PPP1R12A (protein phosphatase 1 regulatory subunit 12A)

Gene

• Entrez ID: 4659
• Gene name: Protein phosphatase 1 regulatory subunit 12A
• Gene symbol: PPP1R12A
• Synonyms (NCBI Gene): GUBS, M130, MBS, MYPT1
• Chromosome: 12
• Chromosome location: 12q21.2-q21.31
• Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosp

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1356631664	G>A,T	Pathogenic	Synonymous variant, stop gained, coding sequence variant
rs1592629980	GA>-	Pathogenic	Stop gained, coding sequence variant
rs1592661703	T>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024772	hsa-miR-215-5p	Microarray	19074876
MIRT026571	hsa-miR-192-5p	Microarray	19074876
MIRT027917	hsa-miR-96-5p	Sequencing	20371350
MIRT028611	hsa-miR-30a-5p	Proteomics	18668040
MIRT047894	hsa-miR-30c-5p	CLASH	23622248
MIRT047621	hsa-miR-10a-5p	CLASH	23622248
MIRT038793	hsa-miR-93-3p	CLASH	23622248
MIRT547017	hsa-miR-5700	PAR-CLIP	20371350
MIRT547016	hsa-miR-1179	PAR-CLIP	20371350
MIRT547015	hsa-miR-5007-3p	PAR-CLIP	20371350
MIRT547014	hsa-miR-448	PAR-CLIP	20371350
MIRT555375	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT555374	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT027917	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT555373	hsa-miR-3662	PAR-CLIP	21572407
MIRT555372	hsa-miR-4761-3p	PAR-CLIP	21572407
MIRT555371	hsa-miR-4645-3p	PAR-CLIP	21572407
MIRT555370	hsa-miR-3616-3p	PAR-CLIP	21572407
MIRT555369	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT555368	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT555367	hsa-miR-4736	PAR-CLIP	21572407
MIRT555366	hsa-miR-518d-5p	PAR-CLIP	21572407
MIRT555365	hsa-miR-518e-5p	PAR-CLIP	21572407
MIRT555364	hsa-miR-518f-5p	PAR-CLIP	21572407
MIRT555363	hsa-miR-519a-5p	PAR-CLIP	21572407
MIRT555362	hsa-miR-519b-5p	PAR-CLIP	21572407
MIRT555361	hsa-miR-519c-5p	PAR-CLIP	21572407
MIRT555360	hsa-miR-520c-5p	PAR-CLIP	21572407
MIRT555359	hsa-miR-522-5p	PAR-CLIP	21572407
MIRT555358	hsa-miR-523-5p	PAR-CLIP	21572407
MIRT555357	hsa-miR-526a	PAR-CLIP	21572407
MIRT555356	hsa-miR-4777-5p	PAR-CLIP	21572407
MIRT555355	hsa-miR-7150	PAR-CLIP	21572407
MIRT547017	hsa-miR-5700	PAR-CLIP	21572407
MIRT547016	hsa-miR-1179	PAR-CLIP	21572407
MIRT547015	hsa-miR-5007-3p	PAR-CLIP	21572407
MIRT547014	hsa-miR-448	PAR-CLIP	21572407
MIRT028611	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726894	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT047894	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726893	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726892	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT732628	hsa-miR-141-3p	qRT-PCR	34180758
MIRT733962	hsa-miR-30b-3p	Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	31926547
MIRT547017	hsa-miR-5700	PAR-CLIP	20371350
MIRT547016	hsa-miR-1179	PAR-CLIP	20371350
MIRT547015	hsa-miR-5007-3p	PAR-CLIP	20371350
MIRT547014	hsa-miR-448	PAR-CLIP	20371350
MIRT555375	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT555374	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT027917	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT555373	hsa-miR-3662	PAR-CLIP	21572407
MIRT555372	hsa-miR-4761-3p	PAR-CLIP	21572407
MIRT555371	hsa-miR-4645-3p	PAR-CLIP	21572407
MIRT555370	hsa-miR-3616-3p	PAR-CLIP	21572407
MIRT555369	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT555368	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT555367	hsa-miR-4736	PAR-CLIP	21572407
MIRT555366	hsa-miR-518d-5p	PAR-CLIP	21572407
MIRT555365	hsa-miR-518e-5p	PAR-CLIP	21572407
MIRT555364	hsa-miR-518f-5p	PAR-CLIP	21572407
MIRT555363	hsa-miR-519a-5p	PAR-CLIP	21572407
MIRT555362	hsa-miR-519b-5p	PAR-CLIP	21572407
MIRT555361	hsa-miR-519c-5p	PAR-CLIP	21572407
MIRT555360	hsa-miR-520c-5p	PAR-CLIP	21572407
MIRT555359	hsa-miR-522-5p	PAR-CLIP	21572407
MIRT555358	hsa-miR-523-5p	PAR-CLIP	21572407
MIRT555357	hsa-miR-526a	PAR-CLIP	21572407
MIRT555356	hsa-miR-4777-5p	PAR-CLIP	21572407
MIRT555355	hsa-miR-7150	PAR-CLIP	21572407
MIRT547017	hsa-miR-5700	PAR-CLIP	21572407
MIRT547016	hsa-miR-1179	PAR-CLIP	21572407
MIRT547015	hsa-miR-5007-3p	PAR-CLIP	21572407
MIRT547014	hsa-miR-448	PAR-CLIP	21572407
MIRT1255365	hsa-miR-132	CLIP-seq
MIRT1255366	hsa-miR-148a	CLIP-seq
MIRT1255367	hsa-miR-148b	CLIP-seq
MIRT1255368	hsa-miR-152	CLIP-seq
MIRT1255369	hsa-miR-1827	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255373	hsa-miR-212	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255377	hsa-miR-2682	CLIP-seq
MIRT1255378	hsa-miR-300	CLIP-seq
MIRT1255379	hsa-miR-3120-3p	CLIP-seq
MIRT1255380	hsa-miR-3126-3p	CLIP-seq
MIRT1255381	hsa-miR-3140-3p	CLIP-seq
MIRT1255382	hsa-miR-3143	CLIP-seq
MIRT1255383	hsa-miR-3149	CLIP-seq
MIRT1255384	hsa-miR-3176	CLIP-seq
MIRT1255385	hsa-miR-3200-5p	CLIP-seq
MIRT1255386	hsa-miR-331-5p	CLIP-seq
MIRT1255387	hsa-miR-338-5p	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT1255389	hsa-miR-369-3p	CLIP-seq
MIRT1255390	hsa-miR-374c	CLIP-seq
MIRT1255391	hsa-miR-381	CLIP-seq
MIRT1255392	hsa-miR-3922-3p	CLIP-seq
MIRT1255393	hsa-miR-412	CLIP-seq
MIRT1255394	hsa-miR-4422	CLIP-seq
MIRT1255395	hsa-miR-4495	CLIP-seq
MIRT1255396	hsa-miR-449c	CLIP-seq
MIRT1255397	hsa-miR-4501	CLIP-seq
MIRT1255398	hsa-miR-4517	CLIP-seq
MIRT1255399	hsa-miR-455-5p	CLIP-seq
MIRT1255400	hsa-miR-4649-3p	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT1255402	hsa-miR-4678	CLIP-seq
MIRT1255403	hsa-miR-4717-3p	CLIP-seq
MIRT1255404	hsa-miR-4773	CLIP-seq
MIRT1255405	hsa-miR-4797-3p	CLIP-seq
MIRT1255406	hsa-miR-543	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT1255408	hsa-miR-584	CLIP-seq
MIRT1255409	hsa-miR-655	CLIP-seq
MIRT1255410	hsa-miR-885-5p	CLIP-seq
MIRT1255411	hsa-miR-936	CLIP-seq
MIRT1255412	hsa-miR-940	CLIP-seq
MIRT1255413	hsa-miR-1227	CLIP-seq
MIRT1255414	hsa-miR-1271	CLIP-seq
MIRT1255415	hsa-miR-1287	CLIP-seq
MIRT1255416	hsa-miR-129-5p	CLIP-seq
MIRT1255417	hsa-miR-1323	CLIP-seq
MIRT1255418	hsa-miR-1324	CLIP-seq
MIRT1255419	hsa-miR-140-5p	CLIP-seq
MIRT1255420	hsa-miR-141	CLIP-seq
MIRT1255421	hsa-miR-182	CLIP-seq
MIRT1255369	hsa-miR-1827	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255422	hsa-miR-200a	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255423	hsa-miR-214	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255424	hsa-miR-2681	CLIP-seq
MIRT1255378	hsa-miR-300	CLIP-seq
MIRT1255425	hsa-miR-30a	CLIP-seq
MIRT1255426	hsa-miR-30b	CLIP-seq
MIRT1255427	hsa-miR-30c	CLIP-seq
MIRT1255428	hsa-miR-30d	CLIP-seq
MIRT1255429	hsa-miR-30e	CLIP-seq
MIRT1255379	hsa-miR-3120-3p	CLIP-seq
MIRT1255430	hsa-miR-3124-3p	CLIP-seq
MIRT1255380	hsa-miR-3126-3p	CLIP-seq
MIRT1255431	hsa-miR-3135b	CLIP-seq
MIRT1255382	hsa-miR-3143	CLIP-seq
MIRT1255383	hsa-miR-3149	CLIP-seq
MIRT1255432	hsa-miR-3166	CLIP-seq
MIRT1255433	hsa-miR-3173-3p	CLIP-seq
MIRT1255384	hsa-miR-3176	CLIP-seq
MIRT1255385	hsa-miR-3200-5p	CLIP-seq
MIRT1255386	hsa-miR-331-5p	CLIP-seq
MIRT1255387	hsa-miR-338-5p	CLIP-seq
MIRT1255434	hsa-miR-3607-3p	CLIP-seq
MIRT1255435	hsa-miR-3619-5p	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT1255436	hsa-miR-3664-5p	CLIP-seq
MIRT1255389	hsa-miR-369-3p	CLIP-seq
MIRT1255390	hsa-miR-374c	CLIP-seq
MIRT1255437	hsa-miR-380	CLIP-seq
MIRT1255391	hsa-miR-381	CLIP-seq
MIRT1255392	hsa-miR-3922-3p	CLIP-seq
MIRT1255438	hsa-miR-3924	CLIP-seq
MIRT1255439	hsa-miR-4276	CLIP-seq
MIRT1255440	hsa-miR-4291	CLIP-seq
MIRT1255441	hsa-miR-4328	CLIP-seq
MIRT1255442	hsa-miR-4330	CLIP-seq
MIRT1255443	hsa-miR-4428	CLIP-seq
MIRT1255444	hsa-miR-4477b	CLIP-seq
MIRT1255395	hsa-miR-4495	CLIP-seq
MIRT1255397	hsa-miR-4501	CLIP-seq
MIRT1255445	hsa-miR-450b-5p	CLIP-seq
MIRT1255446	hsa-miR-4524	CLIP-seq
MIRT1255399	hsa-miR-455-5p	CLIP-seq
MIRT1255447	hsa-miR-4633-3p	CLIP-seq
MIRT1255400	hsa-miR-4649-3p	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT1255402	hsa-miR-4678	CLIP-seq
MIRT1255448	hsa-miR-4714-5p	CLIP-seq
MIRT1255449	hsa-miR-4728-3p	CLIP-seq
MIRT1255405	hsa-miR-4797-3p	CLIP-seq
MIRT1255450	hsa-miR-490-5p	CLIP-seq
MIRT1255451	hsa-miR-494	CLIP-seq
MIRT1255452	hsa-miR-507	CLIP-seq
MIRT1255453	hsa-miR-548o	CLIP-seq
MIRT1255454	hsa-miR-557	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT1255455	hsa-miR-577	CLIP-seq
MIRT1255456	hsa-miR-646	CLIP-seq
MIRT1255409	hsa-miR-655	CLIP-seq
MIRT1255457	hsa-miR-761	CLIP-seq
MIRT1255458	hsa-miR-889	CLIP-seq
MIRT1255459	hsa-miR-922	CLIP-seq
MIRT1255460	hsa-miR-942	CLIP-seq
MIRT1255461	hsa-miR-96	CLIP-seq
MIRT1255414	hsa-miR-1271	CLIP-seq
MIRT1255462	hsa-miR-1279	CLIP-seq
MIRT1255365	hsa-miR-132	CLIP-seq
MIRT1255420	hsa-miR-141	CLIP-seq
MIRT1255366	hsa-miR-148a	CLIP-seq
MIRT1255367	hsa-miR-148b	CLIP-seq
MIRT1255368	hsa-miR-152	CLIP-seq
MIRT1255421	hsa-miR-182	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255422	hsa-miR-200a	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255373	hsa-miR-212	CLIP-seq
MIRT1255423	hsa-miR-214	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255463	hsa-miR-25	CLIP-seq
MIRT1255424	hsa-miR-2681	CLIP-seq
MIRT1255377	hsa-miR-2682	CLIP-seq
MIRT1255464	hsa-miR-27a	CLIP-seq
MIRT1255465	hsa-miR-27b	CLIP-seq
MIRT1255379	hsa-miR-3120-3p	CLIP-seq
MIRT1255382	hsa-miR-3143	CLIP-seq
MIRT1255383	hsa-miR-3149	CLIP-seq
MIRT1255432	hsa-miR-3166	CLIP-seq
MIRT1255466	hsa-miR-3179	CLIP-seq
MIRT1255467	hsa-miR-32	CLIP-seq
MIRT1255386	hsa-miR-331-5p	CLIP-seq
MIRT1255468	hsa-miR-34b	CLIP-seq
MIRT1255435	hsa-miR-3619-5p	CLIP-seq
MIRT1255469	hsa-miR-363	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT1255436	hsa-miR-3664-5p	CLIP-seq
MIRT1255470	hsa-miR-367	CLIP-seq
MIRT1255438	hsa-miR-3924	CLIP-seq
MIRT1255471	hsa-miR-3936	CLIP-seq
MIRT1255393	hsa-miR-412	CLIP-seq
MIRT1255472	hsa-miR-4255	CLIP-seq
MIRT1255440	hsa-miR-4291	CLIP-seq
MIRT1255441	hsa-miR-4328	CLIP-seq
MIRT1255396	hsa-miR-449c	CLIP-seq
MIRT1255397	hsa-miR-4501	CLIP-seq
MIRT1255446	hsa-miR-4524	CLIP-seq
MIRT1255473	hsa-miR-4659a-5p	CLIP-seq
MIRT1255474	hsa-miR-4659b-5p	CLIP-seq
MIRT1255402	hsa-miR-4678	CLIP-seq
MIRT1255448	hsa-miR-4714-5p	CLIP-seq
MIRT1255403	hsa-miR-4717-3p	CLIP-seq
MIRT1255475	hsa-miR-4719	CLIP-seq
MIRT1255476	hsa-miR-4764-3p	CLIP-seq
MIRT1255477	hsa-miR-4766-3p	CLIP-seq
MIRT1255404	hsa-miR-4773	CLIP-seq
MIRT1255478	hsa-miR-4798-3p	CLIP-seq
MIRT1255450	hsa-miR-490-5p	CLIP-seq
MIRT1255451	hsa-miR-494	CLIP-seq
MIRT1255479	hsa-miR-513a-5p	CLIP-seq
MIRT1255480	hsa-miR-513b	CLIP-seq
MIRT1255406	hsa-miR-543	CLIP-seq
MIRT1255481	hsa-miR-548l	CLIP-seq
MIRT1255482	hsa-miR-548n	CLIP-seq
MIRT1255483	hsa-miR-548p	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT1255455	hsa-miR-577	CLIP-seq
MIRT1255484	hsa-miR-642b	CLIP-seq
MIRT1255456	hsa-miR-646	CLIP-seq
MIRT1255457	hsa-miR-761	CLIP-seq
MIRT1255458	hsa-miR-889	CLIP-seq
MIRT1255459	hsa-miR-922	CLIP-seq
MIRT1255485	hsa-miR-92a	CLIP-seq
MIRT1255486	hsa-miR-92b	CLIP-seq
MIRT1255411	hsa-miR-936	CLIP-seq
MIRT1255412	hsa-miR-940	CLIP-seq
MIRT1255461	hsa-miR-96	CLIP-seq
MIRT1255394	hsa-miR-4422	CLIP-seq
MIRT1552531	hsa-miR-548a-3p	CLIP-seq
