Gene Gene information from NCBI Gene database.
Entrez ID 4673
Gene name Nucleosome assembly protein 1 like 1
Gene symbol NAP1L1
Synonyms (NCBI Gene)
NAP1NAP1LNRP
Chromosome 12
Chromosome location 12q21.2
Summary This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing res
miRNA miRNA information provided by mirtarbase database.
732
miRTarBase ID miRNA Experiments Reference
MIRT021853 hsa-miR-132-3p Microarray 17612493
MIRT028667 hsa-miR-30a-5p Proteomics 18668040
MIRT051035 hsa-miR-17-5p CLASH 23622248
MIRT050612 hsa-miR-20a-5p CLASH 23622248
MIRT050052 hsa-miR-26b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IBA
GO:0003682 Function Chromatin binding IBA
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 11940655, 16169070, 18226242, 18331838, 20195357, 21044950, 23414517, 24981860, 25852190, 28514442, 29128334, 32296183, 32707033, 33961781
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164060 7637 ENSG00000187109
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P55209
Protein name Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)
Protein function Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chrom
PDB 7BP5 , 7UN3 , 7UN6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00956 NAP 76 345 Nucleosome assembly protein (NAP) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed.
Sequence
Sequence length 391
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 29773756
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 10974570
★☆☆☆☆
Found in Text Mining only
Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder) Emery-Dreifuss Muscular Dystrophy BEFREE 16478798
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 10974570, 15208678, 18981988
★☆☆☆☆
Found in Text Mining only
Brain Tumor, Primary Brain Neoplasms BEFREE 10974570
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 17875699, 26805761
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 35351053 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 10519393
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 34959221 Associate
★☆☆☆☆
Found in Text Mining only
Central Diabetes Insipidus Diabetes Insipidus BEFREE 18216211, 19081526, 19755166, 21487764, 24213847, 25782900, 28125650, 28501926, 28645479, 29174729, 29846557, 30052178, 30170546
★☆☆☆☆
Found in Text Mining only