Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4325
Gene name	Matrix metallopeptidase 16
Gene symbol	MMP16
Synonyms (NCBI Gene)	C8orf57MMP-X2MT-MMP2MT-MMP3MT3-MMP
Chromosome	8
Chromosome location	8q21.3
Summary	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004978	hsa-miR-31-5p	Luciferase reporter assayqRT-PCRWestern blot	19524507
MIRT004978	hsa-miR-31-5p	Luciferase reporter assayqRT-PCRWestern blot	19524507
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assayqRT-PCRWestern blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assayqRT-PCRWestern blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assayqRT-PCRWestern blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assayqRT-PCRWestern blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assayqRT-PCRWestern blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assayqRT-PCRWestern blot	21823013
MIRT052989	hsa-miR-328-3p	Luciferase reporter assayqRT-PCRWestern blot	22453125
MIRT052989	hsa-miR-328-3p	Luciferase reporter assayqRT-PCRWestern blot	22453125
MIRT053318	hsa-miR-155-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blotZymography	22348515
MIRT053318	hsa-miR-155-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blotZymography	22348515
MIRT053318	hsa-miR-155-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blotZymography	22348515
MIRT004887	hsa-miR-146b-5p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	23796692
MIRT004887	hsa-miR-146b-5p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	23796692
MIRT724192	hsa-miR-99a-3p	HITS-CLIP	19536157
MIRT724191	hsa-miR-99b-3p	HITS-CLIP	19536157
MIRT724190	hsa-miR-6796-3p	HITS-CLIP	19536157
MIRT724189	hsa-miR-4318	HITS-CLIP	19536157
MIRT724188	hsa-miR-892a	HITS-CLIP	19536157
MIRT724187	hsa-miR-4693-5p	HITS-CLIP	19536157
MIRT629031	hsa-miR-4502	HITS-CLIP	19536157
MIRT629030	hsa-miR-767-3p	HITS-CLIP	19536157
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT629028	hsa-miR-3171	HITS-CLIP	19536157
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	19536157
MIRT629026	hsa-let-7c-3p	HITS-CLIP	19536157
MIRT522465	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT522463	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT522461	hsa-miR-628-3p	HITS-CLIP	21572407
MIRT522460	hsa-miR-325	HITS-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT522457	hsa-miR-3924	HITS-CLIP	21572407
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT522463	hsa-miR-154-3p	PAR-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	21572407
MIRT522461	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT522460	hsa-miR-325	PAR-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT522457	hsa-miR-3924	PAR-CLIP	21572407
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522463	hsa-miR-154-3p	PAR-CLIP	23446348
