Gene Gene information from NCBI Gene database.
Entrez ID 4267
Gene name CD99 molecule (Xg blood group)
Gene symbol CD99
Synonyms (NCBI Gene)
HBA71MIC2MIC2XMIC2YMSK5X
Chromosome X|Y
Chromosome location X;Y
Summary The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may
miRNA miRNA information provided by mirtarbase database.
892
miRTarBase ID miRNA Experiments Reference
MIRT051929 hsa-let-7b-5p CLASH 23622248
MIRT040346 hsa-miR-615-3p CLASH 23622248
MIRT036971 hsa-miR-877-3p CLASH 23622248
MIRT036971 hsa-miR-877-3p CLASH 23622248
MIRT438620 hsa-miR-30a-5p Luciferase reporter assayqRT-PCRWestern blot 22986530
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Activation 17473187
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20374249
GO:0005737 Component Cytoplasm TAS 2479542
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane TAS 2465491
GO:0005925 Component Focal adhesion HDA 21423176
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
313470 N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14209
Protein name CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)
Protein function Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but
PDB 7SFX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12301 CD99L2 33 181 CD99 antigen like protein 2 Family
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules
Leukocyte transendothelial migration
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CD99 Positive Neoplastic Cells Present Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHONDROSARCOMA, MESENCHYMAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 27002769, 30484860
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 12172043, 17473187
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 12172043
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 26000982
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 11304041
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 12172043
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28886485
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 1867320, 23737970, 30845661 Associate
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 24797829, 30845661
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 28886485
★☆☆☆☆
Found in Text Mining only