MAN2A2 (mannosidase alpha class 2A member 2)

Gene

• Entrez ID: 4122
• Gene name: Mannosidase alpha class 2A member 2
• Gene symbol: MAN2A2
• Synonyms (NCBI Gene): MANA2X, alpha-MIIx
• Chromosome: 15
• Chromosome location: 15q26.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024425	hsa-miR-215-5p	Microarray	19074876
MIRT026963	hsa-miR-192-5p	Microarray	19074876
MIRT042114	hsa-miR-484	CLASH	23622248
MIRT679229	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT679228	hsa-miR-1245a	HITS-CLIP	23824327
MIRT679227	hsa-miR-8079	HITS-CLIP	23824327
MIRT679226	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT679225	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT679224	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679223	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679222	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679221	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679220	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679219	hsa-miR-6131	HITS-CLIP	23824327
MIRT679218	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679217	hsa-miR-640	HITS-CLIP	23824327
MIRT679216	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679215	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT569475	hsa-miR-6816-3p	PAR-CLIP	20371350
MIRT569474	hsa-miR-6801-3p	PAR-CLIP	20371350
MIRT569473	hsa-miR-6810-3p	PAR-CLIP	20371350
MIRT569472	hsa-miR-6752-3p	PAR-CLIP	20371350
MIRT569471	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT569470	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT569469	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT569468	hsa-miR-4715-3p	PAR-CLIP	20371350
MIRT679229	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT679228	hsa-miR-1245a	HITS-CLIP	23824327
MIRT679227	hsa-miR-8079	HITS-CLIP	23824327
MIRT679226	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT679225	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT679224	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679223	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679222	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679221	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679220	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679219	hsa-miR-6131	HITS-CLIP	23824327
MIRT679218	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679217	hsa-miR-640	HITS-CLIP	23824327
MIRT679216	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679215	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT569475	hsa-miR-6816-3p	PAR-CLIP	20371350
MIRT569474	hsa-miR-6801-3p	PAR-CLIP	20371350
MIRT569473	hsa-miR-6810-3p	PAR-CLIP	20371350
MIRT569472	hsa-miR-6752-3p	PAR-CLIP	20371350
MIRT569471	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT569470	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT569469	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT569468	hsa-miR-4715-3p	PAR-CLIP	20371350
MIRT1127268	hsa-let-7a	CLIP-seq
MIRT1127269	hsa-let-7b	CLIP-seq
MIRT1127270	hsa-let-7c	CLIP-seq
MIRT1127271	hsa-let-7d	CLIP-seq
MIRT1127272	hsa-let-7e	CLIP-seq
MIRT1127273	hsa-let-7f	CLIP-seq
MIRT1127274	hsa-let-7g	CLIP-seq
MIRT1127275	hsa-let-7i	CLIP-seq
MIRT1127276	hsa-miR-100	CLIP-seq
MIRT1127277	hsa-miR-106a	CLIP-seq
MIRT1127278	hsa-miR-106b	CLIP-seq
MIRT1127279	hsa-miR-1245	CLIP-seq
MIRT1127280	hsa-miR-1252	CLIP-seq
MIRT1127281	hsa-miR-1294	CLIP-seq
