Gene Gene information from NCBI Gene database.
Entrez ID 441478
Gene name NOTCH regulated ankyrin repeat protein
Gene symbol NRARP
Synonyms (NCBI Gene)
-
Chromosome 9
Chromosome location 9q34.3
miRNA miRNA information provided by mirtarbase database.
403
miRTarBase ID miRNA Experiments Reference
MIRT046074 hsa-miR-125b-5p CLASH 23622248
MIRT041444 hsa-miR-193b-3p CLASH 23622248
MIRT566603 hsa-miR-548m PAR-CLIP 20371350
MIRT324564 hsa-miR-4803 PAR-CLIP 20371350
MIRT566601 hsa-miR-4678 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001569 Process Branching involved in blood vessel morphogenesis IBA
GO:0001569 Process Branching involved in blood vessel morphogenesis IEA
GO:0001935 Process Endothelial cell proliferation IEA
GO:0002040 Process Sprouting angiogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619987 33843 ENSG00000198435
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z6K4
Protein name Notch-regulated ankyrin repeat-containing protein
Protein function Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate end
PDB 6PY8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 18 112 Ankyrin repeats (3 copies) Repeat
Sequence
Sequence length 114
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Notch signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BRAIN NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Ataxia Telangiectasia Ataxia telangiectasia Pubtator 31690634 Inhibit
★☆☆☆☆
Found in Text Mining only
Benign neoplasm of brain, unspecified Brain Neoplasms CTD_human_DG 21127729
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms CTD_human_DG 21127729
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Brain Tumor, Primary Brain Neoplasms CTD_human_DG 21127729
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 24778018
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30274778 Associate
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 31586130
★☆☆☆☆
Found in Text Mining only
Leukemia Leukemia Pubtator 31586130 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of brain Brain Neoplasms CTD_human_DG 21127729
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 24778018
★☆☆☆☆
Found in Text Mining only