Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	4071
Gene name	Transmembrane 4 L six family member 1
Gene symbol	TM4SF1
Synonyms (NCBI Gene)	H-L6L6M3S1TAAL6
Chromosome	3
Chromosome location	3q25.1
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022021	hsa-miR-128-3p	Microarray	17612493
MIRT698455	hsa-miR-548e-5p	HITS-CLIP	23313552
MIRT698454	hsa-miR-708-3p	HITS-CLIP	23313552
MIRT698453	hsa-miR-32-3p	HITS-CLIP	23313552
MIRT698452	hsa-miR-338-5p	HITS-CLIP	23313552
MIRT698451	hsa-miR-4640-3p	HITS-CLIP	23313552
MIRT698450	hsa-miR-1278	HITS-CLIP	23313552
MIRT698449	hsa-miR-1245a	HITS-CLIP	23313552
MIRT698448	hsa-miR-8079	HITS-CLIP	23313552
MIRT698447	hsa-miR-8062	HITS-CLIP	23313552
MIRT698446	hsa-miR-3163	HITS-CLIP	23313552
MIRT698445	hsa-miR-4666a-3p	HITS-CLIP	23313552
MIRT698444	hsa-miR-3976	HITS-CLIP	23313552
MIRT698443	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT698442	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT698441	hsa-miR-622	HITS-CLIP	23313552
MIRT698440	hsa-miR-4528	HITS-CLIP	23313552
MIRT698439	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT698438	hsa-miR-6072	HITS-CLIP	23313552
MIRT698437	hsa-miR-6891-3p	HITS-CLIP	23313552
MIRT698436	hsa-miR-4305	HITS-CLIP	23313552
MIRT698435	hsa-miR-4330	HITS-CLIP	23313552
MIRT698434	hsa-miR-4264	HITS-CLIP	23313552
MIRT698433	hsa-miR-6758-3p	HITS-CLIP	23313552
MIRT698432	hsa-miR-3607-3p	HITS-CLIP	23313552
MIRT698431	hsa-miR-6773-3p	HITS-CLIP	23313552
MIRT698430	hsa-miR-302b-5p	HITS-CLIP	23313552
MIRT698429	hsa-miR-302d-5p	HITS-CLIP	23313552
MIRT698428	hsa-miR-1911-5p	HITS-CLIP	23313552
MIRT698427	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT698426	hsa-miR-5589-3p	HITS-CLIP	23313552
MIRT698425	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT698424	hsa-miR-206	HITS-CLIP	23313552
MIRT698423	hsa-miR-613	HITS-CLIP	23313552
MIRT698422	hsa-miR-1293	HITS-CLIP	23313552
MIRT698421	hsa-miR-4483	HITS-CLIP	23313552
MIRT698420	hsa-miR-876-3p	HITS-CLIP	23313552
MIRT698419	hsa-miR-5087	HITS-CLIP	23313552
MIRT698418	hsa-miR-8068	HITS-CLIP	23313552
MIRT698417	hsa-miR-4775	HITS-CLIP	23313552
MIRT698416	hsa-miR-6798-3p	HITS-CLIP	23313552
MIRT698415	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT698414	hsa-let-7a-3p	HITS-CLIP	23313552
MIRT698413	hsa-let-7b-3p	HITS-CLIP	23313552
MIRT698412	hsa-let-7f-1-3p	HITS-CLIP	23313552
MIRT698411	hsa-miR-98-3p	HITS-CLIP	23313552
MIRT698410	hsa-miR-3686	HITS-CLIP	23313552
MIRT698409	hsa-miR-6505-5p	HITS-CLIP	23313552
MIRT466301	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT466300	hsa-miR-382-5p	PAR-CLIP	23592263
MIRT466299	hsa-miR-3529-3p	PAR-CLIP	23592263
MIRT466298	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT466297	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT466296	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT466295	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT466294	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT466293	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT466292	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT466291	hsa-miR-586	PAR-CLIP	23592263
MIRT466290	hsa-miR-5003-5p	PAR-CLIP	23592263
MIRT466289	hsa-miR-4310	PAR-CLIP	23592263
MIRT466288	hsa-miR-7157-5p	PAR-CLIP	23592263
MIRT466287	hsa-miR-4468	PAR-CLIP	23592263
MIRT466286	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT466285	hsa-miR-107	PAR-CLIP	23592263
MIRT466284	hsa-miR-8070	PAR-CLIP	23592263
MIRT439454	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439454	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT698455	hsa-miR-548e-5p	HITS-CLIP	23313552
MIRT698454	hsa-miR-708-3p	HITS-CLIP	23313552
MIRT698453	hsa-miR-32-3p	HITS-CLIP	23313552
MIRT698452	hsa-miR-338-5p	HITS-CLIP	23313552
MIRT698451	hsa-miR-4640-3p	HITS-CLIP	23313552
MIRT698450	hsa-miR-1278	HITS-CLIP	23313552
MIRT698449	hsa-miR-1245a	HITS-CLIP	23313552
MIRT698448	hsa-miR-8079	HITS-CLIP	23313552
MIRT698447	hsa-miR-8062	HITS-CLIP	23313552
MIRT698446	hsa-miR-3163	HITS-CLIP	23313552
MIRT698445	hsa-miR-4666a-3p	HITS-CLIP	23313552
MIRT698444	hsa-miR-3976	HITS-CLIP	23313552
