MMP8 (matrix metallopeptidase 8)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4317
Gene name Matrix metallopeptidase 8
Gene symbol MMP8
Synonyms (NCBI Gene)
CLG1HNCMMP-8PMNL-CL
Chromosome 11
Chromosome location 11q22.2
Summary This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such
miRNA miRNA information provided by mirtarbase database.
33
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (33)
miRTarBase ID miRNA Experiments Reference
MIRT028875 hsa-miR-26b-5p Microarray 19088304
MIRT1153518 hsa-miR-1237 CLIP-seq
MIRT1153519 hsa-miR-1248 CLIP-seq
MIRT1153520 hsa-miR-1343 CLIP-seq
MIRT1153521 hsa-miR-3124-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (40)
GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IEA
GO:0004175 Function Endopeptidase activity IMP 25049354
GO:0004222 Function Metalloendopeptidase activity IBA
GO:0004222 Function Metalloendopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
120355 7175 ENSG00000118113
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P22894
Protein name Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
Protein function Can degrade fibrillar type I, II, and III collagens.
PDB 1A85 , 1A86 , 1BZS , 1I73 , 1I76 , 1JAN , 1JAO , 1JAP , 1JAQ , 1JH1 , 1JJ9 , 1KBC , 1MMB , 1MNC , 1ZP5 , 1ZS0 , 1ZVX , 2OY2 , 2OY4 , 3DNG , 3DPE , 3DPF , 3TT4 , 4QKZ , 5H8X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 26 → 86 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 107 → 262 Matrixin Domain
PF00045 Hemopexin 285 → 327 Hemopexin Repeat
PF00045 Hemopexin 329 → 372 Hemopexin Repeat
PF00045 Hemopexin 377 → 422 Hemopexin Repeat
Tissue specificity TISSUE SPECIFICITY: Neutrophils.
Sequence
Sequence length 467
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (13)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CAROTID ARTERY DISEASES — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONTACT DERMATITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DERMATITIS, CONTACT — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (209)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 28278213
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 22292754
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 27171278
★★★★★
★☆☆☆☆
Found in Text Mining only
Aggressive Periodontitis Aggressive Periodontitis BEFREE 22092455, 28753101
★★★★★
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 30170451
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Aortic aneurysm Pubtator 14522424, 17322367 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Aortic aneurysm Pubtator 16432074, 28209269 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 16432074, 28209269
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm LHGDN 16432074
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Ruptured Aortic Aneurysm BEFREE 16432074
★★★★★
★☆☆☆☆
Found in Text Mining only