ASGR2 (asialoglycoprotein receptor 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 433
Gene name Asialoglycoprotein receptor 2
Gene symbol ASGR2
Synonyms (NCBI Gene)
ASGP-R2ASGPR2CLEC4H2HBXBPHL-2
Chromosome 17
Chromosome location 17p13.1
Summary This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed term
miRNA miRNA information provided by mirtarbase database.
480
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (480)
miRTarBase ID miRNA Experiments Reference
MIRT646689 hsa-miR-6769a-3p HITS-CLIP 23824327
MIRT646688 hsa-miR-5695 HITS-CLIP 23824327
MIRT646687 hsa-miR-767-3p HITS-CLIP 23824327
MIRT646686 hsa-miR-3120-5p HITS-CLIP 23824327
MIRT646685 hsa-miR-346 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0004873 Function Asialoglycoprotein receptor activity TAS 3863106
GO:0005515 Function Protein binding IPI 11408579, 21988832, 32296183
GO:0005537 Function D-mannose binding IBA
GO:0005886 Component Plasma membrane TAS
GO:0006897 Process Endocytosis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
108361 743 ENSG00000161944
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07307
Protein name Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
Protein function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding
PDB 8URF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03954 Lectin_N 29 → 167 Family
PF00059 Lectin_C 194 → 302 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed exclusively in hepatic parenchymal cells.
Sequence
Sequence length 311
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Thyroid hormone synthesis   Asparagine N-linked glycosylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (3)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CONGENITAL HEART DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERLIPIDEMIA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (2)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 36982982 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia Pubtator 37552420 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only