MIRT1552532	hsa-miR-548e	CLIP-seq
MIRT1552533	hsa-miR-548f	CLIP-seq
MIRT2075264	hsa-miR-103b	CLIP-seq
MIRT2075265	hsa-miR-105	CLIP-seq
MIRT1255413	hsa-miR-1227	CLIP-seq
MIRT1255462	hsa-miR-1279	CLIP-seq
MIRT1255418	hsa-miR-1324	CLIP-seq
MIRT1255369	hsa-miR-1827	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255463	hsa-miR-25	CLIP-seq
MIRT1255378	hsa-miR-300	CLIP-seq
MIRT1255379	hsa-miR-3120-3p	CLIP-seq
MIRT1255380	hsa-miR-3126-3p	CLIP-seq
MIRT1255381	hsa-miR-3140-3p	CLIP-seq
MIRT1255383	hsa-miR-3149	CLIP-seq
MIRT2075266	hsa-miR-3160-3p	CLIP-seq
MIRT2075267	hsa-miR-3163	CLIP-seq
MIRT1255384	hsa-miR-3176	CLIP-seq
MIRT2075268	hsa-miR-3182	CLIP-seq
MIRT1255467	hsa-miR-32	CLIP-seq
MIRT1255385	hsa-miR-3200-5p	CLIP-seq
MIRT1255386	hsa-miR-331-5p	CLIP-seq
MIRT1255387	hsa-miR-338-5p	CLIP-seq
MIRT1255434	hsa-miR-3607-3p	CLIP-seq
MIRT2075269	hsa-miR-3611	CLIP-seq
MIRT2075270	hsa-miR-3613-3p	CLIP-seq
MIRT1255469	hsa-miR-363	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT1255470	hsa-miR-367	CLIP-seq
MIRT2075271	hsa-miR-3671	CLIP-seq
MIRT1255389	hsa-miR-369-3p	CLIP-seq
MIRT1255390	hsa-miR-374c	CLIP-seq
MIRT2075272	hsa-miR-376a	CLIP-seq
MIRT2075273	hsa-miR-376b	CLIP-seq
MIRT1255391	hsa-miR-381	CLIP-seq
MIRT1255392	hsa-miR-3922-3p	CLIP-seq
MIRT2075274	hsa-miR-409-3p	CLIP-seq
MIRT2075275	hsa-miR-4272	CLIP-seq
MIRT1255441	hsa-miR-4328	CLIP-seq
MIRT1255442	hsa-miR-4330	CLIP-seq
MIRT1255394	hsa-miR-4422	CLIP-seq
MIRT1255397	hsa-miR-4501	CLIP-seq
MIRT1255445	hsa-miR-450b-5p	CLIP-seq
MIRT1255398	hsa-miR-4517	CLIP-seq
MIRT2075276	hsa-miR-4539	CLIP-seq
MIRT1255399	hsa-miR-455-5p	CLIP-seq
MIRT1255400	hsa-miR-4649-3p	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT2075277	hsa-miR-4668-3p	CLIP-seq
MIRT2075278	hsa-miR-4677-3p	CLIP-seq
MIRT1255402	hsa-miR-4678	CLIP-seq
MIRT2075279	hsa-miR-4679	CLIP-seq
MIRT2075280	hsa-miR-4699-5p	CLIP-seq
MIRT2075281	hsa-miR-4709-5p	CLIP-seq
MIRT1255405	hsa-miR-4797-3p	CLIP-seq
MIRT2075282	hsa-miR-544	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT1255455	hsa-miR-577	CLIP-seq
MIRT2075283	hsa-miR-582-5p	CLIP-seq
MIRT2075284	hsa-miR-607	CLIP-seq
MIRT2075285	hsa-miR-621	CLIP-seq
MIRT1255409	hsa-miR-655	CLIP-seq
MIRT1255410	hsa-miR-885-5p	CLIP-seq
MIRT1255458	hsa-miR-889	CLIP-seq
MIRT2075286	hsa-miR-891b	CLIP-seq
MIRT1255485	hsa-miR-92a	CLIP-seq
MIRT1255486	hsa-miR-92b	CLIP-seq
MIRT2301867	hsa-miR-101	CLIP-seq
MIRT2075265	hsa-miR-105	CLIP-seq
MIRT1255414	hsa-miR-1271	CLIP-seq
MIRT1255462	hsa-miR-1279	CLIP-seq
MIRT1255415	hsa-miR-1287	CLIP-seq
MIRT1255417	hsa-miR-1323	CLIP-seq
MIRT2301868	hsa-miR-144	CLIP-seq
MIRT1255421	hsa-miR-182	CLIP-seq
MIRT1255369	hsa-miR-1827	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255423	hsa-miR-214	CLIP-seq
MIRT2301869	hsa-miR-2355-5p	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255463	hsa-miR-25	CLIP-seq
MIRT1255377	hsa-miR-2682	CLIP-seq
MIRT1255464	hsa-miR-27a	CLIP-seq
MIRT1255465	hsa-miR-27b	CLIP-seq
MIRT2301870	hsa-miR-298	CLIP-seq
MIRT1255378	hsa-miR-300	CLIP-seq
MIRT2301871	hsa-miR-3074-3p	CLIP-seq
MIRT1255425	hsa-miR-30a	CLIP-seq
MIRT1255426	hsa-miR-30b	CLIP-seq
MIRT1255427	hsa-miR-30c	CLIP-seq
MIRT1255428	hsa-miR-30d	CLIP-seq
MIRT1255429	hsa-miR-30e	CLIP-seq
MIRT1255379	hsa-miR-3120-3p	CLIP-seq
MIRT1255380	hsa-miR-3126-3p	CLIP-seq
MIRT1255431	hsa-miR-3135b	CLIP-seq
MIRT1255382	hsa-miR-3143	CLIP-seq
MIRT1255383	hsa-miR-3149	CLIP-seq
MIRT2075267	hsa-miR-3163	CLIP-seq
MIRT1255433	hsa-miR-3173-3p	CLIP-seq
MIRT1255466	hsa-miR-3179	CLIP-seq
MIRT1255467	hsa-miR-32	CLIP-seq
MIRT1255385	hsa-miR-3200-5p	CLIP-seq
MIRT2301872	hsa-miR-323-5p	CLIP-seq
MIRT1255386	hsa-miR-331-5p	CLIP-seq
