Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	440738
Gene name	Microtubule associated protein 1 light chain 3 gamma
Gene symbol	MAP1LC3C
Synonyms (NCBI Gene)	ATG8JLC3C
Chromosome	1
Chromosome location	1q43
Summary	Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

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Show/Hide all (200)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029586	hsa-miR-26b-5p	Microarray	19088304
MIRT1127814	hsa-miR-10a	CLIP-seq
MIRT1127815	hsa-miR-10b	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT1127817	hsa-miR-1827	CLIP-seq
MIRT1127818	hsa-miR-298	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127821	hsa-miR-34b	CLIP-seq
MIRT1127822	hsa-miR-3612	CLIP-seq
MIRT1127823	hsa-miR-3613-3p	CLIP-seq
MIRT1127824	hsa-miR-3614-5p	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT1127827	hsa-miR-3667-5p	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT1127831	hsa-miR-3926	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127833	hsa-miR-4443	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT1127836	hsa-miR-451b	CLIP-seq
MIRT1127837	hsa-miR-4651	CLIP-seq
MIRT1127838	hsa-miR-4695-5p	CLIP-seq
MIRT1127839	hsa-miR-4696	CLIP-seq
MIRT1127840	hsa-miR-4725-5p	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127844	hsa-miR-4787-5p	CLIP-seq
MIRT1127845	hsa-miR-504	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT1127847	hsa-miR-548s	CLIP-seq
MIRT1127848	hsa-miR-607	CLIP-seq
MIRT1127849	hsa-miR-608	CLIP-seq
MIRT1127850	hsa-miR-650	CLIP-seq
MIRT1127851	hsa-miR-658	CLIP-seq
MIRT1127852	hsa-miR-665	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT1127831	hsa-miR-3926	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT1127837	hsa-miR-4651	CLIP-seq
MIRT2036276	hsa-miR-4691-3p	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT2036277	hsa-miR-4731-3p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127844	hsa-miR-4787-5p	CLIP-seq
MIRT2036278	hsa-miR-4801	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT2036279	hsa-miR-548aa	CLIP-seq
MIRT1127847	hsa-miR-548s	CLIP-seq
MIRT1127849	hsa-miR-608	CLIP-seq
MIRT2036280	hsa-miR-634	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT1127817	hsa-miR-1827	CLIP-seq
MIRT1127818	hsa-miR-298	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT2266565	hsa-miR-3160-3p	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127821	hsa-miR-34b	CLIP-seq
MIRT1127822	hsa-miR-3612	CLIP-seq
MIRT1127824	hsa-miR-3614-5p	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT2266566	hsa-miR-4252	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT2266567	hsa-miR-4633-3p	CLIP-seq
MIRT1127838	hsa-miR-4695-5p	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT1127850	hsa-miR-650	CLIP-seq
MIRT1127851	hsa-miR-658	CLIP-seq
MIRT1127852	hsa-miR-665	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT2453648	hsa-miR-3650	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT2453649	hsa-miR-4293	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT2453650	hsa-miR-4684-5p	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT2453651	hsa-miR-548c-3p	CLIP-seq
MIRT2453652	hsa-miR-596	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT1127814	hsa-miR-10a	CLIP-seq
MIRT1127815	hsa-miR-10b	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT1127817	hsa-miR-1827	CLIP-seq
MIRT2566203	hsa-miR-2278	CLIP-seq
MIRT1127818	hsa-miR-298	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127821	hsa-miR-34b	CLIP-seq
MIRT1127822	hsa-miR-3612	CLIP-seq
MIRT1127824	hsa-miR-3614-5p	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT2566204	hsa-miR-3622b-5p	CLIP-seq
MIRT2453648	hsa-miR-3650	CLIP-seq
MIRT1127827	hsa-miR-3667-5p	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT1127831	hsa-miR-3926	CLIP-seq
MIRT2453649	hsa-miR-4293	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT1127836	hsa-miR-451b	CLIP-seq
MIRT2453650	hsa-miR-4684-5p	CLIP-seq
MIRT1127838	hsa-miR-4695-5p	CLIP-seq
MIRT1127839	hsa-miR-4696	CLIP-seq
MIRT1127840	hsa-miR-4725-5p	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127845	hsa-miR-504	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT2453651	hsa-miR-548c-3p	CLIP-seq
MIRT1127847	hsa-miR-548s	CLIP-seq
MIRT2453652	hsa-miR-596	CLIP-seq
MIRT1127850	hsa-miR-650	CLIP-seq
MIRT1127851	hsa-miR-658	CLIP-seq
MIRT1127852	hsa-miR-665	CLIP-seq
MIRT1127814	hsa-miR-10a	CLIP-seq
MIRT1127815	hsa-miR-10b	CLIP-seq
MIRT1127816	hsa-miR-1293	CLIP-seq
MIRT2566203	hsa-miR-2278	CLIP-seq
MIRT1127819	hsa-miR-3122	CLIP-seq
MIRT1127820	hsa-miR-3165	CLIP-seq
MIRT1127823	hsa-miR-3613-3p	CLIP-seq
MIRT1127825	hsa-miR-3622a-3p	CLIP-seq
MIRT1127826	hsa-miR-3622b-3p	CLIP-seq
MIRT2566204	hsa-miR-3622b-5p	CLIP-seq
MIRT2453648	hsa-miR-3650	CLIP-seq
MIRT1127827	hsa-miR-3667-5p	CLIP-seq
MIRT1127828	hsa-miR-3689a-3p	CLIP-seq
MIRT1127829	hsa-miR-3689c	CLIP-seq
MIRT1127830	hsa-miR-3913-5p	CLIP-seq
MIRT1127831	hsa-miR-3926	CLIP-seq
MIRT2453649	hsa-miR-4293	CLIP-seq
MIRT1127832	hsa-miR-4433	CLIP-seq
MIRT1127834	hsa-miR-4459	CLIP-seq
MIRT1127835	hsa-miR-4483	CLIP-seq
MIRT1127836	hsa-miR-451b	CLIP-seq
MIRT2453650	hsa-miR-4684-5p	CLIP-seq
MIRT1127839	hsa-miR-4696	CLIP-seq
MIRT1127840	hsa-miR-4725-5p	CLIP-seq
MIRT1127841	hsa-miR-4728-5p	CLIP-seq
MIRT1127842	hsa-miR-4768-3p	CLIP-seq
MIRT1127843	hsa-miR-4786-5p	CLIP-seq
MIRT1127845	hsa-miR-504	CLIP-seq
MIRT1127846	hsa-miR-544b	CLIP-seq
MIRT2453651	hsa-miR-548c-3p	CLIP-seq
MIRT1127847	hsa-miR-548s	CLIP-seq
MIRT2453652	hsa-miR-596	CLIP-seq
MIRT1127848	hsa-miR-607	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IBA
GO:0000421	Component	Autophagosome membrane	IBA
GO:0000421	Component	Autophagosome membrane	IEA
GO:0000421	Component	Autophagosome membrane	TAS
GO:0000423	Process	Mitophagy	IBA
GO:0005515	Function	Protein binding	IPI	19250911, 20562859, 22354992, 22470510, 23459205, 24290141, 24668264, 25684205, 26347139, 28404643, 28514442, 32296183, 33436498, 33961781, 34524948, 34799561, 37219487, 37443287
GO:0005543	Function	Phospholipid binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005776	Component	Autophagosome	IDA	28223137
GO:0005776	Component	Autophagosome	IEA
GO:0005776	Component	Autophagosome	ISS	12740394
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006914	Process	Autophagy	IEA
GO:0006950	Process	Response to stress	IEA
GO:0006995	Process	Cellular response to nitrogen starvation	IBA
GO:0008429	Function	Phosphatidylethanolamine binding	IBA
GO:0008429	Function	Phosphatidylethanolamine binding	IDA	12740394
GO:0009267	Process	Cellular response to starvation	IDA	28223137
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IDA	28223137
GO:0016236	Process	Macroautophagy	IEA
GO:0031090	Component	Organelle membrane	ISS	12740394
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	25127057
GO:0032527	Process	Protein exit from endoplasmic reticulum	IMP	26431026
GO:0035973	Process	Aggrephagy	IMP	28404643
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0097352	Process	Autophagosome maturation	IBA
GO:0097352	Process	Autophagosome maturation	IDA	28223137