MIRT1127282	hsa-miR-150	CLIP-seq
MIRT1127283	hsa-miR-15a	CLIP-seq
MIRT1127284	hsa-miR-15b	CLIP-seq
MIRT1127285	hsa-miR-16	CLIP-seq
MIRT1127286	hsa-miR-17	CLIP-seq
MIRT1127287	hsa-miR-1827	CLIP-seq
MIRT1127288	hsa-miR-195	CLIP-seq
MIRT1127289	hsa-miR-202	CLIP-seq
MIRT1127290	hsa-miR-20a	CLIP-seq
MIRT1127291	hsa-miR-20b	CLIP-seq
MIRT1127292	hsa-miR-2682	CLIP-seq
MIRT1127293	hsa-miR-297	CLIP-seq
MIRT1127294	hsa-miR-3124-3p	CLIP-seq
MIRT1127295	hsa-miR-3126-3p	CLIP-seq
MIRT1127296	hsa-miR-3149	CLIP-seq
MIRT1127297	hsa-miR-3180-5p	CLIP-seq
MIRT1127298	hsa-miR-3188	CLIP-seq
MIRT1127299	hsa-miR-3192	CLIP-seq
MIRT1127300	hsa-miR-3195	CLIP-seq
MIRT1127301	hsa-miR-3612	CLIP-seq
MIRT1127302	hsa-miR-3689a-3p	CLIP-seq
MIRT1127303	hsa-miR-3689c	CLIP-seq
MIRT1127304	hsa-miR-371-3p	CLIP-seq
MIRT1127305	hsa-miR-374a	CLIP-seq
MIRT1127306	hsa-miR-374b	CLIP-seq
MIRT1127307	hsa-miR-3927	CLIP-seq
MIRT1127308	hsa-miR-3940-5p	CLIP-seq
MIRT1127309	hsa-miR-3942-5p	CLIP-seq
MIRT1127310	hsa-miR-424	CLIP-seq
MIRT1127311	hsa-miR-4265	CLIP-seq
MIRT1127312	hsa-miR-4277	CLIP-seq
MIRT1127313	hsa-miR-4294	CLIP-seq
MIRT1127314	hsa-miR-4296	CLIP-seq
MIRT1127315	hsa-miR-4314	CLIP-seq
MIRT1127316	hsa-miR-4316	CLIP-seq
MIRT1127317	hsa-miR-432	CLIP-seq
MIRT1127318	hsa-miR-4322	CLIP-seq
MIRT1127319	hsa-miR-4326	CLIP-seq
MIRT1127320	hsa-miR-4443	CLIP-seq
MIRT1127321	hsa-miR-4451	CLIP-seq
MIRT1127322	hsa-miR-4458	CLIP-seq
MIRT1127323	hsa-miR-4474-3p	CLIP-seq
MIRT1127324	hsa-miR-449c	CLIP-seq
MIRT1127325	hsa-miR-4500	CLIP-seq
MIRT1127326	hsa-miR-4507	CLIP-seq
MIRT1127327	hsa-miR-4646-5p	CLIP-seq
MIRT1127328	hsa-miR-4677-3p	CLIP-seq
MIRT1127329	hsa-miR-4679	CLIP-seq
MIRT1127330	hsa-miR-4703-5p	CLIP-seq
MIRT1127331	hsa-miR-4728-5p	CLIP-seq
MIRT1127332	hsa-miR-4757-5p	CLIP-seq
MIRT1127333	hsa-miR-497	CLIP-seq
MIRT1127334	hsa-miR-519d	CLIP-seq
MIRT1127335	hsa-miR-520a-5p	CLIP-seq
MIRT1127336	hsa-miR-520g	CLIP-seq
MIRT1127337	hsa-miR-520h	CLIP-seq
MIRT1127338	hsa-miR-525-5p	CLIP-seq
MIRT1127339	hsa-miR-570	CLIP-seq
MIRT1127340	hsa-miR-593	CLIP-seq
MIRT1127341	hsa-miR-644	CLIP-seq
MIRT1127342	hsa-miR-650	CLIP-seq
MIRT1127343	hsa-miR-924	CLIP-seq
MIRT1127344	hsa-miR-93	CLIP-seq
MIRT1127345	hsa-miR-98	CLIP-seq
MIRT1127346	hsa-miR-99a	CLIP-seq
MIRT1127347	hsa-miR-99b	CLIP-seq
MIRT1127277	hsa-miR-106a	CLIP-seq
MIRT1127278	hsa-miR-106b	CLIP-seq
MIRT2036063	hsa-miR-1207-5p	CLIP-seq
MIRT1127280	hsa-miR-1252	CLIP-seq
MIRT2036064	hsa-miR-128	CLIP-seq
MIRT1127282	hsa-miR-150	CLIP-seq
MIRT1127286	hsa-miR-17	CLIP-seq
MIRT1127290	hsa-miR-20a	CLIP-seq
MIRT1127291	hsa-miR-20b	CLIP-seq
MIRT2036065	hsa-miR-3064-3p	CLIP-seq
MIRT1127295	hsa-miR-3126-3p	CLIP-seq
MIRT2036066	hsa-miR-3128	CLIP-seq
MIRT2036067	hsa-miR-3622b-5p	CLIP-seq
MIRT1127304	hsa-miR-371-3p	CLIP-seq
MIRT1127305	hsa-miR-374a	CLIP-seq
MIRT1127306	hsa-miR-374b	CLIP-seq
MIRT2036068	hsa-miR-3976	CLIP-seq
MIRT1127319	hsa-miR-4326	CLIP-seq
MIRT1127323	hsa-miR-4474-3p	CLIP-seq
MIRT2036069	hsa-miR-4717-5p	CLIP-seq
MIRT2036070	hsa-miR-4720-5p	CLIP-seq
MIRT2036071	hsa-miR-4736	CLIP-seq
MIRT1127332	hsa-miR-4757-5p	CLIP-seq
MIRT2036072	hsa-miR-4763-3p	CLIP-seq
MIRT2036073	hsa-miR-4777-5p	CLIP-seq
MIRT2036074	hsa-miR-4799-3p	CLIP-seq
MIRT1127334	hsa-miR-519d	CLIP-seq
MIRT1127336	hsa-miR-520g	CLIP-seq
MIRT1127337	hsa-miR-520h	CLIP-seq
MIRT1127341	hsa-miR-644	CLIP-seq
MIRT1127344	hsa-miR-93	CLIP-seq
MIRT2036075	hsa-miR-940	CLIP-seq
MIRT2036063	hsa-miR-1207-5p	CLIP-seq
MIRT2266389	hsa-miR-122	CLIP-seq
MIRT2266390	hsa-miR-1244	CLIP-seq
MIRT2266391	hsa-miR-149	CLIP-seq
MIRT2266392	hsa-miR-1909	CLIP-seq
MIRT2266393	hsa-miR-3064-5p	CLIP-seq
MIRT1127295	hsa-miR-3126-3p	CLIP-seq
MIRT2036066	hsa-miR-3128	CLIP-seq
MIRT2266394	hsa-miR-3135b	CLIP-seq
MIRT2036067	hsa-miR-3622b-5p	CLIP-seq
MIRT2266395	hsa-miR-3652	CLIP-seq
MIRT1127304	hsa-miR-371-3p	CLIP-seq
MIRT2266396	hsa-miR-371b-3p	CLIP-seq
MIRT2266397	hsa-miR-411	CLIP-seq
MIRT1127319	hsa-miR-4326	CLIP-seq
MIRT2266398	hsa-miR-4430	CLIP-seq
MIRT2266399	hsa-miR-4684-3p	CLIP-seq
MIRT2266400	hsa-miR-4687-3p	CLIP-seq
MIRT2036070	hsa-miR-4720-5p	CLIP-seq
MIRT2036071	hsa-miR-4736	CLIP-seq
MIRT1127332	hsa-miR-4757-5p	CLIP-seq
MIRT2036072	hsa-miR-4763-3p	CLIP-seq
MIRT2266401	hsa-miR-4794	CLIP-seq
MIRT2036074	hsa-miR-4799-3p	CLIP-seq
MIRT2266402	hsa-miR-515-3p	CLIP-seq
MIRT2266403	hsa-miR-519e	CLIP-seq
MIRT2266404	hsa-miR-587	CLIP-seq
MIRT2266405	hsa-miR-647	CLIP-seq
MIRT2453640	hsa-miR-147	CLIP-seq
MIRT2453641	hsa-miR-3911	CLIP-seq
MIRT1127341	hsa-miR-644	CLIP-seq
MIRT2453642	hsa-miR-663b	CLIP-seq
MIRT2453643	hsa-miR-892a	CLIP-seq
MIRT2565687	hsa-miR-1184	CLIP-seq
MIRT2565688	hsa-miR-1202	CLIP-seq
MIRT2565689	hsa-miR-1205	CLIP-seq
MIRT2565690	hsa-miR-1251	CLIP-seq
MIRT2565691	hsa-miR-1343	CLIP-seq
MIRT2565692	hsa-miR-188-3p	CLIP-seq
MIRT2565693	hsa-miR-193a-5p	CLIP-seq
MIRT2565694	hsa-miR-1972	CLIP-seq
MIRT2565695	hsa-miR-216b	CLIP-seq
MIRT2565696	hsa-miR-3074-5p	CLIP-seq
MIRT1127294	hsa-miR-3124-3p	CLIP-seq
MIRT2565697	hsa-miR-3158-5p	CLIP-seq
MIRT1127297	hsa-miR-3180-5p	CLIP-seq
MIRT2565698	hsa-miR-3667-3p	CLIP-seq
MIRT2565699	hsa-miR-3675-3p	CLIP-seq
MIRT2266396	hsa-miR-371b-3p	CLIP-seq
MIRT2565700	hsa-miR-376c	CLIP-seq
MIRT2565701	hsa-miR-3937	CLIP-seq
MIRT2565702	hsa-miR-3972	CLIP-seq
MIRT2565703	hsa-miR-431	CLIP-seq
MIRT2565704	hsa-miR-4480	CLIP-seq
MIRT2565705	hsa-miR-4662a-5p	CLIP-seq
MIRT2036069	hsa-miR-4717-5p	CLIP-seq
MIRT2565706	hsa-miR-4719	CLIP-seq
MIRT2565707	hsa-miR-4769-3p	CLIP-seq
MIRT2565708	hsa-miR-4775	CLIP-seq
MIRT2565709	hsa-miR-4776-3p	CLIP-seq
MIRT2036073	hsa-miR-4777-5p	CLIP-seq
MIRT2266401	hsa-miR-4794	CLIP-seq
MIRT2565710	hsa-miR-494	CLIP-seq
MIRT2565711	hsa-miR-499a-5p	CLIP-seq
MIRT1127335	hsa-miR-520a-5p	CLIP-seq
MIRT1127338	hsa-miR-525-5p	CLIP-seq
MIRT2565712	hsa-miR-544	CLIP-seq
MIRT2565713	hsa-miR-609	CLIP-seq
MIRT2565690	hsa-miR-1251	CLIP-seq
MIRT2565695	hsa-miR-216b	CLIP-seq
MIRT2565699	hsa-miR-3675-3p	CLIP-seq
MIRT2036073	hsa-miR-4777-5p	CLIP-seq
MIRT2565710	hsa-miR-494	CLIP-seq
MIRT2565713	hsa-miR-609	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0003824	Function	Catalytic activity	IEA
GO:0004559	Function	Alpha-mannosidase activity	IBA
GO:0004559	Function	Alpha-mannosidase activity	IEA
GO:0004572	Function	Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005794	Component	Golgi apparatus	IEA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006013	Process	Mannose metabolic process	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006491	Process	N-glycan processing	IBA
GO:0015923	Function	Mannosidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0016799	Function	Hydrolase activity, hydrolyzing N-glycosyl compounds	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 600988
• HGNC: 6825
• e!Ensembl: ENSG00000196547

