Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	441027
Gene name	Transmembrane protein 150C
Gene symbol	TMEM150C
Synonyms (NCBI Gene)	TTN3
Chromosome	4
Chromosome location	4q21.22
Summary	This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically a

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miRTarBase ID	miRNA	Experiments
MIRT1431470	hsa-miR-128	CLIP-seq
MIRT1431471	hsa-miR-148a	CLIP-seq
MIRT1431472	hsa-miR-148b	CLIP-seq
MIRT1431473	hsa-miR-152	CLIP-seq
MIRT1431474	hsa-miR-198	CLIP-seq
MIRT1431475	hsa-miR-27a	CLIP-seq
MIRT1431476	hsa-miR-27b	CLIP-seq
MIRT1431477	hsa-miR-3162-3p	CLIP-seq
MIRT1431478	hsa-miR-342-3p	CLIP-seq
MIRT1431479	hsa-miR-3688-5p	CLIP-seq
MIRT1431480	hsa-miR-3960	CLIP-seq
MIRT1431481	hsa-miR-3978	CLIP-seq
MIRT1431482	hsa-miR-4264	CLIP-seq
MIRT1431483	hsa-miR-4643	CLIP-seq
MIRT1431484	hsa-miR-4645-5p	CLIP-seq
MIRT1431485	hsa-miR-4650-5p	CLIP-seq
MIRT1431486	hsa-miR-466	CLIP-seq
MIRT1431487	hsa-miR-4673	CLIP-seq
MIRT1431488	hsa-miR-4704-3p	CLIP-seq
MIRT1431489	hsa-miR-4711-5p	CLIP-seq
MIRT1431490	hsa-miR-4789-3p	CLIP-seq
MIRT1431491	hsa-miR-4797-3p	CLIP-seq
MIRT1431492	hsa-miR-622	CLIP-seq
MIRT2129309	hsa-miR-1183	CLIP-seq
MIRT1431470	hsa-miR-128	CLIP-seq
MIRT1431471	hsa-miR-148a	CLIP-seq
MIRT1431472	hsa-miR-148b	CLIP-seq
MIRT2129310	hsa-miR-150	CLIP-seq
MIRT1431473	hsa-miR-152	CLIP-seq
MIRT2129311	hsa-miR-185	CLIP-seq
MIRT2129312	hsa-miR-186	CLIP-seq
MIRT2129313	hsa-miR-1914	CLIP-seq
MIRT2129314	hsa-miR-193a-3p	CLIP-seq
MIRT2129315	hsa-miR-193b	CLIP-seq
MIRT1431474	hsa-miR-198	CLIP-seq
MIRT2129316	hsa-miR-218	CLIP-seq
MIRT2129317	hsa-miR-23a	CLIP-seq
MIRT2129318	hsa-miR-23b	CLIP-seq
MIRT2129319	hsa-miR-23c	CLIP-seq
MIRT1431475	hsa-miR-27a	CLIP-seq
MIRT1431476	hsa-miR-27b	CLIP-seq
MIRT2129320	hsa-miR-3133	CLIP-seq
MIRT2129321	hsa-miR-3140-3p	CLIP-seq
MIRT2129322	hsa-miR-3145-3p	CLIP-seq
MIRT2129323	hsa-miR-3158-3p	CLIP-seq
MIRT2129324	hsa-miR-361-3p	CLIP-seq
MIRT2129325	hsa-miR-3657	CLIP-seq
MIRT2129326	hsa-miR-3659	CLIP-seq
MIRT2129327	hsa-miR-3689a-5p	CLIP-seq
MIRT2129328	hsa-miR-3689b	CLIP-seq
MIRT2129329	hsa-miR-3689e	CLIP-seq
MIRT2129330	hsa-miR-3689f	CLIP-seq
MIRT1431481	hsa-miR-3978	CLIP-seq
MIRT1431482	hsa-miR-4264	CLIP-seq
MIRT2129331	hsa-miR-4286	CLIP-seq
MIRT2129332	hsa-miR-4306	CLIP-seq
MIRT2129333	hsa-miR-4491	CLIP-seq
MIRT1431483	hsa-miR-4643	CLIP-seq
MIRT2129334	hsa-miR-4644	CLIP-seq
MIRT2129335	hsa-miR-4657	CLIP-seq
MIRT2129336	hsa-miR-4658	CLIP-seq
MIRT1431486	hsa-miR-466	CLIP-seq
MIRT2129337	hsa-miR-4669	CLIP-seq
MIRT2129338	hsa-miR-4677-3p	CLIP-seq
MIRT1431488	hsa-miR-4704-3p	CLIP-seq
MIRT1431489	hsa-miR-4711-5p	CLIP-seq
MIRT2129339	hsa-miR-4749-3p	CLIP-seq
MIRT1431490	hsa-miR-4789-3p	CLIP-seq
MIRT1431491	hsa-miR-4797-3p	CLIP-seq
MIRT2129340	hsa-miR-574-5p	CLIP-seq
MIRT2129341	hsa-miR-636	CLIP-seq
MIRT2129342	hsa-miR-642b	CLIP-seq
MIRT2129343	hsa-miR-676	CLIP-seq
MIRT2129344	hsa-miR-892b	CLIP-seq
MIRT2350899	hsa-miR-1269	CLIP-seq
MIRT2350900	hsa-miR-1269b	CLIP-seq
MIRT1431470	hsa-miR-128	CLIP-seq
MIRT2350901	hsa-miR-133a	CLIP-seq