MIM	HGNC	e!Ensembl
609605	13353	ENSG00000197769

Q9BXW4

Protein name

Microtubule-associated protein 1 light chain 3 gamma (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (Microtubule-associated proteins 1A/1B light chain 3C) (MAP1A/MAP1B LC3 C) (MAP1A/

Protein function

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 (PubMed:23022382). Recruits all ATG8 family members to infecting bacteria such as S.typhimurium (PubMed:23022382).

PDB

2NCN , 3VVW , 3WAM , 3WAP , 5DPW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02991	Atg8	21 → 126	Autophagy protein Atg8 ubiquitin like	Domain

Tissue specificity

TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary. {ECO:0000269|PubMed:12740394}.

Sequence

MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLV
PQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYA
SQETFGCLESAAPRDGSSLEDRPCNPL

Sequence length

147

Interactions

View interactions

	KEGG		Reactome
	Mitophagy - animal Autophagy - animal Ferroptosis Apelin signaling pathway NOD-like receptor signaling pathway Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Kaposi sarcoma-associated herpesvirus infection		Macroautophagy

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BILIARY ATRESIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	26208877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26208877	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	34887858	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 2	Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome	BEFREE	28404643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	35572821	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30374741		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30374741, 33357130, 34315829	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Development Disorder	BEFREE	28404643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	32425885	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	32425885	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	35611939	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	33988680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26208877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	22647376, 26208877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26208877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26378792		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23555580, 23922894, 30374741		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	22647376, 26208877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	26208877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36173625	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MAP1LC3C (microtubule associated protein 1 light chain 3 gamma)