Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	401494
Gene name	3-hydroxyacyl-CoA dehydratase 4
Gene symbol	HACD4
Synonyms (NCBI Gene)	PTPLAD2
Chromosome	9
Chromosome location	9p21.3

194

Show/Hide all (194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT708724	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708723	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708722	hsa-miR-5193	HITS-CLIP	19536157
MIRT708721	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT708718	hsa-miR-6835-5p	HITS-CLIP	19536157
MIRT708717	hsa-miR-6752-5p	HITS-CLIP	19536157
MIRT708716	hsa-miR-6842-5p	HITS-CLIP	19536157
MIRT708715	hsa-miR-7110-5p	HITS-CLIP	19536157
MIRT708710	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708709	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708708	hsa-miR-6751-5p	HITS-CLIP	19536157
MIRT708707	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT716121	hsa-miR-2115-3p	HITS-CLIP	19536157
MIRT716120	hsa-miR-10b-3p	HITS-CLIP	19536157
MIRT716119	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT716118	hsa-miR-3612	HITS-CLIP	19536157
MIRT716117	hsa-miR-650	HITS-CLIP	19536157
MIRT716116	hsa-miR-4443	HITS-CLIP	19536157
MIRT716115	hsa-miR-6515-5p	HITS-CLIP	19536157
MIRT708725	hsa-miR-3675-5p	HITS-CLIP	19536157
MIRT514860	hsa-miR-6890-5p	HITS-CLIP	19536157
MIRT708724	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708723	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708722	hsa-miR-5193	HITS-CLIP	19536157
MIRT708721	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT708720	hsa-miR-190a-5p	HITS-CLIP	19536157
MIRT708719	hsa-miR-190b	HITS-CLIP	19536157
MIRT708718	hsa-miR-6835-5p	HITS-CLIP	19536157
MIRT708717	hsa-miR-6752-5p	HITS-CLIP	19536157
MIRT708716	hsa-miR-6842-5p	HITS-CLIP	19536157
MIRT708715	hsa-miR-7110-5p	HITS-CLIP	19536157
MIRT708714	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT708713	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT708712	hsa-miR-3689e	HITS-CLIP	19536157
MIRT708711	hsa-miR-3689f	HITS-CLIP	19536157
MIRT708710	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708709	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708708	hsa-miR-6751-5p	HITS-CLIP	19536157
MIRT708707	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT643088	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT643087	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT643086	hsa-miR-5693	HITS-CLIP	23824327
MIRT643085	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT643084	hsa-miR-3135b	HITS-CLIP	23824327
MIRT643083	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT643082	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT643081	hsa-miR-4284	HITS-CLIP	23824327
MIRT643080	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT643079	hsa-miR-3652	HITS-CLIP	23824327
MIRT643077	hsa-miR-4430	HITS-CLIP	23824327
MIRT643078	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT643076	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT643075	hsa-miR-5698	HITS-CLIP	23824327
MIRT629307	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629306	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT449201	hsa-miR-4635	HITS-CLIP	23824327
MIRT629305	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT629304	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT629303	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT629302	hsa-miR-6131	HITS-CLIP	23824327
MIRT629301	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT629300	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT629299	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT514861	hsa-miR-5680	PAR-CLIP	21572407
MIRT514860	hsa-miR-6890-5p	PAR-CLIP	21572407
MIRT514859	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT514858	hsa-miR-4716-5p	PAR-CLIP	21572407
MIRT541728	hsa-miR-4755-3p	PAR-CLIP	21572407
MIRT514857	hsa-miR-193b-5p	PAR-CLIP	21572407
MIRT514855	hsa-miR-197-3p	PAR-CLIP	21572407
MIRT514854	hsa-miR-548s	PAR-CLIP	21572407
MIRT514853	hsa-miR-4701-5p	PAR-CLIP	21572407
MIRT514852	hsa-miR-588	PAR-CLIP	21572407
MIRT514851	hsa-miR-4435	PAR-CLIP	21572407
MIRT514849	hsa-miR-3187-3p	PAR-CLIP	21572407
MIRT514850	hsa-miR-3170	PAR-CLIP	21572407
MIRT514848	hsa-miR-6855-5p	PAR-CLIP	21572407
MIRT541727	hsa-miR-5096	PAR-CLIP	21572407
MIRT514861	hsa-miR-5680	PAR-CLIP	23446348
MIRT514856	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT514860	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT514859	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT514858	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT514857	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT514856	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT514855	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT514854	hsa-miR-548s	PAR-CLIP	23446348
MIRT514853	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT514852	hsa-miR-588	PAR-CLIP	23446348
MIRT514851	hsa-miR-4435	PAR-CLIP	23446348
MIRT514849	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT514850	hsa-miR-3170	PAR-CLIP	23446348
MIRT514848	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT449203	hsa-miR-4311	PAR-CLIP	22100165
