PAIP2B (poly(A) binding protein interacting protein 2B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 400961 |
| Gene name | Poly(A) binding protein interacting protein 2B |
| Gene symbol | PAIP2B |
| Synonyms (NCBI Gene) |
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| Chromosome | 2 |
| Chromosome location | 2p13.3 |
| Summary | Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) t |
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miRNA
miRNA information provided by mirtarbase database.
426
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9ULR5 | ||||||||||
| Protein name | Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B) | ||||||||||
| Protein function | Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis. {ECO:0000269|PubMed:16804161}. | ||||||||||
| Sequence |
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| Sequence length | 123 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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