MMP7 (matrix metallopeptidase 7)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4316
Gene name Matrix metallopeptidase 7
Gene symbol MMP7
Synonyms (NCBI Gene)
MMP-7MPSL1PUMP-1
Chromosome 11
Chromosome location 11q22.2
Summary This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT007268 hsa-miR-126-5p Luciferase reporter assay 23437250
MIRT007268 hsa-miR-126-5p Luciferase reporter assay 23437250
MIRT007269 hsa-miR-126-3p Luciferase reporter assay 23437250
MIRT007269 hsa-miR-126-3p Luciferase reporter assay 23437250
MIRT052917 hsa-miR-148a-3p In situ hybridizationMicroarrayqRT-PCRWestern blot 24283384
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CTNNB1 Activation 11158322;15000152
ETV4 Activation 11158322
ETV4 Unknown 12851697
FOS Unknown 11774399
FOXA2 Activation 22268124
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002779 Process Antibacterial peptide secretion IEA
GO:0002780 Process Antibacterial peptide biosynthetic process IEA
GO:0004175 Function Endopeptidase activity IDA 23845380
GO:0004175 Function Endopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
178990 7174 ENSG00000137673
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09237
Protein name Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)
Protein function Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
PDB 1MMP , 1MMQ , 1MMR , 2DDY , 2MZE , 2MZH , 2MZI , 2Y6C , 2Y6D , 5UE2 , 5UE5 , 7WXX , 8JUD , 8JUF , 8JUG , 8K4Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 28 → 82 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 103 → 259 Matrixin Domain
Sequence
Sequence length 267
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Wnt signaling pathway
Human T-cell leukemia virus 1 infection 		  Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Extra-nuclear estrogen signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (10)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Cervical cancer Uncertain significance ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder Uncertain significance ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (380)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 10713661, 11181677, 11408348, 11640889, 15930031, 17145868, 17695477, 18823373, 19596921, 23527119, 29767419, 8068180, 9137088
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 15239678
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 7945802, 8062282
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 11487270
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 15860507
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 28919743
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of prostate Prostate adenocarcinoma BEFREE 10398277, 1848860, 27375020
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma LHGDN 17029196
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 10713661, 11158322, 11713587, 19123982, 23682078, 24425843, 26398937, 8068180, 8531010, 8608568, 9290698
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma LHGDN 18500535
★★★★★
★☆☆☆☆
Found in Text Mining only