MCM3 (minichromosome maintenance complex component 3)

Gene

• Entrez ID: 4172
• Gene name: Minichromosome maintenance complex component 3
• Gene symbol: MCM3
• Synonyms (NCBI Gene): HCC5, P1-MCM3, P1.h, RLFB
• Chromosome: 6
• Chromosome location: 6p12.2
• Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016314	hsa-miR-193b-3p	Microarray	20304954
MIRT023522	hsa-miR-1-3p	Proteomics	18668040
MIRT024312	hsa-miR-215-5p	Microarray	19074876
MIRT025232	hsa-miR-34a-5p	Proteomics	21566225
MIRT026151	hsa-miR-192-5p	Microarray	19074876
MIRT026151	hsa-miR-192-5p	Sequencing	20371350
MIRT028827	hsa-miR-26b-5p	Microarray	19088304
MIRT049183	hsa-miR-92a-3p	CLASH	23622248
MIRT046726	hsa-miR-222-3p	CLASH	23622248
MIRT044198	hsa-miR-99b-5p	CLASH	23622248
MIRT038726	hsa-miR-93-3p	CLASH	23622248
MIRT052696	hsa-miR-1260b	CLASH	23622248
MIRT052696	hsa-miR-1260b	CLASH	23622248
MIRT054205	hsa-miR-210-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23028679
MIRT054211	hsa-miR-147a	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23028679
MIRT054215	hsa-miR-147b	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23028679
MIRT756223	hsa-miR-4270	Luciferase reporter assay, Western blotting, qRT-PCR	38200573
MIRT1137659	hsa-miR-4313	CLIP-seq
MIRT1137660	hsa-miR-4699-3p	CLIP-seq
MIRT1137661	hsa-miR-510	CLIP-seq
MIRT1137662	hsa-miR-512-5p	CLIP-seq
MIRT1137663	hsa-miR-548k	CLIP-seq
MIRT1137664	hsa-miR-548n	CLIP-seq
MIRT1137665	hsa-miR-570	CLIP-seq
MIRT1137659	hsa-miR-4313	CLIP-seq
MIRT1137661	hsa-miR-510	CLIP-seq
MIRT1137662	hsa-miR-512-5p	CLIP-seq
MIRT1137663	hsa-miR-548k	CLIP-seq
MIRT1137664	hsa-miR-548n	CLIP-seq
MIRT2039104	hsa-miR-660	CLIP-seq
MIRT2269102	hsa-miR-1208	CLIP-seq
MIRT2269103	hsa-miR-1238	CLIP-seq
MIRT2269104	hsa-miR-1307	CLIP-seq
MIRT2269105	hsa-miR-141	CLIP-seq
MIRT2269106	hsa-miR-147	CLIP-seq
MIRT2269107	hsa-miR-200a	CLIP-seq
MIRT2269108	hsa-miR-3124-3p	CLIP-seq
MIRT2269109	hsa-miR-3153	CLIP-seq
MIRT2269110	hsa-miR-3201	CLIP-seq
MIRT2269111	hsa-miR-3911	CLIP-seq
MIRT2269112	hsa-miR-3940-5p	CLIP-seq
MIRT2269113	hsa-miR-4261	CLIP-seq
MIRT756223	hsa-miR-4270	CLIP-seq
MIRT2269114	hsa-miR-4272	CLIP-seq
MIRT2269115	hsa-miR-4279	CLIP-seq
MIRT1137659	hsa-miR-4313	CLIP-seq
MIRT2269116	hsa-miR-433	CLIP-seq
MIRT2269117	hsa-miR-4441	CLIP-seq
MIRT2269118	hsa-miR-4452	CLIP-seq
MIRT2269119	hsa-miR-4475	CLIP-seq
MIRT2269120	hsa-miR-4507	CLIP-seq
MIRT2269121	hsa-miR-4638-5p	CLIP-seq
MIRT2269122	hsa-miR-4668-5p	CLIP-seq
MIRT1137660	hsa-miR-4699-3p	CLIP-seq
MIRT2269123	hsa-miR-4782-5p	CLIP-seq
MIRT2269124	hsa-miR-4791	CLIP-seq
MIRT1137661	hsa-miR-510	CLIP-seq
MIRT1137662	hsa-miR-512-5p	CLIP-seq
MIRT2269125	hsa-miR-543	CLIP-seq
MIRT1137663	hsa-miR-548k	CLIP-seq
MIRT1137664	hsa-miR-548n	CLIP-seq
MIRT2269126	hsa-miR-548u	CLIP-seq
MIRT1137665	hsa-miR-570	CLIP-seq
MIRT2269127	hsa-miR-599	CLIP-seq
MIRT2269128	hsa-miR-629	CLIP-seq
MIRT2269129	hsa-miR-644	CLIP-seq
MIRT2269130	hsa-miR-664	CLIP-seq
MIRT2269131	hsa-miR-885-3p	CLIP-seq
MIRT2390710	hsa-miR-106a	CLIP-seq
MIRT2390711	hsa-miR-106b	CLIP-seq
MIRT2390712	hsa-miR-17	CLIP-seq
MIRT2390713	hsa-miR-20a	CLIP-seq
MIRT2390714	hsa-miR-20b	CLIP-seq
MIRT2390715	hsa-miR-302a	CLIP-seq
MIRT2390716	hsa-miR-302b	CLIP-seq
MIRT2390717	hsa-miR-302c	CLIP-seq
MIRT2390718	hsa-miR-302d	CLIP-seq
MIRT2390719	hsa-miR-302e	CLIP-seq
MIRT2390720	hsa-miR-3194-3p	CLIP-seq
MIRT2390721	hsa-miR-372	CLIP-seq
MIRT2390722	hsa-miR-373	CLIP-seq
MIRT2390723	hsa-miR-4434	CLIP-seq
MIRT2390724	hsa-miR-4516	CLIP-seq
MIRT2390725	hsa-miR-4531	CLIP-seq
MIRT2390726	hsa-miR-516b	CLIP-seq
MIRT2390727	hsa-miR-519d	CLIP-seq
MIRT2390728	hsa-miR-520a-3p	CLIP-seq
MIRT2390729	hsa-miR-520b	CLIP-seq
MIRT2390730	hsa-miR-520c-3p	CLIP-seq
MIRT2390731	hsa-miR-520d-3p	CLIP-seq
MIRT2390732	hsa-miR-520e	CLIP-seq
MIRT2390733	hsa-miR-520g	CLIP-seq
MIRT2390734	hsa-miR-520h	CLIP-seq
MIRT2390735	hsa-miR-93	CLIP-seq
MIRT2269103	hsa-miR-1238	CLIP-seq
MIRT2568374	hsa-miR-217	CLIP-seq
MIRT2269108	hsa-miR-3124-3p	CLIP-seq
MIRT2568375	hsa-miR-3140-5p	CLIP-seq
MIRT2568376	hsa-miR-338-5p	CLIP-seq
MIRT2568377	hsa-miR-3907	CLIP-seq
MIRT2269115	hsa-miR-4279	CLIP-seq
MIRT2568378	hsa-miR-4418	CLIP-seq
MIRT2269118	hsa-miR-4452	CLIP-seq
MIRT2568379	hsa-miR-4539	CLIP-seq
MIRT2568380	hsa-miR-4666-3p	CLIP-seq
MIRT2568381	hsa-miR-4680-5p	CLIP-seq
MIRT2568382	hsa-miR-509-3-5p	CLIP-seq
MIRT2568383	hsa-miR-509-5p	CLIP-seq
MIRT1137662	hsa-miR-512-5p	CLIP-seq
MIRT2568384	hsa-miR-518a-5p	CLIP-seq
MIRT2568385	hsa-miR-527	CLIP-seq
MIRT2269125	hsa-miR-543	CLIP-seq
MIRT2568386	hsa-miR-548q	CLIP-seq
MIRT2568387	hsa-miR-582-3p	CLIP-seq
MIRT2039104	hsa-miR-660	CLIP-seq
MIRT2269131	hsa-miR-885-3p	CLIP-seq
MIRT2269103	hsa-miR-1238	CLIP-seq
MIRT2269108	hsa-miR-3124-3p	CLIP-seq
MIRT2568375	hsa-miR-3140-5p	CLIP-seq
MIRT2269115	hsa-miR-4279	CLIP-seq
MIRT2269116	hsa-miR-433	CLIP-seq
MIRT2568379	hsa-miR-4539	CLIP-seq
MIRT2568381	hsa-miR-4680-5p	CLIP-seq
MIRT1137662	hsa-miR-512-5p	CLIP-seq
MIRT2269125	hsa-miR-543	CLIP-seq
MIRT2039104	hsa-miR-660	CLIP-seq
MIRT2269131	hsa-miR-885-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYCN	Activation	17826980

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000727	Process	Double-strand break repair via break-induced replication	IBA
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	1549468
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	12364596, 15232106, 16899510, 17296731, 19150984, 19862764, 22540012, 24299456, 25036637, 26167883, 26496610, 28514442, 29395061, 31467278, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20531406, 21383955, 22474384
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005658	Component	Alpha DNA polymerase:primase complex	TAS	1549468
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA	21383955
GO:0005737	Component	Cytoplasm	IEA
GO:0006260	Process	DNA replication	IDA	22474384
GO:0006260	Process	DNA replication	IEA
GO:0006270	Process	DNA replication initiation	IEA
GO:0006270	Process	DNA replication initiation	TAS	1549468
GO:0006271	Process	DNA strand elongation involved in DNA replication	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017116	Function	Single-stranded DNA helicase activity	IBA
GO:0030174	Process	Regulation of DNA-templated DNA replication initiation	NAS	30069701
GO:0042555	Component	MCM complex	IBA
GO:0042555	Component	MCM complex	IDA	17296731
GO:0042555	Component	MCM complex	IEA
GO:0042555	Component	MCM complex	IPI	22540012
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	20531406
GO:0071162	Component	CMG complex	IPI	22474384
GO:0071162	Component	CMG complex	ISS
GO:1902975	Process	Mitotic DNA replication initiation	IBA

Other IDs

• MIM: 602693
• HGNC: 6945
• e!Ensembl: ENSG00000112118

Protein

• UniProt ID: P25205
• Protein name: DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
• Protein function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the mol
• PDB: 6XTX, 6XTY, 7PFO, 7PLO, 7W1Y, 7W68, 8B9D, 8RWV, 8S09, 8S0A, 8S0B, 8S0D, 8S0E, 8S0F, 8W0E, 8W0F, 8W0G, 8W0I, 9CAQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14551	MCM_N	13 → 158	MCM N-terminal domain	Domain
  PF17207	MCM_OB	110 → 245	MCM OB domain	Domain
  PF00493	MCM	280 → 505	MCM P-loop domain	Domain
  PF17855	MCM_lid	566 → 653	MCM AAA-lid domain	Domain

• Sequence:

  MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEK
  RANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCF
  LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE
  NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT
  YRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLA
  KSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLC
  TAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRT
  AIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFD
  LLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQ
  DTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQ
  DSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEK
  EKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQV
  HTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPF
  SSVEIQAALSKMQDDNQVMVSEGIIFLI

• Sequence length: 808

Pathways

KEGG:

DNA replication
Cell cycle

Reactome:

Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Meier-Gorlin syndrome	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL ARTERIAL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adrenal Cortical Adenoma	Adrenocortical adenoma	BEFREE	30842144		★☆☆☆☆ Found in Text Mining only
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	30413320	Associate	★☆☆☆☆ Found in Text Mining only
Adrenocortical carcinoma	Adrenocortical carcinoma	BEFREE	30842144		★☆☆☆☆ Found in Text Mining only
Adult Medulloblastoma	Medulloblastoma	BEFREE	20661220		★☆☆☆☆ Found in Text Mining only
Ameloblastoma	Ameloblastoma	Pubtator	26823641	Associate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	28087520		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	25046975	Stimulate	★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	25809478	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	28087520		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	31142669		★☆☆☆☆ Found in Text Mining only
Autosomal Recessive Polycystic Kidney Disease	Polycystic kidney disease	BEFREE	10780780		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	23098454		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	LHGDN	15671553		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23098454	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	20648010, 24386425, 38200573, 39766782	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	15623617		★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	Pubtator	28547962	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Adenoid Cystic	Adenoid cystic carcinoma	Pubtator	23886132, 26790448	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30363964	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31737652, 32213663, 32964028	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Mucoepidermoid	Mucoepidermoid carcinoma	Pubtator	23886132	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Mucoepidermoid	Mucoepidermoid carcinoma	Pubtator	26790448	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37464398	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	36445337	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31703725		★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	20661220		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30937307, 31949199	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37218575	Inhibit	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	31186514		★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	BEFREE	20177751		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30150789		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	38200573	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	25046975		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	25046975	Associate	★☆☆☆☆ Found in Text Mining only
Glomerulosclerosis (disorder)	Glomerulosclerosis	BEFREE	30150789		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	14511370	Associate	★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	34449552	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	15623617		★☆☆☆☆ Found in Text Mining only
Lipodystrophy	Lipodystrophy	Pubtator	33654309	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30363964, 31208444		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35360518	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24386425	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31703725		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28424404		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15623617, 30413320, 31142669		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	20661220		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	15623617		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	22805320	Associate	★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	19877719		★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	19877719	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15623617, 20177751, 25046975, 26790448, 27258565, 28493257, 30363964		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	24348903, 33277872	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	BEFREE	31703725		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22805320, 31703725, 34782936	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	27695057, 39310930	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	23821456		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28424404		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	31186514		★☆☆☆☆ Found in Text Mining only
Salivary Gland Neoplasms	Salivary gland neoplasms	Pubtator	23886132	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	10953354		★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	29845250	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	27258565		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	24386425	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	23821456	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	37864896	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	18414413	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34671420, 37445651	Associate	★☆☆☆☆ Found in Text Mining only