MMP3 (matrix metallopeptidase 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4314
Gene name Matrix metallopeptidase 3
Gene symbol MMP3
Synonyms (NCBI Gene)
CHDS6MMP-3SL-1STMYSTMY1STR1
Chromosome 11
Chromosome location 11q22.2
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art
miRNA miRNA information provided by mirtarbase database.
17
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (17)
miRTarBase ID miRNA Experiments Reference
MIRT021683 hsa-miR-138-5p qRT-PCR 21770894
MIRT734092 hsa-miR-18a-3p Luciferase reporter assayqRT-PCRWestern blotting 33392094
MIRT735402 hsa-miR-31-5p Luciferase reporter assayWestern blottingqRT-PCRELISA 31934214
MIRT2572209 hsa-miR-1231 CLIP-seq
MIRT2572210 hsa-miR-1267 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
11
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
ETS1 Unknown 10358095;10949659;11556732;12034715
ETS2 Unknown 10358095
FOS Unknown 9334186
JUN Activation 1429874;15777790
JUN Unknown 9334186
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0004175 Function Endopeptidase activity IDA 15863497, 19022250, 20969476
GO:0004175 Function Endopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity IBA
GO:0004222 Function Metalloendopeptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
185250 7173 ENSG00000149968
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08254
Protein name Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
Protein function Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth fact
PDB 1B3D , 1B8Y , 1BIW , 1BM6 , 1BQO , 1C3I , 1C8T , 1CAQ , 1CIZ , 1CQR , 1D5J , 1D7X , 1D8F , 1D8M , 1G05 , 1G49 , 1G4K , 1HFS , 1HY7 , 1OO9 , 1QIA , 1QIC , 1SLM , 1SLN , 1UEA , 1UMS , 1UMT , 1USN , 2D1O , 2JNP , 2JT5 , 2JT6 , 2SRT , 2USN , 3OHL , 3OHO , 3USN , 4DPE , 4G9L , 4JA1 , 6MAV , 6N9D , 7S7L , 7S7M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 27 → 87 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 108 → 264 Matrixin Domain
PF00045 Hemopexin 296 → 338 Hemopexin Repeat
PF00045 Hemopexin 340 → 383 Hemopexin Repeat
PF00045 Hemopexin 388 → 435 Hemopexin Repeat
PF00045 Hemopexin 437 → 477 Hemopexin Repeat
Sequence
Sequence length 477
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  IL-17 signaling pathway
TNF signaling pathway
Coronavirus disease - COVID-19
Transcriptional misregulation in cancer
Prostate cancer
Rheumatoid arthritis
Lipid and atherosclerosis 		  Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by Gastrin
Interleukin-4 and Interleukin-13 signaling
Extra-nuclear estrogen signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (33)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTERIOSCLEROSIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, EXPERIMENTAL — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (518)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Actinic keratosis Actinic keratosis BEFREE 10362121
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 17027562, 23377317, 29044936
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 15319302, 1848860
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 29761931
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 19321798
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of prostate Prostate adenocarcinoma BEFREE 1848860
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma LHGDN 17125518
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 17125518
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 19728161
★★★★★
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 24079541
★★★★★
★☆☆☆☆
Found in Text Mining only