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	23446348
MIRT522461	hsa-miR-628-3p	PAR-CLIP	23446348
MIRT522460	hsa-miR-325	PAR-CLIP	23446348
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT522457	hsa-miR-3924	PAR-CLIP	23446348
MIRT443658	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT443657	hsa-miR-4712-3p	PAR-CLIP	22100165
MIRT440224	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440224	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT734091	hsa-miR-377-3p	Luciferase reporter assayWestern blotting	33569426
MIRT735294	hsa-let-7g-5p	Western blottingMicroarrayqRT-PCRImmunocytochemistry (ICC)	33352502
MIRT724192	hsa-miR-99a-3p	HITS-CLIP	19536157
MIRT724191	hsa-miR-99b-3p	HITS-CLIP	19536157
MIRT724190	hsa-miR-6796-3p	HITS-CLIP	19536157
MIRT724189	hsa-miR-4318	HITS-CLIP	19536157
MIRT724188	hsa-miR-892a	HITS-CLIP	19536157
MIRT724187	hsa-miR-4693-5p	HITS-CLIP	19536157
MIRT629031	hsa-miR-4502	HITS-CLIP	19536157
MIRT629030	hsa-miR-767-3p	HITS-CLIP	19536157
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT629028	hsa-miR-3171	HITS-CLIP	19536157
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	19536157
MIRT629026	hsa-let-7c-3p	HITS-CLIP	19536157
MIRT522465	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT522463	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT522461	hsa-miR-628-3p	HITS-CLIP	21572407
MIRT522460	hsa-miR-325	HITS-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT522457	hsa-miR-3924	HITS-CLIP	21572407
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT522463	hsa-miR-154-3p	PAR-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	21572407
MIRT522461	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT522460	hsa-miR-325	PAR-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT522457	hsa-miR-3924	PAR-CLIP	21572407
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522463	hsa-miR-154-3p	PAR-CLIP	23446348
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	23446348
MIRT522461	hsa-miR-628-3p	PAR-CLIP	23446348
MIRT522460	hsa-miR-325	PAR-CLIP	23446348
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT522457	hsa-miR-3924	PAR-CLIP	23446348
MIRT443658	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT443657	hsa-miR-4712-3p	PAR-CLIP	22100165
MIRT1153208	hsa-miR-1184	CLIP-seq
MIRT1153209	hsa-miR-1197	CLIP-seq
MIRT1153210	hsa-miR-1205	CLIP-seq
MIRT1153211	hsa-miR-1206	CLIP-seq
MIRT1153212	hsa-miR-1224-3p	CLIP-seq
MIRT1153213	hsa-miR-1227	CLIP-seq
MIRT1153214	hsa-miR-1258	CLIP-seq
MIRT1153215	hsa-miR-1260	CLIP-seq
MIRT1153216	hsa-miR-1260b	CLIP-seq
MIRT1153217	hsa-miR-1280	CLIP-seq
MIRT1153218	hsa-miR-129-5p	CLIP-seq
MIRT1153219	hsa-miR-1297	CLIP-seq
MIRT1153220	hsa-miR-1303	CLIP-seq
MIRT1153221	hsa-miR-1304	CLIP-seq
MIRT1153222	hsa-miR-138	CLIP-seq
MIRT1153223	hsa-miR-150	CLIP-seq
MIRT1153224	hsa-miR-1909	CLIP-seq