MIRT1255387	hsa-miR-338-5p	CLIP-seq
MIRT1255468	hsa-miR-34b	CLIP-seq
MIRT1255434	hsa-miR-3607-3p	CLIP-seq
MIRT2075269	hsa-miR-3611	CLIP-seq
MIRT1255435	hsa-miR-3619-5p	CLIP-seq
MIRT1255469	hsa-miR-363	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT2301873	hsa-miR-3647-3p	CLIP-seq
MIRT1255470	hsa-miR-367	CLIP-seq
MIRT2075271	hsa-miR-3671	CLIP-seq
MIRT1255389	hsa-miR-369-3p	CLIP-seq
MIRT2301874	hsa-miR-371-5p	CLIP-seq
MIRT1255390	hsa-miR-374c	CLIP-seq
MIRT1255391	hsa-miR-381	CLIP-seq
MIRT2301875	hsa-miR-383	CLIP-seq
MIRT1255438	hsa-miR-3924	CLIP-seq
MIRT1255471	hsa-miR-3936	CLIP-seq
MIRT2301876	hsa-miR-3973	CLIP-seq
MIRT1255393	hsa-miR-412	CLIP-seq
MIRT2075275	hsa-miR-4272	CLIP-seq
MIRT2301877	hsa-miR-4277	CLIP-seq
MIRT1255440	hsa-miR-4291	CLIP-seq
MIRT2301878	hsa-miR-4310	CLIP-seq
MIRT2301879	hsa-miR-4320	CLIP-seq
MIRT1255441	hsa-miR-4328	CLIP-seq
MIRT1255442	hsa-miR-4330	CLIP-seq
MIRT1255394	hsa-miR-4422	CLIP-seq
MIRT1255443	hsa-miR-4428	CLIP-seq
MIRT1255444	hsa-miR-4477b	CLIP-seq
MIRT1255395	hsa-miR-4495	CLIP-seq
MIRT2301880	hsa-miR-4496	CLIP-seq
MIRT1255396	hsa-miR-449c	CLIP-seq
MIRT1255397	hsa-miR-4501	CLIP-seq
MIRT1255445	hsa-miR-450b-5p	CLIP-seq
MIRT1255398	hsa-miR-4517	CLIP-seq
MIRT2301881	hsa-miR-4527	CLIP-seq
MIRT2075276	hsa-miR-4539	CLIP-seq
MIRT1255399	hsa-miR-455-5p	CLIP-seq
MIRT1255447	hsa-miR-4633-3p	CLIP-seq
MIRT1255400	hsa-miR-4649-3p	CLIP-seq
MIRT1255473	hsa-miR-4659a-5p	CLIP-seq
MIRT1255474	hsa-miR-4659b-5p	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT2075277	hsa-miR-4668-3p	CLIP-seq
MIRT1255402	hsa-miR-4678	CLIP-seq
MIRT2075280	hsa-miR-4699-5p	CLIP-seq
MIRT2075281	hsa-miR-4709-5p	CLIP-seq
MIRT1255475	hsa-miR-4719	CLIP-seq
MIRT1255449	hsa-miR-4728-3p	CLIP-seq
MIRT2301882	hsa-miR-4742-3p	CLIP-seq
MIRT1255477	hsa-miR-4766-3p	CLIP-seq
MIRT2301883	hsa-miR-4772-5p	CLIP-seq
MIRT1255404	hsa-miR-4773	CLIP-seq
MIRT1255405	hsa-miR-4797-3p	CLIP-seq
MIRT1255451	hsa-miR-494	CLIP-seq
MIRT2301884	hsa-miR-499a-5p	CLIP-seq
MIRT1255452	hsa-miR-507	CLIP-seq
MIRT1255479	hsa-miR-513a-5p	CLIP-seq
MIRT1255480	hsa-miR-513b	CLIP-seq
MIRT2301885	hsa-miR-515-5p	CLIP-seq
MIRT2301886	hsa-miR-548a-5p	CLIP-seq
MIRT2301887	hsa-miR-548ab	CLIP-seq
MIRT2301888	hsa-miR-548ak	CLIP-seq
MIRT2301889	hsa-miR-548b-5p	CLIP-seq
MIRT2301890	hsa-miR-548c-3p	CLIP-seq
MIRT2301891	hsa-miR-548c-5p	CLIP-seq
MIRT2301892	hsa-miR-548d-5p	CLIP-seq
MIRT2301893	hsa-miR-548h	CLIP-seq
MIRT2301894	hsa-miR-548i	CLIP-seq
MIRT2301895	hsa-miR-548j	CLIP-seq
MIRT1255481	hsa-miR-548l	CLIP-seq
MIRT1255482	hsa-miR-548n	CLIP-seq
MIRT1255453	hsa-miR-548o	CLIP-seq
MIRT1255483	hsa-miR-548p	CLIP-seq
MIRT2301896	hsa-miR-548w	CLIP-seq
MIRT2301897	hsa-miR-548y	CLIP-seq
MIRT1255454	hsa-miR-557	CLIP-seq
MIRT2301898	hsa-miR-559	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT1255455	hsa-miR-577	CLIP-seq
MIRT2075283	hsa-miR-582-5p	CLIP-seq
MIRT1255408	hsa-miR-584	CLIP-seq
MIRT2301899	hsa-miR-601	CLIP-seq
MIRT2075284	hsa-miR-607	CLIP-seq
MIRT2301900	hsa-miR-617	CLIP-seq
MIRT2301901	hsa-miR-624	CLIP-seq
MIRT1255456	hsa-miR-646	CLIP-seq
MIRT1255409	hsa-miR-655	CLIP-seq
MIRT2301902	hsa-miR-668	CLIP-seq
MIRT1255457	hsa-miR-761	CLIP-seq
MIRT2301903	hsa-miR-767-3p	CLIP-seq
MIRT2301904	hsa-miR-876-3p	CLIP-seq
MIRT1255410	hsa-miR-885-5p	CLIP-seq
MIRT2301905	hsa-miR-888	CLIP-seq
MIRT1255458	hsa-miR-889	CLIP-seq
MIRT1255459	hsa-miR-922	CLIP-seq
MIRT1255485	hsa-miR-92a	CLIP-seq
MIRT1255486	hsa-miR-92b	CLIP-seq
MIRT2301906	hsa-miR-935	CLIP-seq
MIRT1255411	hsa-miR-936	CLIP-seq
MIRT1255412	hsa-miR-940	CLIP-seq
MIRT1255460	hsa-miR-942	CLIP-seq
MIRT1255461	hsa-miR-96	CLIP-seq
MIRT1255379	hsa-miR-3120-3p	CLIP-seq
