Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4200
Gene name	Malic enzyme 2
Gene symbol	ME2
Synonyms (NCBI Gene)	ODS1
Chromosome	18
Chromosome location	18q21.2
Summary	This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been s

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Show/Hide all (313)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049487	hsa-miR-92a-3p	CLASH	23622248
MIRT1139632	hsa-miR-1228	CLIP-seq
MIRT1139633	hsa-miR-124	CLIP-seq
MIRT1139634	hsa-miR-1247	CLIP-seq
MIRT1139635	hsa-miR-1827	CLIP-seq
MIRT1139636	hsa-miR-24	CLIP-seq
MIRT1139637	hsa-miR-2467-3p	CLIP-seq
MIRT1139638	hsa-miR-3074-5p	CLIP-seq
MIRT1139639	hsa-miR-3122	CLIP-seq
MIRT1139640	hsa-miR-3160-3p	CLIP-seq
MIRT1139641	hsa-miR-3192	CLIP-seq
MIRT1139642	hsa-miR-3202	CLIP-seq
MIRT1139643	hsa-miR-338-3p	CLIP-seq
MIRT1139644	hsa-miR-3545-5p	CLIP-seq
MIRT1139645	hsa-miR-3612	CLIP-seq
MIRT1139646	hsa-miR-3619-3p	CLIP-seq
MIRT1139647	hsa-miR-3652	CLIP-seq
MIRT1139648	hsa-miR-3675-3p	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139651	hsa-miR-3714	CLIP-seq
MIRT1139652	hsa-miR-3910	CLIP-seq
MIRT1139653	hsa-miR-3913-5p	CLIP-seq
MIRT1139654	hsa-miR-3926	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT1139656	hsa-miR-3934	CLIP-seq
MIRT1139657	hsa-miR-3975	CLIP-seq
MIRT1139658	hsa-miR-4257	CLIP-seq
MIRT1139659	hsa-miR-4270	CLIP-seq
MIRT1139660	hsa-miR-4284	CLIP-seq
MIRT1139661	hsa-miR-4290	CLIP-seq
MIRT1139662	hsa-miR-4297	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT1139664	hsa-miR-4430	CLIP-seq
MIRT1139665	hsa-miR-4433	CLIP-seq
MIRT1139666	hsa-miR-4441	CLIP-seq
MIRT1139667	hsa-miR-4455	CLIP-seq
MIRT1139668	hsa-miR-4466	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT1139670	hsa-miR-4487	CLIP-seq
MIRT1139671	hsa-miR-4505	CLIP-seq
MIRT1139672	hsa-miR-4517	CLIP-seq
MIRT1139673	hsa-miR-4530	CLIP-seq
MIRT1139674	hsa-miR-4533	CLIP-seq
MIRT1139675	hsa-miR-4535	CLIP-seq
MIRT1139676	hsa-miR-4645-5p	CLIP-seq
MIRT1139677	hsa-miR-4662a-3p	CLIP-seq
MIRT1139678	hsa-miR-4673	CLIP-seq
MIRT1139679	hsa-miR-4684-5p	CLIP-seq
MIRT1139680	hsa-miR-4704-5p	CLIP-seq
MIRT1139681	hsa-miR-4722-3p	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT1139683	hsa-miR-4743	CLIP-seq
MIRT1139684	hsa-miR-4746-3p	CLIP-seq
MIRT1139685	hsa-miR-4776-5p	CLIP-seq
MIRT1139686	hsa-miR-4796-3p	CLIP-seq
MIRT1139687	hsa-miR-490-3p	CLIP-seq
MIRT1139688	hsa-miR-506	CLIP-seq
MIRT1139689	hsa-miR-520g	CLIP-seq
MIRT1139690	hsa-miR-520h	CLIP-seq
MIRT1139691	hsa-miR-541	CLIP-seq
MIRT1139692	hsa-miR-548c-3p	CLIP-seq
MIRT1139693	hsa-miR-548p	CLIP-seq
MIRT1139694	hsa-miR-548s	CLIP-seq
MIRT1139695	hsa-miR-550a	CLIP-seq
MIRT1139696	hsa-miR-558	CLIP-seq
MIRT1139697	hsa-miR-605	CLIP-seq
MIRT1139698	hsa-miR-609	CLIP-seq
MIRT1139699	hsa-miR-647	CLIP-seq
MIRT1139700	hsa-miR-650	CLIP-seq
MIRT1139701	hsa-miR-654-5p	CLIP-seq
MIRT1139702	hsa-miR-665	CLIP-seq
MIRT1139703	hsa-miR-675	CLIP-seq
MIRT1139704	hsa-miR-766	CLIP-seq
MIRT1139705	hsa-miR-873	CLIP-seq
MIRT1139706	hsa-miR-890	CLIP-seq
MIRT1139635	hsa-miR-1827	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT1139691	hsa-miR-541	CLIP-seq
MIRT1139701	hsa-miR-654-5p	CLIP-seq
MIRT2039505	hsa-miR-1293	CLIP-seq
MIRT1139637	hsa-miR-2467-3p	CLIP-seq
MIRT1139639	hsa-miR-3122	CLIP-seq
MIRT2039506	hsa-miR-3165	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139653	hsa-miR-3913-5p	CLIP-seq
MIRT1139654	hsa-miR-3926	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT2039507	hsa-miR-4483	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT1139686	hsa-miR-4796-3p	CLIP-seq
MIRT1139689	hsa-miR-520g	CLIP-seq
MIRT1139690	hsa-miR-520h	CLIP-seq
MIRT1139632	hsa-miR-1228	CLIP-seq
MIRT2269467	hsa-miR-1273e	CLIP-seq
MIRT2039505	hsa-miR-1293	CLIP-seq
MIRT2269468	hsa-miR-138	CLIP-seq
MIRT2269469	hsa-miR-146a	CLIP-seq
MIRT2269470	hsa-miR-146b-5p	CLIP-seq
MIRT1139635	hsa-miR-1827	CLIP-seq
MIRT2269471	hsa-miR-194	CLIP-seq
MIRT2269472	hsa-miR-2114	CLIP-seq
MIRT2269473	hsa-miR-224	CLIP-seq
MIRT1139636	hsa-miR-24	CLIP-seq
MIRT1139637	hsa-miR-2467-3p	CLIP-seq
MIRT1139639	hsa-miR-3122	CLIP-seq
MIRT1139640	hsa-miR-3160-3p	CLIP-seq
MIRT2039506	hsa-miR-3165	CLIP-seq
MIRT1139641	hsa-miR-3192	CLIP-seq
MIRT1139642	hsa-miR-3202	CLIP-seq
MIRT1139645	hsa-miR-3612	CLIP-seq
MIRT2269474	hsa-miR-3617	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139653	hsa-miR-3913-5p	CLIP-seq
MIRT1139654	hsa-miR-3926	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT1139658	hsa-miR-4257	CLIP-seq
MIRT1139660	hsa-miR-4284	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT2269475	hsa-miR-4456	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT2039507	hsa-miR-4483	CLIP-seq
MIRT1139670	hsa-miR-4487	CLIP-seq
MIRT1139674	hsa-miR-4533	CLIP-seq
MIRT2269476	hsa-miR-4649-3p	CLIP-seq
MIRT2269477	hsa-miR-4705	CLIP-seq
MIRT2269478	hsa-miR-4722-5p	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT2269479	hsa-miR-4768-3p	CLIP-seq
MIRT1139686	hsa-miR-4796-3p	CLIP-seq
MIRT2269480	hsa-miR-485-5p	CLIP-seq
MIRT1139687	hsa-miR-490-3p	CLIP-seq
MIRT1139689	hsa-miR-520g	CLIP-seq
MIRT1139690	hsa-miR-520h	CLIP-seq
MIRT1139691	hsa-miR-541	CLIP-seq
MIRT1139696	hsa-miR-558	CLIP-seq
MIRT2269481	hsa-miR-641	CLIP-seq
MIRT1139700	hsa-miR-650	CLIP-seq
MIRT1139701	hsa-miR-654-5p	CLIP-seq
MIRT1139704	hsa-miR-766	CLIP-seq
MIRT1139706	hsa-miR-890	CLIP-seq
MIRT2269482	hsa-miR-940	CLIP-seq
MIRT2269467	hsa-miR-1273e	CLIP-seq
MIRT2269469	hsa-miR-146a	CLIP-seq
MIRT2269470	hsa-miR-146b-5p	CLIP-seq
MIRT1139635	hsa-miR-1827	CLIP-seq
MIRT1139637	hsa-miR-2467-3p	CLIP-seq
MIRT1139640	hsa-miR-3160-3p	CLIP-seq
MIRT1139641	hsa-miR-3192	CLIP-seq
MIRT1139642	hsa-miR-3202	CLIP-seq
MIRT1139645	hsa-miR-3612	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT1139658	hsa-miR-4257	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT1139670	hsa-miR-4487	CLIP-seq
MIRT1139674	hsa-miR-4533	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT2269479	hsa-miR-4768-3p	CLIP-seq
MIRT1139687	hsa-miR-490-3p	CLIP-seq
MIRT1139691	hsa-miR-541	CLIP-seq
MIRT1139696	hsa-miR-558	CLIP-seq
MIRT1139700	hsa-miR-650	CLIP-seq
MIRT1139701	hsa-miR-654-5p	CLIP-seq
MIRT1139704	hsa-miR-766	CLIP-seq
MIRT1139634	hsa-miR-1247	CLIP-seq
MIRT2453875	hsa-miR-1268	CLIP-seq
MIRT2453876	hsa-miR-1268b	CLIP-seq
MIRT2453877	hsa-miR-1279	CLIP-seq
MIRT2453878	hsa-miR-200b	CLIP-seq
MIRT2453879	hsa-miR-200c	CLIP-seq
MIRT1139642	hsa-miR-3202	CLIP-seq
MIRT2453880	hsa-miR-3613-3p	CLIP-seq
MIRT2453881	hsa-miR-3671	CLIP-seq
MIRT1139648	hsa-miR-3675-3p	CLIP-seq
MIRT2453882	hsa-miR-371b-5p	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT2453883	hsa-miR-429	CLIP-seq
MIRT2453884	hsa-miR-4318	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT1139667	hsa-miR-4455	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT2453885	hsa-miR-4486	CLIP-seq
MIRT1139674	hsa-miR-4533	CLIP-seq
MIRT1139679	hsa-miR-4684-5p	CLIP-seq
MIRT2453886	hsa-miR-4693-5p	CLIP-seq
MIRT1139683	hsa-miR-4743	CLIP-seq
MIRT1139692	hsa-miR-548c-3p	CLIP-seq
MIRT2453887	hsa-miR-585	CLIP-seq
MIRT1139697	hsa-miR-605	CLIP-seq
MIRT1139698	hsa-miR-609	CLIP-seq
MIRT2453888	hsa-miR-892a	CLIP-seq
MIRT1139634	hsa-miR-1247	CLIP-seq
MIRT2453875	hsa-miR-1268	CLIP-seq
MIRT2453876	hsa-miR-1268b	CLIP-seq
MIRT1139648	hsa-miR-3675-3p	CLIP-seq
MIRT1139667	hsa-miR-4455	CLIP-seq
MIRT2453885	hsa-miR-4486	CLIP-seq
MIRT1139679	hsa-miR-4684-5p	CLIP-seq
MIRT1139683	hsa-miR-4743	CLIP-seq
MIRT1139692	hsa-miR-548c-3p	CLIP-seq
MIRT2453887	hsa-miR-585	CLIP-seq
MIRT1139697	hsa-miR-605	CLIP-seq
MIRT1139698	hsa-miR-609	CLIP-seq
MIRT1139634	hsa-miR-1247	CLIP-seq
MIRT2453875	hsa-miR-1268	CLIP-seq
MIRT2453876	hsa-miR-1268b	CLIP-seq
MIRT2269467	hsa-miR-1273e	CLIP-seq
MIRT2039505	hsa-miR-1293	CLIP-seq
MIRT2269469	hsa-miR-146a	CLIP-seq
MIRT2269470	hsa-miR-146b-5p	CLIP-seq
MIRT1139635	hsa-miR-1827	CLIP-seq
MIRT2269471	hsa-miR-194	CLIP-seq
MIRT2269472	hsa-miR-2114	CLIP-seq
MIRT1139637	hsa-miR-2467-3p	CLIP-seq
MIRT1139639	hsa-miR-3122	CLIP-seq
MIRT2039506	hsa-miR-3165	CLIP-seq
MIRT1139641	hsa-miR-3192	CLIP-seq
MIRT1139642	hsa-miR-3202	CLIP-seq
