Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	404037
Gene name	Hyaluronan and proteoglycan link protein 4
Gene symbol	HAPLN4
Synonyms (NCBI Gene)	BRAL2
Chromosome	19
Chromosome location	19p13.11

150

Show/Hide all (150)

miRTarBase ID	miRNA	Experiments
MIRT1040744	hsa-miR-1	CLIP-seq
MIRT1040745	hsa-miR-1205	CLIP-seq
MIRT1040746	hsa-miR-1231	CLIP-seq
MIRT1040747	hsa-miR-1266	CLIP-seq
MIRT1040748	hsa-miR-1275	CLIP-seq
MIRT1040749	hsa-miR-146b-3p	CLIP-seq
MIRT1040750	hsa-miR-1909	CLIP-seq
MIRT1040751	hsa-miR-198	CLIP-seq
MIRT1040752	hsa-miR-199a-5p	CLIP-seq
MIRT1040753	hsa-miR-199b-5p	CLIP-seq
MIRT1040754	hsa-miR-206	CLIP-seq
MIRT1040755	hsa-miR-2110	CLIP-seq
MIRT1040756	hsa-miR-3120-5p	CLIP-seq
MIRT1040757	hsa-miR-3150a-3p	CLIP-seq
MIRT1040758	hsa-miR-3175	CLIP-seq
MIRT1040759	hsa-miR-3176	CLIP-seq
MIRT1040760	hsa-miR-3179	CLIP-seq
MIRT1040761	hsa-miR-3202	CLIP-seq
MIRT1040762	hsa-miR-339-5p	CLIP-seq
MIRT1040763	hsa-miR-3621	CLIP-seq
MIRT1040764	hsa-miR-3656	CLIP-seq
MIRT1040765	hsa-miR-3664-3p	CLIP-seq
MIRT1040766	hsa-miR-3922-3p	CLIP-seq
MIRT1040767	hsa-miR-4259	CLIP-seq
MIRT1040768	hsa-miR-4270	CLIP-seq
MIRT1040769	hsa-miR-4271	CLIP-seq
MIRT1040770	hsa-miR-4312	CLIP-seq
MIRT1040771	hsa-miR-4418	CLIP-seq
MIRT1040772	hsa-miR-4421	CLIP-seq
MIRT1040773	hsa-miR-4434	CLIP-seq
MIRT1040774	hsa-miR-4435	CLIP-seq
MIRT1040775	hsa-miR-4441	CLIP-seq
MIRT1040776	hsa-miR-4516	CLIP-seq
MIRT1040777	hsa-miR-4518	CLIP-seq
MIRT1040778	hsa-miR-4525	CLIP-seq
MIRT1040779	hsa-miR-4531	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT1040781	hsa-miR-4665-5p	CLIP-seq
MIRT1040782	hsa-miR-4667-5p	CLIP-seq
MIRT1040783	hsa-miR-4688	CLIP-seq
MIRT1040784	hsa-miR-4700-5p	CLIP-seq
MIRT1040785	hsa-miR-4723-5p	CLIP-seq
MIRT1040786	hsa-miR-4725-3p	CLIP-seq
MIRT1040787	hsa-miR-4734	CLIP-seq
MIRT1040788	hsa-miR-4738-3p	CLIP-seq
MIRT1040789	hsa-miR-4747-5p	CLIP-seq
MIRT1040790	hsa-miR-4757-5p	CLIP-seq
MIRT1040791	hsa-miR-486-3p	CLIP-seq
MIRT1040792	hsa-miR-490-5p	CLIP-seq
MIRT1040793	hsa-miR-509-3-5p	CLIP-seq
MIRT1040794	hsa-miR-509-5p	CLIP-seq
MIRT1040795	hsa-miR-571	CLIP-seq
MIRT1040796	hsa-miR-596	CLIP-seq
MIRT1040797	hsa-miR-613	CLIP-seq
MIRT1040798	hsa-miR-625	CLIP-seq
MIRT1040799	hsa-miR-637	CLIP-seq
MIRT1040800	hsa-miR-663b	CLIP-seq
MIRT1040801	hsa-miR-939	CLIP-seq
MIRT1040745	hsa-miR-1205	CLIP-seq
MIRT1040747	hsa-miR-1266	CLIP-seq
MIRT1040750	hsa-miR-1909	CLIP-seq
MIRT1040765	hsa-miR-3664-3p	CLIP-seq
MIRT1040771	hsa-miR-4418	CLIP-seq
MIRT1040777	hsa-miR-4518	CLIP-seq
MIRT2008516	hsa-miR-4651	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT2008517	hsa-miR-4695-5p	CLIP-seq
MIRT1040788	hsa-miR-4738-3p	CLIP-seq
MIRT2008518	hsa-miR-4802-5p	CLIP-seq