MIRT1255383	hsa-miR-3149	CLIP-seq
MIRT1255441	hsa-miR-4328	CLIP-seq
MIRT1255405	hsa-miR-4797-3p	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT1255405	hsa-miR-4797-3p	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT1255388	hsa-miR-3646	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT1255401	hsa-miR-4666-3p	CLIP-seq
MIRT1255418	hsa-miR-1324	CLIP-seq
MIRT1255438	hsa-miR-3924	CLIP-seq
MIRT2075282	hsa-miR-544	CLIP-seq
MIRT2301867	hsa-miR-101	CLIP-seq
MIRT2598748	hsa-miR-1200	CLIP-seq
MIRT2598749	hsa-miR-1264	CLIP-seq
MIRT1255365	hsa-miR-132	CLIP-seq
MIRT2301868	hsa-miR-144	CLIP-seq
MIRT1255366	hsa-miR-148a	CLIP-seq
MIRT1255367	hsa-miR-148b	CLIP-seq
MIRT1255368	hsa-miR-152	CLIP-seq
MIRT1255369	hsa-miR-1827	CLIP-seq
MIRT2598750	hsa-miR-188-3p	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255373	hsa-miR-212	CLIP-seq
MIRT2598751	hsa-miR-2276	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT2301871	hsa-miR-3074-3p	CLIP-seq
MIRT1255430	hsa-miR-3124-3p	CLIP-seq
MIRT1255380	hsa-miR-3126-3p	CLIP-seq
MIRT1255382	hsa-miR-3143	CLIP-seq
MIRT2598752	hsa-miR-3158-3p	CLIP-seq
MIRT2075267	hsa-miR-3163	CLIP-seq
MIRT1255384	hsa-miR-3176	CLIP-seq
MIRT1255385	hsa-miR-3200-5p	CLIP-seq
MIRT2301872	hsa-miR-323-5p	CLIP-seq
MIRT2598753	hsa-miR-362-5p	CLIP-seq
MIRT2301873	hsa-miR-3647-3p	CLIP-seq
MIRT2598754	hsa-miR-370	CLIP-seq
MIRT2301875	hsa-miR-383	CLIP-seq
MIRT1255392	hsa-miR-3922-3p	CLIP-seq
MIRT1255438	hsa-miR-3924	CLIP-seq
MIRT2301876	hsa-miR-3973	CLIP-seq
MIRT1255393	hsa-miR-412	CLIP-seq
MIRT2598755	hsa-miR-4324	CLIP-seq
MIRT2598756	hsa-miR-4446-3p	CLIP-seq
MIRT2598757	hsa-miR-4453	CLIP-seq
MIRT2301880	hsa-miR-4496	CLIP-seq
MIRT1255398	hsa-miR-4517	CLIP-seq
MIRT2301881	hsa-miR-4527	CLIP-seq
MIRT2598758	hsa-miR-4538	CLIP-seq
MIRT2075276	hsa-miR-4539	CLIP-seq
MIRT1255399	hsa-miR-455-5p	CLIP-seq
MIRT1255400	hsa-miR-4649-3p	CLIP-seq
MIRT2598759	hsa-miR-4662a-3p	CLIP-seq
MIRT2075277	hsa-miR-4668-3p	CLIP-seq
MIRT1255403	hsa-miR-4717-3p	CLIP-seq
MIRT2301882	hsa-miR-4742-3p	CLIP-seq
MIRT1255476	hsa-miR-4764-3p	CLIP-seq
MIRT1255477	hsa-miR-4766-3p	CLIP-seq
MIRT2598760	hsa-miR-4772-3p	CLIP-seq
MIRT2301883	hsa-miR-4772-5p	CLIP-seq
MIRT2598761	hsa-miR-4777-3p	CLIP-seq
MIRT1255478	hsa-miR-4798-3p	CLIP-seq
MIRT2598762	hsa-miR-500b	CLIP-seq
MIRT2598763	hsa-miR-501-5p	CLIP-seq
MIRT2598764	hsa-miR-520g	CLIP-seq
MIRT2598765	hsa-miR-520h	CLIP-seq
MIRT2598766	hsa-miR-522	CLIP-seq
MIRT1255406	hsa-miR-543	CLIP-seq
MIRT2075282	hsa-miR-544	CLIP-seq
MIRT2598767	hsa-miR-544b	CLIP-seq
MIRT2598768	hsa-miR-548aa	CLIP-seq
MIRT1255481	hsa-miR-548l	CLIP-seq
MIRT1255482	hsa-miR-548n	CLIP-seq
MIRT1255483	hsa-miR-548p	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT2075283	hsa-miR-582-5p	CLIP-seq
MIRT1255408	hsa-miR-584	CLIP-seq
MIRT1255484	hsa-miR-642b	CLIP-seq
MIRT2301904	hsa-miR-876-3p	CLIP-seq
MIRT2301906	hsa-miR-935	CLIP-seq
MIRT2301867	hsa-miR-101	CLIP-seq
MIRT2598748	hsa-miR-1200	CLIP-seq
MIRT2598749	hsa-miR-1264	CLIP-seq
MIRT1255415	hsa-miR-1287	CLIP-seq
MIRT1255365	hsa-miR-132	CLIP-seq
MIRT2301868	hsa-miR-144	CLIP-seq
MIRT1255366	hsa-miR-148a	CLIP-seq
MIRT1255367	hsa-miR-148b	CLIP-seq
MIRT1255368	hsa-miR-152	CLIP-seq
MIRT1255369	hsa-miR-1827	CLIP-seq
MIRT2598750	hsa-miR-188-3p	CLIP-seq
MIRT1255370	hsa-miR-19a	CLIP-seq
MIRT1255371	hsa-miR-19b	CLIP-seq
MIRT1255372	hsa-miR-203	CLIP-seq
MIRT1255373	hsa-miR-212	CLIP-seq
MIRT1255374	hsa-miR-23a	CLIP-seq
MIRT1255375	hsa-miR-23b	CLIP-seq
MIRT1255376	hsa-miR-23c	CLIP-seq
MIRT2301871	hsa-miR-3074-3p	CLIP-seq
MIRT1255425	hsa-miR-30a	CLIP-seq
MIRT1255426	hsa-miR-30b	CLIP-seq
MIRT1255427	hsa-miR-30c	CLIP-seq