MIRT1139645	hsa-miR-3612	CLIP-seq
MIRT1139648	hsa-miR-3675-3p	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139653	hsa-miR-3913-5p	CLIP-seq
MIRT1139654	hsa-miR-3926	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT1139658	hsa-miR-4257	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT1139667	hsa-miR-4455	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT2039507	hsa-miR-4483	CLIP-seq
MIRT2453885	hsa-miR-4486	CLIP-seq
MIRT1139674	hsa-miR-4533	CLIP-seq
MIRT2568777	hsa-miR-4667-3p	CLIP-seq
MIRT1139679	hsa-miR-4684-5p	CLIP-seq
MIRT2269478	hsa-miR-4722-5p	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT1139683	hsa-miR-4743	CLIP-seq
MIRT2269479	hsa-miR-4768-3p	CLIP-seq
MIRT1139686	hsa-miR-4796-3p	CLIP-seq
MIRT1139687	hsa-miR-490-3p	CLIP-seq
MIRT1139689	hsa-miR-520g	CLIP-seq
MIRT1139690	hsa-miR-520h	CLIP-seq
MIRT1139691	hsa-miR-541	CLIP-seq
MIRT1139692	hsa-miR-548c-3p	CLIP-seq
MIRT1139694	hsa-miR-548s	CLIP-seq
MIRT2453887	hsa-miR-585	CLIP-seq
MIRT1139697	hsa-miR-605	CLIP-seq
MIRT1139698	hsa-miR-609	CLIP-seq
MIRT1139700	hsa-miR-650	CLIP-seq
MIRT1139701	hsa-miR-654-5p	CLIP-seq
MIRT1139704	hsa-miR-766	CLIP-seq
MIRT1139706	hsa-miR-890	CLIP-seq
MIRT2269482	hsa-miR-940	CLIP-seq
MIRT1139634	hsa-miR-1247	CLIP-seq
MIRT2453875	hsa-miR-1268	CLIP-seq
MIRT2453876	hsa-miR-1268b	CLIP-seq
MIRT2269467	hsa-miR-1273e	CLIP-seq
MIRT2039505	hsa-miR-1293	CLIP-seq
MIRT2269469	hsa-miR-146a	CLIP-seq
MIRT2269470	hsa-miR-146b-5p	CLIP-seq
MIRT1139635	hsa-miR-1827	CLIP-seq
MIRT2269472	hsa-miR-2114	CLIP-seq
MIRT1139637	hsa-miR-2467-3p	CLIP-seq
MIRT1139639	hsa-miR-3122	CLIP-seq
MIRT1139640	hsa-miR-3160-3p	CLIP-seq
MIRT2039506	hsa-miR-3165	CLIP-seq
MIRT1139641	hsa-miR-3192	CLIP-seq
MIRT1139642	hsa-miR-3202	CLIP-seq
MIRT1139645	hsa-miR-3612	CLIP-seq
MIRT2684774	hsa-miR-3622a-3p	CLIP-seq
MIRT2684775	hsa-miR-3622b-3p	CLIP-seq
MIRT1139648	hsa-miR-3675-3p	CLIP-seq
MIRT1139649	hsa-miR-3689a-3p	CLIP-seq
MIRT1139650	hsa-miR-3689c	CLIP-seq
MIRT1139653	hsa-miR-3913-5p	CLIP-seq
MIRT1139654	hsa-miR-3926	CLIP-seq
MIRT1139655	hsa-miR-3929	CLIP-seq
MIRT1139658	hsa-miR-4257	CLIP-seq
MIRT1139663	hsa-miR-4419b	CLIP-seq
MIRT1139667	hsa-miR-4455	CLIP-seq
MIRT1139669	hsa-miR-4478	CLIP-seq
MIRT2039507	hsa-miR-4483	CLIP-seq
MIRT2453885	hsa-miR-4486	CLIP-seq
MIRT1139670	hsa-miR-4487	CLIP-seq
MIRT1139674	hsa-miR-4533	CLIP-seq
MIRT1139679	hsa-miR-4684-5p	CLIP-seq
MIRT2269478	hsa-miR-4722-5p	CLIP-seq
MIRT1139682	hsa-miR-4728-5p	CLIP-seq
MIRT1139683	hsa-miR-4743	CLIP-seq
MIRT2269479	hsa-miR-4768-3p	CLIP-seq
MIRT1139686	hsa-miR-4796-3p	CLIP-seq
MIRT1139687	hsa-miR-490-3p	CLIP-seq
MIRT1139689	hsa-miR-520g	CLIP-seq
MIRT1139690	hsa-miR-520h	CLIP-seq
MIRT1139691	hsa-miR-541	CLIP-seq