MIRT698443	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT698442	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT698441	hsa-miR-622	HITS-CLIP	23313552
MIRT698440	hsa-miR-4528	HITS-CLIP	23313552
MIRT698439	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT698438	hsa-miR-6072	HITS-CLIP	23313552
MIRT698437	hsa-miR-6891-3p	HITS-CLIP	23313552
MIRT698436	hsa-miR-4305	HITS-CLIP	23313552
MIRT698435	hsa-miR-4330	HITS-CLIP	23313552
MIRT698434	hsa-miR-4264	HITS-CLIP	23313552
MIRT698433	hsa-miR-6758-3p	HITS-CLIP	23313552
MIRT698432	hsa-miR-3607-3p	HITS-CLIP	23313552
MIRT698431	hsa-miR-6773-3p	HITS-CLIP	23313552
MIRT698430	hsa-miR-302b-5p	HITS-CLIP	23313552
MIRT698429	hsa-miR-302d-5p	HITS-CLIP	23313552
MIRT698428	hsa-miR-1911-5p	HITS-CLIP	23313552
MIRT698427	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT698426	hsa-miR-5589-3p	HITS-CLIP	23313552
MIRT698425	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT698424	hsa-miR-206	HITS-CLIP	23313552
MIRT698423	hsa-miR-613	HITS-CLIP	23313552
MIRT698422	hsa-miR-1293	HITS-CLIP	23313552
MIRT698421	hsa-miR-4483	HITS-CLIP	23313552
MIRT698420	hsa-miR-876-3p	HITS-CLIP	23313552
MIRT698419	hsa-miR-5087	HITS-CLIP	23313552
MIRT698418	hsa-miR-8068	HITS-CLIP	23313552
MIRT698417	hsa-miR-4775	HITS-CLIP	23313552
MIRT698416	hsa-miR-6798-3p	HITS-CLIP	23313552
MIRT698415	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT698414	hsa-let-7a-3p	HITS-CLIP	23313552
MIRT698413	hsa-let-7b-3p	HITS-CLIP	23313552
MIRT698412	hsa-let-7f-1-3p	HITS-CLIP	23313552
MIRT698411	hsa-miR-98-3p	HITS-CLIP	23313552
MIRT698410	hsa-miR-3686	HITS-CLIP	23313552
MIRT698409	hsa-miR-6505-5p	HITS-CLIP	23313552
MIRT466301	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT466300	hsa-miR-382-5p	PAR-CLIP	23592263
MIRT466299	hsa-miR-3529-3p	PAR-CLIP	23592263
MIRT466298	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT466297	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT466296	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT466295	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT466294	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT466293	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT466292	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT466291	hsa-miR-586	PAR-CLIP	23592263
MIRT466290	hsa-miR-5003-5p	PAR-CLIP	23592263
MIRT466289	hsa-miR-4310	PAR-CLIP	23592263
MIRT466288	hsa-miR-7157-5p	PAR-CLIP	23592263
MIRT466287	hsa-miR-4468	PAR-CLIP	23592263
MIRT466286	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT466285	hsa-miR-107	PAR-CLIP	23592263
MIRT466284	hsa-miR-8070	PAR-CLIP	23592263
MIRT054660	hsa-miR-141-3p	MicroarrayqRT-PCR	35816043
MIRT1427230	hsa-miR-1911	CLIP-seq
MIRT1427231	hsa-miR-300	CLIP-seq
MIRT1427232	hsa-miR-30a	CLIP-seq
MIRT1427233	hsa-miR-30b	CLIP-seq
MIRT1427234	hsa-miR-30c	CLIP-seq
MIRT1427235	hsa-miR-30d	CLIP-seq
MIRT1427236	hsa-miR-30e	CLIP-seq
MIRT1427237	hsa-miR-3606	CLIP-seq
MIRT1427238	hsa-miR-3613-5p	CLIP-seq
MIRT1427239	hsa-miR-381	CLIP-seq
MIRT1427240	hsa-miR-4666-3p	CLIP-seq
MIRT1427241	hsa-miR-668	CLIP-seq
MIRT2349618	hsa-miR-1229	CLIP-seq
MIRT2349619	hsa-miR-1238	CLIP-seq
MIRT2349620	hsa-miR-1304	CLIP-seq
MIRT2349621	hsa-miR-1322	CLIP-seq
MIRT2349622	hsa-miR-1976	CLIP-seq
MIRT2349623	hsa-miR-2052	CLIP-seq
MIRT2349624	hsa-miR-2682	CLIP-seq
MIRT1427232	hsa-miR-30a	CLIP-seq
MIRT1427233	hsa-miR-30b	CLIP-seq
MIRT1427234	hsa-miR-30c	CLIP-seq
MIRT1427235	hsa-miR-30d	CLIP-seq
MIRT1427236	hsa-miR-30e	CLIP-seq
MIRT2349625	hsa-miR-342-3p	CLIP-seq
MIRT1427238	hsa-miR-3613-5p	CLIP-seq
MIRT2349626	hsa-miR-3714	CLIP-seq
MIRT2349627	hsa-miR-4457	CLIP-seq
MIRT2349628	hsa-miR-449c	CLIP-seq
MIRT2349629	hsa-miR-4716-5p	CLIP-seq
MIRT2349630	hsa-miR-4722-3p	CLIP-seq
MIRT2349631	hsa-miR-4728-3p	CLIP-seq
MIRT2349632	hsa-miR-4731-3p	CLIP-seq
MIRT2349633	hsa-miR-4801	CLIP-seq
MIRT1427241	hsa-miR-668	CLIP-seq
MIRT2349619	hsa-miR-1238	CLIP-seq
MIRT2349622	hsa-miR-1976	CLIP-seq
MIRT2349630	hsa-miR-4722-3p	CLIP-seq
MIRT1427241	hsa-miR-668	CLIP-seq
MIRT2643167	hsa-miR-1914	CLIP-seq
MIRT2643168	hsa-miR-3611	CLIP-seq
MIRT2643169	hsa-miR-3913-3p	CLIP-seq
MIRT2643170	hsa-miR-4699-5p	CLIP-seq
MIRT2643171	hsa-miR-4793-5p	CLIP-seq
MIRT2643172	hsa-miR-489	CLIP-seq

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Transcription factor	Regulation	Reference
HNF1A	Repression	18697801

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001825	Process	Blastocyst formation	IEA
GO:0005515	Function	Protein binding	IPI	11102519
GO:0005886	Component	Plasma membrane	IDA	7510285
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
191155	11853	ENSG00000169908

P30408

Protein name

Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1) (Tumor-associated antigen L6)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05805	L6_membrane	1 → 194	L6 membrane protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Sequence

MCYGKCARCIGHSLVGLALLCIAANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLM
LLPAFVFIGLEQDDCCGCCGHENCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPL
CLDSLGQWNYTFASTEGQYLLDTSTWSECTEPKHIVEWNVSLFSILLALGGIEFILCLIQ
VINGVLGGICGFCCSHQQQYDC

Sequence length

202

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (52)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	26709920		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30344751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	21656834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29175458		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22421941, 29384939, 31413629		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20847343, 26464650, 29384939	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary dysplasia	Pubtator	35790551	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	37443145	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	29665316		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37069693, 39251909	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29175458		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26621839, 31142317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	30876464		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26983891, 28528497, 30135139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30135139, 30537927	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	27974706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	27974706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	35835740	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	30045016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipidemias	Hyperlipidemia	Pubtator	30045016	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	36035368	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22088470, 29123978, 29505836		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	31142317	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22421941, 29384939, 31413629		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	27974706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26621839, 31142317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	30876464		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	24285464, 26709920, 27459514, 28368050		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	21656834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29665316, 30344751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29175458		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26089370, 26709920, 27459514, 31598403		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	26089370, 26983891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	22421941, 31413629		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	Pubtator	21569526	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18270265, 21569526, 22421941, 26089370, 26621839, 27459514, 29505836, 29665316, 30301667, 30344751, 30876464, 31142317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30301667, 31142317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oral Submucous Fibrosis	Oral Submucous Fibrosis	BEFREE	25872484		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	30876464		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32149080, 34995016	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	24285464, 26709920, 27459514, 28368050		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	26709920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	28368050	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	21656834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	31983129	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	27974706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29665316, 30344751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	29665316, 34330293	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37443145	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29384939, 31413629		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	29384939	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35480865, 37968767	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TM4SF1 (transmembrane 4 L six family member 1)