Gene Gene information from NCBI Gene database.
Entrez ID 4082
Gene name Myristoylated alanine rich protein kinase C substrate
Gene symbol MARCKS
Synonyms (NCBI Gene)
80K-LMACSPKCSLPRKCSL
Chromosome 6
Chromosome location 6q21
Summary The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with
miRNA miRNA information provided by mirtarbase database.
1153
miRTarBase ID miRNA Experiments Reference
MIRT001221 hsa-miR-21-5p Luciferase reporter assayWestern blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assayWestern blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assayWestern blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assay 19302977
MIRT020762 hsa-miR-155-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005080 Function Protein kinase C binding IEA
GO:0005516 Function Calmodulin binding IEA
GO:0005516 Function Calmodulin binding TAS 1560845
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
177061 6759 ENSG00000277443
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P29966
Protein name Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Protein function Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:237049
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02063 MARCKS 2 329 MARCKS family Family
Tissue specificity TISSUE SPECIFICITY: Detected in spermatozoa. {ECO:0000269|PubMed:23704996}.
Sequence
Sequence length 332
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Fc gamma R-mediated phagocytosis
MicroRNAs in cancer
  Acetylcholine regulates insulin secretion
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, RHEUMATOID CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, ADENOID CYSTIC CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIFFUSE LARGE B-CELL LYMPHOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 25884180
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 19852062, 25524703
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma CTD_human_DG 16762588
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 26963385 Associate
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 25884180
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 26963385
★☆☆☆☆
Found in Text Mining only
Allergic sensitization Allergic Sensitization BEFREE 30288821
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 15994023
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 37328865 Associate
★☆☆☆☆
Found in Text Mining only
Aneuploidy Aneuploidy Pubtator 39735979 Associate
★☆☆☆☆
Found in Text Mining only