MIRT1040793	hsa-miR-509-3-5p	CLIP-seq
MIRT1040794	hsa-miR-509-5p	CLIP-seq
MIRT2008519	hsa-miR-608	CLIP-seq
MIRT1040799	hsa-miR-637	CLIP-seq
MIRT2008520	hsa-miR-661	CLIP-seq
MIRT2008521	hsa-miR-662	CLIP-seq
MIRT2240967	hsa-miR-1207-3p	CLIP-seq
MIRT2240968	hsa-miR-3145-5p	CLIP-seq
MIRT2240969	hsa-miR-3155	CLIP-seq
MIRT2240970	hsa-miR-3155b	CLIP-seq
MIRT2240971	hsa-miR-3616-3p	CLIP-seq
MIRT2240972	hsa-miR-409-5p	CLIP-seq
MIRT1040774	hsa-miR-4435	CLIP-seq
MIRT2240973	hsa-miR-4446-3p	CLIP-seq
MIRT2240974	hsa-miR-4471	CLIP-seq
MIRT2240975	hsa-miR-4492	CLIP-seq
MIRT2240976	hsa-miR-4498	CLIP-seq
MIRT2240977	hsa-miR-4685-5p	CLIP-seq
MIRT2240978	hsa-miR-4709-5p	CLIP-seq
MIRT2240979	hsa-miR-4710	CLIP-seq
MIRT2240980	hsa-miR-4721	CLIP-seq
MIRT2240981	hsa-miR-4755-3p	CLIP-seq
MIRT2240982	hsa-miR-484	CLIP-seq
MIRT2240983	hsa-miR-615-5p	CLIP-seq
MIRT2240984	hsa-miR-762	CLIP-seq
MIRT2388900	hsa-miR-150	CLIP-seq
MIRT1040758	hsa-miR-3175	CLIP-seq
MIRT2388901	hsa-miR-4713-5p	CLIP-seq
MIRT2388902	hsa-miR-4716-3p	CLIP-seq
MIRT1040785	hsa-miR-4723-5p	CLIP-seq
MIRT2388903	hsa-miR-4779	CLIP-seq
MIRT2388904	hsa-miR-532-3p	CLIP-seq
MIRT2240983	hsa-miR-615-5p	CLIP-seq
MIRT2008521	hsa-miR-662	CLIP-seq
MIRT2388905	hsa-miR-765	CLIP-seq
MIRT2450956	hsa-miR-122	CLIP-seq
MIRT1040746	hsa-miR-1231	CLIP-seq
MIRT2450957	hsa-miR-125a-3p	CLIP-seq
MIRT1040749	hsa-miR-146b-3p	CLIP-seq
MIRT2450958	hsa-miR-2861	CLIP-seq
MIRT1040756	hsa-miR-3120-5p	CLIP-seq
MIRT2450959	hsa-miR-3144-5p	CLIP-seq
MIRT2450960	hsa-miR-3150b-3p	CLIP-seq
MIRT2450961	hsa-miR-3191	CLIP-seq
MIRT1040762	hsa-miR-339-5p	CLIP-seq
MIRT1040772	hsa-miR-4421	CLIP-seq
MIRT2450962	hsa-miR-4481	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT1040782	hsa-miR-4667-5p	CLIP-seq
MIRT2450963	hsa-miR-4689	CLIP-seq
MIRT1040784	hsa-miR-4700-5p	CLIP-seq
MIRT2240979	hsa-miR-4710	CLIP-seq
MIRT2388902	hsa-miR-4716-3p	CLIP-seq
MIRT1040785	hsa-miR-4723-5p	CLIP-seq
MIRT2450964	hsa-miR-4745-5p	CLIP-seq
MIRT2388903	hsa-miR-4779	CLIP-seq
MIRT2450965	hsa-miR-4784	CLIP-seq
MIRT2008520	hsa-miR-661	CLIP-seq
MIRT2388905	hsa-miR-765	CLIP-seq
MIRT2450956	hsa-miR-122	CLIP-seq
MIRT2450958	hsa-miR-2861	CLIP-seq
MIRT2450959	hsa-miR-3144-5p	CLIP-seq
MIRT2450961	hsa-miR-3191	CLIP-seq
MIRT2450962	hsa-miR-4481	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT1040782	hsa-miR-4667-5p	CLIP-seq
MIRT1040784	hsa-miR-4700-5p	CLIP-seq
MIRT2450964	hsa-miR-4745-5p	CLIP-seq
MIRT2008520	hsa-miR-661	CLIP-seq
MIRT2544478	hsa-miR-1204	CLIP-seq
MIRT2544479	hsa-miR-361-3p	CLIP-seq
MIRT2544480	hsa-miR-4648	CLIP-seq
MIRT2008516	hsa-miR-4651	CLIP-seq
MIRT2008519	hsa-miR-608	CLIP-seq
MIRT1040800	hsa-miR-663b	CLIP-seq
MIRT2544478	hsa-miR-1204	CLIP-seq
MIRT2544479	hsa-miR-361-3p	CLIP-seq
MIRT2544480	hsa-miR-4648	CLIP-seq
MIRT2008516	hsa-miR-4651	CLIP-seq
MIRT2008519	hsa-miR-608	CLIP-seq
MIRT1040800	hsa-miR-663b	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence
GO:0001501	Process	Skeletal system development	IBA
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0045202	Component	Synapse	IBA
GO:0051932	Process	Synaptic transmission, GABAergic	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	ISS
GO:0072534	Component	Perineuronal net	IBA
GO:0072534	Component	Perineuronal net	IEA
GO:0072534	Component	Perineuronal net	ISS
GO:0150043	Function	Structural constituent of synapse-associated extracellular matrix	IEA
GO:0150043	Function	Structural constituent of synapse-associated extracellular matrix	ISS
GO:1904862	Process	Inhibitory synapse assembly	IEA
GO:1904862	Process	Inhibitory synapse assembly	ISS

MIM	HGNC	e!Ensembl
619710	31357	ENSG00000187664

Q86UW8

Protein name

Hyaluronan and proteoglycan link protein 4 (Brain link protein 2)

Protein function

Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity). Contr

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	51 → 159	Immunoglobulin V-set domain	Domain
PF00193	Xlink	163 → 267	Extracellular link domain	Domain
PF00193	Xlink	274 → 364	Extracellular link domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in brain. {ECO:0000269|PubMed:12663660}.

Sequence

MVCARAALGPGALWAAAWGVLLLTAPAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHR
GGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQG
DGPGDASLVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPRGGRYKLTFAE
AQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVNRPREPCGGLGGTGSAG
GGGDANGGLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAV
AKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSLGFPDATRRLFG
VYCYRAPGAPDPAPGGWGWGWAGGGGWAGGARDPAAWTPLHV

Sequence length

402

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC EYE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL VARICES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PORTAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	37418754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	37418754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	19633295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	19633295	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	29915430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19633295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	20950796		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	37418754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HAPLN4 (hyaluronan and proteoglycan link protein 4)