MIRT1153225	hsa-miR-193a-3p	CLIP-seq
MIRT1153226	hsa-miR-193b	CLIP-seq
MIRT1153227	hsa-miR-200b	CLIP-seq
MIRT1153228	hsa-miR-200c	CLIP-seq
MIRT1153229	hsa-miR-205	CLIP-seq
MIRT1153230	hsa-miR-2053	CLIP-seq
MIRT1153231	hsa-miR-2113	CLIP-seq
MIRT1153232	hsa-miR-2681	CLIP-seq
MIRT1153233	hsa-miR-26a	CLIP-seq
MIRT1153234	hsa-miR-26b	CLIP-seq
MIRT1153235	hsa-miR-298	CLIP-seq
MIRT1153236	hsa-miR-3074-3p	CLIP-seq
MIRT1153237	hsa-miR-3117-3p	CLIP-seq
MIRT1153238	hsa-miR-3119	CLIP-seq
MIRT1153239	hsa-miR-3123	CLIP-seq
MIRT1153240	hsa-miR-3129-3p	CLIP-seq
MIRT1153241	hsa-miR-3134	CLIP-seq
MIRT1153242	hsa-miR-3158-5p	CLIP-seq
MIRT1153243	hsa-miR-3163	CLIP-seq
MIRT1153244	hsa-miR-3177-5p	CLIP-seq
MIRT1153245	hsa-miR-3187-3p	CLIP-seq
MIRT1153246	hsa-miR-3194-3p	CLIP-seq
MIRT1153247	hsa-miR-320a	CLIP-seq
MIRT1153248	hsa-miR-320b	CLIP-seq
MIRT1153249	hsa-miR-320c	CLIP-seq
MIRT1153250	hsa-miR-320d	CLIP-seq
MIRT1153251	hsa-miR-320e	CLIP-seq
MIRT1153252	hsa-miR-330-3p	CLIP-seq
MIRT1153253	hsa-miR-338-5p	CLIP-seq
MIRT1153254	hsa-miR-3591-3p	CLIP-seq
MIRT1153255	hsa-miR-3622a-3p	CLIP-seq
MIRT1153256	hsa-miR-3622b-3p	CLIP-seq
MIRT1153257	hsa-miR-3646	CLIP-seq
MIRT1153258	hsa-miR-3647-3p	CLIP-seq
MIRT1153259	hsa-miR-3662	CLIP-seq
MIRT1153260	hsa-miR-3665	CLIP-seq
MIRT1153261	hsa-miR-3672	CLIP-seq
MIRT1153262	hsa-miR-369-3p	CLIP-seq
MIRT1153263	hsa-miR-374a	CLIP-seq
MIRT1153264	hsa-miR-374b	CLIP-seq
MIRT1153265	hsa-miR-374c	CLIP-seq
MIRT1153266	hsa-miR-377	CLIP-seq
MIRT1153267	hsa-miR-382	CLIP-seq
MIRT1153268	hsa-miR-3919	CLIP-seq
MIRT1153269	hsa-miR-3922-5p	CLIP-seq
MIRT1153270	hsa-miR-3925-5p	CLIP-seq
MIRT1153271	hsa-miR-425	CLIP-seq
MIRT1153272	hsa-miR-4274	CLIP-seq
MIRT1153273	hsa-miR-4282	CLIP-seq
MIRT1153274	hsa-miR-4289	CLIP-seq
MIRT1153275	hsa-miR-429	CLIP-seq
MIRT1153276	hsa-miR-4310	CLIP-seq
MIRT1153277	hsa-miR-4326	CLIP-seq
MIRT1153278	hsa-miR-4328	CLIP-seq
MIRT1153279	hsa-miR-4428	CLIP-seq
MIRT1153280	hsa-miR-4429	CLIP-seq
MIRT1153281	hsa-miR-4434	CLIP-seq
MIRT1153282	hsa-miR-4446-5p	CLIP-seq
MIRT1153283	hsa-miR-4465	CLIP-seq
MIRT1153284	hsa-miR-4466	CLIP-seq
MIRT1153285	hsa-miR-450b-5p	CLIP-seq
MIRT1153286	hsa-miR-4516	CLIP-seq
MIRT1153287	hsa-miR-4528	CLIP-seq
MIRT1153288	hsa-miR-4529-5p	CLIP-seq
MIRT1153289	hsa-miR-4531	CLIP-seq
MIRT1153290	hsa-miR-4534	CLIP-seq
MIRT1153291	hsa-miR-4645-3p	CLIP-seq
MIRT1153292	hsa-miR-4653-3p	CLIP-seq
MIRT1153293	hsa-miR-4672	CLIP-seq
MIRT1153294	hsa-miR-4694-3p	CLIP-seq
MIRT1153295	hsa-miR-4698	CLIP-seq
MIRT1153296	hsa-miR-4711-5p	CLIP-seq
MIRT1153297	hsa-miR-4713-5p	CLIP-seq
MIRT1153298	hsa-miR-4717-3p	CLIP-seq
MIRT1153299	hsa-miR-4756-3p	CLIP-seq
MIRT1153300	hsa-miR-4762-5p	CLIP-seq
MIRT1153301	hsa-miR-4773	CLIP-seq
MIRT1153302	hsa-miR-4778-3p	CLIP-seq
MIRT1153303	hsa-miR-490-5p	CLIP-seq
MIRT1153304	hsa-miR-507	CLIP-seq
MIRT1153305	hsa-miR-513b	CLIP-seq
MIRT1153306	hsa-miR-522	CLIP-seq
MIRT1153307	hsa-miR-532-3p	CLIP-seq
MIRT1153308	hsa-miR-539	CLIP-seq
MIRT1153309	hsa-miR-548c-3p	CLIP-seq
MIRT1153310	hsa-miR-557	CLIP-seq
MIRT1153311	hsa-miR-569	CLIP-seq
MIRT1153312	hsa-miR-607	CLIP-seq
MIRT1153313	hsa-miR-618	CLIP-seq
MIRT1153314	hsa-miR-630	CLIP-seq
MIRT1153315	hsa-miR-655	CLIP-seq
MIRT1153316	hsa-miR-657	CLIP-seq
MIRT1153317	hsa-miR-659	CLIP-seq
MIRT1153318	hsa-miR-671-5p	CLIP-seq
MIRT1153319	hsa-miR-675	CLIP-seq
MIRT1153320	hsa-miR-889	CLIP-seq
MIRT1153321	hsa-miR-922	CLIP-seq
MIRT1153322	hsa-miR-944	CLIP-seq
MIRT2043890	hsa-miR-204	CLIP-seq
MIRT2043891	hsa-miR-2052	CLIP-seq
MIRT2043892	hsa-miR-211	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT2043895	hsa-miR-328	CLIP-seq
MIRT1153253	hsa-miR-338-5p	CLIP-seq
MIRT2043896	hsa-miR-33a	CLIP-seq
MIRT2043897	hsa-miR-33b	CLIP-seq
MIRT2043898	hsa-miR-34b	CLIP-seq
MIRT2043899	hsa-miR-34c-3p	CLIP-seq
MIRT2043900	hsa-miR-3545-3p	CLIP-seq
MIRT1153258	hsa-miR-3647-3p	CLIP-seq
MIRT1153259	hsa-miR-3662	CLIP-seq
MIRT2043901	hsa-miR-3678-3p	CLIP-seq
MIRT2043902	hsa-miR-3688-3p	CLIP-seq
MIRT1153262	hsa-miR-369-3p	CLIP-seq
MIRT1153263	hsa-miR-374a	CLIP-seq
MIRT1153264	hsa-miR-374b	CLIP-seq
MIRT1153273	hsa-miR-4282	CLIP-seq
MIRT1153282	hsa-miR-4446-5p	CLIP-seq
MIRT2043903	hsa-miR-455-5p	CLIP-seq
MIRT2043904	hsa-miR-4637	CLIP-seq
MIRT2043905	hsa-miR-4687-3p	CLIP-seq
MIRT2043906	hsa-miR-4755-5p	CLIP-seq
MIRT2043907	hsa-miR-4778-5p	CLIP-seq
MIRT2043908	hsa-miR-5096	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT2043910	hsa-miR-544	CLIP-seq
MIRT1153313	hsa-miR-618	CLIP-seq
MIRT2043911	hsa-miR-623	CLIP-seq
MIRT1153320	hsa-miR-889	CLIP-seq
MIRT1153225	hsa-miR-193a-3p	CLIP-seq
MIRT1153226	hsa-miR-193b	CLIP-seq
MIRT2273252	hsa-miR-21	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT2273253	hsa-miR-3140-3p	CLIP-seq
MIRT1153243	hsa-miR-3163	CLIP-seq
MIRT1153245	hsa-miR-3187-3p	CLIP-seq
MIRT2273254	hsa-miR-361-3p	CLIP-seq
MIRT1153258	hsa-miR-3647-3p	CLIP-seq
MIRT2043902	hsa-miR-3688-3p	CLIP-seq
MIRT2273255	hsa-miR-410	CLIP-seq
MIRT1153273	hsa-miR-4282	CLIP-seq
MIRT1153278	hsa-miR-4328	CLIP-seq
MIRT1153285	hsa-miR-450b-5p	CLIP-seq
MIRT1153288	hsa-miR-4529-5p	CLIP-seq
MIRT2273256	hsa-miR-4700-3p	CLIP-seq
MIRT1153297	hsa-miR-4713-5p	CLIP-seq
MIRT2043908	hsa-miR-5096	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT2273257	hsa-miR-590-5p	CLIP-seq
MIRT2273258	hsa-miR-760	CLIP-seq
MIRT1153210	hsa-miR-1205	CLIP-seq
MIRT2273253	hsa-miR-3140-3p	CLIP-seq
MIRT2273254	hsa-miR-361-3p	CLIP-seq
MIRT1153297	hsa-miR-4713-5p	CLIP-seq
MIRT1153236	hsa-miR-3074-3p	CLIP-seq
MIRT1153262	hsa-miR-369-3p	CLIP-seq
MIRT1153263	hsa-miR-374a	CLIP-seq
MIRT1153264	hsa-miR-374b	CLIP-seq
MIRT1153276	hsa-miR-4310	CLIP-seq
MIRT1153313	hsa-miR-618	CLIP-seq
MIRT1153320	hsa-miR-889	CLIP-seq
MIRT2454276	hsa-miR-144	CLIP-seq
MIRT2454277	hsa-miR-203	CLIP-seq
MIRT2454278	hsa-miR-3926	CLIP-seq
MIRT1153293	hsa-miR-4672	CLIP-seq
MIRT2454279	hsa-miR-548s	CLIP-seq
MIRT2572031	hsa-miR-1200	CLIP-seq
MIRT2572032	hsa-miR-1270	CLIP-seq
MIRT2572033	hsa-miR-1298	CLIP-seq
MIRT2572034	hsa-miR-2276	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT1153241	hsa-miR-3134	CLIP-seq
MIRT1153246	hsa-miR-3194-3p	CLIP-seq
MIRT2572035	hsa-miR-3202	CLIP-seq
MIRT1153247	hsa-miR-320a	CLIP-seq
MIRT1153248	hsa-miR-320b	CLIP-seq
MIRT1153249	hsa-miR-320c	CLIP-seq
MIRT1153250	hsa-miR-320d	CLIP-seq
MIRT1153252	hsa-miR-330-3p	CLIP-seq
MIRT2572036	hsa-miR-342-5p	CLIP-seq
MIRT2572037	hsa-miR-3607-3p	CLIP-seq
MIRT2572038	hsa-miR-3660	CLIP-seq
MIRT2572039	hsa-miR-3675-3p	CLIP-seq
MIRT1153265	hsa-miR-374c	CLIP-seq
MIRT1153268	hsa-miR-3919	CLIP-seq
MIRT2572040	hsa-miR-4252	CLIP-seq
MIRT2572041	hsa-miR-4256	CLIP-seq
MIRT1153272	hsa-miR-4274	CLIP-seq
MIRT2572042	hsa-miR-4420	CLIP-seq
MIRT1153280	hsa-miR-4429	CLIP-seq
MIRT2572043	hsa-miR-4436b-5p	CLIP-seq
MIRT1153284	hsa-miR-4466	CLIP-seq
MIRT2572044	hsa-miR-4493	CLIP-seq
MIRT2572045	hsa-miR-4526	CLIP-seq
MIRT1153289	hsa-miR-4531	CLIP-seq
MIRT2572046	hsa-miR-4533	CLIP-seq
MIRT1153290	hsa-miR-4534	CLIP-seq
MIRT2572047	hsa-miR-4651	CLIP-seq
MIRT2572048	hsa-miR-4660	CLIP-seq
MIRT2572049	hsa-miR-4664-5p	CLIP-seq
MIRT2043905	hsa-miR-4687-3p	CLIP-seq
MIRT2572050	hsa-miR-4690-3p	CLIP-seq
MIRT2572051	hsa-miR-4696	CLIP-seq
MIRT1153295	hsa-miR-4698	CLIP-seq
MIRT2572052	hsa-miR-4699-5p	CLIP-seq
MIRT2572053	hsa-miR-4747-5p	CLIP-seq
MIRT1153299	hsa-miR-4756-3p	CLIP-seq
MIRT1153302	hsa-miR-4778-3p	CLIP-seq
MIRT2572054	hsa-miR-4802-5p	CLIP-seq
MIRT2572055	hsa-miR-486-3p	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT1153306	hsa-miR-522	CLIP-seq
MIRT1153309	hsa-miR-548c-3p	CLIP-seq
MIRT2572056	hsa-miR-591	CLIP-seq
MIRT2572057	hsa-miR-608	CLIP-seq
MIRT2572058	hsa-miR-620	CLIP-seq
MIRT2572059	hsa-miR-646	CLIP-seq
MIRT1153315	hsa-miR-655	CLIP-seq
MIRT2572060	hsa-miR-661	CLIP-seq
MIRT2572061	hsa-miR-664	CLIP-seq
MIRT1153318	hsa-miR-671-5p	CLIP-seq
MIRT1153319	hsa-miR-675	CLIP-seq
MIRT2572062	hsa-miR-765	CLIP-seq
MIRT2572063	hsa-miR-9	CLIP-seq
MIRT2572031	hsa-miR-1200	CLIP-seq
MIRT2572033	hsa-miR-1298	CLIP-seq
MIRT2685127	hsa-miR-18a	CLIP-seq
MIRT2685128	hsa-miR-18b	CLIP-seq
MIRT2572034	hsa-miR-2276	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT1153241	hsa-miR-3134	CLIP-seq
MIRT2685129	hsa-miR-3154	CLIP-seq
MIRT2685130	hsa-miR-3179	CLIP-seq
MIRT1153246	hsa-miR-3194-3p	CLIP-seq
MIRT2572035	hsa-miR-3202	CLIP-seq
MIRT1153247	hsa-miR-320a	CLIP-seq
MIRT1153248	hsa-miR-320b	CLIP-seq
MIRT1153249	hsa-miR-320c	CLIP-seq
MIRT1153250	hsa-miR-320d	CLIP-seq
MIRT1153252	hsa-miR-330-3p	CLIP-seq