MIRT1255428	hsa-miR-30d	CLIP-seq
MIRT1255429	hsa-miR-30e	CLIP-seq
MIRT1255430	hsa-miR-3124-3p	CLIP-seq
MIRT1255380	hsa-miR-3126-3p	CLIP-seq
MIRT1255431	hsa-miR-3135b	CLIP-seq
MIRT2598752	hsa-miR-3158-3p	CLIP-seq
MIRT2075267	hsa-miR-3163	CLIP-seq
MIRT1255384	hsa-miR-3176	CLIP-seq
MIRT1255385	hsa-miR-3200-5p	CLIP-seq
MIRT2301872	hsa-miR-323-5p	CLIP-seq
MIRT1255434	hsa-miR-3607-3p	CLIP-seq
MIRT2598753	hsa-miR-362-5p	CLIP-seq
MIRT2301873	hsa-miR-3647-3p	CLIP-seq
MIRT1255392	hsa-miR-3922-3p	CLIP-seq
MIRT1255438	hsa-miR-3924	CLIP-seq
MIRT2301876	hsa-miR-3973	CLIP-seq
MIRT1255393	hsa-miR-412	CLIP-seq
MIRT2598755	hsa-miR-4324	CLIP-seq
MIRT2598756	hsa-miR-4446-3p	CLIP-seq
MIRT2598757	hsa-miR-4453	CLIP-seq
MIRT2301880	hsa-miR-4496	CLIP-seq
MIRT1255398	hsa-miR-4517	CLIP-seq
MIRT2301881	hsa-miR-4527	CLIP-seq
MIRT2598758	hsa-miR-4538	CLIP-seq
MIRT2075276	hsa-miR-4539	CLIP-seq
MIRT1255399	hsa-miR-455-5p	CLIP-seq
MIRT1255447	hsa-miR-4633-3p	CLIP-seq
MIRT1255400	hsa-miR-4649-3p	CLIP-seq
MIRT2598759	hsa-miR-4662a-3p	CLIP-seq
MIRT2075277	hsa-miR-4668-3p	CLIP-seq
MIRT1255403	hsa-miR-4717-3p	CLIP-seq
MIRT1255449	hsa-miR-4728-3p	CLIP-seq
MIRT2301882	hsa-miR-4742-3p	CLIP-seq
MIRT1255477	hsa-miR-4766-3p	CLIP-seq
MIRT2598761	hsa-miR-4777-3p	CLIP-seq
MIRT2598762	hsa-miR-500b	CLIP-seq
MIRT2598763	hsa-miR-501-5p	CLIP-seq
MIRT2598764	hsa-miR-520g	CLIP-seq
MIRT2598765	hsa-miR-520h	CLIP-seq
MIRT2598766	hsa-miR-522	CLIP-seq
MIRT2598767	hsa-miR-544b	CLIP-seq
MIRT2598768	hsa-miR-548aa	CLIP-seq
MIRT1255481	hsa-miR-548l	CLIP-seq
MIRT1255482	hsa-miR-548n	CLIP-seq
MIRT1255483	hsa-miR-548p	CLIP-seq
MIRT1255407	hsa-miR-568	CLIP-seq
MIRT2075283	hsa-miR-582-5p	CLIP-seq
MIRT1255408	hsa-miR-584	CLIP-seq
MIRT1255484	hsa-miR-642b	CLIP-seq
MIRT2301904	hsa-miR-876-3p	CLIP-seq
MIRT1255410	hsa-miR-885-5p	CLIP-seq
MIRT2301906	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IMP	18477460
GO:0000776	Component	Kinetochore	IDA	18477460
GO:0001725	Component	Stress fiber	IEA
GO:0004857	Function	Enzyme inhibitor activity	IBA
GO:0004857	Function	Enzyme inhibitor activity	IDA	19245366
GO:0005515	Function	Protein binding	IPI	11067852, 15292222, 16417406, 18073109, 20195357, 25609649, 32814053, 35271311
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	18477460
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006470	Process	Protein dephosphorylation	IMP	18477460
GO:0007098	Process	Centrosome cycle	IMP	18477460
GO:0007165	Process	Signal transduction	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0017020	Function	Myosin phosphatase regulator activity	IBA
GO:0019208	Function	Phosphatase regulator activity	IDA	20354225
GO:0019208	Function	Phosphatase regulator activity	IEA
GO:0019208	Function	Phosphatase regulator activity	IMP	18477460
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	18477460
GO:0030018	Component	Z disc	IBA
GO:0030018	Component	Z disc	IEA
GO:0030018	Component	Z disc	ISS
GO:0030155	Process	Regulation of cell adhesion	IDA	20354225
GO:0031672	Component	A band	IBA
GO:0031672	Component	A band	IEA
GO:0031672	Component	A band	ISS
GO:0043086	Process	Negative regulation of catalytic activity	IDA	19245366
GO:0043292	Component	Contractile muscle fiber	IDA	20634291
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	19245366
GO:0046822	Process	Regulation of nucleocytoplasmic transport	IEA
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0071466	Process	Cellular response to xenobiotic stimulus	IEA
GO:0071889	Function	14-3-3 protein binding	IDA	20354225
GO:0072357	Component	PTW/PP1 phosphatase complex	IDA	20354225
GO:1903140	Process	Regulation of establishment of endothelial barrier	IMP	25816133

