MT1A (metallothionein 1A)

Gene

• Entrez ID: 4489
• Gene name: Metallothionein 1A
• Gene symbol: MT1A
• Synonyms (NCBI Gene): MT-1A, MT-IA, MT1, MT1S, MTC
• Chromosome: 16
• Chromosome location: 16q13
• Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate meta

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT724135	hsa-miR-370-5p	HITS-CLIP	19536157
MIRT724134	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT724133	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT724132	hsa-miR-3665	HITS-CLIP	19536157
MIRT724131	hsa-miR-657	HITS-CLIP	19536157
MIRT724130	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT724129	hsa-miR-3944-5p	HITS-CLIP	19536157
MIRT724128	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT724127	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT724126	hsa-miR-7159-3p	HITS-CLIP	19536157
MIRT724125	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT724124	hsa-miR-2113	HITS-CLIP	19536157
MIRT714701	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT714702	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT714699	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT714700	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT714698	hsa-miR-6861-5p	HITS-CLIP	19536157
MIRT714697	hsa-miR-555	HITS-CLIP	19536157
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT714696	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT714695	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT714694	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT714693	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327
MIRT724135	hsa-miR-370-5p	HITS-CLIP	19536157
MIRT724134	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT724133	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT724132	hsa-miR-3665	HITS-CLIP	19536157
MIRT724131	hsa-miR-657	HITS-CLIP	19536157
MIRT724130	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT724129	hsa-miR-3944-5p	HITS-CLIP	19536157
MIRT724128	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT724127	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT724126	hsa-miR-7159-3p	HITS-CLIP	19536157
MIRT724125	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT724124	hsa-miR-2113	HITS-CLIP	19536157
MIRT714701	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT714702	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT714699	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT714700	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT714698	hsa-miR-6861-5p	HITS-CLIP	19536157
MIRT714697	hsa-miR-555	HITS-CLIP	19536157
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT714696	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT714695	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT714694	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT714693	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16442532, 16778767
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006882	Process	Intracellular zinc ion homeostasis	IBA
GO:0008270	Function	Zinc ion binding	ISS
GO:0010273	Process	Detoxification of copper ion	IBA
GO:0045926	Process	Negative regulation of growth	ISS
GO:0046872	Function	Metal ion binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0071276	Process	Cellular response to cadmium ion	IBA
GO:0071276	Process	Cellular response to cadmium ion	IEP	16827180
GO:0071280	Process	Cellular response to copper ion	IBA
GO:0071294	Process	Cellular response to zinc ion	IBA
GO:0071294	Process	Cellular response to zinc ion	IEP	11168427

Other IDs

• MIM: 156350
• HGNC: 7393
• e!Ensembl: ENSG00000205362

Protein

• UniProt ID: P04731
• Protein name: Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)
• Protein function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00131	Metallothio	1 → 61	Metallothionein	Domain

• Sequence:

  MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCC
  A

• Sequence length: 61

Pathways

KEGG:

Mineral absorption

Reactome:

Metallothioneins bind metals

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AMYOTROPHIC LATERAL SCLEROSIS 1	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DELIRIUM, DEMENTIA, AMNESTIC, COGNITIVE DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATITIS, CHRONIC	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEARNING DISABILITIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEARNING DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHATIC METASTASIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOTOR NEURON DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOUTH NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOVEMENT DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEPSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	21655256, 9294615, 9506724		★☆☆☆☆ Found in Text Mining only
Aganglionosis, Colonic	Colonic Aganglionosis	BEFREE	18493886		★☆☆☆☆ Found in Text Mining only
Amyloidosis, Primary Cutaneous	Amyloidosis	BEFREE	26438242		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	24163136		★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 1	Lateral Sclerosis	BEFREE	11298796		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amyotrophic Lateral Sclerosis, Sporadic	Lateral Sclerosis	BEFREE	17156946		★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	21910667		★☆☆☆☆ Found in Text Mining only
Androgen-Insensitivity Syndrome	Androgen-Insensitivity Syndrome	BEFREE	21480980		★☆☆☆☆ Found in Text Mining only
Arsenic Encephalopathy	Arsenic Encephalopathy	CTD_human_DG	19953893		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	15367334	Associate	★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	30932010		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	30932010	Stimulate	★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	31302864		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	CTD_human_DG	16565513		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18979234, 19522736, 20050373, 20056651, 23330677, 31092851, 31290783, 9694254		★☆☆☆☆ Found in Text Mining only
C-cell hyperplasia of thyroid	Thyroid Hyperplasia	BEFREE	10876191, 15588381, 18331611, 18976163, 23745650, 24297502, 26876062		★☆☆☆☆ Found in Text Mining only
Carcinoma of larynx	Laryngeal carcinoma	BEFREE	12616185		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	23947958, 25174824		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	19962295		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29269399		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	1584781		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	11053642		★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	BEFREE	24858900		★☆☆☆☆ Found in Text Mining only
Dejerine-Sottas Disease (disorder)	Charcot-Marie-Tooth disease	BEFREE	30445446		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	18349110, 22402369		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	18249147, 18349110, 22402369		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	LHGDN	18249147		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	18349110	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	18349110	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	16249430, 18249147, 18349110, 22402369, 25156968		★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	35741790	Associate	★☆☆☆☆ Found in Text Mining only
Dystrophia myotonica 2	Myotonic dystrophy	BEFREE	18249147		★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine System Diseases	BEFREE	23744408		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	37027423	Associate	★☆☆☆☆ Found in Text Mining only
Familial medullary thyroid carcinoma	Medullary thyroid carcinoma	BEFREE	10876191, 11280716, 15837050, 9950371		★☆☆☆☆ Found in Text Mining only
Fibroadenoma	Fibroadenoma	BEFREE	31092851		★☆☆☆☆ Found in Text Mining only
fibroma	Fibroma	BEFREE	31423894		★☆☆☆☆ Found in Text Mining only
Follicular adenoma	Adenoma	BEFREE	16889486		★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	12215093		★☆☆☆☆ Found in Text Mining only
Glaucoma, Primary Open Angle	Glaucoma	BEFREE	12215093, 15354075, 16280977, 18591929		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30932010		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	30932010	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29408377		★☆☆☆☆ Found in Text Mining only
Glycogen Storage Disease Type IV	Glycogen storage disease	Pubtator	30932010	Stimulate	★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	22090273, 30504400		★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	10323403		★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	9694254		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	21994366		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	31332605		★☆☆☆☆ Found in Text Mining only
Hypoxic-Ischemic Encephalopathy	Hypoxic-Ischemic Encephalopathy	BEFREE	28796402		★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	27343087		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	30098078		★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	12616185		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	17363595, 19363144		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21718361, 22805858, 30504401, 30582799		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23947958	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	18601746		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	LHGDN	18601746		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus Nephritis	BEFREE	18601746		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus Nephritis	LHGDN	18601746		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic Metastasis	CTD_human_DG	17418620		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma, Diffuse	Lymphoma	BEFREE	16322236		★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	35426907	Associate	★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	7735555		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18979234, 19522736, 20050373, 20056651, 23330677, 31092851, 9694254		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of larynx	Larynx cancer	BEFREE	12616185		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	23947958, 25174824		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	CTD_human_DG	17418620		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22856547, 23064315, 31619220		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	30253333		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	CTD_human_DG	16565513		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10876191, 21622722, 22183190, 29854276, 30445446, 9950371		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	11888668, 18979234, 30360728		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	7735555, 8086622, 9674745		★☆☆☆☆ Found in Text Mining only
Medullary carcinoma of thyroid	Megalencephaly, Polymicrogyria, Polydactyly, Hydrocephalus Syndrome	BEFREE	22183190, 24238055, 26876062, 28647780, 30106635, 9294615		★☆☆☆☆ Found in Text Mining only
Melanocytic nevus	Melanocytic nevus	BEFREE	28764861		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	24858900, 28764861		★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth Neoplasms	CTD_human_DG	17418620		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mouth Neoplasms	Mouth neoplasm	Pubtator	33340085	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple endocrine neoplasia Type 2	Multiple Endocrine Neoplasia	BEFREE	10876191, 16532227, 20373984, 29348306		★☆☆☆☆ Found in Text Mining only
Multiple Endocrine Neoplasia Type 2a	Multiple Endocrine Neoplasia	BEFREE	10876191, 20373984, 26920351, 9950371		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	GWASDB_DG	23209447		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18979234, 20056651, 23064051, 23073719, 29408377, 30582799, 30961514, 8844733, 9506724		★☆☆☆☆ Found in Text Mining only
Nephritis	Nephritis	BEFREE	18601746		★☆☆☆☆ Found in Text Mining only
Nephritis	Nephritis	LHGDN	18601746		★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	18349110	Associate	★☆☆☆☆ Found in Text Mining only
Nodular Goiter	Nodular Goiter	BEFREE	28870952, 30504400		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	23064051		★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	Pubtator	34072023	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	18331611, 24858900, 28870952		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	30120245		★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal disease	Pubtator	31540037, 35741790	Associate	★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	31423894		★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Peripheral nervous system disease	Pubtator	32340109	Associate	★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	BEFREE	21655256, 9294615, 9506724		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22856547, 23064315, 31619220		★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic Hyperplasia	LHGDN	18208603		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	11053642		★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett Syndrome	BEFREE	26469135		★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	BEFREE	28889339		★☆☆☆☆ Found in Text Mining only
Severe periodontitis	Periodontitis	BEFREE	31423894		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	CTD_human_DG	17418620		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	25612142	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	33340085	Stimulate	★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	30253333		★☆☆☆☆ Found in Text Mining only
THYROID CARCINOMA, SPORADIC MEDULLARY	Thyroid Carcinoma	BEFREE	12490080, 9617347		★☆☆☆☆ Found in Text Mining only
Thyroid Diseases	Thyroid Diseases	BEFREE	22090273		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	30253333		★☆☆☆☆ Found in Text Mining only
Thyroid Nodule	Thyroid Nodule	BEFREE	22068382		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	30445446		★☆☆☆☆ Found in Text Mining only