Protein

• UniProt ID: P49641
• Protein name: Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)
• Protein function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01074	Glyco_hydro_38N	167 → 497	Glycosyl hydrolases family 38 N-terminal domain	Domain
  PF09261	Alpha-mann_mid	502 → 606	Alpha mannosidase middle domain	Domain
  PF07748	Glyco_hydro_38C	765 → 970	Glycosyl hydrolases family 38 C-terminal domain	Domain

• Sequence:

  MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQL
  LEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFAL
  GGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGW
  IKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGN
  GQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYL
  LRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTC
  GPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL
  VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPG
  ARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHAR
  RSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVII
  HAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQER
  FSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQL
  QLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGL
  LKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPF
  FSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFT
  DLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVIL
  DRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLN
  APALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKG
  FDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPM
  EIATFRLRLG

• Sequence length: 1150

Pathways

KEGG:

N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways

Reactome:

Intra-Golgi traffic
Reactions specific to the complex N-glycan synthesis pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Aganglionic megacolon	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL DISORDER OF GLYCOSYLATION	—	ClinGen	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISORDER OF GLYCOSYLATION	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HIRSCHSPRUNG DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	GWASDB_DG	18839057		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	GWASCAT_DG	18839057		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	33141432	Associate	★☆☆☆☆ Found in Text Mining only
Chronobiology Disorders	Chronobiology disorder	Pubtator	35163208	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	17986135	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	33836805	Associate	★☆☆☆☆ Found in Text Mining only