MIRT2350902	hsa-miR-133b	CLIP-seq
MIRT2350903	hsa-miR-1343	CLIP-seq
MIRT1431471	hsa-miR-148a	CLIP-seq
MIRT1431472	hsa-miR-148b	CLIP-seq
MIRT1431473	hsa-miR-152	CLIP-seq
MIRT2350904	hsa-miR-1913	CLIP-seq
MIRT2350905	hsa-miR-194	CLIP-seq
MIRT2350906	hsa-miR-1976	CLIP-seq
MIRT1431474	hsa-miR-198	CLIP-seq
MIRT2350907	hsa-miR-2681	CLIP-seq
MIRT1431475	hsa-miR-27a	CLIP-seq
MIRT1431476	hsa-miR-27b	CLIP-seq
MIRT1431477	hsa-miR-3162-3p	CLIP-seq
MIRT2350908	hsa-miR-324-3p	CLIP-seq
MIRT2350909	hsa-miR-330-3p	CLIP-seq
MIRT2350910	hsa-miR-331-3p	CLIP-seq
MIRT2350911	hsa-miR-33a	CLIP-seq
MIRT2350912	hsa-miR-33b	CLIP-seq
MIRT1431478	hsa-miR-342-3p	CLIP-seq
MIRT2350913	hsa-miR-3618	CLIP-seq
MIRT1431479	hsa-miR-3688-5p	CLIP-seq
MIRT1431480	hsa-miR-3960	CLIP-seq
MIRT1431482	hsa-miR-4264	CLIP-seq
MIRT2350914	hsa-miR-4276	CLIP-seq
MIRT2350915	hsa-miR-4302	CLIP-seq
MIRT2350916	hsa-miR-4313	CLIP-seq
MIRT2350917	hsa-miR-4328	CLIP-seq
MIRT2350918	hsa-miR-450b-3p	CLIP-seq
MIRT2350919	hsa-miR-4520b-3p	CLIP-seq
MIRT2350920	hsa-miR-4529-3p	CLIP-seq
MIRT1431483	hsa-miR-4643	CLIP-seq
MIRT1431486	hsa-miR-466	CLIP-seq
MIRT1431488	hsa-miR-4704-3p	CLIP-seq
MIRT1431489	hsa-miR-4711-5p	CLIP-seq
MIRT2350921	hsa-miR-4713-3p	CLIP-seq
MIRT2350922	hsa-miR-4724-3p	CLIP-seq
MIRT1431490	hsa-miR-4789-3p	CLIP-seq
MIRT1431491	hsa-miR-4797-3p	CLIP-seq
MIRT2350923	hsa-miR-563	CLIP-seq
MIRT2350924	hsa-miR-593	CLIP-seq
MIRT2350925	hsa-miR-601	CLIP-seq
MIRT1431492	hsa-miR-622	CLIP-seq
MIRT2350926	hsa-miR-638	CLIP-seq
MIRT2129342	hsa-miR-642b	CLIP-seq
MIRT2350927	hsa-miR-654-3p	CLIP-seq
MIRT2350928	hsa-miR-769-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS	25608530
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25608530
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0019230	Process	Proprioception	IEA
GO:0019230	Process	Proprioception	ISS
GO:0071260	Process	Cellular response to mechanical stimulus	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	ISS
GO:0098655	Process	Monoatomic cation transmembrane transport	IEA
GO:0140135	Function	Mechanosensitive monoatomic cation channel activity	IEA
GO:0140135	Function	Mechanosensitive monoatomic cation channel activity	ISS

MIM	HGNC	e!Ensembl
617292	37263	ENSG00000249242

B9EJG8

Protein name

Transmembrane protein 150C (Tentonin 3)

Protein function

Nonselective cationic channel with high permeability to Ca(2+). Component of a mechanosensitive cation channel, confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception. {ECO:0000250|UniProtK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10277	Frag1	8 → 218	Frag1/DRAM/Sfk1 family	Family

Sequence

MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAERKPGVKHAPYISIAGD
DPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNISGLVALCLASFGMTLLGNF
QLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEGRRVGIPRVILSASITLCVVL
YFILMAQSIHMYAARVQWGLVMCFLSYFGTFAVEFRHYRYEIVCSEYQENFLSFSESLSE
ASEYQTDQV

Sequence length

249

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TMEM150C (transmembrane protein 150C)