
MIRT2577394	hsa-miR-3074-5p	CLIP-seq
MIRT2577395	hsa-miR-3127-5p	CLIP-seq
MIRT2279282	hsa-miR-3135b	CLIP-seq
MIRT2577396	hsa-miR-3142	CLIP-seq
MIRT2577397	hsa-miR-3148	CLIP-seq
MIRT2577398	hsa-miR-3153	CLIP-seq
MIRT1173702	hsa-miR-3157-5p	CLIP-seq
MIRT2279284	hsa-miR-3158-5p	CLIP-seq
MIRT2577399	hsa-miR-3193	CLIP-seq
MIRT2577401	hsa-miR-3618	CLIP-seq
MIRT2577402	hsa-miR-3620	CLIP-seq
MIRT2279285	hsa-miR-3678-3p	CLIP-seq
MIRT2577403	hsa-miR-370	CLIP-seq
MIRT2577404	hsa-miR-3918	CLIP-seq
MIRT2577405	hsa-miR-3940-3p	CLIP-seq
MIRT1173705	hsa-miR-4252	CLIP-seq
MIRT1173708	hsa-miR-4269	CLIP-seq
MIRT2577406	hsa-miR-4270	CLIP-seq
MIRT2577407	hsa-miR-4290	CLIP-seq
MIRT2577408	hsa-miR-4434	CLIP-seq
MIRT2050309	hsa-miR-4438	CLIP-seq
MIRT2577409	hsa-miR-4441	CLIP-seq
MIRT1173711	hsa-miR-4456	CLIP-seq
MIRT2577410	hsa-miR-4503	CLIP-seq
MIRT2577411	hsa-miR-4516	CLIP-seq
MIRT2577412	hsa-miR-4518	CLIP-seq
MIRT2577413	hsa-miR-4531	CLIP-seq
MIRT1173716	hsa-miR-4650-5p	CLIP-seq
MIRT2577414	hsa-miR-4659a-3p	CLIP-seq
MIRT2577415	hsa-miR-4659b-3p	CLIP-seq
MIRT1173718	hsa-miR-4690-3p	CLIP-seq
MIRT1173719	hsa-miR-4715-3p	CLIP-seq
MIRT2577416	hsa-miR-4736	CLIP-seq
MIRT2577417	hsa-miR-4751	CLIP-seq
MIRT1173723	hsa-miR-4761-5p	CLIP-seq
MIRT1173724	hsa-miR-4762-3p	CLIP-seq
MIRT2577418	hsa-miR-4763-3p	CLIP-seq
MIRT1173725	hsa-miR-4766-5p	CLIP-seq
MIRT2050310	hsa-miR-5095	CLIP-seq
MIRT2279290	hsa-miR-520a-5p	CLIP-seq
MIRT2279291	hsa-miR-525-5p	CLIP-seq
MIRT2577419	hsa-miR-532-3p	CLIP-seq
MIRT2577421	hsa-miR-548p	CLIP-seq
MIRT2279292	hsa-miR-548v	CLIP-seq
MIRT2577423	hsa-miR-566	CLIP-seq
MIRT1173732	hsa-miR-586	CLIP-seq
MIRT2577424	hsa-miR-601	CLIP-seq
MIRT2577425	hsa-miR-617	CLIP-seq
MIRT2577426	hsa-miR-767-3p	CLIP-seq
MIRT1173735	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IBA
GO:0003682	Function	Chromatin binding	IBA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	22190034, 24981860, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9325046
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	9325046
GO:0005737	Component	Cytoplasm	IEA
GO:0006334	Process	Nucleosome assembly	IBA
GO:0006334	Process	Nucleosome assembly	IDA	9325046
GO:0006334	Process	Nucleosome assembly	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031491	Function	Nucleosome binding	IDA	9325046
GO:0042393	Function	Histone binding	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0051082	Function	Unfolded protein binding	TAS	9325046

Other IDs

• MIM: 601651
• HGNC: 7640
• e!Ensembl: ENSG00000205531

Protein

• UniProt ID: Q99733
• Protein name: Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2)
• Protein function: Acts as a histone chaperone in nucleosome assembly.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00956	NAP	65 → 338	Nucleosome assembly protein (NAP)	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis. {ECO:0000269|PubMed:8923002}.
• Sequence:

  MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLP
  KAVKRRINALKQLQVRCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAE
  SEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
  DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFE
  GPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNESFFNFFNPLKASG
  DGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGD
  EEGEDEDDAEINPKV

• Sequence length: 375

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Neoplasms	Neoplasms	BEFREE	9325046		★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	9325046		★☆☆☆☆ Found in Text Mining only