MIRT1139692	hsa-miR-548c-3p	CLIP-seq
MIRT1139696	hsa-miR-558	CLIP-seq
MIRT2453887	hsa-miR-585	CLIP-seq
MIRT1139697	hsa-miR-605	CLIP-seq
MIRT1139698	hsa-miR-609	CLIP-seq
MIRT1139700	hsa-miR-650	CLIP-seq
MIRT1139701	hsa-miR-654-5p	CLIP-seq
MIRT1139706	hsa-miR-890	CLIP-seq
MIRT2269482	hsa-miR-940	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004470	Function	Malic enzyme activity	IEA
GO:0004470	Function	Malic enzyme activity	IMP	23334421
GO:0004471	Function	Malate dehydrogenase (decarboxylating) (NAD+) activity	IEA
GO:0004471	Function	Malate dehydrogenase (decarboxylating) (NAD+) activity	TAS	1993674
GO:0004473	Function	Malate dehydrogenase (decarboxylating) (NADP+) activity	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006090	Process	Pyruvate metabolic process	IBA
GO:0006108	Process	Malate metabolic process	IBA
GO:0008948	Function	Oxaloacetate decarboxylase activity	IEA
GO:0009055	Function	Electron transfer activity	TAS	1993674
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051287	Function	NAD binding	IEA
GO:1902031	Process	Regulation of NADP metabolic process	IMP	23334421

MIM	HGNC	e!Ensembl
154270	6984	ENSG00000082212

P23368

Protein name

NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)

Protein function

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.

PDB

1DO8 , 1EFK , 1EFL , 1GZ3 , 1GZ4 , 1PJ2 , 1PJ3 , 1PJ4 , 1PJL , 1QR6 , 7BSJ , 7BSK , 7BSL , 7XDE , 7XDF , 7XDG , 9AYI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00390	malic	89 → 270	Malic enzyme, N-terminal domain	Domain
PF03949	Malic_M	280 → 535	Malic enzyme, NAD binding domain	Domain

Sequence

MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIET
QDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLAC
SQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP
VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMK
AITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISK
PISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS
YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALS
NPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVIL
CNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMA
FRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE

Sequence length

584

Interactions

View interactions

	KEGG		Reactome
	Pyruvate metabolism Carbon metabolism		Citric acid cycle (TCA cycle)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (20)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ME2-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONORGANIC PSYCHOSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOTIC DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ME2 (malic enzyme 2)