Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	4674
Gene name	Nucleosome assembly protein 1 like 2
Gene symbol	NAP1L2
Synonyms (NCBI Gene)	BPX
Chromosome	X
Chromosome location	Xq13.2
Summary	The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by R

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021545	hsa-miR-142-3p	Microarray	17612493
MIRT440153	hsa-miR-369-3p	HITS-CLIP	24374217
MIRT440153	hsa-miR-369-3p	HITS-CLIP	24374217
MIRT1173655	hsa-miR-103b	CLIP-seq
MIRT1173656	hsa-miR-2054	CLIP-seq
MIRT1173657	hsa-miR-3144-3p	CLIP-seq
MIRT1173658	hsa-miR-3159	CLIP-seq
MIRT1173659	hsa-miR-3171	CLIP-seq
MIRT1173660	hsa-miR-3200-3p	CLIP-seq
MIRT1173661	hsa-miR-376a	CLIP-seq
MIRT1173662	hsa-miR-376b	CLIP-seq
MIRT1173663	hsa-miR-380	CLIP-seq
MIRT1173664	hsa-miR-3923	CLIP-seq
MIRT1173665	hsa-miR-4457	CLIP-seq
MIRT1173666	hsa-miR-4496	CLIP-seq
MIRT1173667	hsa-miR-4650-5p	CLIP-seq
MIRT1173668	hsa-miR-4714-5p	CLIP-seq
MIRT1173669	hsa-miR-4731-3p	CLIP-seq
MIRT1173670	hsa-miR-4757-5p	CLIP-seq
MIRT1173671	hsa-miR-4766-5p	CLIP-seq
MIRT1173672	hsa-miR-4801	CLIP-seq
MIRT1173673	hsa-miR-633	CLIP-seq
MIRT1173674	hsa-miR-875-5p	CLIP-seq
MIRT1173655	hsa-miR-103b	CLIP-seq
MIRT2050292	hsa-miR-128	CLIP-seq
MIRT2050293	hsa-miR-141	CLIP-seq
MIRT2050294	hsa-miR-200a	CLIP-seq
MIRT2050295	hsa-miR-27a	CLIP-seq
MIRT2050296	hsa-miR-27b	CLIP-seq
MIRT2050297	hsa-miR-3129-3p	CLIP-seq
MIRT2050298	hsa-miR-3150a-5p	CLIP-seq
MIRT2050299	hsa-miR-3150b-5p	CLIP-seq
MIRT1173661	hsa-miR-376a	CLIP-seq
MIRT1173662	hsa-miR-376b	CLIP-seq
MIRT2050300	hsa-miR-410	CLIP-seq
MIRT2050301	hsa-miR-412	CLIP-seq
MIRT2050302	hsa-miR-4528	CLIP-seq
MIRT2050303	hsa-miR-935	CLIP-seq
MIRT2050293	hsa-miR-141	CLIP-seq
MIRT2050294	hsa-miR-200a	CLIP-seq
MIRT2279272	hsa-miR-200b	CLIP-seq
MIRT2279273	hsa-miR-200c	CLIP-seq
MIRT1173656	hsa-miR-2054	CLIP-seq
MIRT2050298	hsa-miR-3150a-5p	CLIP-seq
MIRT2050299	hsa-miR-3150b-5p	CLIP-seq
MIRT1173659	hsa-miR-3171	CLIP-seq
MIRT1173663	hsa-miR-380	CLIP-seq
MIRT2050301	hsa-miR-412	CLIP-seq
MIRT2279274	hsa-miR-429	CLIP-seq
MIRT1173666	hsa-miR-4496	CLIP-seq
MIRT1173669	hsa-miR-4731-3p	CLIP-seq
MIRT1173672	hsa-miR-4801	CLIP-seq
MIRT2050293	hsa-miR-141	CLIP-seq
MIRT2050294	hsa-miR-200a	CLIP-seq
MIRT2050298	hsa-miR-3150a-5p	CLIP-seq
MIRT2050299	hsa-miR-3150b-5p	CLIP-seq
MIRT2050301	hsa-miR-412	CLIP-seq
MIRT2050292	hsa-miR-128	CLIP-seq
MIRT2050293	hsa-miR-141	CLIP-seq
MIRT2050294	hsa-miR-200a	CLIP-seq
MIRT2050295	hsa-miR-27a	CLIP-seq
MIRT2050296	hsa-miR-27b	CLIP-seq
MIRT2050297	hsa-miR-3129-3p	CLIP-seq
MIRT2050298	hsa-miR-3150a-5p	CLIP-seq
MIRT2050299	hsa-miR-3150b-5p	CLIP-seq
MIRT2050300	hsa-miR-410	CLIP-seq
MIRT2050301	hsa-miR-412	CLIP-seq
MIRT2050302	hsa-miR-4528	CLIP-seq
MIRT2050303	hsa-miR-935	CLIP-seq
MIRT2685787	hsa-miR-19a	CLIP-seq
MIRT2685788	hsa-miR-19b	CLIP-seq
MIRT2050298	hsa-miR-3150a-5p	CLIP-seq
MIRT2050299	hsa-miR-3150b-5p	CLIP-seq
MIRT2685789	hsa-miR-338-5p	CLIP-seq
MIRT2685790	hsa-miR-3941	CLIP-seq
MIRT2050300	hsa-miR-410	CLIP-seq
MIRT2685791	hsa-miR-4275	CLIP-seq
MIRT2685792	hsa-miR-455-5p	CLIP-seq
MIRT2685793	hsa-miR-466	CLIP-seq
MIRT2685794	hsa-miR-4672	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IBA
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	18985028, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8789438
GO:0006334	Process	Nucleosome assembly	IBA
GO:0006334	Process	Nucleosome assembly	IEA
GO:0006334	Process	Nucleosome assembly	TAS	8789438
GO:0030182	Process	Neuron differentiation	IEA
GO:0035034	Function	Histone acetyltransferase regulator activity	IEA
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:2000035	Process	Regulation of stem cell division	IEA

MIM	HGNC	e!Ensembl
300026	7638	ENSG00000186462

Q9ULW6

Protein name

Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked)

Protein function

Acidic protein which may be involved in interactions with other proteins or DNA.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00956	NAP	110 → 411	Nucleosome assembly protein (NAP)	Family

Sequence

MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGE
NGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQT
RAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEM
CHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGI
PDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNE
LLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRT
VTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGV
VREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR

Sequence length

460

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of neuronal migration	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALFORMATIONS OF CORTICAL DEVELOPMENT, GROUP II	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acne	Acne	BEFREE	30909327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acne Vulgaris	Acne	BEFREE	30909327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31397210		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	26967585		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	26967585		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neural Tube Defects	Neural Tube Defect	BEFREE	12116227		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	25187168		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36195720	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NAP1L2 (nucleosome assembly protein 1 like 2)