ETV3L (ETS variant transcription factor 3 like)

Gene

• Entrez ID: 440695
• Gene name: ETS variant transcription factor 3 like
• Gene symbol: ETV3L
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT971979	hsa-miR-1228	CLIP-seq
MIRT971980	hsa-miR-128	CLIP-seq
MIRT971981	hsa-miR-181a	CLIP-seq
MIRT971982	hsa-miR-181b	CLIP-seq
MIRT971983	hsa-miR-181c	CLIP-seq
MIRT971984	hsa-miR-181d	CLIP-seq
MIRT971985	hsa-miR-27a	CLIP-seq
MIRT971986	hsa-miR-27b	CLIP-seq
MIRT971987	hsa-miR-3692	CLIP-seq
MIRT971988	hsa-miR-377	CLIP-seq
MIRT971989	hsa-miR-4262	CLIP-seq
MIRT971990	hsa-miR-4761-3p	CLIP-seq
MIRT971991	hsa-miR-664	CLIP-seq
MIRT1987963	hsa-miR-10a	CLIP-seq
MIRT1987964	hsa-miR-10b	CLIP-seq
MIRT1987965	hsa-miR-339-5p	CLIP-seq
MIRT1987966	hsa-miR-3620	CLIP-seq
MIRT1987967	hsa-miR-4421	CLIP-seq
MIRT2387551	hsa-miR-199a-5p	CLIP-seq
MIRT2387552	hsa-miR-199b-5p	CLIP-seq
MIRT2387553	hsa-miR-4286	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0043565	Function	Sequence-specific DNA binding	IEA

Other IDs

• MIM: 621105
• HGNC: 33834
• e!Ensembl: ENSG00000253831

Protein

• UniProt ID: Q6ZN32
• Protein name: ETS translocation variant 3-like protein
• Protein function: Transcriptional regulator.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00178	Ets	40 → 120	Ets-domain	Domain

• Sequence:

  MHCSCLAEGIPANPGNWISGLAFPDWAYKAESSPGSRQIQLWHFILELLQKEEFRHVIAW
  QQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFN
  FSKLIVVNYPLWEVRAPPSPHLLLGAPALCRPALVPVGVQSELLHSMLFAHQAMVEQLTG
  QQTPRGPPETSGDKKGSSSSVYRLGSAPGPCRLGLCCHLGSVQGELPGVASFTPPLPPPL
  PSNWTCLSGPFLPPLPSEQQLPGAFKPDILLPGPRSLPGAWHFPGLPLLAGLGQGAGERL
  WLLSLRPEGLEVKPAPMMEAKGGLDPREVFCPETRRLKTGEESLTSPNLENLKAVWPLDP
  P

• Sequence length: 361

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ETV3L-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Multiple Sclerosis	Multiple sclerosis	Pubtator	27454520	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations