SPDYE5 (speedy/RINGO cell cycle regulator family member E5)

Gene

• Entrez ID: 442590
• Gene name: Speedy/RINGO cell cycle regulator family member E5
• Gene symbol: SPDYE5
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1383497	hsa-miR-1297	CLIP-seq
MIRT1383498	hsa-miR-26a	CLIP-seq
MIRT1383499	hsa-miR-26b	CLIP-seq
MIRT1383500	hsa-miR-3613-3p	CLIP-seq
MIRT1383501	hsa-miR-4274	CLIP-seq
MIRT1383502	hsa-miR-4465	CLIP-seq
MIRT1383503	hsa-miR-4519	CLIP-seq
MIRT1383504	hsa-miR-4803	CLIP-seq
MIRT1383505	hsa-miR-498	CLIP-seq
MIRT1383506	hsa-miR-548a-5p	CLIP-seq
MIRT1383507	hsa-miR-548ab	CLIP-seq
MIRT1383508	hsa-miR-548ak	CLIP-seq
MIRT1383509	hsa-miR-548b-5p	CLIP-seq
MIRT1383510	hsa-miR-548c-5p	CLIP-seq
MIRT1383511	hsa-miR-548d-5p	CLIP-seq
MIRT1383512	hsa-miR-548h	CLIP-seq
MIRT1383513	hsa-miR-548i	CLIP-seq
MIRT1383514	hsa-miR-548j	CLIP-seq
MIRT1383515	hsa-miR-548k	CLIP-seq
MIRT1383516	hsa-miR-548l	CLIP-seq
MIRT1383517	hsa-miR-548p	CLIP-seq
MIRT1383518	hsa-miR-548w	CLIP-seq
MIRT1383519	hsa-miR-548y	CLIP-seq
MIRT1383520	hsa-miR-559	CLIP-seq
MIRT1383521	hsa-miR-607	CLIP-seq
MIRT1383522	hsa-miR-802	CLIP-seq
MIRT2114736	hsa-miR-1208	CLIP-seq
MIRT2114737	hsa-miR-4307	CLIP-seq
MIRT2114738	hsa-miR-4659a-3p	CLIP-seq
MIRT2114739	hsa-miR-4659b-3p	CLIP-seq
MIRT2114740	hsa-miR-4742-3p	CLIP-seq
MIRT2114741	hsa-miR-4777-5p	CLIP-seq
MIRT2114742	hsa-miR-518d-5p	CLIP-seq
MIRT2114743	hsa-miR-519b-5p	CLIP-seq
MIRT2114744	hsa-miR-519c-5p	CLIP-seq
MIRT2114745	hsa-miR-520c-5p	CLIP-seq
MIRT2114746	hsa-miR-526a	CLIP-seq
MIRT2114747	hsa-miR-630	CLIP-seq
MIRT2337557	hsa-miR-1229	CLIP-seq
MIRT2337558	hsa-miR-342-3p	CLIP-seq
MIRT2337559	hsa-miR-4452	CLIP-seq
MIRT2337560	hsa-miR-4680-3p	CLIP-seq
MIRT2460396	hsa-miR-3154	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A6NIY4
• Protein name: Speedy protein E5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11357	Spy1	194 → 308	Cell cycle regulatory protein	Family
  PF11357	Spy1	336 → 398	Cell cycle regulatory protein	Family

• Sequence:

  MDRTETRFRKRGQITEKITTSRQPQPQNEQSPQRSTSGYPLQEVVDDEVLGPSAPGVDPS
  PPCRSLGWKRKREWSDESAEEPEKELAPEPEETWVVEMLCGLKMKLKQQRVSPILPEHHK
  GFNSQLAPGVDPSPPHRSFCWKRKMEWWDESEESLEEEPRKVLAPEPEEIWVAEMLCGLK
  MKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGFPS
  WQYQRIHFFLALYLANDMEEDDEDSKQNIFHFLYGKNRSRIPLLRKRWFQLGRSMNPRAR
  KKRSRIPLLRKRRFQLGRSMNPRARKNRSRIPLLRKRRFQLGRSMNLRARKNRSQIVLFQ
  KRRFQFFCSMSGRAWVSPEELEEIQAYDPEHWVWARDRAHLS

• Sequence length: 402

Pathways

KEGG:

Oocyte meiosis
Progesterone-mediated oocyte maturation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations