Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4670
Gene name	Heterogeneous nuclear ribonucleoprotein M
Gene symbol	HNRNPM
Synonyms (NCBI Gene)	CEARHNRNPM4HNRPMHNRPM4HTGR1NAGR1hnRNP M
Chromosome	19
Chromosome location	19p13.2
Summary	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in th

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Show/Hide all (103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005120	hsa-miR-30a-5p	pSILAC	18668040
MIRT005120	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT029321	hsa-miR-26b-5p	Microarray	19088304
MIRT049986	hsa-miR-29a-3p	CLASH	23622248
MIRT049361	hsa-miR-92a-3p	CLASH	23622248
MIRT048765	hsa-miR-93-5p	CLASH	23622248
MIRT047057	hsa-miR-183-5p	CLASH	23622248
MIRT046439	hsa-miR-15b-5p	CLASH	23622248
MIRT045805	hsa-miR-191-5p	CLASH	23622248
MIRT043473	hsa-miR-331-3p	CLASH	23622248
MIRT042112	hsa-miR-484	CLASH	23622248
MIRT041425	hsa-miR-193b-3p	CLASH	23622248
MIRT040906	hsa-miR-18a-3p	CLASH	23622248
MIRT039993	hsa-miR-615-3p	CLASH	23622248
MIRT038991	hsa-let-7f-1-3p	CLASH	23622248
MIRT038991	hsa-let-7f-1-3p	CLASH	23622248
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT1051872	hsa-miR-1279	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051873	hsa-miR-3065-5p	CLIP-seq
MIRT1051874	hsa-miR-3914	CLIP-seq
MIRT1051875	hsa-miR-3973	CLIP-seq
MIRT1051876	hsa-miR-4680-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT1051877	hsa-miR-4789-5p	CLIP-seq
MIRT1051878	hsa-miR-4795-3p	CLIP-seq
MIRT1051879	hsa-miR-505	CLIP-seq
MIRT1051880	hsa-miR-520g	CLIP-seq
MIRT1051881	hsa-miR-520h	CLIP-seq
MIRT1051882	hsa-miR-873	CLIP-seq
MIRT1051872	hsa-miR-1279	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051873	hsa-miR-3065-5p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2244061	hsa-miR-3662	CLIP-seq
MIRT1051875	hsa-miR-3973	CLIP-seq
MIRT2244062	hsa-miR-4257	CLIP-seq
MIRT1051878	hsa-miR-4795-3p	CLIP-seq
MIRT1051879	hsa-miR-505	CLIP-seq
MIRT1051880	hsa-miR-520g	CLIP-seq
MIRT1051881	hsa-miR-520h	CLIP-seq
MIRT2244063	hsa-miR-522	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2547093	hsa-miR-3671	CLIP-seq
MIRT1051876	hsa-miR-4680-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT2547094	hsa-miR-4760-3p	CLIP-seq
MIRT1051877	hsa-miR-4789-5p	CLIP-seq
MIRT2547095	hsa-miR-548a-5p	CLIP-seq
MIRT2547096	hsa-miR-548ab	CLIP-seq
MIRT2547097	hsa-miR-548ak	CLIP-seq
MIRT2547098	hsa-miR-548b-5p	CLIP-seq
MIRT2547099	hsa-miR-548c-5p	CLIP-seq
MIRT2547100	hsa-miR-548d-5p	CLIP-seq
MIRT2547101	hsa-miR-548h	CLIP-seq
MIRT2547102	hsa-miR-548i	CLIP-seq
MIRT2547103	hsa-miR-548j	CLIP-seq
MIRT2547104	hsa-miR-548n	CLIP-seq
MIRT2547105	hsa-miR-548w	CLIP-seq
MIRT2547106	hsa-miR-548y	CLIP-seq
MIRT2547107	hsa-miR-559	CLIP-seq
MIRT2547108	hsa-miR-607	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2547093	hsa-miR-3671	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT2547094	hsa-miR-4760-3p	CLIP-seq
MIRT2547095	hsa-miR-548a-5p	CLIP-seq
MIRT2547096	hsa-miR-548ab	CLIP-seq
MIRT2547097	hsa-miR-548ak	CLIP-seq
MIRT2547098	hsa-miR-548b-5p	CLIP-seq
MIRT2547099	hsa-miR-548c-5p	CLIP-seq
MIRT2547100	hsa-miR-548d-5p	CLIP-seq
MIRT2547101	hsa-miR-548h	CLIP-seq
MIRT2547102	hsa-miR-548i	CLIP-seq
MIRT2547103	hsa-miR-548j	CLIP-seq
MIRT2547104	hsa-miR-548n	CLIP-seq
MIRT2547105	hsa-miR-548w	CLIP-seq
MIRT2547106	hsa-miR-548y	CLIP-seq
MIRT2547107	hsa-miR-559	CLIP-seq
MIRT2547108	hsa-miR-607	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IMP	19874820
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529, 11991638
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	9731529
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	17435768, 18457437, 19874820, 20467437, 21988832, 24965446, 25416956, 25678563, 30021884, 32296183, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	19874820
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016363	Component	Nuclear matrix	IDA	19874820
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0042382	Component	Paraspeckles	IDA	19874820
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
160994	5046	ENSG00000099783

P52272

Protein name

Heterogeneous nuclear ribonucleoprotein M (hnRNP M)

Protein function

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosin

PDB

2DGV , 2DH9 , 2DO0 , 2OT8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11532	HnRNP_M	41 → 70	Heterogeneous nuclear ribonucleoprotein M	Family
PF00076	RRM_1	73 → 143	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	206 → 275	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	655 → 723	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNR
FEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFK
MEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIP
PSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKD
GKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHG
LGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENM
GRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMG
AGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIG
SGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAG
LERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPAL
GAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNL
PFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGR
EIDVRIDRNA

Sequence length

730

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (30)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	32915499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	31251827		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	24840202, 28393427, 30021377		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30042172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24381081, 35158098	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32915499, 35158098	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30852162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30852162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	17487559		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24381081	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Disease	Coronary artery disease	Pubtator	38105623	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	32915499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	38105623	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	35544458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24381081	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	24840202, 28393427, 30021377		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31251827		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25832000, 30852162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	30852162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial ischemia	Pubtator	38105623	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34274258	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28393427, 30021377, 30852162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	25684943		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prader-Willi Syndrome	Prader-Willi Syndrome	BEFREE	27871485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31251827		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	29036465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	29036465	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	29036465, 32023846	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30093560		★★★★★ ★☆☆☆☆ Found in Text Mining only

HNRNPM (heterogeneous nuclear ribonucleoprotein M)