MIRT449202	hsa-miR-3123	PAR-CLIP	22100165
MIRT449201	hsa-miR-4635	PAR-CLIP	22100165
MIRT449200	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT740384	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT740385	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT740386	hsa-miR-5193	HITS-CLIP	19536157
MIRT740387	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT740388	hsa-miR-6835-5p	HITS-CLIP	19536157
MIRT740389	hsa-miR-6752-5p	HITS-CLIP	19536157
MIRT740390	hsa-miR-6842-5p	HITS-CLIP	19536157
MIRT740391	hsa-miR-7110-5p	HITS-CLIP	19536157
MIRT740392	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT740393	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT740394	hsa-miR-6751-5p	HITS-CLIP	19536157
MIRT740395	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT740499	hsa-miR-2115-3p	HITS-CLIP	19536157
MIRT740500	hsa-miR-10b-3p	HITS-CLIP	19536157
MIRT740501	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT740502	hsa-miR-3612	HITS-CLIP	19536157
MIRT740503	hsa-miR-650	HITS-CLIP	19536157
MIRT740504	hsa-miR-4443	HITS-CLIP	19536157
MIRT740505	hsa-miR-6515-5p	HITS-CLIP	19536157
MIRT740649	hsa-miR-3675-5p	HITS-CLIP	19536157
MIRT740650	hsa-miR-6890-5p	HITS-CLIP	19536157
MIRT740384	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT740385	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT740386	hsa-miR-5193	HITS-CLIP	19536157
MIRT740387	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT740651	hsa-miR-190a-5p	HITS-CLIP	19536157
MIRT740652	hsa-miR-190b	HITS-CLIP	19536157
MIRT740388	hsa-miR-6835-5p	HITS-CLIP	19536157
MIRT740389	hsa-miR-6752-5p	HITS-CLIP	19536157
MIRT740390	hsa-miR-6842-5p	HITS-CLIP	19536157
MIRT740391	hsa-miR-7110-5p	HITS-CLIP	19536157
MIRT740653	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT740654	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT740655	hsa-miR-3689e	HITS-CLIP	19536157
MIRT740656	hsa-miR-3689f	HITS-CLIP	19536157
MIRT740392	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT740393	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT740394	hsa-miR-6751-5p	HITS-CLIP	19536157
MIRT740395	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT742170	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT742171	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT742172	hsa-miR-5693	HITS-CLIP	23824327
MIRT742173	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT742174	hsa-miR-3135b	HITS-CLIP	23824327
MIRT742175	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT742176	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT742177	hsa-miR-4284	HITS-CLIP	23824327
MIRT742178	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT742179	hsa-miR-3652	HITS-CLIP	23824327
MIRT742180	hsa-miR-4430	HITS-CLIP	23824327
MIRT742181	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT742182	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT742183	hsa-miR-5698	HITS-CLIP	23824327
MIRT742393	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT742394	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT742395	hsa-miR-4635	HITS-CLIP	23824327
MIRT742396	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT742397	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT742398	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT742399	hsa-miR-6131	HITS-CLIP	23824327
MIRT742400	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT742401	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT742402	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT754378	hsa-miR-5680	PAR-CLIP	21572407
MIRT740650	hsa-miR-6890-5p	PAR-CLIP	21572407
MIRT754379	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT754380	hsa-miR-4716-5p	PAR-CLIP	21572407
MIRT754381	hsa-miR-4755-3p	PAR-CLIP	21572407
MIRT754382	hsa-miR-193b-5p	PAR-CLIP	21572407
MIRT754383	hsa-miR-197-3p	PAR-CLIP	21572407
MIRT754384	hsa-miR-548s	PAR-CLIP	21572407
MIRT754385	hsa-miR-4701-5p	PAR-CLIP	21572407
MIRT754386	hsa-miR-588	PAR-CLIP	21572407
MIRT754387	hsa-miR-4435	PAR-CLIP	21572407
MIRT754388	hsa-miR-3187-3p	PAR-CLIP	21572407
MIRT754389	hsa-miR-3170	PAR-CLIP	21572407
MIRT754390	hsa-miR-6855-5p	PAR-CLIP	21572407
MIRT754391	hsa-miR-5096	PAR-CLIP	21572407
MIRT754378	hsa-miR-5680	PAR-CLIP	23446348
MIRT754667	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT740650	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT754379	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT754380	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT754382	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT754667	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT754383	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT754384	hsa-miR-548s	PAR-CLIP	23446348
MIRT754385	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT754386	hsa-miR-588	PAR-CLIP	23446348
MIRT754387	hsa-miR-4435	PAR-CLIP	23446348
MIRT754388	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT754389	hsa-miR-3170	PAR-CLIP	23446348
MIRT754390	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT755243	hsa-miR-4311	PAR-CLIP	22100165
MIRT755244	hsa-miR-3123	PAR-CLIP	22100165
MIRT742395	hsa-miR-4635	PAR-CLIP	22100165
MIRT755245	hsa-miR-488-3p	PAR-CLIP	22100165

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IDA	18554506
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0018812	Function	3-hydroxyacyl-CoA dehydratase activity	IBA
GO:0019899	Function	Enzyme binding	IDA	18554506
GO:0030148	Process	Sphingolipid biosynthetic process	IBA
GO:0030497	Process	Fatty acid elongation	IBA
GO:0030497	Process	Fatty acid elongation	IDA	18554506
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IBA
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IDA	18554506
GO:0102158	Function	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IDA	18554506
GO:0102158	Function	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IEA

MIM	HGNC	e!Ensembl
615941	20920	ENSG00000188921

Q5VWC8

Protein name

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 4) (HACD4) (Protein-tyrosine phosphatase-like A domain-containing protein 2)

Protein function

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cyc

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04387	PTPLA	65 → 224	Protein tyrosine phosphatase-like protein, PTPLA	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta. {ECO:0000269|PubMed:18554506}.

Sequence

MGPLALPAWLQPRYRKNAYLFIYYLIQFCGHSWIFTNMTVRFFSFGKDSMVDTFYAIGLV
MRLCQSVSLLELLHIYVGIESNHLLPRFLQLTERIIILFVVITSQEEVQEKYVVCVLFVF
WNLLDMVRYTYSMLSVIGISYAVLTWLSQTLWMPIYPLCVLAEAFAIYQSLPYFESFGTY
STKLPFDLSIYFPYVLKIYLMMLFIGMYFTYSHLYSERRDILGIFPIKKKKM

Sequence length

232

Interactions

View interactions

	KEGG		Reactome
	Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism		Synthesis of very long-chain fatty acyl-CoAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ERECTILE DYSFUNCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anodontia	Anodontia	Pubtator	28803425	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	29031776		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	29031776		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28803425	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24530685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	33116468	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HACD4 (3-hydroxyacyl-CoA dehydratase 4)