MIRT2572036	hsa-miR-342-5p	CLIP-seq
MIRT2572037	hsa-miR-3607-3p	CLIP-seq
MIRT2572038	hsa-miR-3660	CLIP-seq
MIRT2572039	hsa-miR-3675-3p	CLIP-seq
MIRT1153265	hsa-miR-374c	CLIP-seq
MIRT1153268	hsa-miR-3919	CLIP-seq
MIRT2685131	hsa-miR-3936	CLIP-seq
MIRT2685132	hsa-miR-3978	CLIP-seq
MIRT2572040	hsa-miR-4252	CLIP-seq
MIRT2572041	hsa-miR-4256	CLIP-seq
MIRT1153272	hsa-miR-4274	CLIP-seq
MIRT2572042	hsa-miR-4420	CLIP-seq
MIRT1153280	hsa-miR-4429	CLIP-seq
MIRT2572043	hsa-miR-4436b-5p	CLIP-seq
MIRT1153284	hsa-miR-4466	CLIP-seq
MIRT2572044	hsa-miR-4493	CLIP-seq
MIRT2572045	hsa-miR-4526	CLIP-seq
MIRT2572046	hsa-miR-4533	CLIP-seq
MIRT1153290	hsa-miR-4534	CLIP-seq
MIRT2572047	hsa-miR-4651	CLIP-seq
MIRT2572049	hsa-miR-4664-5p	CLIP-seq
MIRT2043905	hsa-miR-4687-3p	CLIP-seq
MIRT2572050	hsa-miR-4690-3p	CLIP-seq
MIRT2572051	hsa-miR-4696	CLIP-seq
MIRT1153295	hsa-miR-4698	CLIP-seq
MIRT2572052	hsa-miR-4699-5p	CLIP-seq
MIRT2685133	hsa-miR-4735-3p	CLIP-seq
MIRT2572053	hsa-miR-4747-5p	CLIP-seq
MIRT1153299	hsa-miR-4756-3p	CLIP-seq
MIRT2572054	hsa-miR-4802-5p	CLIP-seq
MIRT2572055	hsa-miR-486-3p	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT1153306	hsa-miR-522	CLIP-seq
MIRT2572056	hsa-miR-591	CLIP-seq
MIRT2572057	hsa-miR-608	CLIP-seq
MIRT2685134	hsa-miR-629	CLIP-seq
MIRT2572059	hsa-miR-646	CLIP-seq
MIRT1153315	hsa-miR-655	CLIP-seq
MIRT2572060	hsa-miR-661	CLIP-seq
MIRT2572061	hsa-miR-664	CLIP-seq
MIRT1153318	hsa-miR-671-5p	CLIP-seq
MIRT1153319	hsa-miR-675	CLIP-seq
MIRT2572062	hsa-miR-765	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0001503	Process	Ossification	IEA
GO:0001958	Process	Endochondral ossification	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	27229514
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS	7559440
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	7559440
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IDA	24970228
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	14645246
GO:0008047	Function	Enzyme activator activity	TAS	7559440
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IDA	27229514
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	7559440
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IDA	27229514
GO:0016485	Process	Protein processing	TAS	21768085
GO:0016787	Function	Hydrolase activity	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030574	Process	Collagen catabolic process	IBA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035988	Process	Chondrocyte proliferation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048701	Process	Embryonic cranial skeleton morphogenesis	IEA
GO:0060348	Process	Bone development	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IDA	24970228
GO:0070006	Function	Metalloaminopeptidase activity	TAS	14645246
GO:0097094	Process	Craniofacial suture morphogenesis	IEA

