Gene Gene information from NCBI Gene database.
Entrez ID 4602
Gene name MYB proto-oncogene, transcription factor
Gene symbol MYB
Synonyms (NCBI Gene)
Cmybc-mybc-myb_CDSefg
Chromosome 6
Chromosome location 6q23.3
Summary This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocati
miRNA miRNA information provided by mirtarbase database.
355
miRTarBase ID miRNA Experiments Reference
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Luciferase reporter assay 18667440
Transcription factors Transcription factors information provided by TRRUST V2 database.
16
Transcription factor Regulation Reference
BCL3 Unknown 9694711
E2F1 Unknown 8137237
EGR1 Repression 7559553
ETS1 Activation 7848925
FOSL2 Activation 22493372
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
64
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 20531406
GO:0000278 Process Mitotic cell cycle IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 7987850, 25857263
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
189990 7545 ENSG00000118513
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P10242
Protein name Transcriptional activator Myb (Proto-oncogene c-Myb)
Protein function Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00249 Myb_DNA-binding 92 138 Myb-like DNA-binding domain Domain
PF00249 Myb_DNA-binding 144 189 Myb-like DNA-binding domain Domain
PF07988 LMSTEN 267 313 LMSTEN motif Motif
PF09316 Cmyb_C 399 563 C-myb, C-terminal Family
Sequence
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHL
NPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTM
RRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV
NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL
LLMSTENELKGQQ
VLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD
PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT
STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK
YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNF
FCSHHWEGDSLNTQLFTQTSPVA
DAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP
LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
Sequence length 640
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  PI3K-Akt signaling pathway   RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
21
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANGIOCENTRIC GLIOMA Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Abetalipoproteinemia Abetalipoproteinemia BEFREE 28418072
★☆☆☆☆
Found in Text Mining only
Acute Basophilic Leukemia Basophilic Leukemia ORPHANET_DG 21474671
★☆☆☆☆
Found in Text Mining only
Acute basophilic leukemia Basophilic Leukemia Orphanet
★☆☆☆☆
Found in Text Mining only
Acute Basophilic Leukemia Basophilic Leukemia BEFREE 30599775
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia LHGDN 11896618
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 24504520, 3014652
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 1560675, 16029452, 29233926
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 23340802
★☆☆☆☆
Found in Text Mining only
Acute myelomonocytic leukemia Myelomonocytic Leukemia BEFREE 15540222, 18818702, 8630096
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 30335887
★☆☆☆☆
Found in Text Mining only