Other IDs

• MIM: 602021
• HGNC: 7618
• e!Ensembl: ENSG00000058272

Protein

• UniProt ID: O14974
• Protein name: Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
• Protein function: Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460,
• PDB: 2KJY, 5HUZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00023	Ank	72 → 104	Ankyrin repeat	Repeat
  PF00023	Ank	105 → 137	Ankyrin repeat	Repeat
  PF00023	Ank	198 → 230	Ankyrin repeat	Repeat
  PF00023	Ank	231 → 263	Ankyrin repeat	Repeat
  PF15898	PRKG1_interact	931 → 1030	cGMP-dependent protein kinase interacting domain	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269|PubMed:20634291}.
• Sequence:

  MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLL
  HRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD
  IAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
  ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA
  HWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP
  LIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
  EEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATK
  ISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSL
  DNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKN
  SSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGS
  SSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTT
  EVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTR
  EQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTP
  SSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSI
  RERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDR
  YDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDL
  KLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA
  LIRVISKLSK

• Sequence length: 1030

Pathways

KEGG:

cGMP-PKG signaling pathway
cAMP signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Platelet activation
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Proteoglycans in cancer

Reactome:

Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate PAKs

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Genitourinary and/or brain malformation syndrome	Pathogenic; Likely pathogenic	rs2137028448, rs761795743, rs2136997832, rs2548108996, rs2547891962, rs2547884822, rs2547893717, rs2547952219, rs2547952059, rs2548018046, rs1356631664, rs1592661703, rs1592629980, rs1879250715, rs868109198, rs1871420455, rs1871420871	RCV001528129 RCV001814720 RCV002226964 RCV003148564 RCV003229532 RCV003335905 RCV003475573 RCV003986010 RCV004555229 RCV004587687 RCV001027735 RCV001027736 RCV001027737 RCV001250560 RCV001254104 RCV001254623 RCV001261009	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
PPP1R12A-related disorder	Pathogenic	rs2547893717, rs2547891931	RCV003408382 RCV003939337	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GESTATIONAL DIABETES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	23967318		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	24074453		★☆☆☆☆ Found in Text Mining only
Bartter Disease	Bartter syndrome	BEFREE	24356540		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29183848, 37957190	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28074910	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	30946934	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36106411	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma, Neuroendocrine	Carcinoma	BEFREE	30946934		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	17030349		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26113782		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26113782	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	19120700, 19357768		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28245261		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	29955616	Associate	★☆☆☆☆ Found in Text Mining only
Disorders of Sex Development	Disorders of sex development	Pubtator	31883643	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	17451460, 34180758	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	39334371	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy Benign Neonatal	Benign neonatal epilepsy	Pubtator	39334371	Associate	★☆☆☆☆ Found in Text Mining only
Fabry Disease	Fabry disease	Pubtator	30261035	Associate	★☆☆☆☆ Found in Text Mining only
Fragile X Syndrome	Fragile X Syndrome	BEFREE	2018084		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	Pubtator	37678441	Associate	★☆☆☆☆ Found in Text Mining only
Gitelman Syndrome	Gitelman Syndrome	BEFREE	30136149		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	19357768		★☆☆☆☆ Found in Text Mining only
Holoprosencephaly	Holoprosencephaly	GENOMICS_ENGLAND_DG	31883643		★☆☆☆☆ Found in Text Mining only
Holoprosencephaly	Holoprosencephaly	Pubtator	31883643	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	25941073		★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	23481864	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	30065083		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	24674677	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	31883643		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	8097256		★☆☆☆☆ Found in Text Mining only
leiomyosarcoma	Leiomyosarcoma	BEFREE	24712327		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28074910		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	17030349		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28241827, 29974831, 31387585		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	20646208, 29687789		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20646208, 29020905, 9461011		★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	8097256		★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	BEFREE	9461011		★☆☆☆☆ Found in Text Mining only
Necrotizing enterocolitis in fetus OR newborn	Necrotizing Enterocolitis	BEFREE	28962146, 30480807		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26113782, 29974831, 30446228		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28486561		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30076859		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	28586048	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	BEFREE	17030349		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	26842750	Associate	★☆☆☆☆ Found in Text Mining only
Papilloma	Papilloma	BEFREE	27991921		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28241827, 29974831, 31387585		★☆☆☆☆ Found in Text Mining only
Pterygium	Pterygium	BEFREE	29947041, 31547113		★☆☆☆☆ Found in Text Mining only
Retinal Vein Occlusion	Retinal Vein Occlusion	BEFREE	29983234		★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	30946934		★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	Pubtator	30946934	Associate	★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma Alveolar	Rhabdomyosarcoma	Pubtator	30946934	Associate	★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	39334371	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	20646208, 29687789		★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach Diseases	BEFREE	20646208		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	29687789	Inhibit	★☆☆☆☆ Found in Text Mining only
Syndactyly	Syndactyly	Pubtator	31883643	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Diseases	Urinary bladder diseases	Pubtator	30946934	Associate	★☆☆☆☆ Found in Text Mining only
Urogenital Abnormalities	Urogenital abnormalities	Pubtator	31883643, 39334371	Associate	★☆☆☆☆ Found in Text Mining only