MIM	HGNC	e!Ensembl
602262	7162	ENSG00000156103

P51512

Protein name

Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)

Protein function

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also coll

PDB

1RM8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01471	PG_binding_1	38 → 96	Putative peptidoglycan binding domain	Domain
PF00413	Peptidase_M10	126 → 291	Matrixin	Domain
PF00045	Hemopexin	349 → 390	Hemopexin	Repeat
PF00045	Hemopexin	392 → 436	Hemopexin	Repeat
PF00045	Hemopexin	439 → 485	Hemopexin	Repeat
PF00045	Hemopexin	487 → 532	Hemopexin	Repeat
PF11857	DUF3377	537 → 607	Domain of unknown function (DUF3377)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Sequence

MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ
PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW
KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK
EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK
RSMQEWV

Sequence length

607

Interactions

View interactions

	KEGG		Reactome
	Parathyroid hormone synthesis, secretion and action MicroRNAs in cancer		Activation of Matrix Metalloproteinases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANOREXIA NERVOSA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (72)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	BEFREE	26002729		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Clear Cell	Adenocarcinoma	BEFREE	10458406		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Valve Stenosis	Aortic valve stenosis	Pubtator	33129260	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	10857781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	34448644	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	10027400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	10027400	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	33129260	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	26596365		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bladder Neoplasm	Bladder Neoplasm	BEFREE	25017509		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30468477	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	BEFREE	18784838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	LHGDN	18784838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	27292876	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34730679	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	25017509		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	32572898	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Child Development Disorders, Pervasive	Development Disorder	GWASCAT_DG	28540026		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	32813775	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26002729, 28422174		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28422174	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dental Caries	Dental caries	Pubtator	32398053	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dupuytren Contracture	Dupuytren contracture	Pubtator	23554969	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	28871006	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	27292876	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	10027400, 23796692		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	23796692		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31385537		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	31385537	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	29351188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	29351188	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	29351188	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral Disc Degeneration	BEFREE	27227700		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	17419254		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26069248, 29069779		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	27292876	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gastrointestinal tract	Malignant gastrointestinal tract tumors	BEFREE	18204780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	29953617		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	31515968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23593148, 28039167, 28927056, 30874288		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	16651426		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	25017509		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28927056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	22164270	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	28796414	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	BEFREE	26231841		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	Pubtator	26231841	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine with Aura	Migraine with Aura	BEFREE	25388962		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10027400, 12174360, 27292876, 29069779		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28775790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	14730609	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	26605780, 30936722, 31043859		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	26605780	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	31515968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31515968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23593148, 28039167, 28927056, 30874288		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	28927056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30874288	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	29953617		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	10458406		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	10857781		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASDB_DG	21791550		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	26198764, 28540026, 28991256, 29483656, 30285260		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	26596365, 29373732		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Septicemia	Septicemia	BEFREE	25000179		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	24755270	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	27292876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	36941602	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	12174360, 22677901, 27340864	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tongue Neoplasms	Tongue cancer	Pubtator	28939077	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	32317088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	34587931	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MMP16 (matrix metallopeptidase 16)